Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer.


BACKGROUND:Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patients with gastric cancer. In addition, the mechanisms underlying the effect of postoperative complications on outcomes remain to be elucidated. We hypothesized that immunosuppression by postoperative complications may affect long-term outcomes in patients with esophageal cancer. METHODS:In this retrospective study, we assessed in 153 patients with esophageal cancer who underwent curative subtotal esophagectomy at our hospital and examined the correlation between postoperative complications, and multiple clinicopathological factors, and long-term outcomes with the patients stratified by total lymphocyte count (TLC). RESULTS:The median preoperative TLC was 1432. A total of 115 patients (75.2%) had a TLC of ≥ 1000/μL (high TLC group), and the remaining 38 patients (24.8%) had a TLC of < 1000/μL (low TLC group). Postoperative complications occurred in 39 of 153 cases (25.5%). There was no significant correlation between postoperative complications and any of the clinicopathological factors in either group. In the high TLC group, patients with postoperative complications had significantly lower overall and disease-free survival rates compared with those without complications (p < 0.001 and p < 0.01, respectively). In the low TLC group, no survival difference between patients with and without postoperative complications was observed. CONCLUSIONS:Postoperative complications may have a minimal impact on long-term outcomes in immunodeficient patients.


Ann Surg Oncol


Maruyama S,Kawaguchi Y,Akaike H,Shoda K,Saito R,Shimizu H,Furuya S,Hosomura N,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D




Has Abstract


2020-08-01 00:00:00














  • Simultaneous indocyanine green and (99m)Tc-antimony sulfur colloid-guided laparoscopic sentinel basin dissection for gastric cancer.

    abstract:BACKGROUND:There are few reports on a dual dye and isotope approach using laparoscopy in gastric cancer sentinel node mapping. The aim of this study is to evaluate the feasibility of laparoscopic sentinel basin dissection for gastric cancer using simultaneous indocyanine green (ICG) and (99m)Tc-antimony sulfur colloid ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Park DJ,Kim HH,Park YS,Lee HS,Lee WW,Lee HJ,Yang HK

    更新日期:2011-01-01 00:00:00

  • Intra-operative sonography: a valuable aid during breast-conserving surgery for occult breast cancer.

    abstract:BACKGROUND:Breast cancer is increasingly detected during an early non-palpable stage. Together with pre-operative marking of the mass, intra-operative imaging provides invaluable clues. This study was designed to evaluate the usefulness of intra-operative sonography in the hands of the surgeon. METHODS:Between July 20...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Haid A,Knauer M,Dunzinger S,Jasarevic Z,Köberle-Wührer R,Schuster A,Toeppker M,Haid B,Wenzl E,Offner F

    更新日期:2007-11-01 00:00:00

  • Use of recombinant poxviruses to stimulate anti-melanoma T cell reactivity.

    abstract:BACKGROUND:Dendritic cells (DC) are potent professional antigen-presenting cells that can activate naive T lymphocytes and initiate cellular immune responses. As adjuvants, DC may be useful for enhancing immunogenicity and mediating tumor regression. Endogenous expression of antigen by DC could offer the potential adva...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kim CJ,Cormier J,Roden M,Gritz L,Mazzara GP,Fetsch P,Hijazi Y,Lee KH,Rosenberg SA,Marincola FM

    更新日期:1998-01-01 00:00:00

  • Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer.

    abstract:BACKGROUND:Girdin was identified as a novel Akt substrate that contributes to a positive feedback loop between Girdin and Akt. Although several recent studies have demonstrated that Girdin is involved in tumor metastasis, the clinical implications of Girdin in breast cancer remain unclear. METHODS:To retrospectively e...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Peng WT,Hu X,Yao L,Jiang YZ,Shao ZM

    更新日期:2014-12-01 00:00:00

  • The Expression of Melanoma-Associated Antigen D2 Both in Surgically Resected and Serum Samples Serves as Clinically Relevant Biomarker of Gastric Cancer Progression.

