Radiation Therapy is Independently Associated with Worse Survival After R0-Resection for Stage I-II Non-small Cell Lung Cancer: An Analysis of the National Cancer Data Base.

Abstract:

BACKGROUND:The 1998 post-operative radiotherapy meta-analysis for lung cancer showed a survival detriment associated with radiation for stage I-II resected non-small cell lung cancer (NSCLC), but has been criticized for including antiquated radiation techniques. We analyzed the National Cancer Database (NCDB) to determine the impact of radiation after margin-negative (R0) resection for stage I-II NSCLC on survival. METHODS:Adult patients from 2004 to 2014 were analyzed from the NCDB with respect to receiving radiation as part of their first course of treatment for resected stage I-II NSCLC; the primary outcome measure was overall survival. RESULTS:A total of 197,969 patients underwent R0 resection for stage I-II NSCLC, and 4613 received radiation. Median radiation dose was 55 Gy with a 50-60 Gy interquartile range. On adjusted analysis, treatment at a community cancer program, sublobectomy, tumor size (3-7 cm), and pN1/Nx were associated with receiving radiation (odds ratio > 1, p < 0.05). The irradiated group had shorter median survival (45.8 vs. 77.5 months, p < 0.001), and radiation was independently associated with worse overall survival (hazard ratio (HR) 1.339, 95% confidence interval (CI) 1.282-1.399). After propensity score matching, radiation remained associated with worse overall survival (HR 1.313, 95% CI 1.237-1.394, p < 0.001). CONCLUSIONS:Radiotherapy was independently associated with worse survival after R0 resection of stage I-II NSCLC in the NCDB and was more likely to be delivered in community cancer programs.

journal_name

Ann Surg Oncol

authors

Pezzi TA,Mohamed AS,Fuller CD,Blanchard P,Pezzi C,Sepesi B,Hahn SM,Gomez DR,Chun SG

doi

10.1245/s10434-017-5786-6

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

1419-1427

issue

5

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-017-5786-6

journal_volume

24

pub_type

杂志文章
  • Hyperthermic Intraperitoneal Chemotherapy after Secondary Cytoreduction in Epithelial Ovarian Cancer: A Single-center Comparative Analysis.

    abstract:BACKGROUND:Although the standard of care after recurrence of epithelial ovarian cancer (EOC) is chemotherapy, increasing data suggest that combining cytoreductive surgery with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising option for patients with recurrent EOC. Our aim was to determine...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-015-4991-4

    authors: Baiocchi G,Ferreira FO,Mantoan H,da Costa AA,Faloppa CC,Kumagai LY,de Mello CA,Takahashi RM,Nakagawa WT,Aguiar S Jr,Lopes A

    更新日期:2016-04-01 00:00:00

  • Exosomal PD-L1 Retains Immunosuppressive Activity and is Associated with Gastric Cancer Prognosis.

    abstract:BACKGROUND:A recent study showed that circulating exosomal PD-L1 is an effective predictor for anti-PD-1 therapy in melanomas. Exosomal PD-L1 induced immunosuppression microenvironments in cancer patients. However, its prognostic value and immunosuppressive effect in gastric cancer (GC) were poorly understood. METHODS...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07431-7

    authors: Fan Y,Che X,Qu J,Hou K,Wen T,Li Z,Li C,Wang S,Xu L,Liu Y,Qu X

    更新日期:2019-10-01 00:00:00

  • The Prognostic Significance of the Oncotype DX Recurrence Score in T1-2N1M0 Estrogen Receptor-Positive HER2-Negative Breast Cancer Based on the Prognostic Stage in the Updated AJCC 8th Edition.

    abstract:BACKGROUND:This study aimed to evaluate the prognostic significance of the Oncotype DX recurrence score (RS) in T1-2N1M0 estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer based on the prognostic stage in the updated American Joint Commission on Cancer, 8th edition. ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-7068-3

    authors: Wang M,Wu K,Zhang P,Zhang M,Ding A,Chen H

    更新日期:2019-05-01 00:00:00

  • CpG methylation of transcription factor 4 in gastric carcinoma.

