Incomplete ablation after radiofrequency ablation of hepatocellular carcinoma: analysis of risk factors and prognostic factors.

Abstract:

BACKGROUND:Complete ablation rates after a single session of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) vary from 48% to 97%. Limited data are available regarding risk factors and prognostic significance of incomplete ablation. METHODS:Between April 2001 and March 2006, 298 patients underwent RFA of 393 HCC nodules with an intent of complete ablation after a single session. Risk factors for incomplete ablation and its effect on overall survival were analyzed. RESULTS:Two hundred seventy-three (91.6%) underwent complete tumor ablation, whereas the other 25 (8.4%) underwent incomplete tumor ablation after a single session of RFA. By multivariate analysis, tumor size > 3 cm (P = .049) was found to be the only independent risk factor for incomplete ablation. There was no statistically significant difference in overall survival between patients with complete and incomplete ablation. By univariate analysis, no previous transarterial chemoembolization (TACE), preoperative serum alfa-fetoprotein < or = 100 microg/mL, and complete response after further treatment of incomplete ablation were associated with better overall survival in patients with incomplete ablation. CONCLUSIONS:This study demonstrated that incomplete ablation after RFA of HCC was associated with tumor size > 3 cm. Our data also suggest that aggressive further treatment of tumors with incomplete ablation aiming at complete tumor response improves overall survival.

journal_name

Ann Surg Oncol

authors

Lam VW,Ng KK,Chok KS,Cheung TT,Yuen J,Tung H,Tso WK,Fan ST,Poon RT

doi

10.1245/s10434-007-9733-9

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

782-90

issue

3

eissn

1068-9265

issn

1534-4681

journal_volume

15

pub_type

杂志文章
  • Impact of Tumor Size on Probability of Pathologic Complete Response After Neoadjuvant Chemotherapy.

    abstract:BACKGROUND:The prospective Neoadjuvant Breast Symphony Trial (NBRST) study found that MammaPrint/BluePrint functional molecular subtype is superior to conventional immunohistochemistry/fluorescence in situ hybridization subtyping for predicting pathologic complete response (pCR) to neoadjuvant chemotherapy. The purpose...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5030-1

    authors: Baron P,Beitsch P,Boselli D,Symanowski J,Pellicane JV,Beatty J,Richards P,Mislowsky A,Nash C,Lee LA,Murray M,de Snoo FA,Stork-Sloots L,Gittleman M,Akbari S,Whitworth P

    更新日期:2016-05-01 00:00:00

  • The Ethics of Breast Surgery.

    abstract::Breast surgery has evolved as a subspecialty of general surgery and requires a working knowledge of benign and malignant diseases, surgical techniques, shared decision-making with patients, collaboration with a multi-disciplinary team, and a basic foundation in surgical ethics. Ethics is defined as the practice of ana...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-015-4751-5

    authors: Throckmorton A,VanderWalde L,Brackett C,Dominici L,Eisenhauer T,Johnson N,Kong A,Ludwig K,O'Neill J,Pugliese M,Teller P,Sarantou T

    更新日期:2015-10-01 00:00:00

  • Anemia and transfusions in patients undergoing surgery for cancer.

    abstract::Preoperative, operative, and postoperative factors may all contribute to high rates of anemia in patients undergoing surgery for cancer. Allogeneic blood transfusion is associated with both infectious risks and noninfectious risks such as human errors, hemolytic reactions, transfusion-related acute lung injury, transf...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-007-9502-9

    authors: Weber RS,Jabbour N,Martin RC 2nd

    更新日期:2008-01-01 00:00:00

  • A phase I study of hyperthermic isolated hepatic perfusion with oxaliplatin in the treatment of unresectable liver metastases from colorectal cancer.

    abstract::Isolated hepatic perfusion (IHP) is a proven approach for regional delivery of chemotherapy in patients with unresectable primary and metastatic tumors of the liver. Most trials of IHP have utilized melphalan as the active drug in the perfusate. We performed a phase I trial to evaluate the efficacy, safety, and maximu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0179-5

    authors: Zeh HJ 3rd,Brown CK,Holtzman MP,Egorin MJ,Holleran JL,Potter DM,Bartlett DL

    更新日期:2009-02-01 00:00:00

  • Hepatic resection for metastatic melanoma: distinct patterns of recurrence and prognosis for ocular versus cutaneous disease.

    abstract:BACKGROUND:Resection of melanoma metastatic to the liver remains controversial. We evaluated the efficacy of hepatic resection in patients with metastatic ocular and cutaneous melanoma and assessed factors that could affect survival after resection. METHODS:Forty patients with hepatic melanoma metastasis underwent res...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/ASO.2006.01.016

    authors: Pawlik TM,Zorzi D,Abdalla EK,Clary BM,Gershenwald JE,Ross MI,Aloia TA,Curley SA,Camacho LH,Capussotti L,Elias D,Vauthey JN

