Prognostic value of extracapsular invasion of axillary lymph nodes combined with peritumoral vascular invasion in patients with breast cancer.

Abstract:

BACKGROUND:Extracapsular invasion (ECI) of metastatic axillary lymph nodes has been associated with aggressive nodal disease but its prognostic role in breast cancer is unclear. The present study evaluated nodal ECI as a predictor of breast cancer recurrence. METHODS:We evaluated 154 women with histologically proven node-positive breast cancer who were diagnosed with invasive ductal carcinoma, and investigated the relationships between ECI and recurrences and other clinicopathological factors, particularly vascular invasion and the number of lymph node metastases. RESULTS:The presence of ECI at positive nodes was significantly associated with the number of positive nodes, and with disease recurrence and survival in univariate (but not multivariate) analysis. Interestingly, all ECI(+) patients with distant metastases in our series had peritumoral vascular invasion (PVI), which may have reflected systemic disease; ECI with PVI of the primary tumor strongly predicted recurrent disease and shorter survival. CONCLUSION:ECI of axillary metastases combined with PVI indicates high tumor aggressiveness. Patients with ECI and PVI may be considered for stronger adjuvant therapies because of their high risk for distant recurrences.

journal_name

Ann Surg Oncol

authors

Yajima R,Fujii T,Yanagita Y,Fujisawa T,Miyamoto T,Hirakata T,Tsutsumi S,Iijima M,Kuwano H

doi

10.1245/s10434-014-3941-x

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

52-8

issue

1

eissn

1068-9265

issn

1534-4681

journal_volume

22

pub_type

杂志文章
  • Combined intensive chemotherapy and radical surgery for incurable gastric cancer.

    abstract:BACKGROUND:To improve the poor prognosis of patients with advanced incurable gastric cancer, intensive chemotherapy combined with radical surgery was used. PATIENTS AND METHODS:Thirty patients with incurable gastric cancer were treated with a combination of 5-fluorouracil (370 mg/m2) and leucovorin (30 mg/person), giv...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02306611

    authors: Nakajima T,Ota K,Ishihara S,Oyama S,Nishi M,Ohashi Y,Yanagisawa A

    更新日期:1997-04-01 00:00:00

  • Surgical resection of primary tumors in patients who present with stage IV colorectal cancer: an analysis of surveillance, epidemiology, and end results data, 1988 to 2000.

    abstract:BACKGROUND:Surgical resection of the primary tumor for patients who present with incurable stage IV colorectal cancer is controversial. National practice patterns have not been described. We evaluated the use of primary tumor resection in patients presenting with stage IV colorectal cancer. METHODS:Patients with stage...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.06.012

    authors: Cook AD,Single R,McCahill LE

    更新日期:2005-08-01 00:00:00

  • Increased postoperative complications in bilateral mastectomy patients compared to unilateral mastectomy: an analysis of the NSQIP database.

    abstract:BACKGROUND:Recent studies indicate that women with unilateral breast cancer are choosing contralateral prophylactic mastectomy (CPM) at an increasing rate. There is limited literature evaluating the postoperative complication rates associated with CPM without breast reconstruction. The objective of this study was to co...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-013-3116-1

    authors: Osman F,Saleh F,Jackson TD,Corrigan MA,Cil T

    更新日期:2013-10-01 00:00:00

  • Estimating the Prevalence of Pseudomyxoma Peritonei in Europe Using a Novel Statistical Method.

    abstract:BACKGROUND:The determination of the incidence and prevalence of rare diseases is important for economists and health-care providers. Pseudomyxoma peritonei (PMP) is a rare, slow-growing abdominal cancer that represents a substantial burden on both patients and health-care systems. The incidence rate was previously appr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08655-8

    authors: Patrick-Brown TDJH,Carr NJ,Swanson DM,Larsen S,Mohamed F,Flatmark K

    更新日期:2021-01-01 00:00:00

  • Paradigm of metastasis for melanoma and breast cancer based on the sentinel lymph node experience.

