Cure model survival analysis after hepatic resection for colorectal liver metastases.

Abstract:

BACKGROUND:Statistical cure is achieved when a patient population has the same mortality as cancer-free individuals; however, data regarding the probability of cure after hepatectomy of colorectal liver metastases (CLM) have never been provided. We aimed to assess the probability of being statistically cured from CLM by hepatic resection. METHODS:Data from 1,012 consecutive patients undergoing curative resection for CLM (2001-2012) were used to fit a nonmixture cure model to compare mortality after surgery to that expected for the general population matched by sex and age. RESULTS:The 5- and 10-year disease-free survival was 18.9 and 15.8 %; the corresponding overall survival was 44.3 and 32.7 %. In the entire study population, the probability of being cured from CLM was 20 % (95 % confidence interval 16.5-23.5). After the first year, the mortality excess of resected patients, in comparison to the general population, starts to decline until it approaches zero 6 years after surgery. After 6.48 years, patients alive without tumor recurrence can be considered cured with 99 % certainty. Multivariate analysis showed that cure probabilities range from 40.9 % in patients with node-negative primary tumors and metachronous presentation of a single lesion <3 cm, to 1.5 % in patients with node positivity, and synchronous presentation of multiple, large CLMs. A model for the calculation of a cure fraction for each possible clinical scenario is provided. CONCLUSIONS:Using a cure model, the present results indicate that statistical cure of CLM is possible after hepatectomy; providing this information can help clinicians give more precise answer to patients' questions.

journal_name

Ann Surg Oncol

authors

Cucchetti A,Ferrero A,Cescon M,Donadon M,Russolillo N,Ercolani G,Stacchini G,Mazzotti F,Torzilli G,Pinna AD

doi

10.1245/s10434-014-4234-0

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1908-14

issue

6

eissn

1068-9265

issn

1534-4681

journal_volume

22

pub_type

杂志文章
  • Extraskeletal Myxoid Chondrosarcoma with Molecularly Confirmed Diagnosis: A Multicenter Retrospective Study Within the Italian Sarcoma Group.

    abstract:BACKGROUND:Extraskeletal myxoid chondrosarcoma (EMC) is a rare sarcoma of uncertain origin, marked by specific chromosomal translocations involving the NR4A3 gene, and usually characterized by an indolent course. Surgery (with or without radiotherapy) is the treatment of choice in localized disease. The treatment for a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08737-7

    authors: Paioli A,Stacchiotti S,Campanacci D,Palmerini E,Frezza AM,Longhi A,Radaelli S,Donati DM,Beltrami G,Bianchi G,Barisella M,Righi A,Benini S,Fiore M,Picci P,Gronchi A

    更新日期:2021-02-01 00:00:00

  • Levels of Alternatively Spliced Tissue Factor in the Plasma of Patients with Pancreatic Cancer May Help Predict Aggressive Tumor Phenotype.

    abstract:BACKGROUND:Circulating ('blood-borne') tissue factor (TF) is implicated in the pathogenesis of several chronic conditions, most notably cardiovascular disease, diabetes, and cancer. Full-length TF is an integral membrane protein, while alternatively spliced TF (asTF) can be secreted and, owing to its unique C-terminus,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4592-2

    authors: Unruh D,Sagin F,Adam M,Van Dreden P,Woodhams BJ,Hart K,Lindsell CJ,Ahmad SA,Bogdanov VY

    更新日期:2015-12-01 00:00:00

  • Loss of c-met protooncogene in primary and metastatic sites of breast cancer.

    abstract:BACKGROUND:It has been proposed that clones of tumor cells acquire higher metastatic potential as a result of specific genetic alterations. This study was designed to determine the role of the c-met protooncogene in systemic spread by comparing the loss of the c-met protooncogene between primary and metastatic breast c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303675

    authors: Ng EH,Pey HB,Law HY,Ng I,Ji CY,Lin V,Soo KC

    更新日期:1997-09-01 00:00:00

  • Total Laparoscopic Pancreaticoduodenectomy with Venous Reconstruction for Pancreatic Head Cancer with Involvement of the Superior Mesenteric Vein-Portal Vein Confluence.

