Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma.

Abstract:

BACKGROUND:There is increasing evidence that tumor hypoxia plays a significant role in the chemoresistance of melanoma, but to our knowledge, real-time tumor oxygenation during isolated limb infusion (ILI) has not been studied. We sought to demonstrate the feasibility of measuring real-time alterations in tissue oxygenation. METHODS:Consecutive patients with histologically confirmed in-transit melanoma were enrolled onto a prospective single-arm pilot study and administered the hypoxia marker drug EF5. All patients were treated with ILI. Optical spectroscopy readings were obtained at three locations: two discrete target lesions and one normal skin control. Measurements were taken at 11 predefined time points during ILI. RESULTS:A total of six patients were enrolled onto this pilot study. Intratumor and normal skin optical spectroscopy readings were found to have discrete inflection points throughout the duration of therapy, corresponding with established time points. Baseline hypoxia as measured by both optical spectroscopy and EF5 immunofluorescence was variable, but on the basis of optical spectra, tumors appeared to become more hypoxic compared to normal skin after tourniquet application. The optical hypoxia signature was variable between patients while hemoglobin absorption increased. CONCLUSIONS:To our knowledge, this is the first use of real-time optical spectroscopy to evaluate oxygenation and perfusion within melanoma lesions during regional chemotherapy. We report our development of this new noninvasive means of assessing tumor vascular function, which has the potential to be a powerful tool for noninvasive examination of the melanoma tumor microenvironment.

journal_name

Ann Surg Oncol

authors

Speicher PJ,Beasley GM,Jiang B,Lidsky ME,Palmer GM,Scarbrough PM,Mosca PJ,Dewhirst MW,Tyler DS

doi

10.1245/s10434-013-3222-0

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

1435-40

issue

5

eissn

1068-9265

issn

1534-4681

journal_volume

21

pub_type

杂志文章
  • Clinical features and outcome of primary pancreatic lymphoma.

    abstract:INTRODUCTION:Primary pancreatic lymphoma (PPL) is a rare tumor that is often misdiagnosed. Clinicopathologic features, optimal therapy, and outcomes are not well defined. We reviewed our institutional experience with PPL. METHODS:Search of our institutional database identified that between 1987-2012, 21,760 patients w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4176-6

    authors: Sadot E,Yahalom J,Do RK,Teruya-Feldstein J,Allen PJ,Gönen M,D'Angelica MI,Kingham TP,Jarnagin WR,DeMatteo RP

    更新日期:2015-04-01 00:00:00

  • Trends in Regional Nodal Management of Breast Cancer Patients with Low Nodal Burden.

    abstract:BACKGROUND:American College of Surgeons Oncology Group Z0011 confirms the safety of omitting axillary lymph node dissection (ALND) and regional nodal irradiation (RNI) in breast cancer patients with one to two positive sentinel lymph nodes (SLNs), without compromising disease-free survival (DFS) and overall survival (O...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07901-y

    authors: Raber BM,Lin H,Shen Y,Shaitelman SF,Bedrosian I

    更新日期:2019-12-01 00:00:00

  • Cavity Shaving Reduces Involved Margins and Reinterventions Without Increasing Costs in Breast-Conserving Surgery: A Propensity Score-Matched Study.

    abstract:BACKGROUND:Currently, reinterventions for involved margins after breast-conserving surgery remain common. The aim of this study was to assess the capability of the cavity shave margins (CSM) technique to reduce positive margin rates and reoperations compared with simple lumpectomy (SL). The impact of CSM on the various...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5774-x

    authors: Corsi F,Sorrentino L,Bonzini M,Bossi D,Truffi M,Amadori R,Nebuloni M,Brillat B,Mazzucchelli S

    更新日期:2017-06-01 00:00:00

  • Priority of lymph node dissection for Siewert type II/III adenocarcinoma of the esophagogastric junction.