    abstract:BACKGROUND:Sensitive biomarkers are necessary for risk classification of patients with gastric cancer (GC), especially ones at risk of distant metastases. Melanoma-associated antigen (MAGE)-D2 has been reported to play a role in the process of cell adhesion and metastatic potential of tumor cells in colorectal cancer. ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kanda M,Nomoto S,Oya H,Takami H,Shimizu D,Hibino S,Hashimoto R,Kobayashi D,Tanaka C,Yamada S,Fujii T,Nakayama G,Sugimoto H,Koike M,Fujiwara M,Kodera Y

    更新日期:2016-02-01 00:00:00

  • Surgeons' Perspectives of Contralateral Prophylactic Mastectomy.

    abstract:BACKGROUND:Contralateral prophylactic mastectomy (CPM) is commonly performed for the treatment of breast cancer, despite its limited oncologic benefit. Little is known about surgeons' perceptions of performing CPM. We hypothesized that a proportion of surgeons would report discomfort with performing CPM, particularly w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bellavance E,Peppercorn J,Kronsberg S,Greenup R,Keune J,Lynch J,Collyar D,Magder L,Tilburt J,Hlubocky F,Yao K

    更新日期:2016-09-01 00:00:00

  • Effectiveness of OK-432 (Sapylin) to reduce seroma formation after axillary lymphadenectomy for breast cancer.

    abstract:BACKGROUND:The occurrence of seroma formation after axillary lymphadenectomy for breast cancer cannot be ignored. Various approaches have been used in an effort to reduce it, but these results are still controversial. We aimed to describe a new method of application of OK-432 (Sapylin, heat-treated Su strain of Strepto...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验


    authors: Yang Y,Gao E,Liu X,Ye Z,Chen Y,Li Q,Qu J,Dai X,Wang O,Pan Y,Zhang X

    更新日期:2013-05-01 00:00:00

  • Influence of surgical volume on outcome for laparoscopic hysterectomy for endometrial cancer.

    abstract:PURPOSE:The volume of surgical procedures performed by hospitals and surgeons has a strong influence on outcomes for a number of surgeries. We examined the influence of surgeon and hospital case volume on morbidity, mortality, and resource utilization for women with endometrial cancer undergoing laparoscopic hysterecto...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Wright JD,Hershman DL,Burke WM,Lu YS,Neugut AI,Lewin SN,Herzog TJ

    更新日期:2012-03-01 00:00:00

  • Pancreatic resection of isolated metastases from nonpancreatic primary cancers.

    abstract:BACKGROUND:The goal of this study is to report the safety and efficacy of pancreatic resection for isolated metastatic cancers from nonpancreatic primary disease. METHODS:We retrospectively identified patients from a single institution's prospectively gathered pancreaticobiliary database from 1970 to 2007 who underwen...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章


    authors: Reddy S,Edil BH,Cameron JL,Pawlik TM,Herman JM,Gilson MM,Campbell KA,Schulick RD,Ahuja N,Wolfgang CL

    更新日期:2008-11-01 00:00:00

  • Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change.

    abstract:BACKGROUND:The COVID-19 pandemic has posed extraordinary demands from patients, providers, and health care systems. Despite this, surgical oncologists must maintain focus on providing high-quality, empathetic care for the almost 2 million patients nationally who will be diagnosed with operable cancer this year. The foc...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Hwang ES,Balch CM,Balch GC,Feldman SM,Golshan M,Grobmyer SR,Libutti SK,Margenthaler JA,Sasidhar M,Turaga KK,Wong SL,McMasters KM,Tanabe KK

    更新日期:2020-08-01 00:00:00

  • Clinicopathological Features and Outcomes in Individuals with Breast Cancer and ATM, CHEK2, or PALB2 Mutations.

    abstract:INTRODUCTION:The moderate-penetrance germline mutations ATM, CHEK2, and PALB2 are implicated in an increased risk of the development of breast cancer. Whether these mutations provide clinical utility to guide treatment strategies and prognosis remains unknown. METHODS:A retrospective case-control study from a tertiary...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bergstrom C,Pence C,Berg J,Partain N,Sadeghi N,Mauer C,Pirzadeh-Miller S,Gao A,Li H,Unni N,Syed S

