Prognostic Impact of Preoperative Nutritional Risk in Patients Who Undergo Surgery for Pancreatic Adenocarcinoma.

Abstract:

BACKGROUND:Nutritional derangements are common hallmarks of pancreatic cancer (PC). Their early detection and management are usually overlooked in routine practice. This study aimed to explore preoperative nutritional status and its prognostic value in patients undergoing surgery for PC. METHODS:Data from 73 patients who underwent surgery for PC from November 2015 to January 2018 at the General and Pancreatic Surgery Unit, The Pancreas Institute, University Hospital of Verona Hospital, Verona, Italy, were retrospectively evaluated. The Nutritional Risk Screening (NRS)-2002 was used to evaluate the preoperative nutritional risk. Body composition was assessed using bioimpedance vectorial analysis (BIVA) on the day prior to surgery. The effect of clinical, pathological, and nutritional characteristics on overall survival (OS) was investigated using a Cox and logistic regression model. Kaplan-Meier curves were compared using the log-rank test. RESULTS:Most patients (80.8%) were at preoperative risk of malnutrition (NRS-2002 ≥ 3) despite a mean BMI of 24.1 kg/m2(± 4.3). Twenty-four patients (32.9%) received neoadjuvant therapy prior to surgery. Preoperative NRS-2002 was significantly higher in this subset of patients (p = 0.026), with a significant difference by chemotherapy regimens (in favor of FOLFIRINOX, p = 0.035). In a multivariate analysis, the only independent prognostic factor for OS was the NRS-2002 score (HR 5.24, p = 0.013). Particularly, the likelihood of 2-year survival was higher in NRS < 3 (p = 0.009). CONCLUSIONS:Our analysis confirms that preoperative malnutrition has a detrimental impact on OS in PC patients undergoing radical surgery for PC. Careful preoperative nutritional evaluation of PC patients should be mandatory, especially in those who are candidates for neoadjuvant therapy.

journal_name

Ann Surg Oncol

authors

Trestini I,Paiella S,Sandini M,Sperduti I,Elio G,Pollini T,Melisi D,Auriemma A,Soldà C,Bonaiuto C,Tregnago D,Avancini A,Secchettin E,Bonamini D,Lanza M,Pilotto S,Malleo G,Salvia R,Bovo C,Gianotti L,Bassi C,Milel

doi

10.1245/s10434-020-08515-5

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

5325-5334

issue

13

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-020-08515-5

journal_volume

27

pub_type

杂志文章
  • Quality of Care for Cervical and Endometrial Cancer Patients: The Impact of Different Techniques of Sentinel Lymph Node Mapping on Patient Satisfaction.

    abstract:OBJECTIVES:The purpose of this study was to assess the quality of care in patients who underwent sentinel lymph node (SLN) mapping for endometrial and cervical cancer staging, and evaluate the impact of different techniques on patient satisfaction, i.e. radiotracer Tc99m versus indocyanine green (ICG) or methylene blue...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5233-0

    authors: Buda A,Elisei F,Palazzi S,De Ponti E,Arosio M,Vecchione F,Dell'Anna T,Cuzzocrea M,Bussi B,Giuliani D,Di Martino G,Crivellaro C

    更新日期:2016-09-01 00:00:00

  • Demonstration of second-tier lymph nodes during preoperative lymphoscintigraphy for melanoma: incidence varies with primary tumor site.

    abstract:BACKGROUND:Preoperative cutaneous lymphoscintigraphy (LS) to identify sentinel (first-tier) lymph nodes was performed in 250 consecutive melanoma patients before wide local excision only or wide local excision with sentinel node biopsy. METHODS:The location of the sentinel nodes was marked on the overlying skin in all...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303644

    authors: Uren RF,Howman-Giles RB,Thompson JF

    更新日期:1998-09-01 00:00:00

  • Hospital volume and inpatient mortality after cancer-related gastrointestinal resections: the experience of an Asian country.

