A pathway-based approach to identify molecular biomarkers in cancer.

Abstract:

:Many examples highlight the power of gene expression profiles, or signatures, to provide an understanding of biological phenotypes. This is best seen in the context of cancer, where expression signatures have tremendous power to identify new cancer subtypes and to predict clinical outcomes. Gene expression profiles have been developed to personalize medicine, accurately predicting disease recurrence and tumor response to therapy. The use of these signatures as surrogate phenotypes allows us to link diverse experimental systems, which dissect the complexity of biological systems, with the in vivo setting in a way that was not previously feasible. Taken together, these new genomic tools provide the opportunity to develop rational strategies for treating the individual cancer patient.

journal_name

Ann Surg Oncol

authors

Stevenson M,Potti A

doi

10.1245/s10434-011-1855-4

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

S620-4

eissn

1068-9265

issn

1534-4681

journal_volume

19 Suppl 3

pub_type

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