    abstract:OBJECTIVE:The purpose of this study was to clarify the priority of nodal dissection in Siewert types II and III adenocarcinoma of the esophagogastric junction (AEG). METHODS:The priority of nodal dissection was evaluated based on the therapeutic value index calculated by multiplying of the frequency of metastasis to e...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3036-0

    authors: Hasegawa S,Yoshikawa T,Rino Y,Oshima T,Aoyama T,Hayashi T,Sato T,Yukawa N,Kameda Y,Sasaki T,Ono H,Tsuchida K,Cho H,Kunisaki C,Masuda M,Tsuburaya A

    更新日期:2013-12-01 00:00:00

  • Increasing the Number of Examined Lymph Nodes is a Prerequisite for Improvement in the Accurate Evaluation of Overall Survival of Node-Negative Gastric Cancer Patients.

    abstract:BACKGROUND:This study aims to elucidate whether increasing the number of examined lymph nodes (NELN) is mandatory for the accurate prognosis of node-negative gastric cancer (GC) patients after curative gastrectomy in Eastern countries (China and Japan). METHODS:The clinicopathological data of 2455 GC patients (includi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-016-5513-8

    authors: Deng J,Yamashita H,Seto Y,Liang H

    更新日期:2017-03-01 00:00:00

  • Rapid genetic diagnosis with the transcription-reverse transcription concerted reaction system for cancer micrometastasis.

    abstract:BACKGROUND:Detection of cancer micrometastases is required for improvement of cancer therapy. The aim of this study was to establish a rapid and practical genetic assay to detect micrometastasis in gastric cancer and to assess its clinical significance with respect to prognosis. METHODS:A novel RNA amplification syste...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2004.12.043

    authors: Ishii T,Fujiwara Y,Ohnaka S,Hayashi T,Taniguchi H,Takiguchi S,Yasuda T,Yano M,Monden M

    更新日期:2004-08-01 00:00:00

  • Surgical Management of the Axilla in Patients with Occult Breast Cancer (cT0 N+) After Neoadjuvant Chemotherapy.

    abstract:BACKGROUND:Occult breast cancer (OBC) is a rare clinical entity. Current surgical management includes axillary lymphadenectomy (ALND) with or without mastectomy. We sought to investigate the role of sentinel lymph node biopsy (SLNB) in patients with OBC treated with neoadjuvant chemotherapy (NAC). METHODS:Patients wit...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08227-w

    authors: Cohen BL,Collier AL,Kelly KN,Goel N,Kesmodel SB,Yakoub D,Moller M,Avisar E,Franceschi D,Macedo FI

    更新日期:2020-06-01 00:00:00

  • Impact of Patient Age on the Postoperative Survival in Pancreatic Head Cancer.

    abstract:BACKGROUND:Some reports have stated that pancreatoduodenectomy for elderly patients have comparable morbidity and mortality to that of young patients. However, the long-term outcomes of these patients have not been fully evaluated, especially for pancreatic head cancer. METHODS:A total of 227 patients who underwent pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5994-0

    authors: Sugiura T,Okamura Y,Ito T,Yamamoto Y,Ashida R,Uesaka K

    更新日期:2017-10-01 00:00:00

  • Long-term survival of peritoneal carcinomatosis of colorectal origin.

    abstract:BACKGROUND:Peritoneal carcinomatosis of colorectal cancer is probably best treated by cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). In The Netherlands Cancer Institute, this treatment has been performed since 1995. The long tradition of this treatment enabled us to study long-term survival in det...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10434-004-1167-z

    authors: Verwaal VJ,van Ruth S,Witkamp A,Boot H,van Slooten G,Zoetmulder FA

    更新日期:2005-01-01 00:00:00

  • Management of locoregional and systemic recurrence of breast cancer: to stage or not to stage and how.

    abstract::The surveillance of breast cancer patients after potentially curative treatment may result in the identification of locoregional or distant recurrence. While many patients expect frequent imaging studies to monitor for recurrence, there are no data supporting aggressive imaging surveillance beyond mammography. However...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3180-6

    authors: Leitch AM

    更新日期:2013-10-01 00:00:00

  • The utility of intraoperative evaluation of sentinel lymph nodes in breast cancer.

