Microsatellite instability in breast cancer.

Abstract:

BACKGROUND:Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the incidence of microsatellite instability in a series of primary breast carcinoma surgical specimens. METHODS:Using polymerase chain reaction techniques followed by polyacrylamide/urea gel electrophoresis, we analyzed 46 pairs of normal and primary breast tumor samples at seven different microsatellite loci, five of which were located on chromosome 17. RESULTS:Thirteen of our 46 tumors (28.2%) demonstrated microsatellite instability. Five tumors (10.8%) were unstable at two or more loci, and of those, four (8.7%) were unstable at different loci on different chromosomes. An additional five tumors demonstrated loss of heterozygosity alone when compared with their normal counterparts. CONCLUSIONS:These findings indicate that microsatellite instability is present in primary breast cancer populations and, although the mechanism of action has yet to be elucidated, may play a role in breast carcinogenesis.

journal_name

Ann Surg Oncol

authors

Rush EB,Calvano JE,van Zee KJ,Zelenetz AD,Borgen PI

doi

10.1007/BF02303580

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

310-5

issue

4

eissn

1068-9265

issn

1534-4681

journal_volume

4

pub_type

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