Should adjuvant therapy remain the standard of care for patients with resected adenocarcinoma of the pancreas?


:Adenocarcinoma of the pancreas continues to be a formidable disease. In the United States, patients who have had resected disease are generally offered adjuvant chemoradiation. The current National Comprehensive Cancer Network practice guidelines uniformly support this practice. We reviewed seven selected series to evaluate the efficacy of adjuvant therapy for patients who had resected adenocarcinoma of the pancreas. Current evidence-based analysis demonstrates that an adjuvant therapy regimen as a standard of care is lacking. We, therefore, believe that it should be used judiciously because its benefit is confined to only a fraction of patients treated by complete resection (R0); patients with residual microscopic disease (R1) derived negligible benefits. Given the financial constraints and the small effect that current therapies have on this fatal disease, clinicians should concentrate on developing novel therapies and new paradigms to address this age-old problem.


Ann Surg Oncol


Chu QD,Khushalani N,Javle MM,Douglass HO Jr,Gibbs JF





Has Abstract


2003-06-01 00:00:00












  • Uptake and patient outcomes of laparoscopic colon and rectal cancer surgery in a publicly funded system and following financial incentives.

    abstract:PURPOSE:To assess patterns of uptake and outcomes of laparoscopic colon and rectal cancer surgery in Ontario, and the potential influence of surgical fee incentives instituted on October 1, 2005. METHODS:We used Ontario administrative databases from fiscal years 2002 to 2009. Study outcomes were uptake rates of laparo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Simunovic M,Baxter NN,Sutradhar R,Liu N,Cadeddu M,Urbach D

    更新日期:2013-11-01 00:00:00

  • A Temperature of 40 °C Appears to be a Critical Threshold for Potentiating Cytotoxic Chemotherapy In Vitro and in Peritoneal Carcinomatosis Patients Undergoing HIPEC.

    abstract:BACKGROUND:Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a radical but effective treatment option for patients with peritoneal carcinomatosis (PC). Unfortunately, a standardized HIPEC protocol is missing impeding systematic comparisons with regard to minimal effective temperatures...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Schaaf L,van der Kuip H,Zopf W,Winter S,Münch M,Mürdter TE,Thon KP,Steurer W,Aulitzky WE,Ulmer C

    更新日期:2015-12-01 00:00:00

  • Conditional survival after surgical resection of gastric cancer: a multi-institutional analysis of the us gastric cancer collaborative.

    abstract:BACKGROUND:Survival estimates following surgical resection of gastric adenocarcinoma are traditionally reported as survival from the date of surgery. Conditional survival (CS) estimates, however, may be more clinically relevant by accounting for time already survived. We assessed CS following surgical resection for gas...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kim Y,Ejaz A,Spolverato G,Squires MH,Poultsides G,Fields RC,Bloomston M,Weber SM,Votanopoulos K,Acher AW,Jin LX,Hawkins WG,Schmidt C,Kooby D,Worhunsky D,Saunders N,Cho CS,Levine EA,Maithel SK,Pawlik TM

    更新日期:2015-02-01 00:00:00

  • Fluctuating mastectomy rates across time and geography.

    abstract::In 2009, 2 single-institution studies from the United States reported increasing mastectomy rates during the last decade. We have recently reported unilateral mastectomy trends from a European database and demonstrated a significant trend of decreasing mastectomy rates from 38.1 % in 2005 to 13.1 % in 2010. A recent s...

    journal_title:Annals of surgical oncology

    pub_type: 社论


    authors: Garcia-Etienne CA,Tomatis M,Heil J,Danaei M,Rageth CJ,Marotti L,Rosselli Del Turco M,Ponti A

    更新日期:2013-07-01 00:00:00

  • Suitability of sentinel node mapping as an index of metastasis in early gastric cancer following endoscopic resection.

    abstract:BACKGROUND:When pathological diagnosis following endoscopic resection (ER) for early gastric cancer (EGC) suggests probable lymph node metastasis, additional surgery with lymphadenectomy should be performed. The sentinel node (SN) concept has yet to be applied to tumors following ER. The aim of this study was to evalua...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Mayanagi S,Takeuchi H,Kamiya S,Niihara M,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Mukai M,Kitagawa Y

    更新日期:2014-09-01 00:00:00

  • Surgery or Radiotherapy of the Primary Tumor in T1-2 Head and Neck Squamous Cell Carcinoma with Resectable N3 Nodes: A Multicenter GETTEC Study.

