Abstract:
BACKGROUND:The prognosis of advanced nodal (N3) squamous cell carcinoma of the head and neck (HNSCC) is poor. We investigated whether surgery or radiotherapy of early (T1-2) primary stage HSNCC is preferable to limit the overall morbidity after upfront neck dissection (uND) for N3 disease. METHODS:This retrospective multicentric Groupe d'Étude des Tumeurs de la Tête Et du Cou study included patients undergoing uND and surgery or radiotherapy of their primary. Prognostic factors were evaluated using propensity score matching to account for biases in performing surgery depending on primary site and stage. RESULTS:Of 189 T1-2, N3 HNSCC patients, 70 (37.0%) underwent uND: 42 with surgery of their primary and 28 with radiotherapy only. Radiotherapy alone was more frequent in patients with hypopharyngeal primaries. All local (N = 3) and regional (N = 10) relapses (included 2 locoregional relapses) occurred within the first 2 years. There were 16 distant metastatic failures. Five-year locoregional relapse and survival incidences were 15.7% and 66.5% and were similar regardless of the treatment of the primary. The overall morbidity rate was 65.2% and was similar after weighting by the inverse propensity score (p = 0.148). The only prognostic factor for morbidity was the radicality of the uND. Prolonged parenteral feeding was not more frequent in patients only irradiated to their primary (p = 0.118). Prolonged tracheostomy was more frequent after surgery of the primary. CONCLUSIONS:In patients with T1-2, N3 HNSCC undergoing uND, radiotherapy and surgery of the primary yield similar oncological outcomes. Morbidity was related to the extent of neck dissection.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Carsuzaa F,Thariat J,Gorphe P,Righini C,Cosmidis A,Thureau S,Roge M,De Mones E,Servagi-Vernat S,Tonnerre D,Morinière S,Dugas A,Malard O,Pasquier F,Vergez S,Salleron J,Dufour Xdoi
10.1245/s10434-019-07589-0subject
Has Abstractpub_date
2019-10-01 00:00:00pages
3673-3680issue
11eissn
1068-9265issn
1534-4681pii
10.1245/s10434-019-07589-0journal_volume
26pub_type
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