Prognostic significance of osteopontin expression in human gastric carcinoma.

Abstract:

BACKGROUND:Osteopontin (OPN) is a secreted, integrin-binding glycophosphoprotein that has been implicated in the progression of various solid tumors. To evaluate the clinical significance of OPN in gastric carcinoma, we investigated OPN expression in resected tumors. METHODS:Expression of OPN protein by gastric cancer cells was evaluated using western blot analysis. OPN messenger RNA (mRNA) expression in 18 gastric cancers was compared with that in the corresponding normal gastric epithelium by semiquantitative reverse transcription polymerase chain reaction (RT-PCR). Paraffin sections of tumors from 295 patients with gastric cancer were also investigated using immunohistochemistry. RESULTS:All four gastric cancer cell lines analyzed using western blotting had almost the same level of OPN protein expression as the positive control (HeLa cells). OPN mRNA was upregulated in 83% (15/18) of the tumors studied. On immunohistochemical staining, 90 tumors were classified as negative (-), whereas 205 were classified as positive (1+, 2+, or 3+). The level of OPN protein expression was significantly associated with the patient's age (p = 0.04), tumor depth (p = 0.03), histological grade (p = 0.008), and hematogenous metastasis (p = 0.007). Kaplan-Meier analysis showed that OPN positivity was significantly associated with a shorter survival time (p = 0.027). Furthermore, multivariate analysis revealed that OPN positivity was an independent risk factor for hematogenous metastasis (p = 0.034). CONCLUSIONS:The present findings suggest that increased tumor expression of OPN is an important determinant of shorter survival time and that OPN positivity may be useful for predicting the risk of hematogenous metastasis in gastric cancer patients.

journal_name

Ann Surg Oncol

authors

Higashiyama M,Ito T,Tanaka E,Shimada Y

doi

10.1245/s10434-007-9564-8

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

3419-27

issue

12

eissn

1068-9265

issn

1534-4681

journal_volume

14

pub_type

杂志文章
  • Predictors of surgical margin status in breast-conserving surgery within a breast screening program.

    abstract:BACKGROUND:Breast-conserving surgery (BCS) requires clear surgical margins to minimize local recurrence. We sought to identify groups of patients at higher risk of involved margins who might benefit from preoperative counselling and/or more generous excision at the first operation. METHODS:We reviewed demographic, cli...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0054-4

    authors: Kurniawan ED,Wong MH,Windle I,Rose A,Mou A,Buchanan M,Collins JP,Miller JA,Gruen RL,Mann GB

    更新日期:2008-09-01 00:00:00

  • LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer.

    abstract:BACKGROUND:Liver kinase B1 (LKB1) loss by gene mutation, loss of heterozygosity, and promoter methylation rarely occurs in colorectal cancer. We wondered whether LKB1 loss could be deregulated at the transcriptional level to promote tumor progression and poor outcome in colorectal cancer. METHODS:Mechanistic studies w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3824-1

    authors: He TY,Tsai LH,Huang CC,Chou MC,Lee H

    更新日期:2014-12-01 00:00:00

  • Fertility Preservation for the Young Breast Cancer Patient.

    abstract:BACKGROUND:The American Society of Clinical Oncology (ASCO) guidelines include incorporation of fertility preservation guidelines in the care of breast oncology patients. This study aimed to examine the baseline knowledge and preferences concerning fertility preservation among women of childbearing age with newly diagn...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5036-8

    authors: Goldfarb SB,Kamer SA,Oppong BA,Eaton A,Patil S,Junqueira MJ,Olcese C,Kelvin JF,Gemignani ML

    更新日期:2016-05-01 00:00:00

  • Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients.

    abstract:BACKGROUND:Unlike other human tumors, gastric cancer remains a great therapeutic challenge since no standardized postoperative treatment exists. Knowledge of molecular pathways determining the behavior of individual gastric tumors seems to be crucial for therapeutic decisions, and evaluation of vascular endothelial gro...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9596-0

    authors: Lieto E,Ferraraccio F,Orditura M,Castellano P,Mura AL,Pinto M,Zamboli A,De Vita F,Galizia G