    更新日期:2020-09-29 00:00:00

  • Prognostic variables in invasive breast cancer: contribution of comedo versus noncomedo in situ component.

    abstract:BACKGROUND:Many invasive breast cancers are accompanied by a variety of noninvasive components. Histological distinctions have been made between these components, but to understand their importance, it is essential to examine their molecular biology. METHODS:Proliferative indices, oncoproteins, and steroid receptor ex...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Brower ST,Ahmed S,Tartter PI,Bleiweiss I,Amberson JB

    更新日期:1995-09-01 00:00:00

  • Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma.

    abstract:BACKGROUND:Glioma recurrence usually occurs close to the tumor resection margins as a result of residual infiltrating glioma cells. 5-aminolevulinic acid (ALA) fluorescence-guided resection of gliomas has been demonstrated to enhance discrimination of tumor tissue and to improve survival. ALA-based photodynamic therapy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Zhao SG,Chen XF,Wang LG,Yang G,Han DY,Teng L,Yang MC,Wang DY,Shi C,Liu YH,Zheng BJ,Shi CB,Gao X,Rainov NG

    更新日期:2013-12-01 00:00:00

  • Demonstration of second-tier lymph nodes during preoperative lymphoscintigraphy for melanoma: incidence varies with primary tumor site.

    abstract:BACKGROUND:Preoperative cutaneous lymphoscintigraphy (LS) to identify sentinel (first-tier) lymph nodes was performed in 250 consecutive melanoma patients before wide local excision only or wide local excision with sentinel node biopsy. METHODS:The location of the sentinel nodes was marked on the overlying skin in all...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Uren RF,Howman-Giles RB,Thompson JF

    更新日期:1998-09-01 00:00:00

  • Inguinofemoral lymphadenectomy: randomized trial comparing inguinal skin access above or below the inguinal ligament.

    abstract:BACKGROUND:Groin wound breakdown, lymphoceles, cellulitis, and chronic leg edema are the most frequent complications of inguinal lymphadenectomy, resulting in severe patient discomfort and significant lengthening of postoperative stay. Despite all innovations, complication rates are still high and inevitable. Our exper...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验


    authors: Manci N,Marchetti C,Esposito F,De Falco C,Bellati F,Giorgini M,Angioli R,Panici PB

    更新日期:2009-03-01 00:00:00

  • Can surgical oncologists reliably predict the likelihood for non-SLN metastases in breast cancer patients?

    abstract:BACKGROUND:In approximately 40% of the breast cancer patients with sentinel lymph node (SLN) metastases, additional nodal metastases are detected in the completion axillary lymph node dissection (cALND). The MSKCC nomogram can help to quantify a patient's individual risk for non-SLN metastases with fairly accurate pred...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Smidt ML,Strobbe LJ,Groenewoud HM,der Wilt GJ,Van Zee KJ,Wobbes T

    更新日期:2007-02-01 00:00:00

  • Sentinel lymph node biopsy versus axillary lymphadenectomy in patients treated with lumpectomy: an analysis of short-term outcomes.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) has been shown to reduce many of the long-term complications associated with a traditional axillary lymph node dissection (ALND); however, short-term outcomes have yet to be characterized. This study was designed to identify trends and differences in 30-day outcomes of parti...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Khavanin N,Gart MS,Berry T,Thornton B,Saha S,Kim JY

    更新日期:2014-01-01 00:00:00

  • Clinical and socioeconomic factors influence treatment decisions in Graves' disease.

    abstract:BACKGROUND:Definitive treatment of Graves' disease includes radioactive iodine (RAI) and thyroidectomy, but utilization varies. We hypothesize that, in addition to clinical reasons, there are socioeconomic factors that influence whether a patient undergoes thyroidectomy or RAI. METHODS:Patients treated for Graves' dis...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Elfenbein DM,Schneider DF,Havlena J,Chen H,Sippel RS

