Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer.

Abstract:

BACKGROUND:Girdin was identified as a novel Akt substrate that contributes to a positive feedback loop between Girdin and Akt. Although several recent studies have demonstrated that Girdin is involved in tumor metastasis, the clinical implications of Girdin in breast cancer remain unclear. METHODS:To retrospectively evaluate the prognostic value of Girdin in breast cancer, we performed an immunohistochemistry screening for Girdin using tissue microarrays constructed from 250 patients who were histologically confirmed as having invasive ductal breast carcinoma at the Fudan University Shanghai Cancer Center. RESULTS:Our results demonstrated that the levels of Girdin in different subcellular distributions, including Girdin in the nucleus (GN) and the cytoplasm (GC) were each associated with the clinical parameters of breast cancer, including phospho-Akt (S473) [p = 0.014 for GN], phospho-Akt (T308) [p = 0.045 for GC], estrogen receptor (ER) [p = 0.012 for GN and p = 0.004 for GC], progesterone receptor (p = 0.028 for GC) and human epidermal growth factor receptor 2 status (p = 0.004 for GC). Moreover, we showed that elevated expression of GN indicated a worse disease-free survival (p = 0.032) and overall survival (p = 0.011) exclusively in the ER-positive breast cancer population. CONCLUSIONS:Cumulatively, our findings suggest that GN might serve as an important prognostic factor for ER-positive breast carcinoma.

journal_name

Ann Surg Oncol

authors

Peng WT,Hu X,Yao L,Jiang YZ,Shao ZM

doi

10.1245/s10434-014-3746-y

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

S648-56

eissn

1068-9265

issn

1534-4681

journal_volume

21 Suppl 4

pub_type

杂志文章
  • Axillary Response in Patients Undergoing Neoadjuvant Endocrine Treatment for Node-Positive Breast Cancer: Systematic Literature Review and NCDB Analysis.

    abstract:BACKGROUND:Several studies have proven that neoadjuvant endocrine therapy (NET) has a similar beneficial therapeutic effect in estrogen-positive (ER+) breast cancer (BC) with improved breast conservation rate in patients undergoing NET versus neoadjuvant chemotherapy (NAC). The impact of axillary complete pathologic re...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08905-9

    authors: Stafford A,Williams A,Edmiston K,Cocilovo C,Cohen R,Bruce S,Yoon-Flannery K,De La Cruz L

    更新日期:2020-11-01 00:00:00

  • Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level.

    abstract:AIM:We evaluated preoperative serum carcinoembryonic antigen (CEA) as a prognostic factor for colorectal cancer and determined when surveillance of this marker was useful. METHODS:Serum CEA was measured preoperatively in 1,263 patients who underwent curative resection for colorectal cancer at 3-month intervals for the...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0625-z

    authors: Park IJ,Choi GS,Lim KH,Kang BM,Jun SH

    更新日期:2009-11-01 00:00:00

  • mTHPC-mediated photodynamic therapy of early stage oral squamous cell carcinoma: a comparison to surgical treatment.

    abstract:BACKGROUND:mTHPC-mediated photodynamic therapy (PDT) is used for treatment of early head and neck squamous cell carcinoma. This study is a retrospective comparison of PDT with transoral surgery in the treatment of early primary squamous cell carcinoma of the oral cavity/oropharynx. METHODS:PDT data were retrieved from...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-013-3006-6

    authors: de Visscher SA,Melchers LJ,Dijkstra PU,Karakullukcu B,Tan IB,Hopper C,Roodenburg JL,Witjes MJ

    更新日期:2013-09-01 00:00:00

  • Endoscopic Retrograde Biliary Drainage Causes Intra-Abdominal Abscess in Pancreaticoduodenectomy Patients: An Important But Neglected Risk Factor.