    abstract:BACKGROUND:Laparoscopic pancreaticoduodenectomy with venous reconstruction is not commonly performed due to its technical challenges. In this video, we focus on the technical aspects for how to perform this procedure safely. METHODS:In a 69-year-old female with jaundice and diarrhea, a computed tomography scan showed ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6762-5

    authors: Garbarino GM,Fuks D,Cowan J,Ward M,Moisan F,Donatelli G,Beaussier M,Gayet B

    更新日期:2018-12-01 00:00:00

  • Annexin II overexpression predicts rapid recurrence after surgery in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy.

    abstract:BACKGROUND:Gemcitabine has been shown to exhibit significant clinical activity against pancreatic cancer and has become a first-line chemotherapeutic for this disease in recent years. However, there are still many patients who do not respond to this treatment and it is expected to improve the clinical outcome if we can...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0061-5

    authors: Takano S,Togawa A,Yoshitomi H,Shida T,Kimura F,Shimizu H,Yoshidome H,Ohtsuka M,Kato A,Tomonaga T,Nomura F,Miyazaki M

    更新日期:2008-11-01 00:00:00

  • Incomplete ablation after radiofrequency ablation of hepatocellular carcinoma: analysis of risk factors and prognostic factors.

    abstract:BACKGROUND:Complete ablation rates after a single session of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) vary from 48% to 97%. Limited data are available regarding risk factors and prognostic significance of incomplete ablation. METHODS:Between April 2001 and March 2006, 298 patients underwent RFA ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9733-9

    authors: Lam VW,Ng KK,Chok KS,Cheung TT,Yuen J,Tung H,Tso WK,Fan ST,Poon RT

    更新日期:2008-03-01 00:00:00

  • The ability of existing questionnaires to measure symptom change after paracentesis for symptomatic ascites.

    abstract:BACKGROUND:Symptomatic malignant ascites is a problem for patients with advanced intra-abdominal malignancy. Although the goal of paracentesis, the most common therapeutic intervention, is symptom palliation, the best method of assessing symptom improvement is unknown. The aim of this study was to assess the ability of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9370-3

    authors: Easson AM,Bezjak A,Ross S,Wright JG

    更新日期:2007-08-01 00:00:00

  • Prognostic variables in invasive breast cancer: contribution of comedo versus noncomedo in situ component.

    abstract:BACKGROUND:Many invasive breast cancers are accompanied by a variety of noninvasive components. Histological distinctions have been made between these components, but to understand their importance, it is essential to examine their molecular biology. METHODS:Proliferative indices, oncoproteins, and steroid receptor ex...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02306378

    authors: Brower ST,Ahmed S,Tartter PI,Bleiweiss I,Amberson JB

    更新日期:1995-09-01 00:00:00

  • Minimally Invasive Approaches in Locally Advanced Cervical Cancer Patients Undergoing Radical Surgery After Chemoradiotherapy: A Propensity Score Analysis.

    abstract:PURPOSE:Chemoradiation (CT/RT) followed by radical surgery (RS) may play a role in locally advanced cervical cancer (LACC) patients with suboptimal response to CT/RT or in low-income countries with limited access to radiotherapy. Our aim is to evaluate oncological and surgical outcomes of minimally invasive radical sur...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09302-y

    authors: Ferrandina G,Gallotta V,Federico A,Fanfani F,Ercoli A,Chiantera V,Cosentino F,Turco LC,Legge F,Anchora LP,Bizzarri N,Moroni R,Macchia G,Valentini V,Scambia G

    更新日期:2020-11-09 00:00:00

  • Assessing the Role of Neoadjuvant Chemotherapy in Primary High-Risk Truncal/Extremity Soft Tissue Sarcomas: An Analysis of the Multi-institutional U.S. Sarcoma Collaborative.

    abstract:BACKGROUND:The role of neoadjuvant chemotherapy (NCT) for high-risk soft tissue sarcoma (STS) is questioned. This study aimed to define which patients may experience a survival advantage with NCT. METHODS:All the patients from the U.S. Sarcoma Collaborative database (2000-2016) who underwent curative-intent resection ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-019-07639-7

    authors: Zaidi MY,Ethun CG,Tran TB,Poultsides G,Grignol VP,Howard JH,Bedi M,Mogal H,Tseng J,Roggin KK,Chouliaras K,Votanopoulos K,Krasnick B,Fields RC,Oskouei S,Reimer N,Monson D,Maithel SK,Cardona K