    更新日期:2008-01-01 00:00:00

  • Tumor-Infiltrating Lymphocytes in a Contemporary Cohort of Women with Ductal Carcinoma In Situ (DCIS).

    abstract:BACKGROUND:Growing evidence suggests that the tumor immune microenvironment influences breast cancer development and prognosis. Density of tumor-infiltrating lymphocytes (TILs) within invasive breast cancer is correlated with response to therapy, especially in triple-negative disease. The clinical relevance and outcome...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07562-x

    authors: Darvishian F,Ozerdem U,Adams S,Chun J,Pirraglia E,Kaplowitz E,Guth A,Axelrod D,Shapiro R,Price A,Troxel A,Schnabel F,Roses D

    更新日期:2019-10-01 00:00:00

  • Impact of BRCA1/2 Mutations on the Efficacy of Secondary Cytoreductive Surgery.

    abstract:BACKGROUND:Phase III trials evaluating the role of secondary cytoreductive surgery (SCS) in recurrent ovarian cancer have pointed to the importance of patient selection. Two studies showed conflicting results regarding the benefit of SCS in BRCA1/2 mutation carriers. Our aim was to evaluate the impact of SCS on recurre...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09366-w

    authors: Estati FL,Pirolli R,de Alencar VTL,Ribeiro ARG,Formiga MN,Torrezan GT,Carraro DM,Guimarães APG,Baiocchi G,da Costa AABA

    更新日期:2020-11-21 00:00:00

  • Validation of a nomogram to predict the presence of sentinel lymph node metastases in melanoma.

    abstract:BACKGROUND:Lymph node involvement is a very important prognostic factor for cutaneous melanoma. In this paper we try to validate a nomogram that was created at the Memorial Sloan-Kettering Cancer Center, New York, to predict the probability of metastases in the sentinel nodes of patients with cutaneous melanoma. METHO...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0077-x

    authors: Piñero A,Canteras M,Ortiz E,Martínez-Barba E,Parrilla P

    更新日期:2008-10-01 00:00:00

  • An alternative access technique under direct vision for preperitoneoscopic pelvic surgery: easier for the beginners.

    abstract:BACKGROUND:We present an alternative access technique to facilitate preperitoneoscopic (extraperitoneal laparoscopic) approach for radical prostatectomy, herniorrhaphy, and other pelvic procedures. METHODS:A 0 degrees telescope was mounted into a Visiport Optical Trocar (Visiport), and via a periumbilical incision it ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9883-4

    authors: Tai HC,Lai MK,Chueh SC,Chen SC,Hsieh MH,Yu HJ

    更新日期:2008-09-01 00:00:00

  • Up-regulation of NEK2 by microRNA-128 methylation is associated with poor prognosis in colorectal cancer.

    abstract:BACKGROUND:NIMA-related kinase 2 (NEK2), an enzyme involved in the development and progression of cancer, is abnormally expressed in a wide variety of human cancers, including colorectal cancer (CRC), and is known to have roles in cell division and mitotic regulation through centrosome splitting. We investigated the cl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3264-3

    authors: Takahashi Y,Iwaya T,Sawada G,Kurashige J,Matsumura T,Uchi R,Ueo H,Takano Y,Eguchi H,Sudo T,Sugimachi K,Yamamoto H,Doki Y,Mori M,Mimori K

    更新日期:2014-01-01 00:00:00

  • Suitability of sentinel node mapping as an index of metastasis in early gastric cancer following endoscopic resection.

    abstract:BACKGROUND:When pathological diagnosis following endoscopic resection (ER) for early gastric cancer (EGC) suggests probable lymph node metastasis, additional surgery with lymphadenectomy should be performed. The sentinel node (SN) concept has yet to be applied to tumors following ER. The aim of this study was to evalua...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3662-1

    authors: Mayanagi S,Takeuchi H,Kamiya S,Niihara M,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Mukai M,Kitagawa Y

