Can We Predict the Lateral Compartment Lymph Node Involvement in RET-Negative Patients with Medullary Thyroid Carcinoma?

Abstract:

BACKGROUND:Lateral lymph node dissection (LND) in the absence of macroscopic nodal metastasis remains controversial in sporadic medullary thyroid carcinoma (MTC). OBJECTIVES:The aims of our study were to determine the risk of lateral lymph node (LN) metastases with a focus on lateral contralateral N1, and to define a risk-adapted surgical treatment for these patients. METHODS:All patients who underwent surgery from 1980 to 2012 for previously untreated RET-negative MTC were reviewed. We focused on the lateral compartments of LN metastases and identified three groups: no lateral LN metastases, ipsilateral lateral (ILL)-LN metastases with no contralateral LN involvement, and contralateral lateral (CLL)-LN metastases. RESULTS:Overall, 131 patients underwent surgery for RET-negative MTC. A total thyroidectomy with LND was performed in 112 patients (85 %), including 97 patients who had an ILL-LND and 92 patients who had a CLL-LND. Lateral LN metastases (N1) occurred in 40 patients (37 %): 31 patients (32 %) had ILL-LN metastases with no contralateral LN involvement, and 9 patients (10 %) had CLL-LN metastases. The preoperative cut-offs for LN metastases in the ILL compartment were very low, with a smallest tumor size of 5 mm, and lowest serum calcitonin level of 38 pg/ml. Disease-free survival rates decreased from 92 % for patients with no lateral LN metastases to 41 % for patients with ILL-LN metastases and 0 % for patients with CLL-LN metastases. CONCLUSIONS:ILL-LND should be performed in every patient and only a minority of MTC patients with small micro-MTC, and low serum calcitonin levels should not have a CLL-LND.

journal_name

Ann Surg Oncol

authors

Chandeze MM,Noullet S,Faron M,Trésallet C,Godiris-Petit G,Tissier F,Buffet C,Leenhardt L,Chereau N,Menegaux F

doi

10.1245/s10434-016-5292-2

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

3653-3659

issue

11

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-016-5292-2

journal_volume

23

pub_type

杂志文章
  • Feasibility of breast preserving therapy with single fraction in situ radiotherapy delivered intraoperatively.

    abstract:BACKGROUND:Accelerated partial breast irradiation (APBI) has gained widespread interest as a means of improving the convenience and availability of breast conserving radiotherapy. Intraoperative radiation therapy (IORT) is an APBI technique that delivers breast radiotherapy as a single dose at the time of partial maste...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9154-1

    authors: Ollila DW,Klauber-DeMore N,Tesche LJ,Kuzmiak CM,Pavic D,Goyal LK,Lian J,Chang S,Livasy CA,Sherron RF,Sartor CI

    更新日期:2007-02-01 00:00:00

  • Defining venous involvement in borderline resectable pancreatic cancer.

    abstract:BACKGROUND:Pancreatic adenocarcinoma impinging the portal and/or superior mesenteric vein (PV-SMV) is classified as borderline resectable, and preoperative chemoradiation is recommended to increase the margin-negative resection rate. There is no consensus about what degree of venous impingement constitutes borderline r...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1284-9

    authors: Chun YS,Milestone BN,Watson JC,Cohen SJ,Burtness B,Engstrom PF,Haluszka O,Tokar JL,Hall MJ,Denlinger CS,Astsaturov I,Hoffman JP

    更新日期:2010-11-01 00:00:00

  • Pitfalls of positive findings in staging esophageal cancer with F-18-fluorodeoxyglucose positron emission tomography.

    abstract:BACKGROUND:18-F-fluorodeoxyglucose positron emission tomography (FDG-PET) is valuable in staging of esophageal cancer. However, FDG-PET may falsely upstage patients leading to incorrect exclusion from surgical treatment. This study was performed to determine the false-positive rate and possible causes. METHODS:The rat...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/aso.2003.03.005

    authors: van Westreenen HL,Heeren PA,Jager PL,van Dullemen HM,Groen H,Plukker JT

    更新日期:2003-11-01 00:00:00

  • The ability of existing questionnaires to measure symptom change after paracentesis for symptomatic ascites.

