Micrometastasis to in-transit lymph nodes from extremity and truncal malignant melanoma.

Abstract:

BACKGROUND:The sentinel lymph node (SLN) is the first lymph node in the regional nodal basin to receive metastatic cells. In-transit nodes are found between the primary melanoma site and regional nodal basins. To date, this is one of the first reports on micrometastasis to in-transit nodes. METHODS:Retrospective database and medical records were reviewed from October 21, 1993, to November 19. 1999. At the UCSF Melanoma Center, patients with tumor thickness > 1 mm or < 1 mm with high-risk features are managed with preoperative lymphoscintigraphy, selective SLN dissection, and wide local excision. RESULTS:Thirty (5%) out of 557 extremity and truncal melanoma patients had in-transit SLNs. Three patients had positive in-transit SLNs and negative SLNs in the regional nodal basin. Two patients had positive in-transit and regional SLNs. Three patients had negative in-transit SLNs but positive regional SLNs. The remaining 22 patients were negative for in-transit and regional SLNs. CONCLUSIONS:In-transit SLNs may harbor micrometastasis. About 10% of the time, micrometastasis may involve the in-transit and not the regional SLN. Therefore, both in-transit and regional SLNs should be harvested.

journal_name

Ann Surg Oncol

authors

Thelmo MC,Morita ET,Treseler PA,Nguyen LH,Allen RE Jr,Sagebiel RW,Kashani-Sabet M,Leong SP

doi

10.1007/s10434-001-0444-3

keywords:

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

444-8

issue

5

eissn

1068-9265

issn

1534-4681

journal_volume

8

pub_type

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