    abstract:BACKGROUND:Patients with periampullary cancer frequently suffer obstructive jaundice and commonly require preoperative biliary drainage (PBD) for relief and to avoid related complications. Although research has established a correlation between PBD and surgical wound infection, the impact of PBD on major infectious com...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07189-y

    authors: Wu JM,Ho TW,Yen HH,Wu CH,Kuo TC,Yang CY,Tien YW

    更新日期:2019-04-01 00:00:00

  • Transcutaneously tunneled central venous lines in cancer patients: an analysis of device-related morbidity factors based on prospective data collection.

    abstract:BACKGROUND:Long-term transcutaneous tunneled central venous catheters are frequently placed in cancer patients, accounting for significant costs and morbidity. Factors influencing outcome, though, are poorly studied. METHODS:Between June 1991 and June 1993, 923 central venous tunneled catheters were placed in 791 pati...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-000-0441-y

    authors: Schwarz RE,Coit DG,Groeger JS

    更新日期:2000-07-01 00:00:00

  • Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study.

    abstract:BACKGROUND/AIM:Perioperative administration of immunoenriched diets attenuates the perioperative inflammatory response and reduces postoperative infection complications. However, many questions still remain unresolved in this area, such as the length of diet administration, diet composition, and the mechanisms involved...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-007-9407-7

    authors: Giger U,Büchler M,Farhadi J,Berger D,Hüsler J,Schneider H,Krähenbühl S,Krähenbühl L

    更新日期:2007-10-01 00:00:00

  • A prospective study of false-positive diagnosis of micrometastatic cells in the sentinel lymph nodes in colorectal cancer.

    abstract:INTRODUCTION:Sentinel lymph node mapping (SLNM) with multilevel sections (MLS) and cytokeratin immunohistochemistry (CK-IHC) of sentinel lymph nodes (SLNs) upstages 15-20% of patients (pts). False-positive SLNs occur in breast cancer due to mechanical transport of cells during mapping procedures, or to pre-existing ben...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0497-2

    authors: Wiese D,Saha S,Yestrepsky B,Korant A,Sirop S

    更新日期:2009-08-01 00:00:00

  • Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer.

    abstract:BACKGROUND:The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze cl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5448-0

    authors: Kim HW,Kim JH,Lim BJ,Kim H,Kim H,Park JJ,Youn YH,Park H,Noh SH,Kim JW,Choi SH

    更新日期:2016-12-01 00:00:00

  • Should adjuvant therapy remain the standard of care for patients with resected adenocarcinoma of the pancreas?

    abstract::Adenocarcinoma of the pancreas continues to be a formidable disease. In the United States, patients who have had resected disease are generally offered adjuvant chemoradiation. The current National Comprehensive Cancer Network practice guidelines uniformly support this practice. We reviewed seven selected series to ev...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/aso.2003.06.015

    authors: Chu QD,Khushalani N,Javle MM,Douglass HO Jr,Gibbs JF

    更新日期:2003-06-01 00:00:00

  • Toxicity of oxaliplatin plus fluorouracil/leucovorin adjuvant chemotherapy in elderly patients with stage III colon cancer: a population-based study.

    abstract:BACKGROUND:Results concerning the side effects of oxaliplatin associated with fluorouracil and leucovorin (FOLFOX) in older patients are controversial. The objective of this study was to assess the use and the toxicity of FOLFOX in patients aged 70 years and older as administered in current practice. METHODS:Among 305...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3438-z

    authors: Hamza S,Bouvier AM,Rollot F,Lepage C,Faivre J,Bedenne L

    更新日期:2014-08-01 00:00:00

  • Simultaneous indocyanine green and (99m)Tc-antimony sulfur colloid-guided laparoscopic sentinel basin dissection for gastric cancer.