    abstract:BACKGROUND:Using 4-year nationwide population-based data for Taiwan, this study compared in-hospital surgical mortality rates with hospital volume for five cancer-related gastrointestinal resections. METHODS:The study sample was drawn from the Taiwan National Health Insurance Research Database. A total of 34,715 patie...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9005-0

    authors: Lin HC,Xirasagar S,Lee HC,Chai CY

    更新日期:2006-09-01 00:00:00

  • ASO Author Reflections: The Role of Tumor Size in the Prognosis of Anal Squamous Cell Carcinoma: A Validation on the New American Joint Committee on Cancer Subclassification of Stage IIA and B.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6969-5

    authors: Goffredo P,Hassan I

    更新日期:2018-12-01 00:00:00

  • Fibrosis-4 Index, a Noninvasive Fibrosis Marker, Predicts Survival Outcomes After Hepatectomy for Colorectal Cancer Liver Metastases.

    abstract:BACKGROUND:Liver fibrosis influences liver regeneration and surgical outcomes, and several noninvasive models based on laboratory data have been developed to predict liver fibrosis. This study was performed to determine whether the Fibrosis-4 (FIB-4) index, a noninvasive fibrosis marker, can predict the prognosis in pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08828-5

    authors: Akiyama T,Miyamoto Y,Imai K,Yamashita Y,Nomoto D,Daitoku N,Sakamoto Y,Kiyozumi Y,Tokunaga R,Eto K,Harada K,Hiyoshi Y,Iwatsuki M,Nagai Y,Iwagami S,Baba Y,Yoshida N,Baba H

    更新日期:2020-09-01 00:00:00

  • Cost Effectiveness of Risk-Reducing Mastectomy versus Surveillance in BRCA Mutation Carriers with a History of Ovarian Cancer.

    abstract:BACKGROUND:The appropriate management of breast cancer risk in BRCA mutation carriers following ovarian cancer diagnosis remains unclear. We sought to determine the survival benefit and cost effectiveness of risk-reducing mastectomy (RRM) among women with BRCA1/2 mutations following stage II-IV ovarian cancer. DESIGN:...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5995-z

    authors: Gamble C,Havrilesky LJ,Myers ER,Chino JP,Hollenbeck S,Plichta JK,Kelly Marcom P,Shelley Hwang E,Kauff ND,Greenup RA

    更新日期:2017-10-01 00:00:00

  • Endoscopic Retrograde Biliary Drainage Causes Intra-Abdominal Abscess in Pancreaticoduodenectomy Patients: An Important But Neglected Risk Factor.

    abstract:BACKGROUND:Patients with periampullary cancer frequently suffer obstructive jaundice and commonly require preoperative biliary drainage (PBD) for relief and to avoid related complications. Although research has established a correlation between PBD and surgical wound infection, the impact of PBD on major infectious com...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07189-y

    authors: Wu JM,Ho TW,Yen HH,Wu CH,Kuo TC,Yang CY,Tien YW

    更新日期:2019-04-01 00:00:00

  • A phase I study of hyperthermic isolated hepatic perfusion with oxaliplatin in the treatment of unresectable liver metastases from colorectal cancer.

    abstract::Isolated hepatic perfusion (IHP) is a proven approach for regional delivery of chemotherapy in patients with unresectable primary and metastatic tumors of the liver. Most trials of IHP have utilized melphalan as the active drug in the perfusate. We performed a phase I trial to evaluate the efficacy, safety, and maximu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0179-5

    authors: Zeh HJ 3rd,Brown CK,Holtzman MP,Egorin MJ,Holleran JL,Potter DM,Bartlett DL

    更新日期:2009-02-01 00:00:00

  • Loss of c-met protooncogene in primary and metastatic sites of breast cancer.

    abstract:BACKGROUND:It has been proposed that clones of tumor cells acquire higher metastatic potential as a result of specific genetic alterations. This study was designed to determine the role of the c-met protooncogene in systemic spread by comparing the loss of the c-met protooncogene between primary and metastatic breast c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303675

    authors: Ng EH,Pey HB,Law HY,Ng I,Ji CY,Lin V,Soo KC

    更新日期:1997-09-01 00:00:00

  • The Dual Inhibition of Met and EGFR by ME22S, a Novel Met/EGFR Bispecific Monoclonal Antibody, Suppresses the Proliferation and Invasion of Laryngeal Cancer.

