Experience of pediatric osteosarcoma of the extremity at a single institution in Taiwan: prognostic factors and impact on survival.

Abstract:

PURPOSE:To identify the prognostic factors and evaluate the impact of chemotherapy regimens on the outcomes of pediatric osteosarcoma of the extremities. METHODS:Patients younger than 18 years and diagnosed with high-grade osteosarcoma of the extremities during the period between January 2004 and December 2011 were included for retrospective analysis. Demographic characteristics and tumor features were compared between nonmetastatic and metastatic patients. Univariate analyses of overall survival (OS) and progression-free survival (PFS) were performed to evaluate the efficacy of various chemotherapy regimens. RESULTS:A total of 74 patients (58 with nonmetastatic and 16 with metastatic disease) were enrolled and treated with three protocols consisting of various cycles of high-dose methotrexate, adriamycin (doxorubicin), cisplatin, and high-dose ifosfamide (MACI regimens) during the 8-year study period. Presence of metastasis was inversely correlated with OS and PFS. Alkaline phosphatase levels at diagnosis and histologic response to preoperative chemotherapy were correlated with OS. Tumor size was correlated with PFS. The 5-year OS and PFS were 77 and 70 % for all patients, and 90.4 and 83.3 % for those with nonmetastatic osteosarcoma; and the rates were both 25 % in those with metastatic osteosarcoma. The chemotherapy regimens increased good response rates by 30 % and survival rates by 20 % compared to the outcomes in patients treated before 2004. CONCLUSIONS:Poor prognostic factors for osteosarcoma in pediatric patients were identified under homogeneous surgical and chemotherapy schemes. The four-drug regimens consisting of MACI contributed to the remarkably increased good response rates and consequent improvement in the survival rates.

journal_name

Ann Surg Oncol

authors

Hung GY,Yen HJ,Yen CC,Chen WM,Chen PC,Wu HT,Chiou HJ,Chang WH,Hsu HE

doi

10.1245/s10434-014-4154-z

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

1080-7

issue

4

eissn

1068-9265

issn

1534-4681

journal_volume

22

pub_type

临床试验,杂志文章
  • Use of the Nerve Integrity Monitor during Thyroid Surgery Aids Identification of the External Branch of the Superior Laryngeal Nerve.

    abstract:BACKGROUND:The external branch of the superior laryngeal nerve (EBSLN) is at risk during thyroid surgery. Despite meticulous dissection and visualization, the EBSLN can be mistaken for other structures. The nerve integrity monitor (NIM) allows EBSLN confirmation with cricothyroid twitch on stimulation. AIMS:The aim of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4142-3

    authors: Glover AR,Norlén O,Gundara JS,Morris M,Sidhu SB

    更新日期:2015-01-01 00:00:00

  • ASO Author Reflections: Health Disparities in Pancreatic Cancer.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6961-0

    authors: Lutfi W,Hogg ME

    更新日期:2018-12-01 00:00:00

  • Current status of sentinel lymphadenectomy in breast cancer.

    abstract::Investigators at many cancer centers have verified that the sentinel node (SN) is the first lymph node to receive lymphatic drainage from a primary breast cancer and therefore the node most likely to contain metastatic tumor cells. When sentinel lymph node dissection (SLND) is undertaken by an experienced multidiscipl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:

    authors: Giuliano AE

    更新日期:2001-10-01 00:00:00

  • Extranodal Spread is Associated with Recurrence and Poor Survival in Stage III Cutaneous Melanoma Patients.

    abstract:BACKGROUND:Inconsistent data suggests extranodal spread (ENS) is an adverse prognostic factor in Stage III melanoma patients but it remains contentious. By rigorously matching cohorts, this study sought to clarify associations with recurrence and survival. METHODS:Melanoma patients with lymph node metastases (AJCC Sta...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5723-0

    authors: Crookes TR,Scolyer RA,Lo S,Drummond M,Spillane AJ

    更新日期:2017-05-01 00:00:00

  • Long-term analysis of gemcitabine-based chemoradiation after surgical resection for pancreatic adenocarcinoma.

