Abstract：
BACKGROUND:A small differentiated gastric cancer with minute submucosal invasion after endoscopic resection is regarded as the curative resection criterion of an expanded indication. However, recent studies have shown a high incidence of lymph node metastasis in those meeting the expanded criteria. The aim of this study was to evaluate the validity of the 500 μm criterion and to determine an optimal cutoff value for the expanded indication. METHODS:We reviewed the clinicopathological data of 1,322 patients who underwent curative resection for submucosal gastric cancer between 2001 and 2013. The full thickness of the submucosa and the incidence of lymph node metastasis according to the depth of the submucosal invasion were evaluated. The sensitivity, specificity, and positive and negative predictive values were calculated with receiver operating characteristic (ROC) curve analysis. RESULTS:The mean full thickness of the submucosa was 2,605 ± 1,760 μm, and the incidence of lymph node metastasis in 103 tumors meeting the expanded indication was 3.9 % (4/103). In the ROC analysis, the area under the curve was 0.664 (95 % confidence interval 0.538-0.791; p = 0.017), and the highest negative predictive value of 98 % was observed when the cutoff value was 300 μm. CONCLUSIONS:This study suggests that a range reduction in the depth of submucosal invasion is required to obtain a high negative predictive value. Further large-scale studies are required to validate the optimal cutoff value proposed in this study.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Eom BW,Yu JS,Ryu KW,Kook MC,Kim YI,Cho SJ,Lee JY,Kim CG,Choi IJ,Yoon HM,Kim YWdoi
10.1245/s10434-014-4308-zsubject
Has Abstractpub_date
2015-01-01 00:00:00pages
1806-12issue
6eissn
1068-9265issn
1534-4681journal_volume
22pub_type
杂志文章abstract：BACKGROUND:Considering the typical rapid progression and high mortality of pancreatic cancer (PC), early detection may lead to an improved outcome. To date, there is no safe, sensitive, and cost-effective screening strategy to detect PC. Currently, screening is focused on individuals at the highest risk of developing P...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-5026-x
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Bone marrow (BM) biopsy has been suggested as an independent prognostic factor in patients with breast cancer. METHODS:Patients operated for breast cancer from June 2000 to April 2008 were enrolled in this protocol after signing an informed consent. After primary surgery, BM aspirate from the iliac crest wa...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-009-0619-x
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Complete ablation rates after a single session of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) vary from 48% to 97%. Limited data are available regarding risk factors and prognostic significance of incomplete ablation. METHODS:Between April 2001 and March 2006, 298 patients underwent RFA ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-007-9733-9
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:The extent of neck dissection (ND) appropriate for necks yielding clinical evidence of metastases of papillary thyroid carcinoma (PTC) is controversial. The need for level IIb lymph node (LN) dissection is particularly uncertain in view of its association with postoperative shoulder dysfunction. In the prese...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-009-0367-y
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Metastatic breast cancer is an aggressive disease associated with recurrence and decreased survival. To improve outcomes and develop more effective treatment strategies for patients with breast cancer, it is important to understand the molecular mechanisms underlying metastasis. METHODS:We used allelic imba...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-008-9815-3
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Local treatment of colorectal cancer, including endoscopic removal of colonic polyps and transanal resection of rectal tumors, has become widely accepted. However, risk factors predicting the presence of lymph node metastasis have not been fully investigated. To determine the criteria for local excision of c...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/s10434-999-0385-9
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Because fine-needle aspiration cannot reliably discriminate between benign and malignant follicular thyroid lesions, some surgeons use intraoperative frozen section (FS) to guide operative management. To determine the utility of FS for these lesions, we reviewed our institutional experience. METHODS:Between...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02524352
更新日期：2004-01-01 00:00:00
abstract：:Multiple randomized trials, as well as a meta-analysis of these studies, have confirmed the equivalence of breast-conservation and mastectomy. In addition, in unselected populations, adjuvant radiation therapy following lumpectomy has been shown to decrease in-breast recurrence and improve overall survival. However, r...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-4713-y
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Not all patients respond equally to neoadjuvant chemoradiotherapy (nCRT), with subsequent effects on survival. The systemic inflammatory response has been shown to predict long-term outcomes in colorectal cancer. The current study examined the association between systemic inflammation and nCRT in patients wi...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5684-3
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Although an age cutoff of 45 years has often been adopted to stratify cancer risk in papillary thyroid carcinoma (PTC), both cancer-specific survival (CSS) and disease-specific survival (DFS) continue to worsen beyond this cutoff. This study aimed to determine whether advanced age (i.e., >60 years) at diagno...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-4055-1
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Data from randomized controlled trials support use of a diverting stoma in rectal cancer patients with low anastomoses, but there is little data on how this impacts patient quality of life (QOL). This study prospectively evaluates QOL in stage I-III rectal cancer patients undergoing sphincter-preserving surg...