    abstract:BACKGROUND:There are few reports on a dual dye and isotope approach using laparoscopy in gastric cancer sentinel node mapping. The aim of this study is to evaluate the feasibility of laparoscopic sentinel basin dissection for gastric cancer using simultaneous indocyanine green (ICG) and (99m)Tc-antimony sulfur colloid ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1221-y

    authors: Park DJ,Kim HH,Park YS,Lee HS,Lee WW,Lee HJ,Yang HK

    更新日期:2011-01-01 00:00:00

  • Tumor-associated macrophages promote oral cancer progression through activation of the Axl signaling pathway.

    abstract:BACKGROUND:Recent studies suggest that tumor-associated macrophages (TAMs) promote tumor growth and metastasis. Our previous report demonstrated that Axl signaling promotes carcinogenesis and progression of oral squamous cell carcinoma (OSCC). This study aims to test the potential involvement of growth arrest-specific ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3400-0

    authors: Lee CH,Liu SY,Chou KC,Yeh CT,Shiah SG,Huang RY,Cheng JC,Yen CY,Shieh YS

    更新日期:2014-03-01 00:00:00

  • Composite pelvic exenteration: is it worthwhile?

    abstract:BACKGROUND:In locally advanced pelvic cancer, tumor fixation to the bony pelvis is regarded as unresectable and often inoperable. Few data exist regarding the futility or utility of pelvic exenteration with en bloc resection of involved portions of the bony pelvis. METHODS:Thirty-four of 625 patients undergoing radica...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02524342

    authors: Lopez MJ,Luna-Pérez P

    更新日期:2004-01-01 00:00:00

  • Long-Term Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery.

    abstract:BACKGROUND:Postoperative complications are associated with poor cancer-specific survival in various types of cancer surgery. Recent studies suggest that systemic inflammation induced by surgical trauma can accelerate the adhesion of circulating tumor cells to the vascular endothelium of distant organs, resulting in ear...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5655-8

    authors: Nojiri T,Hamasaki T,Inoue M,Shintani Y,Takeuchi Y,Maeda H,Okumura M

    更新日期:2017-04-01 00:00:00

  • Postoperative Lower Extremity Edema in Patients with Primary Endometrial Cancer.

    abstract:PURPOSE:The goal of this study was to investigate clinical manifestations of lower extremity edema (LEE) after lymph node dissection in patients with primary endometrial cancer. METHODS:Women with primary endometrial cancer who underwent staging surgery between November 2001 and March 2011 were included in the study. ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4613-1

    authors: Bae HS,Lim MC,Lee JS,Lee Y,Nam BH,Seo SS,Kang S,Chung SH,Kim JY,Park SY

    更新日期:2016-01-01 00:00:00

  • Workload Differentiates Breast Surgical Procedures: NSM Associated with Higher Workload Demand than SSM.

    abstract:BACKGROUND:Breast surgery has evolved with more focus on improving cosmetic outcomes, which requires increased operative time and technical complexity. Implications of these technical advances in surgery for the surgeon are unclear, but they may increase intraoperative demands, both mentally and physically. We prospect...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08159-0

    authors: Hallbeck MS,Law KE,Lowndes BR,Linden AR,Morrow M,Blocker RC,Cain SM,Degnim AC,Hieken TJ,Jakub JW,Racz JM,Farley DR,Nelson H,Boughey JC

    更新日期:2020-05-01 00:00:00

  • Is There a Correlation Between Clinical Complete Response and Pathological Complete Response After Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Cancer?

    abstract:OBJECTIVE:The aim of this study was to investigate the correlation between clinical complete response (cCR) and pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (CRT) for esophageal squamous cell cancer (ESCC). METHODS:Between May 2001 and April 2013, a total of 158 patients with thoracic ESCC tr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4764-0

    authors: Liu SL,Xi M,Yang H,Yang YD,Wu YJ,Zhao L,Zhang P,Luo LL,Liu MZ

    更新日期:2016-01-01 00:00:00

  • STC2: a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma.