    abstract:BACKGROUND:In breast cancer treatment, intraoperative sentinel lymph node (SLN) evaluation is used to identify patients who may potentially benefit from immediate completion of axillary lymph node dissection. METHODS:Prospectively collected breast cancer registry data identified 516 SLN biopsies between January 2003 a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9270-y

    authors: Pugliese MS,Tickman R,Wang NP,Atwood M,Beatty JD

    更新日期:2007-03-01 00:00:00

  • Initial results with preoperative tattooing of biopsied axillary lymph nodes and correlation to sentinel lymph nodes in breast cancer patients.

    abstract:BACKGROUND:Pretreatment evaluation of axillary lymph nodes (ALNs) and marking of biopsied nodes in patients with newly diagnosed breast cancer is becoming routine practice. We sought to test tattooing of biopsied ALNs with a sterile black carbon suspension (Spot™). The intraoperative success of identifying tattooed ALN...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4034-6

    authors: Choy N,Lipson J,Porter C,Ozawa M,Kieryn A,Pal S,Kao J,Trinh L,Wheeler A,Ikeda D,Jensen K,Allison K,Wapnir I

    更新日期:2015-02-01 00:00:00

  • Treatment of Diaphragmatic Hernia Occurring After Transhiatal Esophagectomy.

    abstract:BACKGROUND:Postesophagectomy diaphragmatic hernia (DH) is an uncommon problem but an important one to recognize and treat because of the risk of significant complications such as incarceration and strangulation. Diaphragmatic hernia appears to occur more frequently following transhiatal esophagectomy (THE) than after t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4366-x

    authors: Narayanan S,Sanders RL,Herlitz G,Langenfeld J,August DA

    更新日期:2015-10-01 00:00:00

  • Should adjuvant therapy remain the standard of care for patients with resected adenocarcinoma of the pancreas?

    abstract::Adenocarcinoma of the pancreas continues to be a formidable disease. In the United States, patients who have had resected disease are generally offered adjuvant chemoradiation. The current National Comprehensive Cancer Network practice guidelines uniformly support this practice. We reviewed seven selected series to ev...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/aso.2003.06.015

    authors: Chu QD,Khushalani N,Javle MM,Douglass HO Jr,Gibbs JF

    更新日期:2003-06-01 00:00:00

  • Relationship between the lymphatic drainage of the breast and the upper extremity: a postmortem study.

    abstract:BACKGROUND:This anatomic study details the lymphatic drainage of the upper extremity (UE) and breast, as well as its course in the axilla and its relation to axillary reverse mapping. Two aspects important for breast cancer surgery were followed: connection between the lymphatics of the UE and breast, and the possible ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2363-x

    authors: Pavlista D,Eliska O

    更新日期:2012-10-01 00:00:00

  • Severe duodenal involvement in familial adenomatous polyposis treated by pylorus-preserving pancreaticoduodenectomy.

    abstract:PURPOSE:Pancreaticoduodenectomy is an alternative to pancreas-sparing duodenectomy for radical treatment of duodenal lesions. The aims of this study were to assess the results of pylorus-preserving pancreaticoduodenectomy (PPPD) for severe duodenal polyposis in familial adenomatous polyposis in terms of morbidity, long...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2221-x

    authors: Caillié F,Paye F,Desaint B,Bennis M,Lefèvre JH,Parc Y,Svrcek M,Balladur P,Tiret E

    更新日期:2012-09-01 00:00:00

  • Factors Associated with Reoperation in Breast-Conserving Surgery for Cancer: A Prospective Study of American Society of Breast Surgeon Members.

    abstract:BACKGROUND:More than 20% of patients undergoing initial breast-conserving surgery (BCS) for cancer require reoperation. To address this concern, the American Society of Breast Surgeons (ASBrS) endorsed 10 processes of care (tools) in 2015 to be considered by surgeons to de-escalate reoperations. In a planned follow-up,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07547-w

    authors: Landercasper J,Borgert AJ,Fayanju OM,Cody H 3rd,Feldman S,Greenberg C,Linebarger J,Pockaj B,Wilke L