    更新日期:2019-10-01 00:00:00

  • Induction chemotherapy with S-1 plus cisplatin followed by surgery for treatment of gastric cancer with peritoneal dissemination.

    abstract:BACKGROUND:The prognosis of gastric cancer patients with peritoneal dissemination is poor. Recently, chemotherapy with S-1 plus cisplatin has been shown to be highly effective for advanced gastric cancer. METHODS:In 41 patients diagnosed with either macro- or microscopic peritoneal dissemination by staging laparoscopy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0706-z

    authors: Okabe H,Ueda S,Obama K,Hosogi H,Sakai Y

    更新日期:2009-12-01 00:00:00

  • Racial disparities in esophageal cancer outcomes.

    abstract:BACKGROUND:Racial disparities in outcomes have been documented among patients with esophageal cancer. The purpose of this study is to identify mechanisms for ethnicity/race-related differences in the use of cancer-directed surgery and mortality. METHODS:Data from the Surveillance, Epidemiology and End Results (SEER) p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2807-3

    authors: Revels SL,Morris AM,Reddy RM,Akateh C,Wong SL

    更新日期:2013-04-01 00:00:00

  • Cross-Sectional Study on MRI Restaging After Chemoradiotherapy and Interval to Surgery in Rectal Cancer: Influence on Short- and Long-Term Outcomes.

    abstract:BACKGROUND:The time interval between CRT and surgery in rectal cancer patients is still the subject of debate. The aim of this study was to first evaluate the nationwide use of restaging magnetic resonance imaging (MRI) and its impact on timing of surgery, and, second, to evaluate the impact of timing of surgery after ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-07097-7

    authors: Detering R,Borstlap WAA,Broeders L,Hermus L,Marijnen CAM,Beets-Tan RGH,Bemelman WA,van Westreenen HL,Tanis PJ,Dutch Snapshot Research Group.

    更新日期:2019-02-01 00:00:00

  • Iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent or progressive diffuse malignant peritoneal mesothelioma: clinicopathologic characteristics and survival outcome.

    abstract:BACKGROUND:Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive disease for which cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been used with remarkable survival benefits. Our aim was to analyze the clinicopathologic characteristics and prognosis of recurrent DMPM ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3977-y

    authors: Ihemelandu C,Bijelic L,Sugarbaker PH

    更新日期:2015-05-01 00:00:00

  • Touch imprint cytology of the sentinel lymph nodes might not be indicated in early breast cancer patients with ultrasonically uninvolved axillary lymph nodes.

    abstract:BACKGROUND:Touch imprint cytology (TIC) is a fast, cheap and specific intraoperative examination of the sentinel lymph nodes (SLNs) in early breast cancer patients. The results of TIC in patients with ultrasonically (US) uninvolved axillary lymph nodes are not known. The objective of our study was to compare the result...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9957-3

    authors: Perhavec A,Besić N,Hocevar M,Zgajnar J

    更新日期:2008-08-01 00:00:00

  • Development of criteria for ovarian preservation in cervical cancer patients treated with radical surgery with or without neoadjuvant chemotherapy: a multicenter retrospective study and meta-analysis.

    abstract:BACKGROUND:There is no consensus on the selection criteria for ovarian preservation in cervical cancer, and the role of neoadjuvant chemotherapy (NACT) on ovarian metastasis (OM) is also unknown. METHODS:A total of 1,889 cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stages ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-012-2632-8

    authors: Hu T,Wu L,Xing H,Yang R,Li X,Huang K,Jia Y,Zhang Q,Chen Z,Wang S,Liu D,Han X,Lin Z,Qu P,Cai H,Song X,Tian X,Wang H,Wang S,Xie X,Li S,Ma D

    更新日期:2013-03-01 00:00:00

  • Msi-1 is a predictor of survival and a novel therapeutic target in colon cancer.

    abstract:BACKGROUND:Musashi1 (Msi-1), a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Recently, aberrant expression of Msi-1 has been detected in several malignancies. However, its role in the progression of colon cancer is largely unknown. MATERIALS AND METHODS:We u...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1567-9

    authors: Li D,Peng X,Yan D,Tang H,Huang F,Yang Y,Peng Z

    更新日期:2011-07-01 00:00:00

  • Quilting prevents seroma formation following breast cancer surgery: closing the dead space by quilting prevents seroma following axillary lymph node dissection and mastectomy.

