Toxicity of oxaliplatin plus fluorouracil/leucovorin adjuvant chemotherapy in elderly patients with stage III colon cancer: a population-based study.


BACKGROUND:Results concerning the side effects of oxaliplatin associated with fluorouracil and leucovorin (FOLFOX) in older patients are controversial. The objective of this study was to assess the use and the toxicity of FOLFOX in patients aged 70 years and older as administered in current practice. METHODS:Among 305 stage III colon cancers registered in a well-defined population in Burgundy between 2004 and 2009, 210 had adjuvant chemotherapy, including 156 with FOLFOX. The cumulated rates of toxicity were calculated by using the Kaplan-Meier method. The risks of overall toxicity and of severe toxicity (grade 3 or 4) in patients less than 70 years and in older patients were compared by using a Cox model. RESULTS:There was no difference between the group of the patients less than 70 years and the older age group for the cumulative incidence of hematologic, neurologic, digestive, and general toxicity. There was also no difference between the two groups for the severity of side effects (grade 3 or 4, 31.4 vs. 39.0 %; p = 0.576). The multivariate analysis indicated after adjustment on sex and the Charlson comorbidity score that there was no difference between the two age groups for toxicity (hazard ratio = 1.28; 95 % CI 0.68-2.41; p = 0.439). CONCLUSIONS:Cancer registries can be used to evaluate the toxicity of chemotherapy at the population level. Tolerance to the FOLFOX regimen among elderly patients did not significantly differ from that in younger patients. This treatment should be considered regardless of patients' age alone, but consideration should be given to the capacity of patients to tolerate adverse events.


Ann Surg Oncol


Hamza S,Bouvier AM,Rollot F,Lepage C,Faivre J,Bedenne L




Has Abstract


2014-08-01 00:00:00












  • Cervicothoracoscopic Approach for Esophageal Cancer in a Patient with Right-Sided Aortic Arch.

    abstract:BACKGROUND:Esophageal cancer frequently metastasizes to lymph nodes along the recurrent laryngeal nerve (RLN),1 therefore it is essential to dissect RLN nodes for curative esophagectomy.2 Right-sided aortic arch (RAA), a rare congenital anomaly, occurs in approximately 0.1% of adults.3 Because RAA forms a vascular ring...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Okamura A,Watanabe M,Yuda M,Shoji Y,Yamashita K,Hayami M,Imamura Y,Mine S

    更新日期:2018-05-01 00:00:00

  • Sentinel lymph node mapping for thick (>or=4-mm) melanoma: should we be doing it?

    abstract:BACKGROUND:Thick (>or=4-mm) primary melanomas are believed to be associated with a high incidence of occult distant metastases. The use of sentinel lymph node (SLN) mapping and biopsy in the treatment lesions has been questioned. METHODS:A retrospective review of a computerized database identified 114 patients who und...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Carlson GW,Murray DR,Hestley A,Staley CA,Lyles RH,Cohen C

    更新日期:2003-05-01 00:00:00

  • Sestamibi imaging for primary hyperparathyroidism: the impact of surgeon interpretation and radiologist volume.

    abstract:BACKGROUND:Preoperative localization is the first step towards minimally invasive targeted parathyroidectomy. While there are data emphasizing that surgeon experience optimizes operative outcomes, the role of the radiologist's experience in successful preoperative imaging is unclear. We hypothesized that the accuracy o...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Zia S,Sippel RS,Chen H

    更新日期:2012-11-01 00:00:00

  • Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches.

    abstract:BACKGROUND:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors known to affect humans and carries a dismal prognosis. Our primary aim was to review its epidemiology, biology, risk factors, and prognostic indicators. We also reviewed the individual and combined roles of surgery, radiotherapy, c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Are C,Shaha AR

    更新日期:2006-04-01 00:00:00

  • Breast cancer in Hong Kong, Southern China: the first population-based analysis of epidemiological characteristics, stage-specific, cancer-specific, and disease-free survival in breast cancer patients: 1997-2001.

    abstract:BACKGROUND:Cancer registries have been set up worldwide to provide information for cancer health planning. There are known variations in breast cancer incidence and mortality worldwide. However, breast cancer incidence, pathological characteristics, and survival data is still under-reported in Asian countries. This is ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kwong A,Mang OW,Wong CH,Chau WW,Law SC,Hong Kong Breast Cancer Research Group.