    更新日期:2019-10-01 00:00:00

  • Up-regulation of NEK2 by microRNA-128 methylation is associated with poor prognosis in colorectal cancer.

    abstract:BACKGROUND:NIMA-related kinase 2 (NEK2), an enzyme involved in the development and progression of cancer, is abnormally expressed in a wide variety of human cancers, including colorectal cancer (CRC), and is known to have roles in cell division and mitotic regulation through centrosome splitting. We investigated the cl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3264-3

    authors: Takahashi Y,Iwaya T,Sawada G,Kurashige J,Matsumura T,Uchi R,Ueo H,Takano Y,Eguchi H,Sudo T,Sugimachi K,Yamamoto H,Doki Y,Mori M,Mimori K

    更新日期:2014-01-01 00:00:00

  • Axillary recurrence after a tumor-positive sentinel lymph node biopsy without axillary treatment: a review of the literature.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) has become standard of care as a staging procedure in patients with invasive breast cancer. A positive SLNB allows completion axillary lymph node dissection (cALND) to be performed. The axillary recurrence rate (ARR) after cALND in patients with positive SLNB is low. Recentl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-012-2490-4

    authors: Francissen CM,Dings PJ,van Dalen T,Strobbe LJ,van Laarhoven HW,de Wilt JH

    更新日期:2012-12-01 00:00:00

  • Toxicity of Immune Checkpoint Inhibitors: Considerations for the Surgeon.

    abstract:BACKGROUND:The use of immunotherapeutic agents, specifically immune checkpoint inhibitors (ICIs) for solid malignancies, is rapidly rising, and many new agents and treatment combinations are in development. However, ICIs have a unique side-effect profile of immune-related adverse events (irAEs) compared with chemothera...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-019-08183-0

    authors: Helmink BA,Roland CL,Kiernan CM,Wargo JA

    更新日期:2020-05-01 00:00:00

  • Risk of Regional Recurrence After Negative Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence.

    abstract:BACKGROUND:Repeat sentinel lymph node biopsy (rSLNB) has increasingly been used in patients with ipsilateral breast tumor recurrence (IBTR). The safety in terms of regional disease control after this procedure remains unclear. This study evaluates occurrence of regional recurrence as first event in patients with IBTR a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6384-y

    authors: Poodt IGM,Vugts G,Maaskant-Braat AJG,Schipper RJ,Voogd AC,Nieuwenhuijzen GAP,Sentinel Node and Recurrent Breast Cancer (SNARB) study group.

    更新日期:2018-05-01 00:00:00

  • Sestamibi imaging for primary hyperparathyroidism: the impact of surgeon interpretation and radiologist volume.

    abstract:BACKGROUND:Preoperative localization is the first step towards minimally invasive targeted parathyroidectomy. While there are data emphasizing that surgeon experience optimizes operative outcomes, the role of the radiologist's experience in successful preoperative imaging is unclear. We hypothesized that the accuracy o...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2581-2

    authors: Zia S,Sippel RS,Chen H

    更新日期:2012-11-01 00:00:00

  • Validation of statistical predictive models meant to select melanoma patients for sentinel lymph node biopsy.

    abstract:INTRODUCTION:To identify melanoma patients at sufficiently low risk of nodal metastases who could avoid sentinel lymph node biopsy (SLNB), several statistical models have been proposed based upon patient/tumor characteristics, including logistic regression, classification trees, random forests, and support vector machi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1979-6

    authors: Sabel MS,Rice JD,Griffith KA,Lowe L,Wong SL,Chang AE,Johnson TM,Taylor JM

    更新日期:2012-01-01 00:00:00

  • Impact of hepatectomy surgical complexity on outcomes and hospital quality rankings.