    更新日期:2014-09-01 00:00:00

  • The Landmark Series: Neuroendocrine Tumor Liver Metastases.

    abstract:BACKGROUND:Neuroendocrine tumors are becoming increasingly prevalent, with many patients presenting with or developing metastatic disease to the liver. METHODS:In this landmark series paper, we highlight the critical studies that have defined the surgical management of neuroendocrine tumor liver metastases, as well as...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-020-08787-x

    authors: Gangi A,Howe JR

    更新日期:2020-09-01 00:00:00

  • Increasing Appropriate BRCA1/2 Mutation Testing: The Role of Family History Documentation and Genetic Counseling in a Multidisciplinary Clinic.

    abstract:BACKGROUND:Findings show that 5-10 % of women with a diagnosis of breast cancer (BCa) have actionable genetic mutations. The National Comprehensive Cancer Network guidelines for testing to detect BRCA1/2 mutations include personal history (PH) variables such as age of 45 years or younger and a family history (FH) varia...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5545-0

    authors: Kishan AU,Gomez CL,Dawson NA,Dvorak R,Foster NM,Hoyt A,Hurvitz SA,Kusske A,Silver EL,Tseng C,McCloskey SA

    更新日期:2016-12-01 00:00:00

  • The First Human Trial of Transoral Robotic Surgery Using a Single-Port Robotic System in the Treatment of Laryngo-Pharyngeal Cancer.

    abstract:BACKGROUND:This study aimed to evaluate the feasibility and safety of the DaVinci SP system for performing transoral robotic surgery (TORS) in patients with head and neck cancer. METHODS:From October 2018 to April 2019, the medical records of 41 patients who underwent TORS using the DaVinci SP system were retrospectiv...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07802-0

    authors: Park YM,Kim DH,Kang MS,Lim JY,Choi EC,Koh YW,Kim SH

    更新日期:2019-12-01 00:00:00

  • Clinical features and outcome of primary pancreatic lymphoma.

    abstract:INTRODUCTION:Primary pancreatic lymphoma (PPL) is a rare tumor that is often misdiagnosed. Clinicopathologic features, optimal therapy, and outcomes are not well defined. We reviewed our institutional experience with PPL. METHODS:Search of our institutional database identified that between 1987-2012, 21,760 patients w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4176-6

    authors: Sadot E,Yahalom J,Do RK,Teruya-Feldstein J,Allen PJ,Gönen M,D'Angelica MI,Kingham TP,Jarnagin WR,DeMatteo RP

    更新日期:2015-04-01 00:00:00

  • Management for Peritoneal Metastasis of Colonic Origin: Role of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy: A Single Institution's Experience During Two Decades.

    abstract:BACKGROUND:Peritoneal metastasis of colonic origin is associated with a poor prognosis. This study aimed to analyze the clinicopathologic characteristics and prognostic predictors of survival in a cohort of patients treated with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (POIC) during tw...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5698-x

    authors: Ihemelandu C,Sugarbaker PH

    更新日期:2017-04-01 00:00:00

  • Composite pelvic exenteration: is it worthwhile?

    abstract:BACKGROUND:In locally advanced pelvic cancer, tumor fixation to the bony pelvis is regarded as unresectable and often inoperable. Few data exist regarding the futility or utility of pelvic exenteration with en bloc resection of involved portions of the bony pelvis. METHODS:Thirty-four of 625 patients undergoing radica...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02524342

    authors: Lopez MJ,Luna-Pérez P

    更新日期:2004-01-01 00:00:00

  • Impact of tumor grade on prognosis in pancreatic cancer: should we include grade in AJCC staging?