    abstract:BACKGROUND:Seroma is a frequent problem after mastectomy (ME) and axillary lymph node dissection (ALND). Seroma is associated with pain, discomfort, impaired mobilisation and repeated aspirations, often resulting in a surgical site infection (SSI). It has already been demonstrated that minimizing dead space through fix...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3359-x

    authors: ten Wolde B,van den Wildenberg FJ,Keemers-Gels ME,Polat F,Strobbe LJ

    更新日期:2014-03-01 00:00:00

  • Routine screening for local recurrence following breast-conserving therapy for cancer with dynamic contrast-enhanced magnetic resonance imaging of the breast.

    abstract:BACKGROUND:Dynamic contrast-enhanced magnetic resonance imaging (MRI) of the breast is highly sensitive for the diagnosis of primary breast malignancy. We investigated the clinical application of dedicated dynamic breast MR for routine screening for local recurrence following breast-conserving therapy. METHODS:Patient...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303784

    authors: Drew PJ,Kerin MJ,Turnbull LW,Imrie M,Carleton PJ,Fox JN,Monson JR

    更新日期:1998-04-01 00:00:00

  • Nomogram predicting severe adverse events after musculoskeletal tumor surgery: analysis of a national administrative database.

    abstract:BACKGROUND:There have been no nationwide surveys of postoperative adverse events (AEs) after musculoskeletal tumor surgery focusing on their severity. Therefore, we developed a nomogram to predict severe AEs after musculoskeletal tumor surgery. METHODS:We identified patients in the Diagnosis Procedure Combination data...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3760-0

    authors: Ogura K,Yasunaga H,Horiguchi H,Fushimi K,Tanaka S,Kawano H

    更新日期:2014-10-01 00:00:00

  • Optical See-Through Cancer Vision Goggles Enable Direct Patient Visualization and Real-Time Fluorescence-Guided Oncologic Surgery.

    abstract:BACKGROUND:The inability to visualize the patient and surgical site directly, limits the use of current near infrared fluorescence-guided surgery systems for real-time sentinel lymph node biopsy and tumor margin assessment. METHODS:We evaluated an optical see-through goggle augmented imaging and navigation system (GAI...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5804-8

    authors: Mondal SB,Gao S,Zhu N,Habimana-Griffin L,Akers WJ,Liang R,Gruev V,Margenthaler J,Achilefu S

    更新日期:2017-07-01 00:00:00

  • Sentinel Lymph Node Biopsy Is Prognostic in Thickest Melanoma Cases and Should Be Performed for Thick Melanomas.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) is recommended for intermediate thickness melanoma, but for thick melanoma, guidelines are less definitive about the use of SLNB in this population. We present a study on thick melanoma evaluating for prognostic factors. PATIENTS AND METHODS:The Sentinel Lymph Node Working ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08706-0

    authors: Han D,Han G,Duque MT,Morrison S,Leong SP,Kashani-Sabet M,Vetto J,White R,Schneebaum S,Pockaj B,Mozzillo N,Sondak VK,Zager JS

    更新日期:2021-02-01 00:00:00

  • mTHPC-mediated photodynamic therapy of early stage oral squamous cell carcinoma: a comparison to surgical treatment.

    abstract:BACKGROUND:mTHPC-mediated photodynamic therapy (PDT) is used for treatment of early head and neck squamous cell carcinoma. This study is a retrospective comparison of PDT with transoral surgery in the treatment of early primary squamous cell carcinoma of the oral cavity/oropharynx. METHODS:PDT data were retrieved from...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-013-3006-6

    authors: de Visscher SA,Melchers LJ,Dijkstra PU,Karakullukcu B,Tan IB,Hopper C,Roodenburg JL,Witjes MJ

    更新日期:2013-09-01 00:00:00

  • Prophylactic lymphadenectomy of neck level II in clinically node-positive papillary thyroid carcinoma.