    abstract:BACKGROUND:There is substantial variation in the surgical complexity of hepatectomy. Currently, the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) risk adjusts for hospital quality comparisons using only the primary procedure code. Our objectives were to (1) assess the associatio...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3500-5

    authors: Paruch JL,Merkow RP,Bentrem DJ,Ko CY,Posner MC,Cohen ME,Bilimoria KY,Weber SM

    更新日期:2014-06-01 00:00:00

  • Prognostic value of extracapsular invasion of axillary lymph nodes combined with peritumoral vascular invasion in patients with breast cancer.

    abstract:BACKGROUND:Extracapsular invasion (ECI) of metastatic axillary lymph nodes has been associated with aggressive nodal disease but its prognostic role in breast cancer is unclear. The present study evaluated nodal ECI as a predictor of breast cancer recurrence. METHODS:We evaluated 154 women with histologically proven n...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3941-x

    authors: Yajima R,Fujii T,Yanagita Y,Fujisawa T,Miyamoto T,Hirakata T,Tsutsumi S,Iijima M,Kuwano H

    更新日期:2015-01-01 00:00:00

  • Practice patterns for the management of hepatic metastases from colorectal cancer: a mixed methods analysis.

    abstract:PURPOSE:The optimal management of colorectal cancer liver metastases (CRC-LM) has changed during the past two decades. However, clinical practice lags behind best evidence recommendations. We sought to characterize the gap between current practice and best evidence for the management of these patients and to identify b...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2698-3

    authors: Wei AC,Sandhu L,Devitt KS,Gagliardi AR,Kennedy ED,Urbach DR,Gallinger S,Baxter NN

    更新日期:2013-05-01 00:00:00

  • Laparoscopic versus open radical hysterectomy for stage IB2-IIB cervical cancer in the setting of neoadjuvant chemotherapy: a multi-institutional cohort study.

    abstract:BACKGROUND:Despite the lack of conclusive evidence supporting this treatment modality, neoadjuvant chemotherapy (NACT) prior to radical surgery is a commonly accepted strategy to manage locally advanced cervical cancer. Radical hysterectomy in chemotherapy-treated patients can be technically challenging due to large vo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-012-2777-5

    authors: Ghezzi F,Cromi A,Ditto A,Vizza E,Malzoni M,Raspagliesi F,Uccella S,Corrado G,Cosentino F,Gotsch F,Martinelli F,Franchi M

    更新日期:2013-06-01 00:00:00

  • Conservative Re-excision is a Safe and Simple Alternative to Radical Resection in Revision Surgery for Dermatofibrosarcoma Protuberans.

    abstract:BACKGROUND:Dermatofibrosarcoma protuberans (DFSP) is a dermal sarcoma often diagnosed by excision biopsy, and is often incompletely excised, with high recurrence rates. Traditional wide excision involves resection margins of 2-4 cm, often resulting in morbid procedures requiring surgical reconstruction. An alternative ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08011-5

    authors: Snow H,Davies E,Strauss DC,Smith M,Hayes AJ

    更新日期:2020-03-01 00:00:00

  • Robotic versus open pancreatectomy: a systematic review and meta-analysis.

    abstract:BACKGROUND:Robotic surgery is gaining momentum with advantages for minimally invasive management of pancreatic diseases. The objective of this meta-analysis is to compare the clinical and oncologic safety and efficacy of robotic versus open pancreatectomy. METHODS:A systematic review of the literature was performed to...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-012-2823-3

    authors: Zhang J,Wu WM,You L,Zhao YP

    更新日期:2013-06-01 00:00:00

  • Sentinel node dissection delays recurrence and prolongs melanoma-related survival: an analysis of 673 patients from a single center with long-term follow-up.

    abstract:BACKGROUND:The status of the sentinel lymph node is an important predictor for survival in melanoma patients, but it is still unclear if early removal of micrometastases by sentinel lymph node dissection (SLND) alters survival. A large series of melanoma patients from a single center with long-term follow-up was analyz...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-010-1318-3

    authors: Satzger I,Meier A,Hoy L,Völker B,Kapp A,Hauschild A,Gutzmer R

    更新日期:2011-02-01 00:00:00