Abstract:
BACKGROUND:Postoperative changes after axillary lymph node surgery may significantly alter breast cancer survivors' (BCS) quality of life. Although sentinel lymph node biopsy (SLNB) has less immediate morbidity than axillary lymph node dissection (ALND), its long-term impact on shoulder abduction, arm swelling, and neurosensory changes has not been evaluated. The purpose of this study was to compare long-term morbidity after SLNB or ALND and breast-conservation surgery. METHODS:Female BCS who remained free of disease at least 3 years after ALND or SLNB for Stage I-III unilateral breast cancer completed a symptom questionnaire and a brief neurosensory physical examination of the upper arm and axilla (range of motion, arm circumference, and sensation to light touch with cotton and needle). RESULTS:The mean age of the 187 participating BCS was 62 years. At a mean follow-up of 6.6 years after ALND and 4.9 years after SLNB, most BCS had full abduction; only 10 cases (8 ALND, 2 SLNB) had a >/=2 cm proximal and/or distal circumference difference on the ipsilateral side compared with the contralateral side. ALND was associated with a significantly greater likelihood of subjective arm numbness (P < .001), chest or axillary numbness (P < .001), arm or hand swelling (P < .001), and objective neurosensory changes in the posterior axilla, medial and distal upper arm (P < .001). Operative procedure was the only significant predictor of neurosensory changes (P < .001). CONCLUSION:SLNB is associated with significantly less subjective and objective long-term morbidity than ALND.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Crane-Okada R,Wascher RA,Elashoff D,Giuliano AEdoi
10.1245/s10434-008-9909-ysubject
Has Abstractpub_date
2008-07-01 00:00:00pages
1996-2005issue
7eissn
1068-9265issn
1534-4681journal_volume
15pub_type
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-015-4379-5
更新日期:2015-12-01 00:00:00
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1007/s10434-999-0155-8
更新日期:1999-03-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:2014-12-01 00:00:00
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更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Annals of surgical oncology
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更新日期:2013-10-01 00:00:00
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更新日期:2014-05-01 00:00:00
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更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Surgery for locally advanced rectal cancers beyond the plane of total mesorectal excision (TME) or extramesorectal nodal involvement should include complete resection. This study evaluated the oncologic feasibility and safety of robot-assisted surgery for rectal cancer beyond the TME plane. METHODS:The stud...
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更新日期:2016-07-01 00:00:00
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更新日期:2019-05-01 00:00:00
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更新日期:2015-08-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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journal_title:Annals of surgical oncology
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更新日期:2007-06-01 00:00:00
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更新日期:2015-12-01 00:00:00
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更新日期:2009-02-01 00:00:00
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更新日期:2016-02-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2019-02-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2009-03-01 00:00:00
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journal_title:Annals of surgical oncology
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更新日期:2021-01-05 00:00:00
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更新日期:2013-11-01 00:00:00