    abstract:BACKGROUND:We sought to identify genes associated with the progression and metastasis of esophageal squamous-cell cancer by comparing the expression profiles of normal, primary cancer, and metastatic cancer cells isolated with laser microdissection. METHODS:Oligo microarray analysis identified several lymph node-speci...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1271-1

    authors: Kita Y,Mimori K,Iwatsuki M,Yokobori T,Ieta K,Tanaka F,Ishii H,Okumura H,Natsugoe S,Mori M

    更新日期:2011-01-01 00:00:00

  • Pleural extension of mucinous tumor in patients with pseudomyxoma peritonei syndrome.

    abstract:BACKGROUND:Pseudomyxoma peritonei syndrome is a rare disease arising from perforation of an adenoma of the appendix. The syndrome is characterized by progressive accumulation of mucinous fluid and tumor within the abdomen and pelvis. Although this tumor is only superficially invasive and does not metastasize, it is a f...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02523654

    authors: Pestieau SR,Esquivel J,Sugarbaker PH

    更新日期:2000-04-01 00:00:00

  • Sentinel Lymph Node Biopsy in Thin Cutaneous Melanoma: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Most patients with melanoma have a thin (≤1.00 mm) lesion. There is uncertainty as to which patients with thin melanoma should undergo sentinel lymph node (SN) biopsy. We sought to quantify the proportion of SN metastases in patients with thin melanoma and to determine the pooled effect of high-risk features...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-016-5137-z

    authors: Cordeiro E,Gervais MK,Shah PS,Look Hong NJ,Wright FC

    更新日期:2016-12-01 00:00:00

  • Parietal peritonectomy.

    abstract::Parietal peritonectomy is an initial part of cytoreductive surgery in patients with peritoneal surface malignancy. After this dissection, the necessary visceral resections, other peritonectomy procedures, and perioperative hyperthermic chemotherapy are administered. The parietal peritoneum is an immobile portion of th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2229-2

    authors: Sugarbaker PH

    更新日期:2012-04-01 00:00:00

  • Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time Trends During the Past 15 years.

    abstract:BACKGROUND:This study aimed to investigate changes in treatment strategy and outcome for patients with primary retroperitoneal sarcoma (RPS) undergoing resection at referral centers during a recent period. METHODS:The study enrolled consecutive adult patients with primary non-metastatic RPS who underwent resection wit...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09065-6

    authors: Callegaro D,Raut CP,Ng D,Strauss DC,Honoré C,Stoeckle E,Bonvalot S,Haas RL,Vassos N,Conti L,Gladdy RA,Fairweather M,van Houdt W,Schrage Y,van Coevorden F,Rutkowski P,Miceli R,Gronchi A,Swallow CJ

    更新日期:2020-10-18 00:00:00

  • Strategies to Increase the Resectability of Patients with Colorectal Liver Metastases: A Multi-center Case-Match Analysis of ALPPS and Conventional Two-Stage Hepatectomy.

    abstract:BACKGROUND:Two-stage hepatectomy (TSH) is well established for the treatment of patients who have colorectal cancer liver metastases (CRLM) with a small liver remnant. The technique of associating liver partitioning and portal vein occlusion for staged hepatectomy (ALPPS) has been advocated as a novel tool to increase ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-014-4291-4

    authors: Ratti F,Schadde E,Masetti M,Massani M,Zanello M,Serenari M,Cipriani F,Bonariol L,Bassi N,Aldrighetti L,Jovine E

    更新日期:2015-01-01 00:00:00

  • Pure laparoscopic right hepatectomy with the hanging maneuver for multiple hepatocellular adenomas.

    abstract::A 54-year-old woman with multiple telangiectatic hepatocellular adenoma without degeneration (>5 cm) underwent laparoscopic right hepatectomy with the hanging maneuver. The patient was installed in the supine position with the legs spread apart. Five trocars were used for the intervention. The liver hanging maneuver w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3809-0

    authors: Dokmak S,Ben Safta Y,Ftériche FS,Aussilhou B,Belghiti J

    更新日期:2014-11-01 00:00:00

  • Lumpectomy closure technique does not affect dosimetry in patients undergoing external-beam-based accelerated partial breast irradiation.