    abstract:BACKGROUND:The prognosis of advanced nodal (N3) squamous cell carcinoma of the head and neck (HNSCC) is poor. We investigated whether surgery or radiotherapy of early (T1-2) primary stage HSNCC is preferable to limit the overall morbidity after upfront neck dissection (uND) for N3 disease. METHODS:This retrospective m...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Carsuzaa F,Thariat J,Gorphe P,Righini C,Cosmidis A,Thureau S,Roge M,De Mones E,Servagi-Vernat S,Tonnerre D,Morinière S,Dugas A,Malard O,Pasquier F,Vergez S,Salleron J,Dufour X

    更新日期:2019-10-01 00:00:00

  • Lymph node dissection after chemoradiation in esophageal cancer: a subgroup analysis of patients with and without pathological response.

    abstract:BACKGROUND:Extensive lymph node dissection (LND) is beneficial in primarily resected esophageal cancer patients. Such benefit was believed to be seen in neoadjuvant chemoradiotherapy (CRT)-treated patients, but evidence was inconsistent. We hypothesized that CRT might offset the benefit of LND in certain subgroup of pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Chao YK,Liu HP,Hsieh MJ,Wu YC,Liu YH,Yeh CH,Chang HK,Tseng CK

    更新日期:2012-10-01 00:00:00

  • Surgical Strategy for T2 Gallbladder Cancer According to Tumor Location.

    abstract:BACKGROUND:Radical cholecystectomy is recommended for T2 gallbladder cancer. However, it is unclear whether hepatic resection is essential for peritoneal-side gallbladder cancer. METHODS:From January 2000 to December 2011, we identified T2 gallbladder cancer patients who had undergone curative intent surgery. A perito...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Lee H,Choi DW,Park JY,Youn S,Kwon W,Heo JS,Choi SH,Jang KT

    更新日期:2015-08-01 00:00:00

  • Risk of colorectal cancer in chronic kidney disease: a matched cohort study based on administrative data.

    abstract:BACKGROUND:The risk of colorectal cancer (CRC) in chronic kidney disease (CKD) patients relative to the general population is unknown. The aim of this population-based study was to investigate the risk of CRC in patients with CKD. METHODS:The study cohort included patients aged ≥18 years diagnosed with CKD between 200...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验


    authors: Wu MY,Chang TC,Chao TY,Huang MT,Lin HW

    更新日期:2013-11-01 00:00:00

  • Iliosacral resections of pelvic malignant tumors and reconstruction with nonvascular bilateral fibular autografts.

    abstract:BACKGROUND:Iliosacral resection of pelvic malignant tumors and subsequent reconstruction have tested the ingenuity of orthopedic oncologists because of the difficulty of oncological wide resection and the complex biomechanics of the sacroiliac joint render reconstruction challenging. This study compared the functional ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Wang J,Tang Q,Xie X,Yin J,Zhao Z,Li Z,Zou C,Huang G,Shen J

    更新日期:2012-12-01 00:00:00

  • Combined hepatectomy and radiofrequency ablation for multifocal hepatocellular carcinomas: long-term follow-up results and prognostic factors.

    abstract:BACKGROUND:For multifocal hepatocellular carcinomas (HCCs) that are untreatable with resection only, locoregional therapies added to hepatectomy have been introduced. However, some preliminary reports have documented average survival results and relatively high complication rates. We evaluated the long-term survival re...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Choi D,Lim HK,Joh JW,Kim SJ,Kim MJ,Rhim H,Kim YS,Yoo BC,Paik SW,Park CK

    更新日期:2007-12-01 00:00:00

  • Touch imprint cytology of the sentinel lymph nodes might not be indicated in early breast cancer patients with ultrasonically uninvolved axillary lymph nodes.

    abstract:BACKGROUND:Touch imprint cytology (TIC) is a fast, cheap and specific intraoperative examination of the sentinel lymph nodes (SLNs) in early breast cancer patients. The results of TIC in patients with ultrasonically (US) uninvolved axillary lymph nodes are not known. The objective of our study was to compare the result...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Perhavec A,Besić N,Hocevar M,Zgajnar J

    更新日期:2008-08-01 00:00:00

  • Disturbed XIAP and XAF1 expression balance is an independent prognostic factor in gastric adenocarcinomas.

    abstract:BACKGROUND:Dysregulation of apoptosis is a key factor in carcinogenesis and tumor progression. X-linked inhibitor of apoptosis (XIAP) is the most potent member of the inhibitor of apoptosis protein (IAP) family, which directly inhibits apoptosis by binding to caspases. Antagonists of XIAP have recently been identified:...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Shibata T,Noguchi T,Takeno S,Gabbert HE,Ramp U,Kawahara K

    更新日期:2008-12-01 00:00:00

  • The Impact of the Affordable Care Act on North Carolinian Breast Cancer Patients Seeking Financial Support for Treatment.