    abstract:PURPOSE:It has been reported that the abnormal activation of receptor tyrosine kinases is associated with the development of many human carcinomas and the high activation of EGFR and Met mediates the tumorigenicity of laryngeal carcinoma. In this study, we have done the therapeutic efficacy of ME22S (a novel EGFR/Met b...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5084-0

    authors: Lee BS,Kim HJ,Hwang JW,Cheong KH,Kim KA,Cha HY,Lee JM,Kim CH

    更新日期:2016-06-01 00:00:00

  • Sentinel Lymph Node Mapping of Liver.

    abstract:BACKGROUND:Although the sentinel lymph node (SLN) hypothesis has been applied to many tissues and organs, liver has remained unstudied. Currently, it is unclear whether hepatic SLNs even exist. If so, they could alter the management of intrahepatic cholangiocarcinoma and other hepatic malignancies by minimizing the ext...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4601-5

    authors: Wada H,Hyun H,Vargas C,Genega EM,Gravier J,Gioux S,Frangioni JV,Choi HS

    更新日期:2015-12-01 00:00:00

  • Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma.

    abstract:PURPOSE:The risk of tumor recurrence after resection of soft tissue sarcoma (STS) necessitates surveillance in follow-up. The objective of this study was to determine the frequency/timing of metastasis and local recurrence following treatment for soft tissue sarcoma, and to use these data to justify an evidence-based f...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08240-z

    authors: Wilson DAJ,Gazendam A,Visgauss J,Perrin D,Griffin AM,Chung PW,Catton CN,Shultz D,Ferguson PC,Wunder JS

    更新日期:2020-06-01 00:00:00

  • Long-term outcomes for older patients with papillary thyroid carcinoma: should another age cutoff beyond 45 years be added?

    abstract:BACKGROUND:Although an age cutoff of 45 years has often been adopted to stratify cancer risk in papillary thyroid carcinoma (PTC), both cancer-specific survival (CSS) and disease-specific survival (DFS) continue to worsen beyond this cutoff. This study aimed to determine whether advanced age (i.e., >60 years) at diagno...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4055-1

    authors: Lang BH,Lo CY,Wong KP,Wan KY

    更新日期:2015-02-01 00:00:00

  • Surgical downstaging in an open-label phase II trial of denosumab in patients with giant cell tumor of bone.

    abstract:BACKGROUND:Surgical resection with curative intent for giant cell tumor of bone (GCTB) may be associated with severe morbidity. This interim analysis evaluated reduction in surgical invasiveness after denosumab treatment in patients with resectable GCTB. METHODS:Patients with primary or recurrent GCTB, for whom the in...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4634-9

    authors: Rutkowski P,Ferrari S,Grimer RJ,Stalley PD,Dijkstra SP,Pienkowski A,Vaz G,Wunder JS,Seeger LL,Feng A,Roberts ZJ,Bach BA

    更新日期:2015-09-01 00:00:00

  • ASO Author Reflections: Surgery and Bevacizumab in Ovarian Cancer.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-7024-2

    authors: Petrillo M,Scambia G,Fagotti A

    更新日期:2018-12-01 00:00:00

  • Upstaging and improved survival of early breast cancer patients after implementation of sentinel node biopsy for axillary staging.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) has become a standard for axillary staging for early breast cancer patients. Prior studies suggest that SLNB may be more sensitive for the identification of lymph node disease than axillary lymph node dissection (ALND). We hypothesized that SLNB use increases the incidence o...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9109-6

    authors: Vanderveen KA,Schneider PD,Khatri VP,Goodnight JE,Bold RJ

    更新日期:2006-11-01 00:00:00

  • Predictors of regional nodal disease in patients with thin melanomas.

    abstract:BACKGROUND:Most melanoma patients present with thin (

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2006.05.011

    authors: Karakousis GC,Gimotty PA,Botbyl JD,Kesmodel SB,Elder DE,Elenitsas R,Ming ME,Guerry D,Fraker DL,Czerniecki BJ,Spitz FR