    abstract:PURPOSE:To evaluate the efficacy in terms of local control (LC) of 24 h infusion of gemcitabine plus radiotherapy after surgery for pancreatic cancer. METHODS:Weekly gemcitabine (100 mg/m(2)) was provided as a 24-hour infusion during the course of radiotherapy (50.4 Gy to the tumor, 39.6 Gy to the nodes). Patients sub...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2767-7

    authors: Mattiucci GC,Ippolito E,D'Agostino GR,Alfieri S,Antinori A,Crucitti A,Balducci M,Deodato F,Luzi S,Macchia G,Smaniotto D,Morganti AG,Valentini V

    更新日期:2013-02-01 00:00:00

  • Population-based outcome of stage IA-IIA resected gastric adenocarcinoma: who should get adjuvant treatment?

    abstract:BACKGROUND:The benefit of adjuvant treatment in gastric adenocarcinoma was demonstrated by randomized, controlled trials of patients with locally advanced tumors. Thus, its role for stage IIB-IIIC disease is widely accepted. We aimed to identify patients with stage IA-IIA gastric adenocarcinoma who have a poor prognosi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2852-y

    authors: Gold JS,Al Natour RH,Saund MS,Yoon C,Sharma AM,Huang Q,Boosalis VA,Whang EE

    更新日期:2013-07-01 00:00:00

  • Barriers to the Interpretation of Body Composition in Colorectal Cancer: A Review of the Methodological Inconsistency and Complexity of the CT-Defined Body Habitus.

    abstract:BACKGROUND:Measurement of body composition by computed tomography (CT) is an advancing field. Sarcopenia, myosteatosis, and visceral obesity (VO) have been identified as predictive of survival in colorectal cancer (CRC). We performed a systematic review of contemporary studies to characterize this association and highl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-018-6395-8

    authors: Hopkins JJ,Skubleny D,Bigam DL,Baracos VE,Eurich DT,Sawyer MB

    更新日期:2018-05-01 00:00:00

  • miR-196a overexpression and miR-196a2 gene polymorphism are prognostic predictors of oral carcinomas.

    abstract:BACKGROUND:Oral squamous cell carcinoma (OSCC) is prevalent worldwide, and survival in OSCC has not improved significantly in the last few decades. MicroRNAs have an important regulatory role in oral carcinogenesis. This study investigated the prognostic implications of miR-196 expression and the rs11614913 genotype of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2618-6

    authors: Liu CJ,Tsai MM,Tu HF,Lui MT,Cheng HW,Lin SC

    更新日期:2013-12-01 00:00:00

  • Surveillance Endoscopy Guidelines for Postgastrectomy Patients Based on Risk of Developing Remnant Gastric Cancer.

    abstract:BACKGROUND:Remnant gastric cancer (RGC) has a major impact on the long-term survival of postgastrectomy patients. In this study, we established surveillance endoscopy guidelines for postgastrectomy patients based on the risk of RGC. PATIENTS AND METHODS:A total of 6365 patients who underwent gastrectomy at Seoul St. M...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08517-3

    authors: Han ES,Seo HS,Kim JH,Lee HH

    更新日期:2020-10-01 00:00:00

  • Optimal submucosal invasion of early gastric cancer for endoscopic resection.

    abstract:BACKGROUND:A small differentiated gastric cancer with minute submucosal invasion after endoscopic resection is regarded as the curative resection criterion of an expanded indication. However, recent studies have shown a high incidence of lymph node metastasis in those meeting the expanded criteria. The aim of this stud...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4308-z

    authors: Eom BW,Yu JS,Ryu KW,Kook MC,Kim YI,Cho SJ,Lee JY,Kim CG,Choi IJ,Yoon HM,Kim YW

    更新日期:2015-01-01 00:00:00

  • Prognostic factor analysis in patients with metastatic spine disease depending on surgery and conservative treatment: review of 577 cases.

    abstract:BACKGROUND:To date, skillful medical management and advanced surgical techniques have provided increased quality of life with less postoperative morbidity in patients with spinal metastasis. We assessed the survival of patients with spinal metastasis according to two treatment modalities: surgery and conservative treat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2644-4

    authors: Lee BH,Kim TH,Chong HS,Moon ES,Park JO,Kim HS,Kim SH,Lee HM,Cho YJ,Kim KN,Moon SH

