Functional down-regulation of beta1 and beta2 integrins of lamina propria lymphocytes (LPL) and tumor-infiltrating lymphocytes (TIL) in colorectal cancer patients.

abstract：BACKGROUND:Hospitalization is associated with negative clinical effects that last beyond discharge. This study aimed to determine whether hospitalization in the year before major oncologic surgery is associated with adverse outcomes. METHODS:Patients 18 years of age or older with stomach, pancreas, colon, or rectal ca...

journal_title：Annals of surgical oncology

authors： Sharoky CE,Collier KT,Wirtalla CJ,Sinnamon AJ,Neuwirth MG,Kuo LE,Roses RE,Fraker DL,Karakousis GC,Kelz RR

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Examination of pathology slides is a routine part of a breast cancer second opinion. The purpose of this study was to determine how often the pathologic second opinion (1) altered the diagnosis and (2) resulted in a change in the surgical procedure. METHODS:Patients presenting between 1997 and 2001 for a se...

journal_title：Annals of surgical oncology

authors： Staradub VL,Messenger KA,Hao N,Wiley EL,Morrow M

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:The goal of this study was to investigate clinical manifestations of lower extremity edema (LEE) after lymph node dissection in patients with primary endometrial cancer. METHODS:Women with primary endometrial cancer who underwent staging surgery between November 2001 and March 2011 were included in the study. ...

journal_title：Annals of surgical oncology

authors： Bae HS,Lim MC,Lee JS,Lee Y,Nam BH,Seo SS,Kang S,Chung SH,Kim JY,Park SY

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Resection has been the standard of care for patients with solitary hepatocellular carcinoma (HCC). Transarterial embolization and percutaneous ablation are alternative therapies often reserved for suboptimal surgical candidates. Here we compare long-term outcomes of patients with solitary HCC treated with re...

journal_title：Annals of surgical oncology

authors： Elnekave E,Erinjeri JP,Brown KT,Thornton RH,Petre EN,Maybody M,Maluccio MA,Hsu M,Sofocleous CT,Getrajdman GI,Brody LA,Solomon SB,Alago W,Fong Y,Jarnagin WR,Covey AM

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Despite a growing body of literature on oncologic and reconstructive outcomes after total skin-sparing mastectomy (TSSM), some questions related to this approach remain unanswered, including strategies for managing tumor involvement of the nipple while maintaining the aesthetic benefits of TSSM. METHODS:A p...

journal_title：Annals of surgical oncology

authors： Amara D,Peled AW,Wang F,Ewing CA,Alvarado M,Esserman LJ

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The lymph node (LN) ratio (LNR) and the log odds of positive LNs (LODDS) have been proposed as sensitive prognosticators in patients with primary gastric cancer, especially in patients with an insufficient number of harvested LNs. We investigated the association of LNR and LODDS with survival in patients wit...

journal_title：Annals of surgical oncology

authors： Kano K,Yamada T,Yamamoto K,Komori K,Watanabe H,Takahashi K,Maezawa Y,Fujikawa H,Numata M,Aoyama T,Tamagawa H,Cho H,Yukawa N,Yoshikawa T,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2021-01-03 00:00:00

abstract：BACKGROUND:In several neoplastic diseases, including breast cancer, immunosuppression correlates with disease stage, progression, and outcome. Thus, thorough analysis of immune parameters in breast cancer patients may be beneficial in designing effective anticancer immune-based therapies. METHODS:We investigated dendr...

journal_title：Annals of surgical oncology

authors： Pockaj BA,Basu GD,Pathangey LB,Gray RJ,Hernandez JL,Gendler SJ,Mukherjee P

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:The efficacy, toxicity, and patterns of failure of esophageal squamous cell carcinoma (ESCC) treated with selective lymph node (SLN) conventional fraction radiotherapy (CFRT) and S-1 plus cisplatin (CDDP) were evaluated. PATIENTS AND METHODS:67 Patients with clinical stage II-IVa ESCC were enrolled. The tot...

journal_title：Annals of surgical oncology

authors： Wang X,Liu X,Li D,Wang X,Huang W,Li B

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:The clinical significance of isolated tumor cells (ITC) in peripheral blood (PB) and bone marrow (BM) as predictive markers in the recurrence or metastasis of breast cancer has not yet been determined. In the current study, we focused on the urokinase plasminogen activator receptor (u-PAR) gene as a powerf...

journal_title：Annals of surgical oncology

authors： Mimori K,Kataoka A,Yamaguchi H,Masuda N,Kosaka Y,Ishii H,Ohno S,Mori M

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemoradiotherapy (CRT) followed by radical surgery including total mesorectal excision (TME) is standard treatment in patients with locally advanced rectal cancer. Emerging data indicate that patients with complete pathologic response (ypCR) after CRT have favorable outcome, suggesting the possi...