    abstract::Lymph node status is the most reliable prognostic indicator for patients with melanoma and breast cancer. Because it is the first node draining the primary cancer, the sentinel lymph node (SLN) is most likely to harbor metastatic cancer cells. The Breslow thickness of the primary melanoma and the size of primary breas...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02523627

    authors: Leong SP

    更新日期:2004-03-01 00:00:00

  • Use of the Nerve Integrity Monitor during Thyroid Surgery Aids Identification of the External Branch of the Superior Laryngeal Nerve.

    abstract:BACKGROUND:The external branch of the superior laryngeal nerve (EBSLN) is at risk during thyroid surgery. Despite meticulous dissection and visualization, the EBSLN can be mistaken for other structures. The nerve integrity monitor (NIM) allows EBSLN confirmation with cricothyroid twitch on stimulation. AIMS:The aim of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4142-3

    authors: Glover AR,Norlén O,Gundara JS,Morris M,Sidhu SB

    更新日期:2015-01-01 00:00:00

  • Current Delivery of Hyperthermic Intraperitoneal Chemotherapy with Cytoreductive Surgery (CS/HIPEC) and Perioperative Practices: An International Survey of High-Volume Surgeons.

    abstract:BACKGROUND:Cytoreductive surgery and heated intraperitoneal chemotherapy (CS/HIPEC) is performed for selected indications at a limited number of specialized centers worldwide. Currently there is no standardized approach to the perioperative care process. We sought to capture current practices in the perioperative manag...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5692-3

    authors: Maciver AH,Al-Sukhni E,Esquivel J,Skitzki JJ,Kane JM 3rd,Francescutti VA

    更新日期:2017-04-01 00:00:00

  • REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy.

    abstract:BACKGROUND:The prognosis for patients with locally advanced thoracic esophageal cancer is extremely unfavorable. We have been administering neoadjuvant chemoradiotherapy (CRT) followed by esophagectomy to these patients and studying whether REG I expression in untreated endoscopic biopsy specimens is predictive of pati...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9075-z

    authors: Motoyama S,Sugiyama T,Ueno Y,Okamoto H,Takasawa S,Nanjo H,Watanabe H,Maruyama K,Okuyama M,Ogawa J

    更新日期:2006-12-01 00:00:00

  • Systematic para-aortic and pelvic lymphadenectomy in early stage epithelial ovarian cancer: a prospective study.

    abstract:BACKGROUND:Lymphadenectomy is important in the surgical treatment of apparent early epithelial ovarian cancers (eEOC); however, its extent is not well defined. We evaluated the role of systematic lymphadenectomy, the risk factors related with lymph node metastases, the implications, and the morbidity of comprehensive s...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2439-7

    authors: Ditto A,Martinelli F,Reato C,Kusamura S,Solima E,Fontanelli R,Haeusler E,Raspagliesi F

    更新日期:2012-11-01 00:00:00

  • The lymphatic anatomy of the breast and its implications for sentinel lymph node biopsy: a human cadaver study.

    abstract:BACKGROUND:Current understanding of the lymphatic system of the breast is derived mainly from the work of the anatomist Sappey in the 1850s, with many observations made during the development and introduction of breast lymphatic mapping and sentinel node biopsy contributing to our knowledge. METHODS:Twenty four breast...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9709-9

    authors: Suami H,Pan WR,Mann GB,Taylor GI

    更新日期:2008-03-01 00:00:00

  • Factors associated with local-regional failure after definitive chemoradiation for locally advanced esophageal cancer.

    abstract:BACKGROUND:Locally advanced esophageal cancer is often treated with a trimodality approach. While a substantial proportion of such patients initially achieve a clinical complete response (cCR) after chemoradiation, only a small proportion achieve durable control. We analyzed patients who reached cCR after definitive ch...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3303-0

    authors: Amini A,Ajani J,Komaki R,Allen PK,Minsky BD,Blum M,Xiao L,Suzuki A,Hofstetter W,Swisher S,Gomez D,Liao Z,Lee JH,Bhutani MS,Welsh JW