    abstract:BACKGROUND:Epigenetic silencing of tumor-related genes by CpG island methylation is an important mechanism for the development of many tumors, including gastric carcinoma. Deregulation of transcription factor 4 (TCF4) by promoter methylation was recently shown to play a key role in gastric carcinogenesis. METHODS:The ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1131-z

    authors: Joo JK,Kim SH,Kim HG,Kim DY,Ryu SY,Lee KH,Lee JH

    更新日期:2010-12-01 00:00:00

  • Race/Ethnicity and County-Level Social Vulnerability Impact Hospice Utilization Among Patients Undergoing Cancer Surgery.

    abstract:BACKGROUND:Integration of palliative care services into the surgical treatment plan is important for holistic patient care. We sought to examine the association between patient race/ethnicity and county-level vulnerability relative to patterns of hospice utilization. PATIENTS AND METHODS:Medicare Standard Analytic Fil...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09227-6

    authors: Abbas A,Madison Hyer J,Pawlik TM

    更新日期:2020-10-14 00:00:00

  • Micrometastasis to in-transit lymph nodes from extremity and truncal malignant melanoma.

    abstract:BACKGROUND:The sentinel lymph node (SLN) is the first lymph node in the regional nodal basin to receive metastatic cells. In-transit nodes are found between the primary melanoma site and regional nodal basins. To date, this is one of the first reports on micrometastasis to in-transit nodes. METHODS:Retrospective datab...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-001-0444-3

    authors: Thelmo MC,Morita ET,Treseler PA,Nguyen LH,Allen RE Jr,Sagebiel RW,Kashani-Sabet M,Leong SP

    更新日期:2001-06-01 00:00:00

  • Routine Computer Tomography Imaging for the Detection of Recurrences in High-Risk Melanoma Patients.

    abstract:BACKGROUND:The use of routine CT imaging for surveillance in asymptomatic patients with cutaneous melanoma is controversial. We report our experience using a surveillance strategy that included CT imaging for a cohort of patients with high-risk melanoma. METHODS:A total of 466 patients with high-risk cutaneous melanom...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5768-8

    authors: Park TS,Phan GQ,Yang JC,Kammula U,Hughes MS,Trebska-McGowan K,Morton KE,White DE,Rosenberg SA,Sherry RM

    更新日期:2017-04-01 00:00:00

  • Outcomes of Concurrent Breast and Gynecologic Risk Reduction Surgery.

    abstract:BACKGROUND:Women considering risk reduction surgery after a diagnosis of breast/ovarian cancer and/or inherited cancer gene mutation face difficult decisions. The safety of combined breast and gynecologic surgery has not been well studied; therefore, we evaluated the outcomes for patients who have undergone coordinated...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5479-6

    authors: Ma IT,Gray RJ,Wasif N,Butler KA,Cornella JL,Magrina JF,Magtibay PM,Casey WJ,Mahabir R,Rebecca AM,Hunt KS,Pockaj BA

    更新日期:2017-01-01 00:00:00

  • Laparoscopic Segment 1 with Partial IVC Resection in Advanced Cirrhosis: How to Do It Safely.

    abstract:BACKGROUND:Laparoscopic versus open hepatocellular carcinoma (HCC) resection reduces morbidity without a compromise in oncologic safety.1-4 Moreover, in the subgroup of cirrhotic patients, a decreased risk of prolonged postoperative ascites and liver decompensation has been reported.5-7 METHODS: A 54-year-old homeless,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08122-z

    authors: Vega EA,Nicolaescu DC,Salehi O,Kozyreva O,Vellayappan U,Ricklan D,McCarty J,Fontan F,Pomposelli F,Conrad C

    更新日期:2020-04-01 00:00:00

  • The Negative Impact of Preoperative Chemotherapy on Survival After Esophagectomy for Vulnerable Elderly Patients with Esophageal Cancer.