    更新日期:2011-10-01 00:00:00

  • Quality of Life Following Sentinel Node Biopsy for Primary Cutaneous Melanoma: Health Economic Implications.

    abstract:BACKGROUND:Sentinel node biopsy (SNB) is commonly performed in contemporary melanoma management, however there is a paucity of long-term quality of life (QoL) estimates required for economic evaluation of this treatment. METHODS:A single-center, prospective, cross-sectional study of adults with American Joint Committe...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Morton RL,Tran A,Vessey JY,Rowbotham N,Winstanley J,Shannon K,Spillane AJ,Stretch J,Thompson JF,Saw RP

    更新日期:2017-08-01 00:00:00

  • Strategies to Increase the Resectability of Patients with Colorectal Liver Metastases: A Multi-center Case-Match Analysis of ALPPS and Conventional Two-Stage Hepatectomy.

    abstract:BACKGROUND:Two-stage hepatectomy (TSH) is well established for the treatment of patients who have colorectal cancer liver metastases (CRLM) with a small liver remnant. The technique of associating liver partitioning and portal vein occlusion for staged hepatectomy (ALPPS) has been advocated as a novel tool to increase ...

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    pub_type: 杂志文章,多中心研究


    authors: Ratti F,Schadde E,Masetti M,Massani M,Zanello M,Serenari M,Cipriani F,Bonariol L,Bassi N,Aldrighetti L,Jovine E

    更新日期:2015-01-01 00:00:00

  • Free flap reconstruction after robot-assisted neck dissection via a modified face-lift or retroauricular approach.

    abstract:BACKGROUND:We performed robot-assisted neck dissection (RAND) via a modified face-lift (MFLA) or retroauricular approach for neck management and carried out free flap reconstruction via these approaches in patients with head and neck cancer. We assessed the feasibility of free flap reconstruction in patients who had un...

    journal_title:Annals of surgical oncology

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    authors: Park YM,Lee WJ,Yun IS,Lee DW,Lew DH,Lee JM,Ha JG,Kim WS,Koh YW,Choi EC

    更新日期:2013-03-01 00:00:00

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    abstract:BACKGROUND:There are few reports on microvascular invasion (MVI) located intra- or extratumorally and prognosis of hepatocellular carcinoma (HCC). OBJECTIVE:The aim of this study was to evaluate patient outcome according to the location of MVI, and to build a nomogram predicting extratumoral MVI. METHODS:We included ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Nitta H,Allard MA,Sebagh M,Ciacio O,Pittau G,Vibert E,Sa Cunha A,Cherqui D,Castaing D,Bismuth H,Guettier C,Lewin M,Samuel D,Baba H,Adam R

    更新日期:2019-08-01 00:00:00

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    abstract:BACKGROUND:This study was conducted to investigate whether annual surgical unit caseload affects extent of breast cancer surgery, breast cancer recurrence or breast cancer-specific survival. METHODS:In a population-based cohort study, 12,604 women diagnosed with breast cancer in Finland during the years 1998-2001 were...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Peltoniemi P,Peltola M,Hakulinen T,Häkkinen U,Pylkkänen L,Holli K

    更新日期:2011-06-01 00:00:00

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    abstract::Over a decade since the discovery of EGFR mutation, and 6 years since prospective clinical trial data proved that routine molecular pathology tests improve survival in stage IV lung cancer, there is still debate whether to test patients with earlier stages of disease (stage I-III). As discoveries of targeted drugs for...

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    authors: Azzoli CG

    更新日期:2015-10-01 00:00:00

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    abstract:BACKGROUND:The Oncotype DX® assay has been validated in predicting response to adjuvant chemotherapy in breast cancer. Its role in neoadjuvant chemotherapy (NCT) has not been established. METHODS:The National Cancer Database was used to identify all patients with T1-T3, ER-positive, HER2-negative primary invasive brea...

