Impact of Patient Age on the Postoperative Survival in Pancreatic Head Cancer.

Abstract:

BACKGROUND:Some reports have stated that pancreatoduodenectomy for elderly patients have comparable morbidity and mortality to that of young patients. However, the long-term outcomes of these patients have not been fully evaluated, especially for pancreatic head cancer. METHODS:A total of 227 patients who underwent pancreatoduodenectomy for pancreatic head cancer between 2007 and 2014 were included. They were stratified according to age: young (<70 years), elderly (70 to <80 years), and very elderly (≥80 years). The short- and long-term outcomes were evaluated. RESULTS:There were no significant differences in terms of morbidity among the three groups. The median disease-free survival times were 15 months in the young, 11 months in the elderly, and 7 months in the very elderly. The disease-free survival of the young patients was significantly better than that in both the elderly and the very elderly (p = 0.012 and p = 0.016). The median overall survival times were 30 months in the young, 20 months in the elderly, and 14 months in the very elderly. The overall survival of the young patients was significantly better than that in both the elderly and the very elderly (p = 0.007 and p < 0.001). The difference was marginal between the elderly and the very elderly (p = 0.053). Multivariate analysis revealed that lymph node metastasis (p < 0.001), age ≥80 years (p = 0.013), lack of adjuvant chemotherapy (p = 0.003), blood transfusion (p = 0.015), and CA 19-9 ≥300 U/ml (p = 0.040) were significant prognostic factors. CONCLUSIONS:Patient age influenced the survival after pancreatoduodenectomy for pancreatic cancer.

journal_name

Ann Surg Oncol

authors

Sugiura T,Okamura Y,Ito T,Yamamoto Y,Ashida R,Uesaka K

doi

10.1245/s10434-017-5994-0

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

3220-3228

issue

11

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-017-5994-0

journal_volume

24

pub_type

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