    更新日期:2006-05-01 00:00:00

  • Occult Tumour Cells in Lymph Nodes from Gastric Cancer Patients: Should Isolated Tumour Cells Also Be Considered?

    abstract:INTRODUCTION:Regional lymph node metastasis is an important prognostic factor for patients with gastric cancer. Occult tumour cells (OTCs), including either micrometastases (MMs) or isolated tumour cells (ITCs), may be a key factor in the development of cancer recurrence in pN0 patients. AIMS:We aimed to determine the...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08524-4

    authors: Tavares A,Wen X,Maciel J,Carneiro F,Dinis-Ribeiro M

    更新日期:2020-10-01 00:00:00

  • Granulomatous mastitis: a New York public hospital experience.

    abstract:BACKGROUND:Granulomatous mastitis is an uncommon chronic inflammatory breast condition that is characterized by granulomatous inflammation. Granulomatous mastitis presents a challenging clinical scenario, because it can mimic carcinoma. The etiology and optimal treatment remain unclear. We report our experience with gr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3895-z

    authors: Joseph KA,Luu X,Mor A

    更新日期:2014-12-01 00:00:00

  • Long-term survival of peritoneal carcinomatosis of colorectal origin.

    abstract:BACKGROUND:Peritoneal carcinomatosis of colorectal cancer is probably best treated by cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). In The Netherlands Cancer Institute, this treatment has been performed since 1995. The long tradition of this treatment enabled us to study long-term survival in det...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10434-004-1167-z

    authors: Verwaal VJ,van Ruth S,Witkamp A,Boot H,van Slooten G,Zoetmulder FA

    更新日期:2005-01-01 00:00:00

  • The role of laparoscopy-assisted renal autotransplantation in the treatment of primary ureteral tumor.

    abstract:BACKGROUND:To evaluate the effect and safety of laparoscopy-assisted renal autotransplantation treatment for primary ureteral cancer (PUC). METHODS:Medical records of patients undergoing hand-assisted retroperitoneoscopic nephroureterectomy–extracorporeal total ureterectomy–renal autotransplantation–pyelocystostomy (L...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3382-y

    authors: Cheng YT,Flechner SM,Chiang PH

    更新日期:2014-10-01 00:00:00

  • Prognostic Factors and Significance of Gastrointestinal Leak After Cytoreductive Surgery (CRS) with Heated Intraperitoneal Chemotherapy (HIPEC).

    abstract:BACKGROUND:Gastrointestinal leak (GIL) after cytoreductive surgery with heated intraperitoneal chemotherapy (CRS/HIPEC) is associated with significant morbidity and mortality. This study aimed to identify GIL prognostic factors and its impact on overall survival. METHODS:A retrospective analysis of a prospectively mai...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5738-6

    authors: Chouliaras K,Levine EA,Fino N,Shen P,Votanopoulos KI

    更新日期:2017-04-01 00:00:00

  • Society of Surgical Oncology 72nd Annual Cancer Symposium.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 新闻

    doi:10.1245/s10434-019-07174-5

    authors:

    更新日期:2019-02-01 00:00:00

  • Hypomethylation of long interspersed nuclear element-1 (LINE-1) is associated with poor prognosis via activation of c-MET in hepatocellular carcinoma.

    abstract:BACKGROUND:Long interspersed nuclear element-1 (LINE-1) methylation status, representing global DNA methylation levels, is associated with patient prognosis in several types of cancer. This study was designed to examine the prognostic significance of LINE-1 methylation in patients with hepatocellular carcinoma (HCC) an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3874-4

    authors: Zhu C,Utsunomiya T,Ikemoto T,Yamada S,Morine Y,Imura S,Arakawa Y,Takasu C,Ishikawa D,Imoto I,Shimada M

    更新日期:2014-12-01 00:00:00

  • Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer.

    abstract:BACKGROUND:Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patients with gastric cance...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08245-8

    authors: Maruyama S,Kawaguchi Y,Akaike H,Shoda K,Saito R,Shimizu H,Furuya S,Hosomura N,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D

    更新日期:2020-08-01 00:00:00

  • Impact of Patient Age on the Postoperative Survival in Pancreatic Head Cancer.

    abstract:BACKGROUND:Some reports have stated that pancreatoduodenectomy for elderly patients have comparable morbidity and mortality to that of young patients. However, the long-term outcomes of these patients have not been fully evaluated, especially for pancreatic head cancer. METHODS:A total of 227 patients who underwent pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5994-0

    authors: Sugiura T,Okamura Y,Ito T,Yamamoto Y,Ashida R,Uesaka K

    更新日期:2017-10-01 00:00:00

  • Re-excision rates of invasive ductal carcinoma with lobular features compared with invasive ductal carcinomas and invasive lobular carcinomas of the breast.