    更新日期:2006-04-01 00:00:00

  • Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer.

    abstract:BACKGROUND:Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patients with gastric cance...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08245-8

    authors: Maruyama S,Kawaguchi Y,Akaike H,Shoda K,Saito R,Shimizu H,Furuya S,Hosomura N,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D

    更新日期:2020-08-01 00:00:00

  • Predictive Value of CD44 in Muscle-Invasive Bladder Cancer and Its Relationship with IL-6 Signaling.

    abstract:BACKGROUND:CD44, a cancer stem cell surface marker, is associated with treatment resistance and prognosis in some cancers. In the present study, we examined the predictive value of CD44 in muscle-invasive bladder cancer (MIBC). METHODS:We retrospectively analyzed the clinical outcomes of 105 MIBC patients and correlat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6706-0

    authors: Wu CT,Lin WY,Chen WC,Chen MF

    更新日期:2018-11-01 00:00:00

  • Risk Stratification in Patients with Stage II Colon Cancer.

    abstract:BACKGROUND:The decision to receive adjuvant chemotherapy is far from evident and remains controversial in patients with American Joint Committee on Cancer stage II colon cancer. This study analyzes several pathological characteristics in order to assess their (combined) predictive value for outcomes in stage II colon c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5387-9

    authors: Amri R,England J,Bordeianou LG,Berger DL

    更新日期:2016-11-01 00:00:00

  • Induction chemotherapy with S-1 plus cisplatin followed by surgery for treatment of gastric cancer with peritoneal dissemination.

    abstract:BACKGROUND:The prognosis of gastric cancer patients with peritoneal dissemination is poor. Recently, chemotherapy with S-1 plus cisplatin has been shown to be highly effective for advanced gastric cancer. METHODS:In 41 patients diagnosed with either macro- or microscopic peritoneal dissemination by staging laparoscopy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0706-z

    authors: Okabe H,Ueda S,Obama K,Hosogi H,Sakai Y

    更新日期:2009-12-01 00:00:00

  • How Effective is Neoadjuvant Endocrine Therapy (NET) in Downstaging the Axilla and Achieving Breast-Conserving Surgery?

    abstract:BACKGROUND:Neoadjuvant endocrine therapy (NET) is effective in downstaging large hormone receptor-positive (HR+) breast cancers and increasing rates of breast-conserving surgery (BCS), but data regarding nodal pathologic complete response (pCR) are sparse. We reported nodal and breast downstaging rates with NET, and co...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08888-7

    authors: Montagna G,Sevilimedu V,Fornier M,Jhaveri K,Morrow M,Pilewskie ML

    更新日期:2020-11-01 00:00:00

  • Survival Impact of Stations of Pathological Lymph Nodes in N2 Non-small Cell Lung Cancer in a French Hospital.

    abstract:BACKGROUND:The prognosis of lung cancer remains poor; only 20% of patients can undergo surgery. N2 non-small cell lung cancer (NSCLC) is a heterogeneous disease. We conducted a retrospective study to analyze the impact of N2 location on survival. METHODS:This study included 342 NSCLC with N2 involvement between 1988 a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6373-1

    authors: Clément-Duchêne C,Luc A,Casse JM,Vignaud JM,Lacomme S,Anne V,Siat J,Ménard O,Martinet Y

    更新日期:2018-05-01 00:00:00

  • Postoperative Infectious Complications are Associated with Adverse Oncologic Outcomes in Esophageal Cancer Patients Undergoing Preoperative Chemotherapy.

    abstract:BACKGROUND:For some types of cancer, postoperative complications can negatively influence survival, but the association between these complications and oncological outcomes is unclear for patients with esophageal cancer who receive preoperative treatments. METHODS:Data were retrospectively analyzed for patients who un...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5045-7

    authors: Yamashita K,Makino T,Miyata H,Miyazaki Y,Takahashi T,Kurokawa Y,Yamasaki M,Nakajima K,Takiguchi S,Mori M,Doki Y

