Should adjuvant therapy remain the standard of care for patients with resected adenocarcinoma of the pancreas?

Abstract:

:Adenocarcinoma of the pancreas continues to be a formidable disease. In the United States, patients who have had resected disease are generally offered adjuvant chemoradiation. The current National Comprehensive Cancer Network practice guidelines uniformly support this practice. We reviewed seven selected series to evaluate the efficacy of adjuvant therapy for patients who had resected adenocarcinoma of the pancreas. Current evidence-based analysis demonstrates that an adjuvant therapy regimen as a standard of care is lacking. We, therefore, believe that it should be used judiciously because its benefit is confined to only a fraction of patients treated by complete resection (R0); patients with residual microscopic disease (R1) derived negligible benefits. Given the financial constraints and the small effect that current therapies have on this fatal disease, clinicians should concentrate on developing novel therapies and new paradigms to address this age-old problem.

journal_name

Ann Surg Oncol

authors

Chu QD,Khushalani N,Javle MM,Douglass HO Jr,Gibbs JF

doi

10.1245/aso.2003.06.015

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

539-45

issue

5

eissn

1068-9265

issn

1534-4681

journal_volume

10

pub_type

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