Abstract：
BACKGROUND:The keystone flap is being promoted as an advance in oncological surgical reconstruction. Wound closure with this island flap involves two V-Y advancements toward the center and along the long axis of the island, at right angles to the line of maximum tension when the wound is closed. It is implied that the long-axis advancements enable closure by relaxing the entire flap of skin, allowing it to be stretched more easily along the short axis. We undertook a study to test this hypothesis. METHODS:We measured tension and extension along perpendicular axes in nine freshly excised specimens of human skin. We held the longitudinal axis fixed while stretching the skin along the transverse axis. We then released the longitudinal axis and measured the resultant drop in transverse tension. Finally, we increased the transverse tension to approximately its previous level, and measured the new transverse extension. RESULTS:There was significant interdependence between longitudinal and transverse tensions. The fall in transverse wound tension associated with longitudinal release varied with starting tensions and with the original site and orientation of the specimen. In the five cases where the longitudinal release was from the in vivo length, the mean increase in transverse stretch attributable to the release was 0.6 mm (95% confidence interval 0.1-1.1 mm). DISCUSSION:The increase in transverse stretch that can be achieved by releasing skin from its longitudinal in vivo length appears trivial, raising questions about the rationale for the use of the prototypical (type 1) keystone flap in wound closure.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Douglas CD,Low NC,Seitz MJdoi
10.1245/s10434-012-2684-9subject
Has Abstractpub_date
2013-03-01 00:00:00pages
973-80issue
3eissn
1068-9265issn
1534-4681journal_volume
20pub_type
杂志文章abstract：BACKGROUND:For patients with colorectal liver metastases, resection is the treatment of choice. Careful selection of these patients is crucial in order to reduce the chance of unexpected findings at laparotomy and abandoning further surgical intervention. Here, we evaluate the predictive value of CT and FDG-PET of the ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-006-9259-6
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Preoperative cutaneous lymphoscintigraphy (LS) to identify sentinel (first-tier) lymph nodes was performed in 250 consecutive melanoma patients before wide local excision only or wide local excision with sentinel node biopsy. METHODS:The location of the sentinel nodes was marked on the overlying skin in all...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02303644
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:Postoperative chemoradiation and perioperative chemotherapy using epirubicin/cisplatin/5-fluorouracil (ECF) represent two standards of care for resectable gastric cancer. In the TOPGEAR (Trial Of Preoperative therapy for Gastric and Esophagogastric junction AdenocaRcinoma) trial, we hypothesized that adding ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1245/s10434-017-5830-6
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:A systematic review with a meta-analysis was performed to determine the prevalence and risk factors for secondary de novo adenocarcinoma in the colon used as a urinary diversion not exposed to the fecal stream. METHODS:The systematic review of the literature identified 47 patients with secondary adenocarcin...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-08300-4
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Retroperitoneal lymphadenectomy (RPLND), chemotherapy, and active surveillance represent treatment options for patients with nonseminomatous germ-cell tumors of the testis (NSGCTT). Our objective was to assess the utilization rate of RPLND in patients with NSGCTT. METHODS:Within the Surveillance, Epidemiolo...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1722-3
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Using 4-year nationwide population-based data for Taiwan, this study compared in-hospital surgical mortality rates with hospital volume for five cancer-related gastrointestinal resections. METHODS:The study sample was drawn from the Taiwan National Health Insurance Research Database. A total of 34,715 patie...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-006-9005-0
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Response to chemotherapy and anatomical spread are significant prognostic factors in patients with esophageal squamous cell carcinoma (ESCC) treated by chemotherapy then surgery. Predicting the response to chemotherapy would allow significant optimization of cancer treatment. METHODS:Genomic mutation and pr...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-009-0851-4
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Intraperitoneal (IP) administration of paclitaxel (PTX) has a great pharmacokinetic advantage to control peritoneal lesions and can be combined with various systemic chemotherapies. In this study, we evaluate the efficacy and tolerability of a combination of IP-PTX and systemic S-1/oxaliplatin (SOX) for indu...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-09388-4
更新日期：2020-12-03 00:00:00
abstract：PURPOSE:To determine survival differences for patients undergoing colonic or rectal resection for cancer on the basis of the specific anatomical location of primary tumor. METHODS:A total of 143,747 patients undergoing segmental colectomy, hemicolectomy, anterior resection, or abdominoperineal resection (APER) for ade...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-3104-5
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:This study aimed to determine the relationship between mammographic calcifications and magnetic resonance imaging (MRI) tumoral enhancement before and after neoadjuvant chemotherapy (NAC) and to assess the impact of these findings on surgical management. METHODS:This Institutional Review Board-approved, Hea...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5741-y
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:The term pseudomyxoma peritonei has been used in reference to any condition, benign or malignant, in which the peritoneal cavity becomes filled with a gelatinous substance. The term is nonspecific and does not denote therapeutic or prognostic significance. Controversy centers around which patients benefit fr...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,评审
doi：10.1007/s10434-999-0797-6
更新日期：1999-12-01 00:00:00
abstract：:Multiple randomized trials, as well as a meta-analysis of these studies, have confirmed the equivalence of breast-conservation and mastectomy. In addition, in unselected populations, adjuvant radiation therapy following lumpectomy has been shown to decrease in-breast recurrence and improve overall survival. However, r...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-4713-y
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Symptomatic malignant ascites is a problem for patients with advanced intra-abdominal malignancy. Although the goal of paracentesis, the most common therapeutic intervention, is symptom palliation, the best method of assessing symptom improvement is unknown. The aim of this study was to assess the ability of...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-007-9370-3
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:Secure methods for clinical detection of the sentinel node (SN) are in great demand to avoid unnecessary resection. This was a clinical exploration/feasibility study of a novel detection system for SN biopsy using indocyanine green (ICG) fluorescence imaging in gastric cancer surgery. METHODS:SN biopsy usin...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-008-9872-7
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Resection of melanoma metastatic to the liver remains controversial. We evaluated the efficacy of hepatic resection in patients with metastatic ocular and cutaneous melanoma and assessed factors that could affect survival after resection. METHODS:Forty patients with hepatic melanoma metastasis underwent res...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,多中心研究
doi：10.1245/ASO.2006.01.016
更新日期：2006-05-01 00:00:00
abstract：: ...