    abstract:BACKGROUND:The Affordable Care Act (ACA) was instated on 23 March 2010 to improve healthcare quality, reduce costs, and increase access. The Pretty in Pink Foundation (PIPF), a non-profit 501(C)(3) organization in North Carolina, provides financial assistance and in-kind support to individuals seeking help with breast ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Obeng-Gyasi S,Tolnitch L,Greenup RA,Shelley Hwang E

    更新日期:2016-10-01 00:00:00

  • Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection: prognostic role and clinical considerations.

    abstract:BACKGROUND:The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). METHODS:OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progre...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Gallotta V,Fanfani F,Fagotti A,Chiantera V,Legge F,Gueli Alletti S,Nero C,Margariti AP,Papa V,Alfieri S,Ciccarone F,Scambia G,Ferrandina G

    更新日期:2014-07-01 00:00:00

  • Troubleshooting Sentinel Lymph Node Biopsy in Breast Cancer Surgery.

    abstract:BACKGROUND:Performing a sentinel lymph node biopsy (SLNB) is the standard of care for axillary nodal staging in patients with invasive breast cancer and clinically negative nodes. The procedure provides valuable staging information with few complications when performed by experienced surgeons. However, variation in pro...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: James TA,Coffman AR,Chagpar AB,Boughey JC,Klimberg VS,Morrow M,Giuliano AE,Harlow SP

    更新日期:2016-10-01 00:00:00

  • Comprehensive needs assessment of clinical breast evaluation skills of primary care residents.

    abstract:BACKGROUND:Health care reform places primary care (PC) physicians in an increasingly significant role for breast cancer screening and diagnosis. This study assessed the adequacy of traditional PC resident training to prepare physicians for this front-line role. METHODS:Sixty-eight primary care residents, representing ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Chalabian J,Formenti S,Russell C,Pearce J,Dunnington G

    更新日期:1998-03-01 00:00:00

  • Outcomes of Lymph Node Dissection for Non-metastatic Pancreatic Neuroendocrine Tumors: A Propensity Score-Weighted Analysis of the National Cancer Database.

    abstract:BACKGROUND:Although the National Comprehensive Cancer Network (NCCN) guidelines recommend use of lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) > 2 cm, there is limited evidence to support the association between use of LND and overall survival (OS). METHODS:Patients with resecte...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Mao R,Zhao H,Li K,Luo S,Turner M,Cai JQ,Blazer D 3rd

    更新日期:2019-09-01 00:00:00

  • The Influence of Repeat Surgery and Residual Disease on Recurrence After Breast-Conserving Surgery: A Danish Breast Cancer Cooperative Group Study.

    abstract:BACKGROUND:A significant proportion of women who have breast-conserving surgery (BCS) subsequently undergo re-excision or proceed to mastectomy. This study aimed to identify factors associated with residual disease after repeat surgery and to determine their effect on ipsilateral breast tumor recurrence (IBTR) and surv...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bodilsen A,Bjerre K,Offersen BV,Vahl P,Ejlertsen B,Overgaard J,Christiansen P

    更新日期:2015-12-01 00:00:00

  • Resection of hepatocellular carcinoma with macroscopic vascular invasion.

    abstract:BACKGROUND:Survival for Child's A patients with hepatocellular cancer (HCC) and macroscopic vascular invasion (MVI) has been reported as approximately 8.1 months with sorafenib. The role of surgery for these patients remains controversial. METHODS:The records of all patients undergoing resection of HCC at a single cen...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Roayaie S,Jibara G,Taouli B,Schwartz M

    更新日期:2013-11-01 00:00:00

  • Minimesohepatectomy for colorectal liver metastasis invading the middle hepatic vein at the hepatocaval confluence.

    abstract:BACKGROUND:In case of liver tumors invading the middle hepatic vein (MHV) at the hepatocaval confluence (HC) major resection is recommended. We describe a new ultrasound-guided conservative operation for patients with colorectal liver metastasis (CLM) invading the MHV at the HC. METHODS:The case of a 65-year-old woman...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Torzilli G,Botea F,Donadon M,Cimino M,Del Fabbro D,Palmisano A

    更新日期:2010-02-01 00:00:00

  • Function-preserving gastrectomy for early gastric cancer.

    abstract::The number of early gastric cancer (EGC) cases has been increasing because of improved diagnostic procedures. Applications of function-preserving gastric cancer surgery may therefore also be increasing because of its low incidence of lymph node metastasis, excellent survival rates, and the possibility of less-invasive...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Hiki N,Nunobe S,Kubota T,Jiang X