    abstract:BACKGROUND:Symptomatic malignant ascites is a problem for patients with advanced intra-abdominal malignancy. Although the goal of paracentesis, the most common therapeutic intervention, is symptom palliation, the best method of assessing symptom improvement is unknown. The aim of this study was to assess the ability of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9370-3

    authors: Easson AM,Bezjak A,Ross S,Wright JG

    更新日期:2007-08-01 00:00:00

  • Relationship between pathologic T-stage and nodal metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer.

    abstract:BACKGROUND:We investigated the relationship between pathologic T-stage and mesorectal metastases after preoperative chemoradiotherapy (CRT) for clinical stage II to III rectal carcinoma. METHODS:The records of consecutive patients with clinical stage II to III carcinoma of the mid or low rectum who underwent surgery a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.03.044

    authors: Pucciarelli S,Capirci C,Emanuele U,Toppan P,Friso ML,Pennelli GM,Crepaldi G,Pasetto L,Nitti D,Lise M

    更新日期:2005-02-01 00:00:00

  • Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010.

    abstract:BACKGROUND:In 2007, the National Quality Forum (NQF) released four performance measures for the treatment of breast cancer. We proposed to study the degree of adherence with these measures among participating institutions in a multi-institutional trial. METHODS:American College of Surgeons Oncology Group (ACOSOG) Z001...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0980-9

    authors: Wilke LG,Ballman KV,McCall LM,Giuliano AE,Whitworth PW,Blumencranz PW,Reintgen DS,Burak WE,Leitch AM,Hunt KK

    更新日期:2010-08-01 00:00:00

  • Long-term morbidity of sentinel node biopsy versus complete axillary dissection for unilateral breast cancer.

    abstract:BACKGROUND:Postoperative changes after axillary lymph node surgery may significantly alter breast cancer survivors' (BCS) quality of life. Although sentinel lymph node biopsy (SLNB) has less immediate morbidity than axillary lymph node dissection (ALND), its long-term impact on shoulder abduction, arm swelling, and neu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9909-y

    authors: Crane-Okada R,Wascher RA,Elashoff D,Giuliano AE

    更新日期:2008-07-01 00:00:00

  • The microRNA-21/PTEN pathway regulates the sensitivity of HER2-positive gastric cancer cells to trastuzumab.

    abstract:BACKGROUND:The ToGA trial demonstrated the significant efficacy of trastuzumab in addition to chemotherapy in patients with HER2-positive gastric cancer (GC). Although trastuzumab has become a key drug in breast cancer treatment, resistance to trastuzumab is a major problem in clinical practice. The aim of the current ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3325-7

    authors: Eto K,Iwatsuki M,Watanabe M,Ida S,Ishimoto T,Iwagami S,Baba Y,Sakamoto Y,Miyamoto Y,Yoshida N,Baba H

    更新日期:2014-01-01 00:00:00

  • A prospective evaluation of palliative outcomes for surgery of advanced malignancies.

    abstract:BACKGROUND:We prospectively evaluated the effectiveness of major surgery in treating symptoms of advanced malignancies. METHODS:Fifty-nine patients were evaluated for major symptoms of intent to treat and were followed up until death or last clinical evaluation. Surgeons identified planned operations before surgery as...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/aso.2003.06.011

    authors: McCahill LE,Smith DD,Borneman T,Juarez G,Cullinane C,Chu DZ,Ferrell BR,Wagman LD

    更新日期:2003-07-01 00:00:00

  • ASO Author Reflections: Abandoning the Drains by Eliminating the Radical Procedures Necessitating the Drains.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6965-9

    authors: Weber WP

    更新日期:2018-12-01 00:00:00

  • Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer.