    更新日期:2015-04-01 00:00:00

  • Increasing the Number of Examined Lymph Nodes is a Prerequisite for Improvement in the Accurate Evaluation of Overall Survival of Node-Negative Gastric Cancer Patients.

    abstract:BACKGROUND:This study aims to elucidate whether increasing the number of examined lymph nodes (NELN) is mandatory for the accurate prognosis of node-negative gastric cancer (GC) patients after curative gastrectomy in Eastern countries (China and Japan). METHODS:The clinicopathological data of 2455 GC patients (includi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Deng J,Yamashita H,Seto Y,Liang H

    更新日期:2017-03-01 00:00:00

  • The Ethics of Breast Surgery.

    abstract::Breast surgery has evolved as a subspecialty of general surgery and requires a working knowledge of benign and malignant diseases, surgical techniques, shared decision-making with patients, collaboration with a multi-disciplinary team, and a basic foundation in surgical ethics. Ethics is defined as the practice of ana...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Throckmorton A,VanderWalde L,Brackett C,Dominici L,Eisenhauer T,Johnson N,Kong A,Ludwig K,O'Neill J,Pugliese M,Teller P,Sarantou T

    更新日期:2015-10-01 00:00:00

  • Population-Based Study on Risk Factors for Tumor-Positive Resection Margins in Patients with Gastric Cancer.

    abstract:BACKGROUND:Radical gastrectomy is the cornerstone of the treatment of locally advanced gastric cancer. This study was designed to evaluate factors associated with a tumor-positive resection margin after gastrectomy and to evaluate the influence of hospital volume. METHODS:In this Dutch cohort study, patients with junc...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: van der Werf LR,Cords C,Arntz I,Belt EJT,Cherepanin IM,Coene PLO,van der Harst E,Heisterkamp J,Langenhoff BS,Lamme B,van Berge Henegouwen MI,Lagarde SM,Wijnhoven BPL

    更新日期:2019-07-01 00:00:00

  • Molecular imaging of tumor-associated angiogenesis using a novel magnetic resonance imaging contrast agent targeting αvβ 3 integrin.

    abstract:BACKGROUND:The recent introduction of biological anticancer therapy has renewed the interest in functional imaging of tumor-associated angiogenesis (TAA) as a tool to monitor early therapy response. The present study evaluated imaging of TAA using P1227, a novel, small molecular magnetic resonance imaging (MRI) probe t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Debergh I,Van Damme N,De Naeyer D,Smeets P,Demetter P,Robert P,Carme S,Pattyn P,Ceelen W

    更新日期:2014-06-01 00:00:00

  • Changing the Default: A Prospective Study of Reducing Discharge Opioid Prescription after Lumpectomy and Sentinel Node Biopsy.

    abstract:BACKGROUND:Whether routinely prescribed opioids are necessary for pain control after discharge among lumpectomy/sentinel node biopsy (Lump/SLNB) patients is unclear. We hypothesize that Lump/SLNB patients could be discharged without opioids, with a failure rate < 10%. This study prospectively examines outcomes after ch...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Moo TA,Pawloski KR,Sevilimedu V,Charyn J,Simon BA,Sclafani LM,Plitas G,Barrio AV,Kirstein LJ,Van Zee KJ,Morrow M

    更新日期:2020-11-01 00:00:00

  • Cure model survival analysis after hepatic resection for colorectal liver metastases.

    abstract:BACKGROUND:Statistical cure is achieved when a patient population has the same mortality as cancer-free individuals; however, data regarding the probability of cure after hepatectomy of colorectal liver metastases (CLM) have never been provided. We aimed to assess the probability of being statistically cured from CLM b...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Cucchetti A,Ferrero A,Cescon M,Donadon M,Russolillo N,Ercolani G,Stacchini G,Mazzotti F,Torzilli G,Pinna AD