    abstract:BACKGROUND:The standard treatment for patients 75 years of age or younger with cStage 2 or 3 esophageal cancer is preoperative chemotherapy followed by esophagectomy. The optimal treatment for elderly patients, especially those considered vulnerable, remains unclear. METHODS:This study retrospectively reviewed the dat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09072-7

    authors: Booka E,Haneda R,Ishii K,Tsushima T,Yasui H,Tsubosa Y

    更新日期:2020-09-02 00:00:00

  • Wilms tumor presenting with abdominal pain: a special subgroup of patients.

    abstract:BACKGROUND:Although significant progress has been made in the management of children with Wilms tumor, two major controversies still exist: the extent of radiographic evaluation necessary before surgery and the role of preoperative chemotherapy. This study sought to determine whether patients with Wilms tumor who prese...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303774

    authors: Davidoff AM,Soutter AD,Shochat SJ

    更新日期:1998-04-01 00:00:00

  • Identification of the sentinel node by ultrasonography in patients with breast cancer.

    abstract:BACKGROUND:Identification of the sentinel node (SN) in patients with breast cancer is done by tracking a radioactive tracer, a vital dye, or both, as the marker(s) reach the axilla. Replacing this method with ultrasonographic (US) recognition of the SN could eventually spare patients the need for systemic anesthesia, p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3570-4

    authors: Kusminsky RE,Witsberger T,Todd Kuenstner J,Willis Trammell S,Schlarb CA,Maxwell D,Richmond BK,Boland JP

    更新日期:2014-06-01 00:00:00

  • Screening for psychological distress in surgical breast cancer patients.

    abstract:BACKGROUND:This pilot study assessed the levels of patient emotional distress and impact on clinic throughput time. METHODS:From April through August 2012, 149 breast cancer patients at the Penn State Hershey Breast Center were screened with the emotions thermometer (ET), a patient-rated visual 0-10 scale that measure...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3919-8

    authors: Schubart JR,Emerich M,Farnan M,Stanley Smith J,Kauffman GL,Kass RB

    更新日期:2014-10-01 00:00:00

  • Improved Survival with Anti-VEGF Therapy in the Treatment of Unresectable Appendiceal Epithelial Neoplasms.

    abstract:BACKGROUND:Currently, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy are accepted treatments for surgically resectable appendiceal epithelial neoplasms. However, for nonsurgical candidates, systemic treatment may be considered. The purpose of this analysis was to determine the benefit of biologic t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4335-9

    authors: Choe JH,Overman MJ,Fournier KF,Royal RE,Ohinata A,Rafeeq S,Beaty K,Phillips JK,Wolff RA,Mansfield PF,Eng C

    更新日期:2015-08-01 00:00:00

  • Using Multilevel Models to Explain Variation in Clinical Practice: Surgeon Volume and the Surgical Treatment of Breast Cancer.

    abstract:PURPOSE:To investigate the relationship between surgeon caseload and surgery type, and variation in the surgical treatment of early stage breast cancer patients in Alberta, Canada. METHODS:All women diagnosed with stage I to III breast cancer in Alberta from 2002 to 2010 were identified from the Alberta Cancer Registr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5118-2

    authors: Fisher S,Yasui Y,Dabbs K,Winget M

    更新日期:2016-06-01 00:00:00

  • Role of surgery combined with kinase inhibition in the management of gastrointestinal stromal tumor (GIST).

    abstract:BACKGROUND:Surgery is the standard treatment for primary, gastrointestinal stromal tumor (GIST); however, surgical resection often is not curative, particularly in large GIST. Five years after complete removal of their tumor, approximately half of treated patients relapse. Imatinib, an oral tyrosine kinase inhibitor (T...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1053-9

    authors: Hohenberger P,Eisenberg B

    更新日期:2010-10-01 00:00:00

  • Anti-tumor effects and tumor immunogenicity following IL2 or IL4 cytokine gene transfection of three mouse mammary tumors.