    更新日期:2013-01-01 00:00:00

  • XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Adaptor proteins, with multimodular structures, can participate in the regulation of various cellular functions. A novel adaptor protein XB130 has been implicated as a substrate and regulator of tyrosine kinase-mediated signaling and in controlling cell proliferation and apoptosis in thyroid and lung cancer ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2474-4

    authors: Shiozaki A,Kosuga T,Ichikawa D,Komatsu S,Fujiwara H,Okamoto K,Iitaka D,Nakashima S,Shimizu H,Ishimoto T,Kitagawa M,Nakou Y,Kishimoto M,Liu M,Otsuji E

    更新日期:2013-09-01 00:00:00

  • Conservative Re-excision is a Safe and Simple Alternative to Radical Resection in Revision Surgery for Dermatofibrosarcoma Protuberans.

    abstract:BACKGROUND:Dermatofibrosarcoma protuberans (DFSP) is a dermal sarcoma often diagnosed by excision biopsy, and is often incompletely excised, with high recurrence rates. Traditional wide excision involves resection margins of 2-4 cm, often resulting in morbid procedures requiring surgical reconstruction. An alternative ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08011-5

    authors: Snow H,Davies E,Strauss DC,Smith M,Hayes AJ

    更新日期:2020-03-01 00:00:00

  • Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study.

    abstract:BACKGROUND/AIM:Perioperative administration of immunoenriched diets attenuates the perioperative inflammatory response and reduces postoperative infection complications. However, many questions still remain unresolved in this area, such as the length of diet administration, diet composition, and the mechanisms involved...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-007-9407-7

    authors: Giger U,Büchler M,Farhadi J,Berger D,Hüsler J,Schneider H,Krähenbühl S,Krähenbühl L

    更新日期:2007-10-01 00:00:00

  • Surgery or Radiotherapy of the Primary Tumor in T1-2 Head and Neck Squamous Cell Carcinoma with Resectable N3 Nodes: A Multicenter GETTEC Study.

    abstract:BACKGROUND:The prognosis of advanced nodal (N3) squamous cell carcinoma of the head and neck (HNSCC) is poor. We investigated whether surgery or radiotherapy of early (T1-2) primary stage HSNCC is preferable to limit the overall morbidity after upfront neck dissection (uND) for N3 disease. METHODS:This retrospective m...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-019-07589-0

    authors: Carsuzaa F,Thariat J,Gorphe P,Righini C,Cosmidis A,Thureau S,Roge M,De Mones E,Servagi-Vernat S,Tonnerre D,Morinière S,Dugas A,Malard O,Pasquier F,Vergez S,Salleron J,Dufour X

    更新日期:2019-10-01 00:00:00

  • Verification of the Optimal Interval Before Esophagectomy After Preoperative Neoadjuvant Chemoradiotherapy for Locally Advanced Thoracic Esophageal Cancer.

    abstract:BACKGROUND:The interval between preoperative chemoradiotherapy and surgery reportedly affects perioperative outcomes and survival; however, the optimal interval in esophageal cancer patients remains uncertain. OBJECTIVE:Our aim was to determine whether a prolonged interval between preoperative neoadjuvant chemoradioth...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09206-x

    authors: Wakita A,Motoyama S,Sato Y,Nagaki Y,Fujita H,Terata K,Imai K,Minamiya Y

    更新日期:2020-10-13 00:00:00

  • Fluctuating mastectomy rates across time and geography.

    abstract::In 2009, 2 single-institution studies from the United States reported increasing mastectomy rates during the last decade. We have recently reported unilateral mastectomy trends from a European database and demonstrated a significant trend of decreasing mastectomy rates from 38.1 % in 2005 to 13.1 % in 2010. A recent s...

    journal_title:Annals of surgical oncology

    pub_type: 社论

    doi:10.1245/s10434-013-2982-x

    authors: Garcia-Etienne CA,Tomatis M,Heil J,Danaei M,Rageth CJ,Marotti L,Rosselli Del Turco M,Ponti A