    更新日期:2015-01-01 00:00:00

  • Profiling Surgeon Performance for Breast Cancer Lumpectomy by Composite Measurement of Reoperations, Cosmetic Outcomes, and Patient Preferences.

    abstract:BACKGROUND:Patients want information to search for destination of care for breast-conserving surgery (BCS). To inform patients wanting a lumpectomy, we aimed to develop a pilot project that communicated composite quality measure (QM) results using a '4-star' rating system. Two patient-centered QMs were included in the ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Dunham AL,Ramirez LD,Vang CA,Linebarger JH,Landercasper J

    更新日期:2018-07-01 00:00:00

  • Experience of pediatric osteosarcoma of the extremity at a single institution in Taiwan: prognostic factors and impact on survival.

    abstract:PURPOSE:To identify the prognostic factors and evaluate the impact of chemotherapy regimens on the outcomes of pediatric osteosarcoma of the extremities. METHODS:Patients younger than 18 years and diagnosed with high-grade osteosarcoma of the extremities during the period between January 2004 and December 2011 were in...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章


    authors: Hung GY,Yen HJ,Yen CC,Chen WM,Chen PC,Wu HT,Chiou HJ,Chang WH,Hsu HE

    更新日期:2015-04-01 00:00:00

  • Resection Margins in Merkel Cell Carcinoma: Is a 1-cm Margin Wide Enough?

    abstract:BACKGROUND:Guidelines regarding specific resection margins for primary Merkel cell carcinoma (MCC) are not well established. The current National Comprehensive Cancer Network (NCCN) guidelines recommend 1- to 2-cm resection margins. This study aimed to determine the impact of margin width on local recurrence (LR), dise...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Perez MC,de Pinho FR,Holstein A,Oliver DE,Naqvi SMH,Kim Y,Messina JL,Burke E,Gonzalez RJ,Sarnaik AA,Cruse CW,Wuthrick EJ,Harrison LB,Sondak VK,Zager JS

    更新日期:2018-10-01 00:00:00

  • Adjuvant therapy with capecitabine postpones recurrence of hepatocellular carcinoma after curative resection: a randomized controlled trial.

    abstract:BACKGROUND:Postoperative recurrence of hepatocellular carcinoma (HCC) is a major problem after surgical resection. To date, adjuvant chemotherapy or other adjuvant modalities have not been proven effective in preventing or delaying recurrence. The aim of this prospective randomized study was to evaluate the effectivene...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验


    authors: Xia Y,Qiu Y,Li J,Shi L,Wang K,Xi T,Shen F,Yan Z,Wu M

    更新日期:2010-12-01 00:00:00

  • Cetuximab shows activity in colorectal cancer patients with tumors for which FISH analysis does not detect an increase in EGFR gene copy number.

    abstract:BACKGROUND:EGFR (epidermal growth factor receptor) gene gain assessed by FISH (fluorescence in situ hybridization) has been shown to be predictive of response to EGFR-targeted therapies in patients with non-small cell lung cancer. The aim or our study was to relate the EGFR gene copy number to therapeutic results in pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Italiano A,Follana P,Caroli FX,Badetti JL,Benchimol D,Garnier G,Gugenheim J,Haudebourg J,Keslair F,Lesbats G,Lledo G,Roussel JF,Pedeutour F,François E

    更新日期:2008-02-01 00:00:00

  • Efficacy of Talimogene Laherparepvec (T-VEC) Therapy in Patients with In-Transit Melanoma Metastasis Decreases with Increasing Lesion Size.

    abstract:BACKGROUND:Talimogene laherparepvec (T-VEC) is the first injectable oncolytic viral therapy approved for in-transit melanoma metastasis, with a reported overall response rate (ORR) of 25% and complete response rate (CRR) of 10%. To ascertain the role of patient selection on outcomes in routine practice, we evaluated th...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章


    authors: Masoud SJ,Hu JB,Beasley GM,Stewart JH 4th,Mosca PJ

    更新日期:2019-12-01 00:00:00