    更新日期:2014-01-01 00:00:00

  • EGFR nuclear import in gallbladder carcinoma: nuclear phosphorylated EGFR upregulates iNOS expression and confers independent prognostic impact.

    abstract:BACKGROUND:The understanding of epidermal growth factor receptor (EGFR) deregulation in carcinogenesis remains incomplete. We investigated the implications of EGFR gene status and EGFR nuclear translocation in gallbladder carcinoma (GBCA). METHODS:Subcellular localization of EGFR and phosphorylated EGFR (pEGFR) was an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1942-6

    authors: Li CF,Fang FM,Wang JM,Tzeng CC,Tai HC,Wei YC,Li SH,Lee YT,Wang YH,Yu SC,Shiue YL,Chu PY,Wang WL,Chen LT,Huang HY

    更新日期:2012-02-01 00:00:00

  • Laparoscopic Spleen-Preserving Total Pancreatectomy for a Main-Duct Intraductal Papillary Mucinous Neoplasm.

    abstract:INTRODUCTION:Main-duct intraductal papillary mucinous neoplasms of the pancreas (M-IPMN) are potentially malignant cystic neoplasms that can degenerate into invasive malignancy in 43 % of cases.1 Although laparoscopic pancreaticoduodenectomy and distal pancreatectomy have been previously described for the management of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5481-z

    authors: Chapman BC,Paniccia A,Ryan C,Schulick RD,Edil BH

    更新日期:2017-02-01 00:00:00

  • Positive bone marrow biopsy is associated with a decreased disease-free survival in patients with operable breast cancer.

    abstract:BACKGROUND:Bone marrow (BM) biopsy has been suggested as an independent prognostic factor in patients with breast cancer. METHODS:Patients operated for breast cancer from June 2000 to April 2008 were enrolled in this protocol after signing an informed consent. After primary surgery, BM aspirate from the iliac crest wa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0619-x

    authors: Fortunato L,Mascaro A,Baldi A,Farina M,Cortese G,Ventrone MA,Amini M,Vitelli C

    更新日期:2009-11-01 00:00:00

  • Relevance of Dissection of the Posterior Superior Pancreaticoduodenal Lymph Nodes in Gallbladder Carcinoma.

    abstract:BACKGROUND:This study was designed to evaluate the prognostic value of positive posterior superior pancreaticoduodenal lymph nodes to clarify the need for dissection of these nodes. METHODS:A total of 148 patients with gallbladder carcinoma who underwent radical resection including dissection of the posterior superior...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5939-7

    authors: Sakata J,Kobayashi T,Tajima Y,Ohashi T,Hirose Y,Takano K,Takizawa K,Miura K,Wakai T

    更新日期:2017-09-01 00:00:00

  • Carcinoma metastatic to cervical lymph nodes from an occult primary tumor: the outcome after combined-modality therapy.

    abstract:BACKGROUND:The aim of this retrospective analysis was to analyze the results of treatment of patients with cervical node metastases from carcinoma of occult primary with a policy including neck dissection and postoperative comprehensive radiotherapy. METHODS:Ninety patients were treated with curative intent from 1990 ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9329-9

    authors: Boscolo-Rizzo P,Gava A,Da Mosto MC

    更新日期:2007-05-01 00:00:00

  • Changing the Default: A Prospective Study of Reducing Discharge Opioid Prescription after Lumpectomy and Sentinel Node Biopsy.

    abstract:BACKGROUND:Whether routinely prescribed opioids are necessary for pain control after discharge among lumpectomy/sentinel node biopsy (Lump/SLNB) patients is unclear. We hypothesize that Lump/SLNB patients could be discharged without opioids, with a failure rate < 10%. This study prospectively examines outcomes after ch...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08886-9

    authors: Moo TA,Pawloski KR,Sevilimedu V,Charyn J,Simon BA,Sclafani LM,Plitas G,Barrio AV,Kirstein LJ,Van Zee KJ,Morrow M