    更新日期:2013-07-01 00:00:00

  • Changing the Default: A Prospective Study of Reducing Discharge Opioid Prescription after Lumpectomy and Sentinel Node Biopsy.

    abstract:BACKGROUND:Whether routinely prescribed opioids are necessary for pain control after discharge among lumpectomy/sentinel node biopsy (Lump/SLNB) patients is unclear. We hypothesize that Lump/SLNB patients could be discharged without opioids, with a failure rate < 10%. This study prospectively examines outcomes after ch...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08886-9

    authors: Moo TA,Pawloski KR,Sevilimedu V,Charyn J,Simon BA,Sclafani LM,Plitas G,Barrio AV,Kirstein LJ,Van Zee KJ,Morrow M

    更新日期:2020-11-01 00:00:00

  • Identification of the NEDD4L gene as a prognostic marker by integrated microarray analysis of copy number and gene expression profiling in non-small cell lung cancer.

    abstract:PURPOSE:The purpose of this study was to identify prognostic genes by integrated microarray analysis between comparative genomic hybridization and gene expression with laser microdissection in non-small cell lung cancer (NSCLC). METHODS:Integrated microarray analysis in 11 lung adenocarcinomas was performed, and sever...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3059-6

    authors: Sakashita H,Inoue H,Akamine S,Ishida T,Inase N,Shirao K,Mori M,Mimori K

    更新日期:2013-12-01 00:00:00

  • Cancer antigen 125 associated with multiple benign and malignant pathologies.

    abstract:BACKGROUND:Cancer antigen (CA) 125 tumor-associated antigen is a high molecular glycoprotein used for follow-up of epithelial ovarian cancer. The test is often requested as a differential diagnosis in patients with pleural or peritoneal fluid. This study analyzes the prevalence of CA-125 increases in a population of pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/aso.2003.05.015

    authors: Miralles C,Orea M,España P,Provencio M,Sánchez A,Cantos B,Cubedo R,Carcereny E,Bonilla F,Gea T

    更新日期:2003-03-01 00:00:00

  • A new policy regarding ovarian resection in young women treated for peritoneal carcinomatosis.

    abstract:OBJECTIVE:To appreciate if the ovaries can be preserved in selected young women with peritoneal carcinomatosis (PC). BACKGROUND:The traditional rule is to resect the ovaries systematically when PC is found at surgery. METHODS:A new policy was developed to preserve the ovaries when they were macroscopically normal in ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-2879-8

    authors: Elias D,Duchalais E,Dartigues P,Duvillard P,Poirot C,Goéré D

    更新日期:2013-06-01 00:00:00

  • Impact of hepatectomy surgical complexity on outcomes and hospital quality rankings.

    abstract:BACKGROUND:There is substantial variation in the surgical complexity of hepatectomy. Currently, the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) risk adjusts for hospital quality comparisons using only the primary procedure code. Our objectives were to (1) assess the associatio...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3500-5

    authors: Paruch JL,Merkow RP,Bentrem DJ,Ko CY,Posner MC,Cohen ME,Bilimoria KY,Weber SM

    更新日期:2014-06-01 00:00:00

  • Contralateral Prophylactic Mastectomy: Factors Predictive of Occult Malignancy or High-Risk Lesion and the Impact of MRI and Genetic Testing.

    abstract:BACKGROUND:Despite decreasing rates of subsequent contralateral breast cancer after diagnosis of unilateral primary breast cancer, the proportion of patients electing contralateral prophylactic mastectomy (CPM) is increasing. Our aim was to identify risk factors associated with the identification of occult malignancy (...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4660-7

    authors: Erdahl LM,Boughey JC,Hoskin TL,Degnim AC,Hieken TJ

    更新日期:2016-01-01 00:00:00

  • Indocyanine Green Compression Technique for Anatomical S8 Dorsal Subsegmentectomy for Hepatocellular Carcinoma.