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    authors: Pease AM,Riba LA,Gruner RA,Tung NM,James TA

    更新日期:2019-02-01 00:00:00

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    abstract:BACKGROUND:The prognosis of advanced nodal (N3) squamous cell carcinoma of the head and neck (HNSCC) is poor. We investigated whether surgery or radiotherapy of early (T1-2) primary stage HSNCC is preferable to limit the overall morbidity after upfront neck dissection (uND) for N3 disease. METHODS:This retrospective m...

    journal_title:Annals of surgical oncology

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    authors: Carsuzaa F,Thariat J,Gorphe P,Righini C,Cosmidis A,Thureau S,Roge M,De Mones E,Servagi-Vernat S,Tonnerre D,Morinière S,Dugas A,Malard O,Pasquier F,Vergez S,Salleron J,Dufour X

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    journal_title:Annals of surgical oncology

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    authors: Olino K,Wada S,Edil BH,Pan X,Meckel K,Weber W,Slansky J,Tamada K,Lauer P,Brockstedt D,Pardoll D,Schulick R,Yoshimura K

    更新日期:2012-07-01 00:00:00

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    authors: Fairweather M,Swanson R,Wang J,Brais LK,Dutton T,Kulke MH,Clancy TE

    更新日期:2017-08-01 00:00:00

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    abstract:BACKGROUND:The value of adjuvant therapy for esophageal squamous cell carcinoma (ESCC) has been controversial, at least partially due to the lack of efficient criteria for selecting suitable patients. This study aimed to explore the existence of parameters related to lymph node (LN) status that can predict the value of...

    journal_title:Annals of surgical oncology

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    authors: Li Y,Zhao W,Ni J,Zou L,Yang X,Yu W,Fu X,Zhao K,Zhang Y,Chen H,Xiang J,Xie C,Zhu Z

    更新日期:2019-08-01 00:00:00

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    journal_title:Annals of surgical oncology

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    authors: Wagner PL,Moo TA,Arora N,Liu YF,Zarnegar R,Scognamiglio T,Fahey TJ 3rd

    更新日期:2008-10-01 00:00:00

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    abstract:BACKGROUND:In primary esophageal cancer, studies have frequently focused on surgical patients in an effort to link outcome to hospital- or surgeon-related experience, with operative mortality used as the main outcome measure. Many studies have found an inverse relationship between operative mortality and hospital volum...

    journal_title:Annals of surgical oncology

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    authors: Verhoef C,van de Weyer R,Schaapveld M,Bastiaannet E,Plukker JT

    更新日期:2007-05-01 00:00:00

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    journal_title:Annals of surgical oncology

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    authors: Wang J,Wang Q,Dong J,Yang K,Ji S,Fan Y,Wang C,Ma Q,Wei Q,Ji G

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    abstract:BACKGROUND:The purpose of this study was to examine the frequency, pattern, and predictive factors associated with occult level II lymph node (LN) metastases in papillary thyroid carcinoma (PTC) patients with clinically metastatic lymph nodes in the lateral neck (level III, IV, and/or V) by preoperative ultrasonography...

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    authors: Koo BS,Seo ST,Lee GH,Kim JM,Choi EC,Lim YC

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Vega EA,Nicolaescu DC,Salehi O,Kozyreva O,Vellayappan U,Ricklan D,McCarty J,Fontan F,Pomposelli F,Conrad C

    更新日期:2020-04-01 00:00:00

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


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    更新日期:2010-05-01 00:00:00

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Wang J,Shen J,Dickinson IC

    更新日期:2011-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Dunham AL,Ramirez LD,Vang CA,Linebarger JH,Landercasper J

    更新日期:2018-07-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Amri R,England J,Bordeianou LG,Berger DL

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    pub_type: 杂志文章


    authors: You YN,Dozois EJ,Boardman LA,Aakre J,Huebner M,Larson DW

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Toshimitsu H,Yoshimoto Y,Augustine CK,Padussis JC,Yoo JS,Angelica Selim M,Pruitt SK,Friedman HS,Ali-Osman F,Tyler DS

    更新日期:2010-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Stanelle EJ,Christison-Lagay ER,Healey JH,Singer S,Meyers PA,La Quaglia MP

    更新日期:2013-01-01 00:00:00