Abstract：
BACKGROUND:Initial therapy for early hepatocellular carcinoma (HCC) with well-compensated cirrhosis is controversial. While we previously reported on the effect of clinical factors and surgeon specialty on choice of therapy for early HCC, other nonclinical factors also may impact decision-making. METHODS:Surgeons who treat HCC were invited to complete a web-based survey that included ten case scenarios. Choice of therapy-liver transplantation (LT), liver resection (LR), or radiofrequency ablation (RFA)-was analyzed using regression models. RESULTS:There were 336 responses for analysis. Most respondents were in academic centers (86 %) that offered LT (71 %). The median number of patients annually evaluated for HCC was 30. Both practice type and HCC case volume were associated with choice of therapy, but these associations were not independent of surgeon specialty. LT surgeons who did not also perform RFA were less likely than those LT surgeons who did offer RFA to choose RFA over LT (relative risk ratios (RRR) 0.38, P < 0.001). Non-LT surgeons were more likely than LT surgeons who also offered RFA to choose RFA over LT (RRR 2.24, P < 0.001). Surgeons who worked at hospitals where LT was performed were much more likely to choose LT over LR and RFA even if they did not personally perform LT (RRR 1.27 and RRR 3.33, P < 0.001). CONCLUSIONS:Surgeon- and institution-related factors impact choice of therapy for early HCC even after adjustment for differences in clinical presentation. These data suggest that choice of therapy for patients with early HCC varies across providers independent of case selection.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Nathan H,Segev DL,Bridges JF,Massie AB,Cameron AM,Hirose K,Schulick RD,Choti MA,Pawlik TMdoi
10.1245/s10434-012-2619-5subject
Has Abstractpub_date
2013-02-01 00:00:00pages
448-56issue
2eissn
1068-9265issn
1534-4681journal_volume
20pub_type
杂志文章abstract：BACKGROUND:High-grade (HG) mucinous appendiceal neoplasms (MAN) have a worse prognosis than low-grade histology. Our objective was to assess the safety and efficacy of cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) in patients with high-grade, high-volume (HG-HV) peritoneal metastase...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-4838-z
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Low incidence of breast cancer in men (BCM) (< 1% of all breast cancers) has led to a paucity of outcome data. This study evaluated the impact of age on BCM outcomes. METHODS:For this study, BCM patients treated between 2000 and 2011 were stratified by age (≤ 65 or > 65 years). Kaplan-Meier methods were use...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-6767-0
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:To investigate the influence of the introduction of total mesorectal excision (TME) on local recurrence rate and survival in patients with rectal cancer. METHODS:A total of 171 consecutive patients underwent anterior or abdominoperineal resection for primary rectal cancer. When the TME technique was introduced...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1571-0
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Resection has been the standard of care for patients with solitary hepatocellular carcinoma (HCC). Transarterial embolization and percutaneous ablation are alternative therapies often reserved for suboptimal surgical candidates. Here we compare long-term outcomes of patients with solitary HCC treated with re...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-2961-2
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Although many experiences using the da Vinci Robot System have been reported by several groups, there is substantial controversy over the role of the robot in thyroidectomy. We performed a systematic review and meta-analyses in order to evaluate the safety and effectiveness of robotic thyroidectomy (RT) comp...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,meta分析,评审
doi：10.1245/s10434-015-4375-9
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Performing a sentinel lymph node biopsy (SLNB) is the standard of care for axillary nodal staging in patients with invasive breast cancer and clinically negative nodes. The procedure provides valuable staging information with few complications when performed by experienced surgeons. However, variation in pro...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5432-8
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:We investigated the effects of telomerase inhibition by using the reverse transcriptase inhibitor azidothymidine (AZT) in the human colorectal cancer cell line HT-29 in the presence and absence of 5-fluorouracil (5-FU). METHODS:HT-29 cells were cultured in the presence of AZT. Telomerase activity was measur...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/aso.2003.03.032
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Results concerning the side effects of oxaliplatin associated with fluorouracil and leucovorin (FOLFOX) in older patients are controversial. The objective of this study was to assess the use and the toxicity of FOLFOX in patients aged 70 years and older as administered in current practice. METHODS:Among 305...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-3438-z
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Inguinal lymph node metastases (ILNM) from rectal adenocarcinoma are rare and staged as systemic disease. This study aimed to provide insight into the treatment and prognosis of ILNM from rectal adenocarcinoma. METHODS:All patients with a diagnosis of synchronous or metachronous ILNM from rectal adenocarcin...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-019-07191-4
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:This multicenter analysis evaluated patient outcome and clinical pathologic features of thymic epithelial tumors after complete surgical resection and adjuvant treatment. METHODS:Histologic classification and clinical staging were performed according to WHO classification and Masaoka staging system, respect...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,多中心研究
doi：10.1245/s10434-013-3018-2
更新日期：2013-09-01 00:00:00
abstract：PURPOSE:To assess patterns of uptake and outcomes of laparoscopic colon and rectal cancer surgery in Ontario, and the potential influence of surgical fee incentives instituted on October 1, 2005. METHODS:We used Ontario administrative databases from fiscal years 2002 to 2009. Study outcomes were uptake rates of laparo...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-3123-2
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Laparoscopic pancreaticoduodenectomy with venous reconstruction is not commonly performed due to its technical challenges. In this video, we focus on the technical aspects for how to perform this procedure safely. METHODS:In a 69-year-old female with jaundice and diarrhea, a computed tomography scan showed ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-6762-5
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Circulating tumor DNA (ctDNA) is a promising technology for treatment selection, prognostication, and surveillance after definitive therapy. Its use in the perioperative setting for patients with metastatic disease has not been well studied. We characterize perioperative plasma ctDNA and its association with...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-08331-x