    abstract:BACKGROUND:The purpose of this study was to examine the frequency, pattern, and predictive factors associated with occult level II lymph node (LN) metastases in papillary thyroid carcinoma (PTC) patients with clinically metastatic lymph nodes in the lateral neck (level III, IV, and/or V) by preoperative ultrasonography...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0958-7

    authors: Koo BS,Seo ST,Lee GH,Kim JM,Choi EC,Lim YC

    更新日期:2010-06-01 00:00:00

  • Minimally Invasive Complete Response Assessment of the Breast After Neoadjuvant Systemic Therapy for Early Breast Cancer (MICRA trial): Interim Analysis of a Multicenter Observational Cohort Study.

    abstract:BACKGROUND:The added value of surgery in breast cancer patients with pathological complete response (pCR) after neoadjuvant systemic therapy (NST) is uncertain. The accuracy of imaging identifying pCR for omission of surgery, however, is insufficient. We investigated the accuracy of ultrasound-guided biopsies identifyi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09273-0

    authors: van Loevezijn AA,van der Noordaa MEM,van Werkhoven ED,Loo CE,Winter-Warnars GAO,Wiersma T,van de Vijver KK,Groen EJ,Blanken-Peeters CFJM,Zonneveld BJGL,Sonke GS,van Duijnhoven FH,Vrancken Peeters MTFD

    更新日期:2020-12-02 00:00:00

  • Predictors of regional nodal disease in patients with thin melanomas.

    abstract:BACKGROUND:Most melanoma patients present with thin (

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2006.05.011

    authors: Karakousis GC,Gimotty PA,Botbyl JD,Kesmodel SB,Elder DE,Elenitsas R,Ming ME,Guerry D,Fraker DL,Czerniecki BJ,Spitz FR

    更新日期:2006-04-01 00:00:00

  • Cardiorespiratory Comorbidity and Postoperative Complications following Esophagectomy: a European Multicenter Cohort Study.

    abstract:BACKGROUND:The impact of cardiorespiratory comorbidity on operative outcomes after esophagectomy remains controversial. This study investigated the effect of cardiorespiratory comorbidity on postoperative complications for patients treated for esophageal or gastroesophageal junction cancer. PATIENTS AND METHODS:A Euro...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-019-07478-6

    authors: Klevebro F,Elliott JA,Slaman A,Vermeulen BD,Kamiya S,Rosman C,Gisbertz SS,Boshier PR,Reynolds JV,Rouvelas I,Hanna GB,van Berge Henegouwen MI,Markar SR

    更新日期:2019-09-01 00:00:00

  • Parietal peritonectomy.

    abstract::Parietal peritonectomy is an initial part of cytoreductive surgery in patients with peritoneal surface malignancy. After this dissection, the necessary visceral resections, other peritonectomy procedures, and perioperative hyperthermic chemotherapy are administered. The parietal peritoneum is an immobile portion of th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2229-2

    authors: Sugarbaker PH

    更新日期:2012-04-01 00:00:00

  • Conditional survival after surgical resection of gastric cancer: a multi-institutional analysis of the us gastric cancer collaborative.

    abstract:BACKGROUND:Survival estimates following surgical resection of gastric adenocarcinoma are traditionally reported as survival from the date of surgery. Conditional survival (CS) estimates, however, may be more clinically relevant by accounting for time already survived. We assessed CS following surgical resection for gas...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4116-5

    authors: Kim Y,Ejaz A,Spolverato G,Squires MH,Poultsides G,Fields RC,Bloomston M,Weber SM,Votanopoulos K,Acher AW,Jin LX,Hawkins WG,Schmidt C,Kooby D,Worhunsky D,Saunders N,Cho CS,Levine EA,Maithel SK,Pawlik TM

    更新日期:2015-02-01 00:00:00

  • Melanoma metastases in regional lymph nodes are accurately detected by proton magnetic resonance spectroscopy of fine-needle aspirate biopsy samples.

    abstract:BACKGROUND:Nonsurgical assessment of sentinel nodes (SNs) would offer advantages over surgical SN excision by reducing morbidity and costs. Proton magnetic resonance spectroscopy (MRS) of fine-needle aspirate biopsy (FNAB) specimens identifies melanoma lymph node metastases. This study was undertaken to determine the a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.03.073

    authors: Stretch JR,Somorjai R,Bourne R,Hsiao E,Scolyer RA,Dolenko B,Thompson JF,Mountford CE,Lean CL

    更新日期:2005-11-01 00:00:00