    abstract:BACKGROUND:The anti-tumor effects of three mouse mammary tumors transfected to express interleukin (IL) 2 or 4 were evaluated. METHODS:Three immunologically different tumors were used: DA3, EMT6, and 410. All three cell lines were successfully transfected using high efficiency viral vectors. Wild-type or transfected t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02307083

    authors: Matory YL,Chen M,Goedegebuure PS,Eberlein TJ

    更新日期:1995-11-01 00:00:00

  • Heat shock protein 27 overexpression in breast cancer lymph node metastasis.

    abstract:BACKGROUND:Heat shock protein 27 (hsp-27) is overexpressed in approximately 67% pure ductal carcinoma in situ (DCIS), in approximately 50% DCIS associated with invasive ductal carcinoma (IDC), and in approximately 25% IDC alone. If this decrease in hsp-27 expression has a role in the progression of malignancy in IDC, w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02306091

    authors: Storm FK,Mahvi DM,Gilchrist KW

    更新日期:1996-11-01 00:00:00

  • Together We Make a Difference.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 社论

    doi:10.1245/s10434-018-6338-4

    authors: Turaga KK,Clark Gamblin T,Richard Alexander H,Edwards R,Bartlett DL

    更新日期:2018-07-01 00:00:00

  • Pylorus-Preserving Surgery Based on the Sentinel Node Concept in Early Gastric Cancer.

    abstract:BACKGROUND:In patients with early stage gastric cancer in the middle third of the stomach, pylorus-preserving gastrectomy (PPG) can be an option as function-preserving surgery, although its oncologic safety is not definitively defined. This issues may be overcome using the sentinel node (SN) concept. The aim of this st...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5358-1

    authors: Shimada A,Takeuchi H,Ono T,Kamiya S,Fukuda K,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Jinzaki M,Murakami K,Kitagawa Y

    更新日期:2016-12-01 00:00:00

  • Outcomes of > 1300 Nipple-Sparing Mastectomies with Immediate Reconstruction: The Impact of Expanding Indications on Complications.

    abstract:BACKGROUND:The enhanced esthetics and demonstrated oncologic safety of nipple-sparing mastectomy (NSM) in selected patients have resulted in increased rates among patients with locally advanced breast cancer and/or additional risk factors (obesity, prior radiation, surgery). Limited data exist on complication and recon...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07560-z

    authors: Young WA,Degnim AC,Hoskin TL,Jakub JW,Nguyen MD,Tran NV,Harless CA,Manrique OJ,Boughey JC,Hieken TJ

    更新日期:2019-10-01 00:00:00

  • Annexin II overexpression predicts rapid recurrence after surgery in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy.

    abstract:BACKGROUND:Gemcitabine has been shown to exhibit significant clinical activity against pancreatic cancer and has become a first-line chemotherapeutic for this disease in recent years. However, there are still many patients who do not respond to this treatment and it is expected to improve the clinical outcome if we can...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0061-5

    authors: Takano S,Togawa A,Yoshitomi H,Shida T,Kimura F,Shimizu H,Yoshidome H,Ohtsuka M,Kato A,Tomonaga T,Nomura F,Miyazaki M

    更新日期:2008-11-01 00:00:00

  • Redefining the Ki-67 Index Stratification for Low-Grade Pancreatic Neuroendocrine Tumors: Improving Its Prognostic Value for Recurrence of Disease.

    abstract:BACKGROUND:The Ki-67 index is an established prognostic marker for recurrence after resection of pancreatic neuroendocrine tumors (PanNETs) that groups tumors into three categories: low grade (< 3%), intermediate grade (3-20%), and high grade (> 20%). Given that the majority of resected PanNETs have a Ki-67 less than 3...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6140-8

    authors: Lopez-Aguiar AG,Ethun CG,Postlewait LM,Zhelnin K,Krasinskas A,El-Rayes BF,Russell MC,Sarmiento JM,Kooby DA,Staley CA,Maithel SK,Cardona K

    更新日期:2018-01-01 00:00:00

  • Toxicity of Immune Checkpoint Inhibitors: Considerations for the Surgeon.