    abstract:BACKGROUND:Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers. MATERIALS AND METHODS:A small, portable version of the FLARE imaging system, termed Mini-FLARE, was developed for capturing color video and two semi-independent channe...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1566-x

    authors: Mieog JS,Troyan SL,Hutteman M,Donohoe KJ,van der Vorst JR,Stockdale A,Liefers GJ,Choi HS,Gibbs-Strauss SL,Putter H,Gioux S,Kuppen PJ,Ashitate Y,Löwik CW,Smit VT,Oketokoun R,Ngo LH,van de Velde CJ,Frangioni JV,Vahrme

    更新日期:2011-09-01 00:00:00

  • Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patients.

    abstract:BACKGROUND:The rarity of melanoma in young patients, particularly pediatric ones, has to date precluded any valid comparisons being made between young patients and adults undergoing sentinel lymph node biopsy (SLNB) for intermediate thickness localized melanoma. The present study takes advantage of the large Sydney Mel...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-009-0657-4

    authors: Howman-Giles R,Shaw HM,Scolyer RA,Murali R,Wilmott J,McCarthy SW,Uren RF,Thompson JF

    更新日期:2010-01-01 00:00:00

  • Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients.

    abstract:BACKGROUND:Response to neoadjuvant chemotherapy is an independent prognostic factor in locally advanced gastric cancer. However, no prospectively tested pretherapeutic parameters predicting response and/or survival in gastric cancer are available in clinical routine. METHODS:We evaluated the prognostic significance of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2254-1

    authors: Lorenzen S,Blank S,Lordick F,Siewert JR,Ott K

    更新日期:2012-07-01 00:00:00

  • Visceral Adiposity and Sarcopenic Visceral Obesity are Associated with Poor Prognosis After Resection of Pancreatic Cancer.

    abstract:BACKGROUND:Visceral fat accumulation and muscle depletion have been identified as poor prognostic factors for various cancers. However, the significance of visceral adiposity and sarcopenic visceral obesity on outcomes after resection of pancreatic cancer remains unclear. METHODS:A retrospective analysis of 301 patien...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6077-y

    authors: Okumura S,Kaido T,Hamaguchi Y,Kobayashi A,Shirai H,Yao S,Yagi S,Kamo N,Hatano E,Okajima H,Takaori K,Uemoto S

    更新日期:2017-11-01 00:00:00

  • ASO Author Reflections: Radiation Therapy in Soft Tissue Sarcoma: Who Benefits and How?

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6970-z

    authors: Albertsmeier M,Roeder F,Angele MK

    更新日期:2018-12-01 00:00:00

  • Can breast surgeons provide breast cancer genetic testing? An American Society of Breast Surgeons survey.

    abstract:BACKGROUND:Whether breast cancer surgeons are adequately trained, skilled, and experienced to provide breast cancer genetic assessment, testing, and counseling came under debate in September 2013 when a major third-party payer excluded nongenetics specialists from ordering such testing. A literature search having faile...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3711-9

    authors: Beitsch PD,Whitworth PW

    更新日期:2014-12-01 00:00:00

  • Chemoprevention Uptake for Breast Cancer Risk Reduction Varies by Risk Factor.

    abstract:BACKGROUND/OBJECTIVE:The efficacy of chemoprevention for breast cancer risk reduction has been demonstrated in randomized controlled trials; however, use remains low. We sought to determine whether uptake differed by risk factors, and to identify reasons for refusal and termination. METHODS:Women seen in a high-risk c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07236-8

    authors: Flanagan MR,Zabor EC,Stempel M,Mangino DA,Morrow M,Pilewskie ML

    更新日期:2019-07-01 00:00:00

  • Influence of Age on the Clinical Outcome of Breast Cancer for Men and the Development of Second Primary Cancers.