    更新日期:2016-06-01 00:00:00

  • Experience of pediatric osteosarcoma of the extremity at a single institution in Taiwan: prognostic factors and impact on survival.

    abstract:PURPOSE:To identify the prognostic factors and evaluate the impact of chemotherapy regimens on the outcomes of pediatric osteosarcoma of the extremities. METHODS:Patients younger than 18 years and diagnosed with high-grade osteosarcoma of the extremities during the period between January 2004 and December 2011 were in...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-014-4154-z

    authors: Hung GY,Yen HJ,Yen CC,Chen WM,Chen PC,Wu HT,Chiou HJ,Chang WH,Hsu HE

    更新日期:2015-04-01 00:00:00

  • miR-23b-3p Plays an Oncogenic Role in Hepatocellular Carcinoma.

    abstract:BACKGROUND:Reports show miR-23b to be a cancer-related biomarker in various cancer types. Interestingly, it has a dual role of oncogenic and tumor-suppressive functions, depending on the cancer type. This study focused on the unknown association of miR-23b-3p with hepatocellular carcinoma (HCC). METHODS:Expression of ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09283-y

    authors: Hayashi M,Yamada S,Kurimoto K,Tanabe H,Hirabayashi S,Sonohara F,Inokawa Y,Takami H,Kanda M,Tanaka C,Nakayama G,Koike M,Kodera Y

    更新日期:2020-11-02 00:00:00

  • Educating Surgical Oncology Providers on Perioperative Opioid Use: Results of a Departmental Survey on Perceptions of Opioid Needs and Prescribing Habits.

    abstract:BACKGROUND:Patients undergoing oncologic surgery are at risk for persistent postoperative opioid use. As a quality improvement initiative, this study sought to characterize provider perceptions regarding opioid-prescribing after oncologic procedures. METHODS:Surgical oncology attending physicians, clinical fellows, an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07321-y

    authors: Lillemoe HA,Newhook TE,Vreeland TJ,Arvide EM,Dewhurst WL,Grubbs EG,Aloia TA,Vauthey JN,Lee JE,Tzeng CD

    更新日期:2019-07-01 00:00:00

  • The First Human Trial of Transoral Robotic Surgery Using a Single-Port Robotic System in the Treatment of Laryngo-Pharyngeal Cancer.

    abstract:BACKGROUND:This study aimed to evaluate the feasibility and safety of the DaVinci SP system for performing transoral robotic surgery (TORS) in patients with head and neck cancer. METHODS:From October 2018 to April 2019, the medical records of 41 patients who underwent TORS using the DaVinci SP system were retrospectiv...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07802-0

    authors: Park YM,Kim DH,Kang MS,Lim JY,Choi EC,Koh YW,Kim SH

    更新日期:2019-12-01 00:00:00

  • Systematic para-aortic and pelvic lymphadenectomy in early stage epithelial ovarian cancer: a prospective study.

    abstract:BACKGROUND:Lymphadenectomy is important in the surgical treatment of apparent early epithelial ovarian cancers (eEOC); however, its extent is not well defined. We evaluated the role of systematic lymphadenectomy, the risk factors related with lymph node metastases, the implications, and the morbidity of comprehensive s...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2439-7

    authors: Ditto A,Martinelli F,Reato C,Kusamura S,Solima E,Fontanelli R,Haeusler E,Raspagliesi F

    更新日期:2012-11-01 00:00:00

  • Laparoscopic HIPEC for Low-Volume Peritoneal Metastasis in Gastric and Gastroesophageal Adenocarcinoma.

    abstract:BACKGROUND:We seek to determine whether laparoscopic hyperthermic intraperitoneal chemoperfusion (LS-HIPEC) improves overall survival (OS) in patients with gastric and gastroesophageal adenocarcinoma and low-volume peritoneal metastasis compared with standard of care treatment. PATIENTS AND METHODS:We reviewed data fr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08968-8

    authors: Blumenthaler AN,Allen CJ,Ikoma N,Blum M,Das P,Minsky BD,Mansfield PF,Ajani JA,Badgwell BD

    更新日期:2020-12-01 00:00:00