    更新日期:2020-11-01 00:00:00

  • Toxicity of Immune Checkpoint Inhibitors: Considerations for the Surgeon.

    abstract:BACKGROUND:The use of immunotherapeutic agents, specifically immune checkpoint inhibitors (ICIs) for solid malignancies, is rapidly rising, and many new agents and treatment combinations are in development. However, ICIs have a unique side-effect profile of immune-related adverse events (irAEs) compared with chemothera...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-019-08183-0

    authors: Helmink BA,Roland CL,Kiernan CM,Wargo JA

    更新日期:2020-05-01 00:00:00

  • The usefulness of neoadjuvant chemoradiation therapy for locally advanced esophageal cancer with multiple lymph-node metastases.

    abstract:BACKGROUND:The prognosis of patients with esophageal squamous-cell cancer (ESCC) and multiple lymph-node metastases is quite poor. We examined whether neoadjuvant chemoradiation therapy (CRT) has a beneficial effect in such patients. METHODS:A total of 50 consecutive patients with T3-4 tumors and without organ metasta...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3688-4

    authors: Okumura H,Uchikado Y,Omoto I,Kita Y,Sasaki K,Arigami T,Uenosono Y,Matsushita D,Hiraki Y,Owaki T,Ishigami S,Natsugoe S

    更新日期:2014-09-01 00:00:00

  • Postoperative Lower Extremity Edema in Patients with Primary Endometrial Cancer.

    abstract:PURPOSE:The goal of this study was to investigate clinical manifestations of lower extremity edema (LEE) after lymph node dissection in patients with primary endometrial cancer. METHODS:Women with primary endometrial cancer who underwent staging surgery between November 2001 and March 2011 were included in the study. ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4613-1

    authors: Bae HS,Lim MC,Lee JS,Lee Y,Nam BH,Seo SS,Kang S,Chung SH,Kim JY,Park SY

    更新日期:2016-01-01 00:00:00

  • DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.

    abstract:BACKGROUND:Rad51 is a protein which plays a vital role in DNA double-strand break repair and maintenance of telomeres. However, the underlying mechanism for its action in esophageal squamous cell carcinoma (ESCC) remains unclear. PATIENTS AND METHODS:Eighty-seven patients with ESCC were enrolled in this study. Express...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08043-x

    authors: Chiu WC,Fang PT,Lee YC,Wang YY,Su YH,Hu SC,Chen YK,Tsui YT,Kao YH,Huang MY,Yuan SF

    更新日期:2020-06-01 00:00:00

  • Breast cancer in Hong Kong, Southern China: the first population-based analysis of epidemiological characteristics, stage-specific, cancer-specific, and disease-free survival in breast cancer patients: 1997-2001.

    abstract:BACKGROUND:Cancer registries have been set up worldwide to provide information for cancer health planning. There are known variations in breast cancer incidence and mortality worldwide. However, breast cancer incidence, pathological characteristics, and survival data is still under-reported in Asian countries. This is ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1960-4

    authors: Kwong A,Mang OW,Wong CH,Chau WW,Law SC,Hong Kong Breast Cancer Research Group.

    更新日期:2011-10-01 00:00:00

  • ASO Author Reflections: Incorporating Lymphovascular Invasion to Improve the Prognostic Reliability of the T-Staging System for Adrenocortical Carcinoma-A Multicenter Study.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6876-9

    authors: Poorman CE,Ethun CG,Maithel SK

    更新日期:2018-12-01 00:00:00

  • Neoadjuvant chemoradiotherapy affects the indications for lateral pelvic node dissection in mid/low rectal cancer with clinically suspected lateral node involvement: a multicenter retrospective cohort study.

    abstract:BACKGROUND:Although lateral pelvic node dissection (LPND) is recommended for rectal cancer with clinically metastatic lateral pelvic lymph nodes (LPNs), LPNs may respond to neoadjuvant chemoradiotherapy (nCRT). Our aim was to determine the optimal indication for LPND after nCRT for mid/low rectal cancer. METHODS:Of 2,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-014-3559-z

    authors: Oh HK,Kang SB,Lee SM,Lee SY,Ihn MH,Kim DW,Park JH,Kim YH,Lee KH,Kim JS,Kim JW,Kim JH,Chang TY,Park SC,Sohn DK,Oh JH,Park JW,Ryoo SB,Jeong SY,Park KJ