    abstract:BACKGROUND:Low incidence of breast cancer in men (BCM) (< 1% of all breast cancers) has led to a paucity of outcome data. This study evaluated the impact of age on BCM outcomes. METHODS:For this study, BCM patients treated between 2000 and 2011 were stratified by age (≤ 65 or > 65 years). Kaplan-Meier methods were use...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6767-0

    authors: Cronin PA,Romanoff A,Zabor EC,Stempel M,Eaton A,Smyth LM,Ho AY,Morrow M,El-Tamer M,Gemignani ML

    更新日期:2018-12-01 00:00:00

  • Clinical and Radiologic Predictors of a Pathologic Complete Response to Neoadjuvant Chemotherapy (NACT) in Patients Undergoing Cytoreductive Surgery for Colorectal Peritoneal Metastases: Results of a Prospective Multi-center Study.

    abstract:BACKGROUND:Patients undergoing cytoreductive surgery for colorectal peritoneal metastases who have a pathologic complete response (pCR) to neoadjuvant chemotherapy experience a significantly longer survival than those with residual disease. This response is known only after surgery. This study aimed to examine clinical...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09330-8

    authors: Bhatt A,Rousset P,Benzerdjeb N,Kammar P,Mehta S,Parikh L,Goswami G,Shaikh S,Kepenekian V,Passot G,Glehen O

    更新日期:2020-11-18 00:00:00

  • Topographic genotyping of colorectal carcinoma: from a molecular carcinogenesis model to clinical relevance.

    abstract:BACKGROUND:In recent years, as a result of refinement in molecular biology techniques, significant progress has been made in the understanding of colorectal carcinogenesis. Particular attention has been drawn to identification of genetic mutation that may predispose to colorectal carcinoma (familial syndromes) and may ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02306621

    authors: Pricolo VE,Finkelstein SD,Bland KI

    更新日期:1997-04-01 00:00:00

  • Extent of microinvasion in ductal carcinoma in situ is not associated with sentinel lymph node metastases.

    abstract:BACKGROUND:Ductal carcinoma in situ with microinvasion (DCISM) is a rare diagnosis with a good prognosis. Although nodal metastases are uncommon, sentinel lymph node biopsy (SLNB) remains standard care. Volume of disease in invasive breast cancer is associated with SLNB positivity, and, thus we hypothesized that in a l...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3920-2

    authors: Matsen CB,Hirsch A,Eaton A,Stempel M,Heerdt A,Van Zee KJ,Cody HS 3rd,Morrow M,Plitas G

    更新日期:2014-10-01 00:00:00

  • Functional down-regulation of beta1 and beta2 integrins of lamina propria lymphocytes (LPL) and tumor-infiltrating lymphocytes (TIL) in colorectal cancer patients.

    abstract::Integrins play an important role in various lymphocyte functions. In this study, we isolated lamina propria lymphocytes (LPL) and tumor-infiltrating lymphocytes (TIL) from normal and malignant tissues in patients with colorectal cancer, and examined the expression of beta1 and beta2 integrins on these lymphocytes quan...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-999-0500-y

    authors: Kitayama J,Tuno N,Nakayama H,Shibata Y,Muto T,Nagawa H

    更新日期:1999-07-01 00:00:00

  • A Population-Based Study of the Effects of a Regional Guideline for Completion Axillary Lymph Node Dissection on Axillary Surgery in Patients with Breast Cancer.

    abstract:INTRODUCTION:Evidence from the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial suggests completion axillary lymph node dissection (cALND) after positive sentinel lymph node biopsy (+SLNB) does not improve outcomes in select patients, leading to practice variation. A multidisciplinary group of surgeons,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5310-4

    authors: Tsao MW,Cornacchi SD,Hodgson N,Simunovic M,Thabane L,Cheng J,O'Brien MA,Strang B,Mukherjee SD,Lovrics PJ

    更新日期:2016-10-01 00:00:00

  • Changing the Default: A Prospective Study of Reducing Discharge Opioid Prescription after Lumpectomy and Sentinel Node Biopsy.

