Abstract:
BACKGROUND:The prognosis of lung cancer remains poor; only 20% of patients can undergo surgery. N2 non-small cell lung cancer (NSCLC) is a heterogeneous disease. We conducted a retrospective study to analyze the impact of N2 location on survival. METHODS:This study included 342 NSCLC with N2 involvement between 1988 and 2014. Patient-related data were collected through the CRB biobank and included demographic, therapeutic, and survival data. Survival was analyzed according to Kaplan-Maier method. Cox's regression analysis and analysis of variance (ANOVA) were used to determine factors significantly associated with survival. RESULTS:The population average age was 61.6 years; 82.2% were men, a majority were former smokers (87.1%), and 45.3% had adenocarcinoma. The main prognostic factors were male gender (p = 0.01), number of nodes (p < 0.0001), and tumor size (p < 0.0001). N2 disease had a poor survival (16 months) compared with N0 (32 months) and N1 (21.1 months) disease (p < 0.0001). The patients with involvement of station 4 (survival = 17.8 months) seemed to have a prognosis between those with station 7 (survival = 10.5 months) and N1 (survival = 22.6 months), p = 0.0005. CONCLUSIONS:N2 location has a prognostic impact in surgically NSCLC, and station 4 involvement has a better prognostic than station 7.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Clément-Duchêne C,Luc A,Casse JM,Vignaud JM,Lacomme S,Anne V,Siat J,Ménard O,Martinet Ydoi
10.1245/s10434-018-6373-1subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1262-1268issue
5eissn
1068-9265issn
1534-4681pii
10.1245/s10434-018-6373-1journal_volume
25pub_type
杂志文章abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) has been shown to reduce many of the long-term complications associated with a traditional axillary lymph node dissection (ALND); however, short-term outcomes have yet to be characterized. This study was designed to identify trends and differences in 30-day outcomes of parti...
journal_title:Annals of surgical oncology
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abstract:: ...
journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
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