journal_title：Annals of surgical oncology

authors： Belluco C,De Paoli A,Canzonieri V,Sigon R,Fornasarig M,Buonadonna A,Boz G,Innocente R,Perin T,Cossaro M,Polesel J,De Marchi F

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:This study evaluates the accuracy of computed tomography (CT) scoring of the peritoneal cancer index (PCI) and examines its association with surgical morbidity and outcomes in pseudomyxoma peritonei. METHODS:Forty-seven patients with pseudomyxoma peritonei had preoperative evaluation of CT scans and were tr...

journal_title：Annals of surgical oncology

authors： Chua TC,Al-Zahrani A,Saxena A,Glenn D,Liauw W,Zhao J,Morris DL

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:We investigated the effects of telomerase inhibition by using the reverse transcriptase inhibitor azidothymidine (AZT) in the human colorectal cancer cell line HT-29 in the presence and absence of 5-fluorouracil (5-FU). METHODS:HT-29 cells were cultured in the presence of AZT. Telomerase activity was measur...

journal_title：Annals of surgical oncology

authors： Brown T,Sigurdson E,Rogatko A,Broccoli D

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Contralateral prophylactic mastectomy (CPM) is expected to add surgical morbidity but this incremental risk has not yet been defined. We sought to quantify the additional risks associated with CPM and determine how these risks influence the time to adjuvant therapy. METHODS:We identified women undergoing ma...

journal_title：Annals of surgical oncology

authors： Eck DL,Perdikis G,Rawal B,Bagaria S,McLaughlin SA

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Although the National Comprehensive Cancer Network (NCCN) guidelines recommend use of lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) > 2 cm, there is limited evidence to support the association between use of LND and overall survival (OS). METHODS:Patients with resecte...

journal_title：Annals of surgical oncology

authors： Mao R,Zhao H,Li K,Luo S,Turner M,Cai JQ,Blazer D 3rd

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Retroperitoneal lymphadenectomy (RPLND), chemotherapy, and active surveillance represent treatment options for patients with nonseminomatous germ-cell tumors of the testis (NSGCTT). Our objective was to assess the utilization rate of RPLND in patients with NSGCTT. METHODS:Within the Surveillance, Epidemiolo...

journal_title：Annals of surgical oncology

authors： Sun M,Abdollah F,Budaüs L,Liberman D,Tian Z,Morgan M,Johal R,Schmitges J,Shariat SF,Montorsi F,Greafen M,Perrotte P,Karakiewicz PI

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:This work is aimed at comparing mucinous colorectal adenocarcinomas (MUC) and non-mucinous colorectal adenocarcinomas (non-MUC), and at verifying the existence of two different subgroups of MUC, in terms of clinicopathological features, chromosomal alterations, and outcome, in a geographical area where mucin...

journal_title：Annals of surgical oncology

authors： Leopoldo S,Lorena B,Cinzia A,Gabriella DC,Angela Luciana B,Renato C,Antonio M,Carlo S,Cristina P,Stefano C,Maurizio T,Luigi R,Cesare B

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Lymph node involvement is a very important prognostic factor for cutaneous melanoma. In this paper we try to validate a nomogram that was created at the Memorial Sloan-Kettering Cancer Center, New York, to predict the probability of metastases in the sentinel nodes of patients with cutaneous melanoma. METHO...

journal_title：Annals of surgical oncology

authors： Piñero A,Canteras M,Ortiz E,Martínez-Barba E,Parrilla P

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Results from randomized trials indicate a 5.4% survival advantage associated with axillary dissection. To gain insight on survival outcomes when less than an axillary dissection is performed, we performed a retrospective analysis to determine survival outcome for node-negative and node-positive breast cancer...

journal_title：Annals of surgical oncology

authors： Krag DN,Single RM

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:It has been reported that the abnormal activation of receptor tyrosine kinases is associated with the development of many human carcinomas and the high activation of EGFR and Met mediates the tumorigenicity of laryngeal carcinoma. In this study, we have done the therapeutic efficacy of ME22S (a novel EGFR/Met b...

journal_title：Annals of surgical oncology

authors： Lee BS,Kim HJ,Hwang JW,Cheong KH,Kim KA,Cha HY,Lee JM,Kim CH

更新日期：2016-06-01 00:00:00

abstract：:Cancer Prevention is an emerging field, capturing the old traditional concept of anticipating the development of a major disease and preventing its full impact by early detection, treatment, or aborting the tumorigenic process by a "molecular vaccine" and alleviating the full impact of the disease. Surgeons are import...