    abstract:BACKGROUND:Whether routinely prescribed opioids are necessary for pain control after discharge among lumpectomy/sentinel node biopsy (Lump/SLNB) patients is unclear. We hypothesize that Lump/SLNB patients could be discharged without opioids, with a failure rate < 10%. This study prospectively examines outcomes after ch...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08886-9

    authors: Moo TA,Pawloski KR,Sevilimedu V,Charyn J,Simon BA,Sclafani LM,Plitas G,Barrio AV,Kirstein LJ,Van Zee KJ,Morrow M

    更新日期:2020-11-01 00:00:00

  • Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms.

    abstract:BACKGROUND:Peritoneal carcinomatosis (PC) in the setting of mucinous appendiceal neoplasms is characterized by the intraperitoneal accumulation of mucinous ascites and mucin-secreting epithelial cells that leads to progressive compression of intra-abdominal organs, morbidity, and eventual death. We assessed postoperati...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2241-6

    authors: Austin F,Mavanur A,Sathaiah M,Steel J,Lenzner D,Ramalingam L,Holtzman M,Ahrendt S,Pingpank J,Zeh HJ,Bartlett DL,Choudry HA

    更新日期:2012-05-01 00:00:00

  • Lymph node dissection after chemoradiation in esophageal cancer: a subgroup analysis of patients with and without pathological response.

    abstract:BACKGROUND:Extensive lymph node dissection (LND) is beneficial in primarily resected esophageal cancer patients. Such benefit was believed to be seen in neoadjuvant chemoradiotherapy (CRT)-treated patients, but evidence was inconsistent. We hypothesized that CRT might offset the benefit of LND in certain subgroup of pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2402-7

    authors: Chao YK,Liu HP,Hsieh MJ,Wu YC,Liu YH,Yeh CH,Chang HK,Tseng CK

    更新日期:2012-10-01 00:00:00

  • Phase II Trial of Adjuvant Dendritic Cell Vaccine in Combination with Celecoxib, Interferon-α, and Rintatolimod in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastases.

    abstract:BACKGROUND:Peritoneal metastases portend poor prognosis in the setting of standard chemotherapy. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) improves outcomes, but relapse is common. We report a phase II trial evaluating the safety and efficacy of adjuvant αDC1 vaccination with chemo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09464-9

    authors: Ramanathan R,Choudry H,Jones H,Girgis M,Gooding W,Kalinski P,Bartlett DL

    更新日期:2021-01-05 00:00:00

  • Increasing Appropriate BRCA1/2 Mutation Testing: The Role of Family History Documentation and Genetic Counseling in a Multidisciplinary Clinic.

    abstract:BACKGROUND:Findings show that 5-10 % of women with a diagnosis of breast cancer (BCa) have actionable genetic mutations. The National Comprehensive Cancer Network guidelines for testing to detect BRCA1/2 mutations include personal history (PH) variables such as age of 45 years or younger and a family history (FH) varia...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5545-0

    authors: Kishan AU,Gomez CL,Dawson NA,Dvorak R,Foster NM,Hoyt A,Hurvitz SA,Kusske A,Silver EL,Tseng C,McCloskey SA

    更新日期:2016-12-01 00:00:00

  • Is FGFR2 a Suitable Target to Treat Scirrhous-Type Gastric Cancer?

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 社论

    doi:10.1245/s10434-018-07146-1

    authors: Yasui W

    更新日期:2019-04-01 00:00:00

  • Neuroendocrine tumors of the colon and rectum: prognostic relevance and comparative performance of current staging systems.

    abstract:BACKGROUND:With increasing interest in neuroendocrine tumors (NETs), three staging systems for NETs of the colon and rectum have been published. Their prognostic relevance has not been examined and compared in an independent clinical database. METHODS:From the National Cancer Database (NCDB), 5457 patients diagnosed w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2746-z

    authors: Chagpar R,Chiang YJ,Xing Y,Cormier JN,Feig BW,Rashid A,Chang GJ,You YN

    更新日期:2013-04-01 00:00:00