    abstract:BACKGROUND:Invasive ductal carcinoma (IDC) with lobular features (IDC-L) is not recognized as a subtype of breast cancer. We previously showed that IDC-L may be a variant of IDC with clinicopathological characteristics more similar to invasive lobular carcinoma (ILC). We sought to determine the re-excision rates of IDC...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3871-7

    authors: Arps DP,Jorns JM,Zhao L,Bensenhaver J,Kleer CG,Pang JC

    更新日期:2014-12-01 00:00:00

  • Topographic genotyping of colorectal carcinoma: from a molecular carcinogenesis model to clinical relevance.

    abstract:BACKGROUND:In recent years, as a result of refinement in molecular biology techniques, significant progress has been made in the understanding of colorectal carcinogenesis. Particular attention has been drawn to identification of genetic mutation that may predispose to colorectal carcinoma (familial syndromes) and may ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02306621

    authors: Pricolo VE,Finkelstein SD,Bland KI

    更新日期:1997-04-01 00:00:00

  • (18)F-FDG-PET/CT to select patients with peritoneal carcinomatosis for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

    abstract:BACKGROUND:Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with significantly longer survival in patients with peritoneal carcinomatosis (PC). So far, no morphological imaging method has proven to accurately assess the intra-abdominal tumor spread. This study was design...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0387-7

    authors: Pfannenberg C,Königsrainer I,Aschoff P,Oksüz MO,Zieker D,Beckert S,Symons S,Nieselt K,Glatzle J,Weyhern CV,Brücher BL,Claussen CD,Königsrainer A

    更新日期:2009-05-01 00:00:00

  • A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion.

    abstract:BACKGROUND:L-phenylalanine mustard (LPAM) has been the standard for use in regional chemotherapy (RC) for unresectable in-transit melanoma. Preclinical data demonstrated that regional temozolomide (TMZ) may be more effective. METHODS:Patients with AJCC Stage IIIB or IIIC extremity melanoma who failed previous LPAM-bas...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-014-3887-z

    authors: Beasley GM,Speicher P,Augustine CK,Dolber PC,Peterson BL,Sharma K,Mosca PJ,Royal R,Ross M,Zager JS,Tyler DS

    更新日期:2015-01-01 00:00:00

  • XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Adaptor proteins, with multimodular structures, can participate in the regulation of various cellular functions. A novel adaptor protein XB130 has been implicated as a substrate and regulator of tyrosine kinase-mediated signaling and in controlling cell proliferation and apoptosis in thyroid and lung cancer ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2474-4

    authors: Shiozaki A,Kosuga T,Ichikawa D,Komatsu S,Fujiwara H,Okamoto K,Iitaka D,Nakashima S,Shimizu H,Ishimoto T,Kitagawa M,Nakou Y,Kishimoto M,Liu M,Otsuji E

    更新日期:2013-09-01 00:00:00

  • Disturbed XIAP and XAF1 expression balance is an independent prognostic factor in gastric adenocarcinomas.

    abstract:BACKGROUND:Dysregulation of apoptosis is a key factor in carcinogenesis and tumor progression. X-linked inhibitor of apoptosis (XIAP) is the most potent member of the inhibitor of apoptosis protein (IAP) family, which directly inhibits apoptosis by binding to caspases. Antagonists of XIAP have recently been identified:...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0062-4

    authors: Shibata T,Noguchi T,Takeno S,Gabbert HE,Ramp U,Kawahara K

    更新日期:2008-12-01 00:00:00

  • Clinically occult breast carcinoma: diagnostic approaches and role of axillary node dissection.

    abstract:BACKGROUND:Nonpalpable breast lesions are being detected with increasing frequency with the advent of improved mammographic techniques. Although only 20-30% of these lesions are malignant, definitive diagnosis has usually required a needle-localization excisional biopsy, which is costly and increases the psychological ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02307063

    authors: Meterissian S,Fornage BD,Singletary SE

    更新日期:1995-07-01 00:00:00

  • Intraoperative Sentinel Lymph Node Evaluation: Implications of Cytokeratin 19 Expression for the Adoption of OSNA in Oral Squamous Cell Carcinoma.

    abstract:BACKGROUND:Intraoperative analysis of sentinel lymph nodes would enhance the care of early-stage oral squamous cell carcinoma (OSCC). We determined the frequency and extent of cytokeratin 19 (CK19) expression in OSCC primary tumours and surrounding tissues to explore the feasibility of a "clinic-ready" intraoperative d...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5337-6

    authors: Shaw R,Christensen A,Java K,Maddani RE,Liloglou T,Asterios T,von Buchwald C,Wessel I,Kiss K,Kjaer A,Lelkaitis G,Long A,Risk J,Robinson M