    abstract:BACKGROUND:AJCC staging of pancreatic cancer (PAC) is used to determine prognosis, yet survival within each stage shows wide variation and remains unpredictable. We hypothesized that tumor grade might be responsible for some of this variation and that the addition of grade to current AJCC staging would provide improved...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1071-7

    authors: Wasif N,Ko CY,Farrell J,Wainberg Z,Hines OJ,Reber H,Tomlinson JS

    更新日期:2010-09-01 00:00:00

  • ASO Author Reflections: Incorporating Lymphovascular Invasion to Improve the Prognostic Reliability of the T-Staging System for Adrenocortical Carcinoma-A Multicenter Study.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6876-9

    authors: Poorman CE,Ethun CG,Maithel SK

    更新日期:2018-12-01 00:00:00

  • Verification of musculoskeletal FDG-PET-CT findings performed for melanoma staging.

    abstract:BACKGROUND:The purpose of this study is to establish the validity of F-18-deoxyglucose positron emission tomography-computed tomography (FDG-PET-CT) scan staging for cutaneous melanoma when a musculoskeletal image abnormality is detected. METHODS:An institutional review board (IRB)-approved prospective database was qu...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-009-0843-4

    authors: Mansour AA 3rd,Kelley MC,Hatmaker AR,Holt GE,Schwartz HS

    更新日期:2010-04-01 00:00:00

  • Trends in the treatment and outcome of pancreatic cancer in the United States.

    abstract:BACKGROUND:Although pancreatic cancer is the fourth leading cause of cancer death, few studies have evaluated population-based trends in diagnosis, management, and outcome. METHODS:We used the Surveillance, Epidemiology, and End Results (SEER) registry to evaluate treatment trends and outcomes for patients 18 or older...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9249-8

    authors: Baxter NN,Whitson BA,Tuttle TM

    更新日期:2007-04-01 00:00:00

  • Reoperative Surgery in Patients with Multiple Endocrine Neoplasia Type 1 Associated Primary Hyperparathyroidism.

    abstract:BACKGROUND:Persistent/recurrent primary hyperparathyroidism (pHPT) occurs frequently in multiple endocrine neoplasia type 1 (MEN1). We assessed the usefulness of intraoperative PTH (IOPTH) and preoperative localizing studies based on the outcome of patients with MEN1-associated pHPT undergoing reoperative surgery. MET...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5467-x

    authors: Keutgen XM,Nilubol N,Agarwal S,Welch J,Cochran C,Marx SJ,Weinstein LS,Simonds WF,Kebebew E

    更新日期:2016-12-01 00:00:00

  • 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis.

    abstract:BACKGROUND:Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity. METHODS:8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5374-1

    authors: Sugimachi K,Yamaguchi R,Eguchi H,Ueda M,Niida A,Sakimura S,Hirata H,Uchi R,Shinden Y,Iguchi T,Morita K,Yamamoto K,Miyano S,Mori M,Maehara Y,Mimori K

    更新日期:2016-08-01 00:00:00

  • Routine screening for local recurrence following breast-conserving therapy for cancer with dynamic contrast-enhanced magnetic resonance imaging of the breast.

    abstract:BACKGROUND:Dynamic contrast-enhanced magnetic resonance imaging (MRI) of the breast is highly sensitive for the diagnosis of primary breast malignancy. We investigated the clinical application of dedicated dynamic breast MR for routine screening for local recurrence following breast-conserving therapy. METHODS:Patient...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303784

    authors: Drew PJ,Kerin MJ,Turnbull LW,Imrie M,Carleton PJ,Fox JN,Monson JR

    更新日期:1998-04-01 00:00:00

  • Decreased expression of FOXJ1 is a potential prognostic predictor for progression and poor survival of gastric cancer.

    abstract:BACKGROUND:FOXJ1 is a member of the forkhead transcription factor family, which has been mostly studied for its role in the development of ciliated epithelium and immunology. However, the role of FOXJ1 in tumorigenesis remains largely unknown or even conflicting. We thus investigated FOXJ1 expression in gastric cancer ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3742-2

    authors: Wang J,Cai X,Xia L,Zhou J,Xin J,Liu M,Shang X,Liu J,Li X,Chen Z,Nie Y,Fan D