    abstract:BACKGROUND:During the breast lumpectomy procedure, surgeons traditionally elect to use either a superficial or full-thickness closure when sealing the wound depending on surgeon preference as well as desired outcomes. The purpose of this study was to examine dosimetric endpoints in patients with superficial versus full...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2775-7

    authors: Shaikh T,Narra V,Goyal S,Ahlawat S,Kirstein L,Kearney T,Haffty BG,Khan AJ

    更新日期:2013-04-01 00:00:00

  • Lobe-Specific Lymph Node Dissection for Clinical Early-Stage (cIA) Peripheral Non-small Cell Lung Cancer Patients: What and How?

    abstract:OBJECTIVE:We investigated the possible lobe-specific lymph node (LN) metastasis pattern of early-stage peripheral non-small cell lung cancers (NSCLC) and define the extent of lobe-specific LN dissection for them. METHODS:We retrospectively collected clinical data of patients undergoing lobectomy or segmentectomy with ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07926-3

    authors: Deng HY,Zhou J,Wang RL,Jiang R,Zhu DX,Tang XJ,Zhou Q

    更新日期:2020-02-01 00:00:00

  • Malnutrition and Perioperative Nutritional Support in Retroperitoneal Sarcoma Patients: Results from a Prospective Study.

    abstract:INTRODUCTION:Retroperitoneal soft tissue sarcomas (RPSs) are mesenchymal neoplasms. The prevalence of protein energetic malnutrition (PEM) and its impact in RPS patients who were candidates for surgery is unknown. MATERIALS AND METHODS:A prospective feasibility study enrolled 35 patients with primary RPS who were cand...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08121-0

    authors: Previtali P,Fiore M,Colombo J,Arendar I,Fumagalli L,Pizzocri M,Colombo C,Rampello NN,Mariani L,Gronchi A,Codazzi D

    更新日期:2020-06-01 00:00:00

  • Robot versus laparoscopic gastrectomy for cancer by an experienced surgeon: comparisons of surgery, complications, and surgical stress.

    abstract:BACKGROUND:No previous robotic studies present an equivalent surgical quality comparison in an experienced setting for gastric cancer. In addition, a reliable postoperative complication assessment is needed to accurately evaluate surgical outcomes. METHODS:After 20 cases of robotic-assisted gastrectomy (RAG), a total ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2679-6

    authors: Hyun MH,Lee CH,Kwon YJ,Cho SI,Jang YJ,Kim DH,Kim JH,Park SH,Mok YJ,Park SS

    更新日期:2013-04-01 00:00:00

  • ROS1 receptor tyrosine kinase, a druggable target, is frequently overexpressed in non-small cell lung carcinomas via genetic and epigenetic mechanisms.

    abstract:BACKGROUND:Microarray analyses have revealed significantly elevated expression of the proto-oncogene ROS1 receptor tyrosine kinase in 20-30% of non-small cell lung carcinomas (NSCLC). Selective and potent ROS1 kinase inhibitors have recently been developed and oncogenic rearrangement of ROS1 in NSCLC identified. METHO...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2553-6

    authors: Lee HJ,Seol HS,Kim JY,Chun SM,Suh YA,Park YS,Kim SW,Choi CM,Park SI,Kim DK,Kim YH,Jang SJ

    更新日期:2013-01-01 00:00:00

  • Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis.

    abstract:BACKGROUND:COX inhibitors and beta-blockers were recently suggested to reduce cancer progression through inhibition of tumor proliferation and growth factor secretion, induction of tumor apoptosis, and prevention of cellular immune suppression during the critical perioperative period. Here we evaluated the perioperativ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9890-5

    authors: Benish M,Bartal I,Goldfarb Y,Levi B,Avraham R,Raz A,Ben-Eliyahu S

    更新日期:2008-07-01 00:00:00