    更新日期:2013-08-01 00:00:00

  • Comparison of Tissue and Blood Concentrations of Oxaliplatin Administrated by Different Modalities of Intraperitoneal Chemotherapy.

    abstract:BACKGROUND:Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new technology for delivering intraperitoneal chemotherapy. It is generally assumed that with PIPAC, the ratio of peritoneal to systemic drug concentration is superior to liquid hyperthermic intraperitoneal chemotherapy (HIPEC). To date, no direct...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Giger-Pabst U,Bucur P,Roger S,Falkenstein TA,Tabchouri N,Le Pape A,Lerondel S,Demtröder C,Salamé E,Ouaissi M

    更新日期:2019-12-01 00:00:00

  • Surgical approach and perioperative complications determine short-term outcomes in patients with insulinoma: results of a bi-institutional study.

    abstract:BACKGROUND:Despite advancements in radiologic imaging and minimally invasive surgery, the evaluation and management of insulinomas is institution and surgeon dependent. Therefore, the reported surgical outcomes are highly variable. We compared the surgical management and outcomes of insulinomas between two internationa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Roland CL,Lo CY,Miller BS,Holt S,Nwariaku FE

    更新日期:2008-12-01 00:00:00

  • Observation after a positive sentinel lymph node biopsy in patients with melanoma.

    abstract:BACKGROUND:The benefit of completion lymph node dissection (CLND) in melanoma patients with a positive sentinel lymph node (SLN) remains unknown. METHODS:We identified patients with a positive SLN from 1994 to 2012. Patient and tumor characteristics, reasons for not undergoing CLND, patterns of recurrence, and melanom...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bamboat ZM,Konstantinidis IT,Kuk D,Ariyan CE,Brady MS,Coit DG

    更新日期:2014-09-01 00:00:00

  • Experience with seed localization for nonpalpable breast lesions in a public health care system.

    abstract:BACKGROUND:Seed localization uses a radioactive source to identify nonpalpable breast lesions for excision; it is an emerging alternative to wire localization (WL). Previous single health system studies report decreased rates of re-excision and improved patient convenience with this technique. This study is the first t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Rao R,Moldrem A,Sarode V,White J,Amen M,Rao M,Andrews V,Euhus D,Radford L,Ulissey M

    更新日期:2010-12-01 00:00:00

  • Metaplastic Breast Cancer Treatment and Outcomes in 2500 Patients: A Retrospective Analysis of a National Oncology Database.

    abstract:BACKGROUND:Metaplastic breast cancer (MBC) is characterized by chemoresistance and hematogenous spread. We sought to identify factors associated with improved MBC outcomes and increased likelihood of MBC diagnosis. METHODS:Women ≥ 18 years of age with stage I-III MBC and non-MBC diagnosed between 2010 and 2014 were id...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Ong CT,Campbell BM,Thomas SM,Greenup RA,Plichta JK,Rosenberger LH,Force J,Hall A,Hyslop T,Hwang ES,Fayanju OM

    更新日期:2018-08-01 00:00:00

  • Palpable breast cancers are inherently different from nonpalpable breast cancers.

    abstract:BACKGROUND:We examined the clinicopathologic profile of T1 cancers to determine whether palpable cancers are different from nonpalpable cancers. METHODS:A prospective database was reviewed. Palpable T1 cancers were compared with nonpalpable T1 cancers. Initial significance was determined by chi2 analysis. Factors foun...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Skinner KA,Silberman H,Sposto R,Silverstein MJ

    更新日期:2001-10-01 00:00:00

  • Surgeons' Perspectives of Contralateral Prophylactic Mastectomy.

    abstract:BACKGROUND:Contralateral prophylactic mastectomy (CPM) is commonly performed for the treatment of breast cancer, despite its limited oncologic benefit. Little is known about surgeons' perceptions of performing CPM. We hypothesized that a proportion of surgeons would report discomfort with performing CPM, particularly w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bellavance E,Peppercorn J,Kronsberg S,Greenup R,Keune J,Lynch J,Collyar D,Magder L,Tilburt J,Hlubocky F,Yao K

    更新日期:2016-09-01 00:00:00

  • Effects of Antihypertensive Drugs on Outcomes of Breast Reconstruction.

    abstract:BACKGROUND:Angiotensin receptor blocker (ARB), a commonly used antihypertensive drug, is reported to affect wound healing and flap survival in animal models. However, this has not been elucidated in a clinical series. This study aimed to investigate the impact that perioperative use of ARB has on outcomes after breast ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Park JW,Lee KT,Jeon BJ,Pyon JK,Bang SI,Mun GH

    更新日期:2019-06-01 00:00:00