    更新日期:2015-02-01 00:00:00

  • Learning curve for percutaneous radiofrequency ablation of pulmonary metastases from colorectal carcinoma: a prospective study of 70 consecutive cases.

    abstract:BACKGROUND:Percutaneous radiofrequency ablation (RFA) for inoperable colorectal pulmonary metastases is associated with a morbidity rate of 30% to 40%. A learning curve in this treatment approach has not been documented before. METHODS:The clinical and treatment-related data regarding 70 consecutive percutaneous RFA p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9010-3

    authors: Yan TD,King J,Sjarif A,Glenn D,Steinke K,Morris DL

    更新日期:2006-12-01 00:00:00

  • The Negative Impact of Preoperative Chemotherapy on Survival After Esophagectomy for Vulnerable Elderly Patients with Esophageal Cancer.

    abstract:BACKGROUND:The standard treatment for patients 75 years of age or younger with cStage 2 or 3 esophageal cancer is preoperative chemotherapy followed by esophagectomy. The optimal treatment for elderly patients, especially those considered vulnerable, remains unclear. METHODS:This study retrospectively reviewed the dat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09072-7

    authors: Booka E,Haneda R,Ishii K,Tsushima T,Yasui H,Tsubosa Y

    更新日期:2020-09-02 00:00:00

  • Intraoperative Sentinel Lymph Node Evaluation: Implications of Cytokeratin 19 Expression for the Adoption of OSNA in Oral Squamous Cell Carcinoma.

    abstract:BACKGROUND:Intraoperative analysis of sentinel lymph nodes would enhance the care of early-stage oral squamous cell carcinoma (OSCC). We determined the frequency and extent of cytokeratin 19 (CK19) expression in OSCC primary tumours and surrounding tissues to explore the feasibility of a "clinic-ready" intraoperative d...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5337-6

    authors: Shaw R,Christensen A,Java K,Maddani RE,Liloglou T,Asterios T,von Buchwald C,Wessel I,Kiss K,Kjaer A,Lelkaitis G,Long A,Risk J,Robinson M

    更新日期:2016-11-01 00:00:00

  • Impact of a temporary stoma on the quality of life of rectal cancer patients undergoing treatment.

    abstract:BACKGROUND:Data from randomized controlled trials support use of a diverting stoma in rectal cancer patients with low anastomoses, but there is little data on how this impacts patient quality of life (QOL). This study prospectively evaluates QOL in stage I-III rectal cancer patients undergoing sphincter-preserving surg...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-010-1446-9

    authors: Neuman HB,Patil S,Fuzesi S,Wong WD,Weiser MR,Guillem JG,Paty PB,Nash GM,Temple LK

    更新日期:2011-05-01 00:00:00

  • Comparison of angiogenic factor levels in tumor drainage and peripheral venous blood from colorectal cancer patients.

    abstract:BACKGROUND:The main objective of this study was to determine whether there was a correlation in the levels of various angiogenesis-related factors between the tumor drainage and peripheral venous blood and whether appraisal of angiogenic factor levels in the tumor drainage venous blood could provide better prognostic i...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9042-8

    authors: Tien YW,Chang KJ,Chiu YF,Huang KW,Lee PH

    更新日期:2006-11-01 00:00:00

  • Salvage treatment for isolated regional failure of nasopharyngeal carcinoma after primary radiotherapy.

    abstract:BACKGROUND:Isolated regional failure of nasopharyngeal carcinoma (NPC) after primary treatment is traditionally treated with radical neck dissection (RND). The roles of modified radical neck dissection (MRND) and postoperative radiotherapy after salvage surgery currently remain unclear. METHODS:Medical records from ou...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2018-3

    authors: Lo WC,Wang CP,Ko JY,Lou PJ,Yang TL,Wang CW,Hu YL,Chen TC

    更新日期:2012-03-01 00:00:00