journal_title：Annals of surgical oncology

authors： Chu DZ,Gibson G,David D,Yen Y

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Effective therapeutic combinations targeting the oncogenic pathway still are unknown in human hepatocellular carcinoma (HCC). The authors previously identified aberrant expression of aurora B kinase as the independent predictor for the lethal recurrence of HCC, showing that AZD1152 induced in vitro and in vi...

journal_title：Annals of surgical oncology

authors： Matsunaga H,Tanaka S,Aihara A,Ogawa K,Matsumura S,Ban D,Ochiai T,Irie T,Kudo A,Nakamura N,Arii S,Tanabe M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:We seek to determine whether laparoscopic hyperthermic intraperitoneal chemoperfusion (LS-HIPEC) improves overall survival (OS) in patients with gastric and gastroesophageal adenocarcinoma and low-volume peritoneal metastasis compared with standard of care treatment. PATIENTS AND METHODS:We reviewed data fr...

journal_title：Annals of surgical oncology

authors： Blumenthaler AN,Allen CJ,Ikoma N,Blum M,Das P,Minsky BD,Mansfield PF,Ajani JA,Badgwell BD

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Traditional teaching maintains that patients with primary colorectal adenocarcinoma require timely resection to prevent bleeding, perforation, or obstruction. The true benefits of primary tumor resection remain undocumented for patients presenting with metastatic disease, however. We postulated that resectio...

journal_title：Annals of surgical oncology

authors： Scoggins CR,Meszoely IM,Blanke CD,Beauchamp RD,Leach SD

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:We provide a statistical analysis of the learning phase for sentinel node biopsy. METHODS:Four learning phases were analyzed: 25, 50, 75, and 150 procedures with a corresponding number of 10, 20, 30, and 60 tumor-positive cases. Critical values of nonidentification rate and false-negative rate were defined....

journal_title：Annals of surgical oncology

authors： Tanis PJ,Nieweg OE,Hart AA,Kroon BB

更新日期：2002-03-01 00:00:00

abstract：:There is increasing evidence regarding extracapsular lymph node involvement (LNI) as a prognostic factor for recurrence and poor prognosis in gastrointestinal malignancies. The aim of this study was to assess the prevalence and prognostic impact of LNI in patients with resected esophageal cancer, comparing adenocarcin...

journal_title：Annals of surgical oncology

authors： Metzger R,Drebber U,Baldus SE,Mönig SP,Hölscher AH,Bollschweiler E

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Pancreatic metastases are uncommon and little is known about the oncologic outcome after resection or prognostic parameters. This study was designed to evaluate perioperative and follow-up results after resection for pancreatic metastases and to define prognostic factors. METHODS:From a prospective database...

journal_title：Annals of surgical oncology

authors： Strobel O,Hackert T,Hartwig W,Bergmann F,Hinz U,Wente MN,Fritz S,Schneider L,Büchler MW,Werner J

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Sarcopenia, characterized by loss of skeletal muscle mass, is recognized as a prognostic factor in patients with gastric cancer. However, wide variability exists in the cutoff values of muscle mass for defining sarcopenia across previous studies, and the best cutoff values to predict survival remain unknown....

journal_title：Annals of surgical oncology

authors： Nishigori T,Tsunoda S,Obama K,Hisamori S,Hashimoto K,Itatani Y,Okada K,Sakai Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Subtotal thyroidectomy or lobectomy without radioactive iodide ((131)I) treatment is sufficient for postoperative treatment of incidental papillary thyroid microcarcinoma (PTMC). Aggressive surgical treatment with (131)I therapy is indicated for nonincidental PTMC. METHODS:This is a retrospective analysis o...

journal_title：Annals of surgical oncology

authors： Lin JD,Kuo SF,Chao TC,Hsueh C

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Heat shock protein 27 (hsp-27) is overexpressed in approximately 67% pure ductal carcinoma in situ (DCIS), in approximately 50% DCIS associated with invasive ductal carcinoma (IDC), and in approximately 25% IDC alone. If this decrease in hsp-27 expression has a role in the progression of malignancy in IDC, w...

journal_title：Annals of surgical oncology

authors： Storm FK,Mahvi DM,Gilchrist KW

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:We sought to examine how splenectomy as part of up-front cytoreductive surgery in ovarian cancer influences the postoperative course and affects survival. METHODS:We reviewed cases of ovarian cancer diagnosed at Massachusetts General Hospital from 1994 to 2008 and found 44 patients who had a splenectomy as par...

journal_title：Annals of surgical oncology

authors： McCann CK,Growdon WB,Munro EG,Del Carmen MG,Boruta DM,Schorge JO,Goodman A

更新日期：2011-10-01 00:00:00