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Meta-analysis of the clamp-crushing technique for transection of the parenchyma in elective hepatic resection: back to where we started?

Abstract：

BACKGROUND:After introduction of the clamp-crushing technique in the 1970s, various devices have been developed for transection of the liver with the aim of further reducing blood loss and improving the outcome of patients who undergo hepatic resection. We performed a meta-analysis to quantitatively compare the clamp-crushing technique to any subsequently introduced transection technique with respect to patients' perioperative outcome. METHODS:A systematic literature search was conducted to identify randomized controlled trials comparing the clamp-crushing technique to any alternative method of hepatic transection. Relative risks (RR) were calculated for each outcome and reported along with their 95% confidence intervals (95% CI). Meta-analyses were stratified for the various types of transection techniques compared with the clamp-crushing technique and were carried out by a random effects model. RESULTS:Seven randomized controlled trials with a total of 554 patients were included in final analyses. Analyses of overall morbidity (RR .89; 95% CI, .63-1.25), biliary leakage (RR 1.03; 95% CI, .50-2.13), transfusion rates (RR .69; 95% CI, .31-1.51), and mortality RR (.20; 95% CI, .02-1.65) revealed no difference between the clamp-crushing and alternative transection techniques. None of the identified studies demonstrated a clinically important benefit of an alternative transection method in terms of blood loss, parenchymal injury, transection time, and hospital stay. CONCLUSIONS:This meta-analysis does not indicate a benefit of any alternative transection technique on patients' perioperative outcome compared with the clamp-crushing technique. The clamp-crushing technique remains the reference technique for transection of the parenchyma in elective hepatic resection.

journal_name

Ann Surg Oncol

journal_title

Annals of surgical oncology

authors

Rahbari NN,Koch M,Schmidt T,Motschall E,Bruckner T,Weidmann K,Mehrabi A,Büchler MW,Weitz J

doi

10.1245/s10434-008-0266-7

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

630-9

issue

eissn

1068-9265

issn

1534-4681

journal_volume

pub_type

杂志文章,meta分析

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Meta-analysis of the clamp-crushing technique for transection of the parenchyma in elective hepatic resection: back to where we started?