journal_title：Annals of surgical oncology
pub_type： 临床试验,杂志文章
doi：10.1245/s10434-010-1446-9
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Thoracoscopic lobectomy is well established for the treatment of early non-small cell lung cancer (NSCLC). Its safety and efficacy for advanced-stage disease remain uncertain. METHODS:Between January 1, 2002, and July 31, 2007, a total of 125 patients were evaluated for thoracoscopic lobectomy for advanced ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1834-9
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:The role of postmastectomy radiotherapy (PMRT) in breast cancer patients receiving neoadjuvant chemotherapy (NAC) is controversial. We aimed to evaluate the effectiveness of radiotherapy in patients treated with NAC and mastectomy in the Japanese Breast Cancer Registry. METHODS:We enrolled patients who rece...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-019-07453-1
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Definitive treatment of Graves' disease includes radioactive iodine (RAI) and thyroidectomy, but utilization varies. We hypothesize that, in addition to clinical reasons, there are socioeconomic factors that influence whether a patient undergoes thyroidectomy or RAI. METHODS:Patients treated for Graves' dis...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-4095-6
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Tumor-associated glycoprotein-72 (TAG-72) is a mucin-like high-molecular-weight glycosylated protein complex overexpressed by many adenocarcinomas. Antigen-directed cancer surgery using radiolabeled anti-TAG-72 murine monoclonal antibodies (muMAbs) has been previously investigated for colorectal cancer. Surv...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1880-3
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Pseudomyxoma peritonei syndrome is a rare disease arising from perforation of an adenoma of the appendix. The syndrome is characterized by progressive accumulation of mucinous fluid and tumor within the abdomen and pelvis. Although this tumor is only superficially invasive and does not metastasize, it is a f...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02523654
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:HER-2/neu (c-erbB-2, HER2) gene amplification and protein overexpression have been associated with poor prognosis in several solid tumors, including breast and gastric cancer. Its incidence and significance in esophageal adenocarcinoma is unknown. MATERIALS AND METHODS:Tissue microarrays were successfully c...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1554-1
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Laparoscopic versus open hepatocellular carcinoma (HCC) resection reduces morbidity without a compromise in oncologic safety.1-4 Moreover, in the subgroup of cirrhotic patients, a decreased risk of prolonged postoperative ascites and liver decompensation has been reported.5-7 METHODS: A 54-year-old homeless,...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-019-08122-z
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Esophageal cancer is an aggressive cancer with poor prognosis. However, little is known about the immune response in the tumor microenvironment after neoadjuvant chemotherapy. PURPOSE:To investigate the immunological impact of neoadjuvant chemotherapy in the tumor microenvironment of esophageal squamous cel...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1906-x
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:To assess patterns of uptake and outcomes of laparoscopic colon and rectal cancer surgery in Ontario, and the potential influence of surgical fee incentives instituted on October 1, 2005. METHODS:We used Ontario administrative databases from fiscal years 2002 to 2009. Study outcomes were uptake rates of laparo...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-3123-2
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The current standard for obtaining accurate sentinel lymph node (SLN) mapping is intraparenchymal lymphophilic dye/radiocolloid injection close to the breast tumor. We hypothesized that common lymphatic trunks drain both a large volume of breast parenchyma and skin and that intradermal or intraparenchymal ro...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/s10434-001-0837-3
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:The diagnostic phase of care is an anxiety-provoking and stressful experience for the potential breast cancer patient. A multidisciplinary team of breast cancer specialists embarked on a new initiative to pilot a Rapid Diagnosis and Support (RADS) Clinic to coordinate the diagnostic workup and nursing suppor...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-3120-5
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:The 1998 post-operative radiotherapy meta-analysis for lung cancer showed a survival detriment associated with radiation for stage I-II resected non-small cell lung cancer (NSCLC), but has been criticized for including antiquated radiation techniques. We analyzed the National Cancer Database (NCDB) to determ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-017-5786-6
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:The utility of sentinel lymph node biopsy (SLNB) for desmoplastic melanoma (DM) is debated. We describe a large single-institution experience with SLNB for DM to determine clinicopathologic factors predictive of SLN metastasis. METHODS:Retrospective review identified 205 patients with DM who underwent SLNB ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-2883-z
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Sentinel lymph node mapping (SLNM) and neoadjuvant chemotherapy are becoming established components of therapy for selected patients with breast carcinoma. However, neoadjuvant therapy has been considered a relative contraindication to SLNM. In an effort to learn whether patients who have received preoperati...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02573061
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:Intraperitoneal chemotherapy is used to treat peritoneal surface-spreading malignancies. We sought to determine whether volume and surface area of the intraperitoneal chemotherapy compartments are associated with overall survival and posttreatment glomerular filtration rate (GFR) in malignant peritoneal meso...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-2976-8
更新日期：2013-12-01 00:00:00
abstract：:Many examples highlight the power of gene expression profiles, or signatures, to provide an understanding of biological phenotypes. This is best seen in the context of cancer, where expression signatures have tremendous power to identify new cancer subtypes and to predict clinical outcomes. Gene expression profiles ha...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1855-4
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Some reports have stated that pancreatoduodenectomy for elderly patients have comparable morbidity and mortality to that of young patients. However, the long-term outcomes of these patients have not been fully evaluated, especially for pancreatic head cancer. METHODS:A total of 227 patients who underwent pa...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-017-5994-0
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the outcome of patients that received neoadjuvant chemotherapy prior to resection for colorectal liver metastases (CRLM) and compare them with a matched cohort of patients that underwent resection followed by adjuvant chemotherapy. METHODS:687 patients have undergone cur...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-007-9533-2
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:L1, a new target gene for Wnt/beta-catenin-TCF signaling, has been identified in the invasive front of colorectal cancer cells in vitro study. The L1 molecule is localized on the cell surface in tumor tissues, accompanied with loss of beta-catenin and E-cadherin. However, such association between L1 expressi...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-006-9281-8
更新日期：2007-05-01 00:00:00