    更新日期:2014-07-01 00:00:00

  • A prospective study of total gastrectomy for CDH1-positive hereditary diffuse gastric cancer.

    abstract:BACKGROUND:Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome. Up to 30% of families with HDGC have mutations in the E-cadherin gene, CDH1. The role of prophylactic versus therapeutic gastrectomy for HDGC was studied prospectively. METHODS:Eighteen consecutive patients with CDH1 mutation...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1648-9

    authors: Chen Y,Kingham K,Ford JM,Rosing J,Van Dam J,Jeffrey RB,Longacre TA,Chun N,Kurian A,Norton JA

    更新日期:2011-09-01 00:00:00

  • Surrogate End Points for Overall Survival in Metastatic, Locally Advanced, or Unresectable Pancreatic Cancer: A Systematic Review and Meta-Analysis of 24 Randomized Controlled Trials.

    abstract:BACKGROUND:Overall survival (OS) has traditionally been the primary end point in studies evaluating the clinical benefit of first-line chemotherapy in metastatic, locally advanced, or unresectable pancreatic cancer (MLAUPC). Given the prolonged follow-up assessment required to obtain OS and its potential to be confound...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-017-5826-2

    authors: Makris EA,MacBarb R,Harvey DJ,Poultsides GA

    更新日期:2017-08-01 00:00:00

  • Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light.

    abstract:BACKGROUND:Neuroendocrine tumors of the pancreas, such as insulinoma, are difficult to localize, and complete resection is essential for cure. Our hypothesis is that a near-infrared (NIR) fluorophore exhibiting uptake in insulinoma could provide high-sensitivity detection intraoperatively. MATERIALS AND METHODS:The op...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0868-8

    authors: Winer JH,Choi HS,Gibbs-Strauss SL,Ashitate Y,Colson YL,Frangioni JV

    更新日期:2010-04-01 00:00:00

  • Is There a Correlation Between Clinical Complete Response and Pathological Complete Response After Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Cancer?

    abstract:OBJECTIVE:The aim of this study was to investigate the correlation between clinical complete response (cCR) and pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (CRT) for esophageal squamous cell cancer (ESCC). METHODS:Between May 2001 and April 2013, a total of 158 patients with thoracic ESCC tr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4764-0

    authors: Liu SL,Xi M,Yang H,Yang YD,Wu YJ,Zhao L,Zhang P,Luo LL,Liu MZ

    更新日期:2016-01-01 00:00:00

  • Do hospital attributes predict guideline-recommended gastric cancer care in the United States?

    abstract:BACKGROUND:Hospital attributes have been shown to impact short- and long-term outcomes after cancer surgery. However, the effect of hospital attributes on processes of cancer care in terms of delivery of guideline recommended care has not been evaluated. We examined the impact of hospital attributes (volume and type) o...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1973-z

    authors: Dudeja V,Gay G,Habermann EB,Tuttle TM,Tseng JF,Feig BW,Al-Refaie WB

    更新日期:2012-02-01 00:00:00

  • Increasing Appropriate BRCA1/2 Mutation Testing: The Role of Family History Documentation and Genetic Counseling in a Multidisciplinary Clinic.

    abstract:BACKGROUND:Findings show that 5-10 % of women with a diagnosis of breast cancer (BCa) have actionable genetic mutations. The National Comprehensive Cancer Network guidelines for testing to detect BRCA1/2 mutations include personal history (PH) variables such as age of 45 years or younger and a family history (FH) varia...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5545-0

    authors: Kishan AU,Gomez CL,Dawson NA,Dvorak R,Foster NM,Hoyt A,Hurvitz SA,Kusske A,Silver EL,Tseng C,McCloskey SA

    更新日期:2016-12-01 00:00:00