    更新日期:2016-11-01 00:00:00

  • In Patients with Localized and Resectable Gastric Cancer, What is the Optimal Extent of Lymph Node Dissection-D1 Versus D2 Versus D3?

    abstract:BACKGROUND:Despite advances in the treatment of patients with gastric cancer, the debate over the optimal extent of lymphadenectomy continues. METHOD:A review of the classification, rationale for, and boundaries of lymphadenectomy is presented. A review of the available literature comparing D1 versus D2 versus D3 lymp...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07417-5

    authors: Mogal H,Fields R,Maithel SK,Votanopoulos K

    更新日期:2019-09-01 00:00:00

  • Simultaneous indocyanine green and (99m)Tc-antimony sulfur colloid-guided laparoscopic sentinel basin dissection for gastric cancer.

    abstract:BACKGROUND:There are few reports on a dual dye and isotope approach using laparoscopy in gastric cancer sentinel node mapping. The aim of this study is to evaluate the feasibility of laparoscopic sentinel basin dissection for gastric cancer using simultaneous indocyanine green (ICG) and (99m)Tc-antimony sulfur colloid ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1221-y

    authors: Park DJ,Kim HH,Park YS,Lee HS,Lee WW,Lee HJ,Yang HK

    更新日期:2011-01-01 00:00:00

  • Clinical significance of GAB2, a scaffolding/docking protein acting downstream of EGFR in human colorectal cancer.

    abstract:PURPOSE:Recent studies indicated that the scaffolding adaptor protein GAB2 (GRB2-associated binding protein 2) plays a critical role in the proliferation and migration of various cancers. This study aimed to determine the role of aberrant GAB2 expression in human colorectal cancer (CRC). METHODS:Quantitative real-time...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3889-x

    authors: Matsumura T,Sugimachi K,Takahashi Y,Uchi R,Sawada G,Ueda M,Hirata H,Sakimura S,Ueo H,Takano Y,Kurashige J,Shinden Y,Eguchi H,Sudo T,Yamamoto H,Doki Y,Mori M,Mimori K

    更新日期:2014-12-01 00:00:00

  • Optimal submucosal invasion of early gastric cancer for endoscopic resection.

    abstract:BACKGROUND:A small differentiated gastric cancer with minute submucosal invasion after endoscopic resection is regarded as the curative resection criterion of an expanded indication. However, recent studies have shown a high incidence of lymph node metastasis in those meeting the expanded criteria. The aim of this stud...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4308-z

    authors: Eom BW,Yu JS,Ryu KW,Kook MC,Kim YI,Cho SJ,Lee JY,Kim CG,Choi IJ,Yoon HM,Kim YW

    更新日期:2015-01-01 00:00:00

  • Robotic versus open pancreatectomy: a systematic review and meta-analysis.

    abstract:BACKGROUND:Robotic surgery is gaining momentum with advantages for minimally invasive management of pancreatic diseases. The objective of this meta-analysis is to compare the clinical and oncologic safety and efficacy of robotic versus open pancreatectomy. METHODS:A systematic review of the literature was performed to...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-012-2823-3

    authors: Zhang J,Wu WM,You L,Zhao YP

    更新日期:2013-06-01 00:00:00

  • Preoperative Pazopanib in High-Risk Soft Tissue Sarcoma: Phase II Window-of Opportunity Study of the German Interdisciplinary Sarcoma Group (NOPASS/GISG-04).

    abstract:BACKGROUND:Preoperative devascularization might improve local control and thus the outcome of patients with soft tissue sarcoma (STS). The multikinase inhibitor pazopanib has antiangiogenic effects and is approved for treating metastatic STS. We conducted a trial of preoperative pazopanib therapy in high-risk STS. MET...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07183-4

    authors: Ronellenfitsch U,Karampinis I,Dimitrakopoulou-Strauss A,Sachpekidis C,Jakob J,Kasper B,Nowak K,Pilz L,Attenberger U,Gaiser T,Derigs HG,Schwarzbach M,Hohenberger P

    更新日期:2019-05-01 00:00:00

  • Morbidity and mortality in 1,174 patients undergoing hepatic parenchymal transection using a stapler device.

    abstract:BACKGROUND:Transection of liver parenchyma using staplers is now commonly performed. Large studies are needed to assess the usefulness of the technique as well as perioperative outcomes. METHODS:This is a retrospective study of a prospectively maintained database. A total of 1,174 patients undergoing liver resections ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3331-9

    authors: Raoof M,Aloia TA,Vauthey JN,Curley SA

    更新日期:2014-03-01 00:00:00

  • ASO Author Reflections: Radiation Therapy in Soft Tissue Sarcoma: Who Benefits and How?

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6970-z

    authors: Albertsmeier M,Roeder F,Angele MK

    更新日期:2018-12-01 00:00:00