journal_title：Annals of surgical oncology
pub_type： 评论,杂志文章
doi：10.1245/s10434-018-6891-x
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Malignant obstruction of the proximal colon (MOPC) traditionally has been treated with acute resection. However, morbidity and mortality rates following these emergency surgeries are high. Initial bowel decompression by stent placement or stoma construction has been used for distal obstructions as an alterna...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5247-7
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the usefulness of shear wave elastography (SWE) for predicting cervical lymph node (LN) metastasis and the prognostic implication of SWE as histopathologic factors of papillary thyroid carcinoma (PTC). METHODS:Eighty-four LNs of 66 patients with PTC underwent B-mode ultras...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-3627-4
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Trastuzumab in association with systemic cytotoxic chemotherapy is the standard of care for patients with advanced HER2-positive gastric carcinoma (GC). However, HER2 as a prognostic factor in GC remains controversial. METHODS:HER2 overexpression and amplification was evaluated by immunohistochemistry (IHC)...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-012-2818-0
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Postmastectomy radiation (PMRT) and regional nodal irradiation (RNI) improve outcomes for patients at high risk of locoregional recurrence (LRR). Node-negative patients with the triple-negative (TN) subtype and those who do not have a pCR with neoadjuvant chemotherapy (NAC) are at increased risk for LRR, but...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-09136-8
更新日期：2020-09-21 00:00:00
abstract：BACKGROUND:Adjuvant chemoradiotherapy improved survival in patients with resected gastric adenocarcinoma in the Southwest Oncology Group/Intergroup 0116 trial. Our objective was to examine the impact of adjuvant treatment on overall survival (OS) in the general population. METHODS:Patients 18-85 years old who had unde...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-007-9640-0
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:The treatment of Wilms' tumor has undergone major advances in the past four decades. Current therapy is based on both the stage and pathology of the tumor. We have reviewed our recent experience with this tumor to assess the results of treatment on protocols that generally avoid the use of doxorubicin. METH...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02303542
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:In synovial sarcomas alterations in the cyclin D1-CDK4/6-Rb axis have been described. Also, β-catenin, a cyclin D1 regulator, is often overexpressed. Additionally, studies have shown that the t(X;18) translocation influences tumor behavior partly through cyclin D1 activation. We investigated how alterations ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5341-x
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Heated intraoperative intraperitoneal chemotherapy achieves high peritoneal concentrations with limited systemic absorption and has become an important tool in the management of patients with peritoneal carcinomatosis from low-grade malignancies such as pseudomyxoma peritonei and in selected cases of high-gr...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/s10434-000-0296-2
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Patients want information to search for destination of care for breast-conserving surgery (BCS). To inform patients wanting a lumpectomy, we aimed to develop a pilot project that communicated composite quality measure (QM) results using a '4-star' rating system. Two patient-centered QMs were included in the ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-6479-5
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:The relative effects of growth hormone on tumor versus host growth and protein metabolism are not known. This study examines the influence of recombinant rat growth hormone (r-rGH) on host and tumor growth, host body composition, and protein synthesis of tumor and host in tumor-bearing rats. METHODS:After l...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02303570
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:Several clinical risk scores for patients with colorectal liver metastases (CLM) were established in cohorts of patients undergoing liver resection (LR) without neoadjuvant chemotherapy (NAC). The purpose of the study was to evaluate the predictive values of four common risk scores in the setting of NAC and ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5615-3
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Most melanoma patients present with thin ( journal_title：Annals of surgical oncology pub_type： 杂志文章 doi：10.1245/ASO.2006.05.011 更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:Surgical resection of the primary tumor for patients who present with incurable stage IV colorectal cancer is controversial. National practice patterns have not been described. We evaluated the use of primary tumor resection in patients presenting with stage IV colorectal cancer. METHODS:Patients with stage...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/ASO.2005.06.012
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:The rising incidence of incidental thyroid carcinoma (ITC) detected during fluoro-2-deoxy-D: -glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) scanning poses a challenge to clinicians. The present study aims to critically evaluate the clinicopathological characteristics of ITC detect...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-010-1287-6
更新日期：2011-02-01 00:00:00
