Abstract:
BACKGROUND:The determination of the incidence and prevalence of rare diseases is important for economists and health-care providers. Pseudomyxoma peritonei (PMP) is a rare, slow-growing abdominal cancer that represents a substantial burden on both patients and health-care systems. The incidence rate was previously approximated at 1-2 people per million per year; this incidence has never been challenged, and the prevalence has not been estimated. METHODS:Epidemiological data from Norway and England were obtained and analysed to calculate a minimum incidence rate based on the number of patients having a first surgical intervention for PMP. A novel method was then used to determine a prevalence rate for PMP, incorporating incidence, death, and cure rates in a multi-year analysis that accounted for the increasing population of Europe over a 10-year period. RESULTS:An incidence rate of 3.2 people per million per year was calculated, with a corresponding estimated prevalence rate of 22 people per million per year. By this calculation, 11,736 people in Europe were estimated to be living with PMP in 2018. CONCLUSION:Incidence and prevalence are essential tools for assessment of the financial and human cost of a disease. For rare diseases, such as PMP, the lack of accurate registries presents a particular challenge in determining such health-related statistical parameters. Based on our calculations, a significant number of people are living with PMP in Europe, underlining the need for appropriate resource allocation to ensure that adequate health-care measures are provided.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Patrick-Brown TDJH,Carr NJ,Swanson DM,Larsen S,Mohamed F,Flatmark Kdoi
10.1245/s10434-020-08655-8subject
Has Abstractpub_date
2021-01-01 00:00:00pages
252-257issue
1eissn
1068-9265issn
1534-4681pii
10.1245/s10434-020-08655-8journal_volume
28pub_type
杂志文章abstract:BACKGROUND:Phase III trials evaluating the role of secondary cytoreductive surgery (SCS) in recurrent ovarian cancer have pointed to the importance of patient selection. Two studies showed conflicting results regarding the benefit of SCS in BRCA1/2 mutation carriers. Our aim was to evaluate the impact of SCS on recurre...
journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章,meta分析
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abstract:BACKGROUND:Traditional teaching maintains that patients with primary colorectal adenocarcinoma require timely resection to prevent bleeding, perforation, or obstruction. The true benefits of primary tumor resection remain undocumented for patients presenting with metastatic disease, however. We postulated that resectio...
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
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abstract:: ...
journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
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更新日期:2019-01-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Annals of surgical oncology
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pub_type: 临床试验,杂志文章
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journal_title:Annals of surgical oncology
pub_type: 杂志文章,评审
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