    abstract:BACKGROUND:Anatomical resection (AR) is a recommended surgical treatment for hepatocellular carcinoma (HCC), although the conventional procedure (dye injection) for AR is difficult to reproduce.1,2 The tumor-feeding portal pedicle compression technique has been proposed as an easy, reversible, repeatable, and oncologic...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08644-x

    authors: Procopio F,Cimino M,Costa G,Branciforte B,Poretti D,Torzilli G

    更新日期:2020-12-01 00:00:00

  • Effectiveness of OK-432 (Sapylin) to reduce seroma formation after axillary lymphadenectomy for breast cancer.

    abstract:BACKGROUND:The occurrence of seroma formation after axillary lymphadenectomy for breast cancer cannot be ignored. Various approaches have been used in an effort to reduce it, but these results are still controversial. We aimed to describe a new method of application of OK-432 (Sapylin, heat-treated Su strain of Strepto...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-012-2728-1

    authors: Yang Y,Gao E,Liu X,Ye Z,Chen Y,Li Q,Qu J,Dai X,Wang O,Pan Y,Zhang X

    更新日期:2013-05-01 00:00:00

  • The Pretreatment Systemic Inflammatory Response is an Important Determinant of Poor Pathologic Response for Patients Undergoing Neoadjuvant Therapy for Rectal Cancer.

    abstract:BACKGROUND:Not all patients respond equally to neoadjuvant chemoradiotherapy (nCRT), with subsequent effects on survival. The systemic inflammatory response has been shown to predict long-term outcomes in colorectal cancer. The current study examined the association between systemic inflammation and nCRT in patients wi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5684-3

    authors: Dreyer SB,Powell AG,McSorley ST,Waterston A,Going JJ,Edwards J,McMillan DC,Horgan PG

    更新日期:2017-05-01 00:00:00

  • Sentinel Lymph Node Biopsy in Thin Cutaneous Melanoma: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Most patients with melanoma have a thin (≤1.00 mm) lesion. There is uncertainty as to which patients with thin melanoma should undergo sentinel lymph node (SN) biopsy. We sought to quantify the proportion of SN metastases in patients with thin melanoma and to determine the pooled effect of high-risk features...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-016-5137-z

    authors: Cordeiro E,Gervais MK,Shah PS,Look Hong NJ,Wright FC

    更新日期:2016-12-01 00:00:00

  • Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker.

    abstract:BACKGROUND:Biomarkers for accurate diagnosis of early hepatocellular carcinoma (HCC) are limited in number and clinical validation. We applied SELDI-TOF-MS ProteinChip technology to identify serum profile for distinguishing HCC and liver cirrhosis (LC) and to compare the accuracy of SELDI-TOF-MS profile and alpha-fetop...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1038-8

    authors: Chen L,Ho DW,Lee NP,Sun S,Lam B,Wong KF,Yi X,Lau GK,Ng EW,Poon TC,Lai PB,Cai Z,Peng J,Leng X,Poon RT,Luk JM

    更新日期:2010-09-01 00:00:00

  • Back to Basics: Traditional Nottingham Grade Mitotic Counts Alone are Significant in Predicting Survival in Invasive Breast Carcinoma.

    abstract:BACKGROUND:Newer multigene molecular profiling assays for breast carcinoma rely heavily on the quantification of genes of proliferation, whereas traditional histological grading reports the mitotic count. The mitotic activity of invasive breast carcinomas may be undervalued; therefore, an evaluation of the prognostic s...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4616-y

    authors: Chang JM,McCullough AE,Dueck AC,Kosiorek HE,Ocal IT,Lidner TK,Gray RJ,Wasif N,Northfelt DW,Anderson KS,Pockaj BA

    更新日期:2015-12-01 00:00:00

  • Recent experience with Wilms' tumor: 1978-1991.

    abstract:BACKGROUND:The treatment of Wilms' tumor has undergone major advances in the past four decades. Current therapy is based on both the stage and pathology of the tumor. We have reviewed our recent experience with this tumor to assess the results of treatment on protocols that generally avoid the use of doxorubicin. METH...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303542

    authors: Shamberger RC,Macklis RM,Sallan SE

    更新日期:1994-01-01 00:00:00