    abstract:BACKGROUND:The use of immunotherapeutic agents, specifically immune checkpoint inhibitors (ICIs) for solid malignancies, is rapidly rising, and many new agents and treatment combinations are in development. However, ICIs have a unique side-effect profile of immune-related adverse events (irAEs) compared with chemothera...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-019-08183-0

    authors: Helmink BA,Roland CL,Kiernan CM,Wargo JA

    更新日期:2020-05-01 00:00:00

  • Outcomes in Peritoneal Carcinomatosis from Appendiceal Goblet Cell Carcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC).

    abstract:BACKGROUND:Appendiceal goblet cell adenocarcinoma (GCA) is often misclassified and mistreated due to mixed histologic features. In general, cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is standard of care for peritoneal carcinomatosis (PC) from mucinous appendiceal tumors; however, i...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07932-5

    authors: Zambrano-Vera K,Sardi A,Munoz-Zuluaga C,Studeman K,Nieroda C,Sittig M,King MC,Sipok A,Gushchin V

    更新日期:2020-01-01 00:00:00

  • Comparison of multiphase CT, FDG-PET and intra-operative ultrasound in patients with colorectal liver metastases selected for surgery.

    abstract:BACKGROUND:For patients with colorectal liver metastases, resection is the treatment of choice. Careful selection of these patients is crucial in order to reduce the chance of unexpected findings at laparotomy and abandoning further surgical intervention. Here, we evaluate the predictive value of CT and FDG-PET of the ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9259-6

    authors: Wiering B,Ruers TJ,Krabbe PF,Dekker HM,Oyen WJ

    更新日期:2007-02-01 00:00:00

  • Prognostic significance of osteopontin expression in human gastric carcinoma.

    abstract:BACKGROUND:Osteopontin (OPN) is a secreted, integrin-binding glycophosphoprotein that has been implicated in the progression of various solid tumors. To evaluate the clinical significance of OPN in gastric carcinoma, we investigated OPN expression in resected tumors. METHODS:Expression of OPN protein by gastric cancer...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9564-8

    authors: Higashiyama M,Ito T,Tanaka E,Shimada Y

    更新日期:2007-12-01 00:00:00

  • Peritoneovenous shunts for palliation of the patient with malignant ascites.

    abstract:METHODS:This study evaluated the effectiveness and morbidity associated with 116 peritoneovenous shunts inserted into 89 patients for symptomatic malignant ascites between 1981 and 1991. All patients had previously failed standard medical therapy of salt and fluid restriction, diuretics, and intermittent peritoneal asp...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02303809

    authors: Schumacher DL,Saclarides TJ,Staren ED

    更新日期:1994-09-01 00:00:00

  • Portal vein segmentation of a 3D-planning system for liver surgery--in vivo evaluation in a porcine model.

    abstract:BACKGROUND:Computer systems allow the planning of complex liver operations. The segmentation of intrahepatic vessels builds the basis for the calculation of liver segments and resection proposals. For surgical use, it is essential to know the capabilities and limitations of the segmentation. The aim of this study was t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9934-x

    authors: Lehmann KS,Ritz JP,Valdeig S,Schenk A,Holmer C,Peitgen HO,Buhr HJ,Frericks BB

    更新日期:2008-07-01 00:00:00

  • p53 genotype predicts response to chemotherapy in patients with squamous cell carcinoma of the esophagus.

    abstract:BACKGROUND:Response to chemotherapy and anatomical spread are significant prognostic factors in patients with esophageal squamous cell carcinoma (ESCC) treated by chemotherapy then surgery. Predicting the response to chemotherapy would allow significant optimization of cancer treatment. METHODS:Genomic mutation and pr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0851-4

    authors: Yamasaki M,Miyata H,Fujiwara Y,Takiguchi S,Nakajima K,Nishida T,Yasuda T,Matsuyama J,Mori M,Doki Y

    更新日期:2010-02-01 00:00:00