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:FOXJ1 is a member of the forkhead transcription factor family, which has been mostly studied for its role in the development of ciliated epithelium and immunology. However, the role of FOXJ1 in tumorigenesis remains largely unknown or even conflicting. We thus investigated FOXJ1 expression in gastric cancer ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-3742-2
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Sentinel lymph node biopsy (SLNB) has become standard of care as a staging procedure in patients with invasive breast cancer. A positive SLNB allows completion axillary lymph node dissection (cALND) to be performed. The axillary recurrence rate (ARR) after cALND in patients with positive SLNB is low. Recentl...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,评审
doi：10.1245/s10434-012-2490-4
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:Our study aims to determine whether patients with lobular-type breast cancer have significantly improved rates of breast conservation (BCT) after neoadjuvant chemotherapy (nCT). METHODS:Patients who received nCT and surgery within three prospective trials between 1995 and 2007 at the Medical University of...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1879-9
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:To date, skillful medical management and advanced surgical techniques have provided increased quality of life with less postoperative morbidity in patients with spinal metastasis. We assessed the survival of patients with spinal metastasis according to two treatment modalities: surgery and conservative treat...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-012-2644-4
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:The external branch of the superior laryngeal nerve (EBSLN) is at risk during thyroid surgery. Despite meticulous dissection and visualization, the EBSLN can be mistaken for other structures. The nerve integrity monitor (NIM) allows EBSLN confirmation with cricothyroid twitch on stimulation. AIMS:The aim of...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-4142-3
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:The oncological safety of skin-sparing mastectomy (SSM) has been the object of several studies. METHODS:From June 2003 to January 2004, 42 breast cancer patients, stage 0 to IIIA, underwent SSM. Before surgery, two lines were drawn on the breast skin, representing SSM and conventional mastectomy incisions. ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/ASO.2005.11.027
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:The routine use of external beam radiotherapy (EBRT) is not recommended for parathyroid carcinoma (PC). However, case series have demonstrated a potential benefit in preventing local recurrence with EBRT. We aimed to characterize the patient population treated with EBRT and identify any impact of EBRT on ove...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-08825-8
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Carcinomatosis of colorectal origin is increasingly treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS-HIPEC). This procedure commonly involves multivisceral resection (MVR) with potentially high morbidity. We analyzed the effect of MVR on the outcome after CS-HIPEC. METHODS:...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-008-0105-x
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:Lymph node (LN) status is one of the strongest prognostic factors after gallbladder cancer (GBC) resection. The adequate extension of LN dissection and the stratification of the prognosis in N+ patients have been debated. The present study aims to clarify these issues. METHODS:A total of 112 consecutive pat...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-4044-4
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Preoperative breast and lung markers have significant drawbacks, including migration, patient discomfort, and scheduling difficulties. SignalMark is a novel localizer device with a unique signal on Doppler ultrasound. OBJECTIVE:We aimed to evaluate intraoperative identification of SignalMark microspheres co...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-6707-z
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:To examine the association between the number of lymph nodes retrieved and oncologic outcome after preoperative chemoradiation for rectal cancer according to tumor regression grade. METHODS:Patients with rectal cancer who underwent curative surgery between May 2004 and December 2012 were analyzed retrospective...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-4235-z
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Studies assessing outcomes in occult breast cancer have often included women treated before the routine use of magnetic resonance imaging (MRI). This study examined outcomes for patients presenting with axillary adenopathy and no primary breast tumor detectable by MRI or other imaging methods. METHODS:All p...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-017-5965-5
更新日期：2017-10-01 00:00:00
abstract：INTRODUCTION:Regional nodal status is the most powerful predictor of recurrence and survival in women with breast cancer. Lymphatic mapping and sentinel lymph node (SLN) biopsy have been found to accurately predict the regional nodal status. Preoperative lymphoscintigraphy has been used in melanoma patients to identify...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/s10434-001-0354-4
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:The association between chemotherapy-induced ovarian dysfunction (CIOD) and response to neoadjuvant chemotherapy (NAC) is not known. We therefore investigated the impact of CIOD on response to NAC in breast cancer patients according to estrogen receptor (ER) status. METHODS:In total, 343 premenopausal breas...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-4806-7
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The prognosis of advanced nodal (N3) squamous cell carcinoma of the head and neck (HNSCC) is poor. We investigated whether surgery or radiotherapy of early (T1-2) primary stage HSNCC is preferable to limit the overall morbidity after upfront neck dissection (uND) for N3 disease. METHODS:This retrospective m...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,多中心研究
doi：10.1245/s10434-019-07589-0
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Recent population-based studies have highlighted a disproportionate increase in the incidence of rectal cancer among adults younger than aged 50 years. To determine whether different intervention and surveillance strategies might be needed for younger patients, the patterns of care and oncologic outcomes amo...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1674-7
更新日期：2011-09-01 00:00:00
abstract：PURPOSE:Aromatic amines, well-known bladder carcinogens, derived from cigarette smoke are activated by acidic urine. We herein determined whether urinary pH levels are associated with bladder recurrence in upper tract urothelial carcinoma patients with a positive smoking history. METHODS:A total of 256 upper tract uro...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5555-y
更新日期：2016-12-01 00:00:00
