Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer.

abstract：BACKGROUND:Circulating ('blood-borne') tissue factor (TF) is implicated in the pathogenesis of several chronic conditions, most notably cardiovascular disease, diabetes, and cancer. Full-length TF is an integral membrane protein, while alternatively spliced TF (asTF) can be secreted and, owing to its unique C-terminus,...

journal_title：Annals of surgical oncology

authors： Unruh D,Sagin F,Adam M,Van Dreden P,Woodhams BJ,Hart K,Lindsell CJ,Ahmad SA,Bogdanov VY

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Among all in-breast tumor recurrences (IBTR) following breast-conserving therapy (BCT), some comprise metachronous new primaries (NPs) while others are true recurrences (TRs). Establishing this distinction remains a challenge. METHODS:We studied 3932 women who underwent BCT for stage I-III breast cancer fro...

journal_title：Annals of surgical oncology

authors： Laird J,Lok B,Siu C,Cahlon O,Khan AJ,McCormick B,Powell SN,Cody H,Wen HY,Ho A,Braunstein LZ

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Liver kinase B1 (LKB1) loss by gene mutation, loss of heterozygosity, and promoter methylation rarely occurs in colorectal cancer. We wondered whether LKB1 loss could be deregulated at the transcriptional level to promote tumor progression and poor outcome in colorectal cancer. METHODS:Mechanistic studies w...

journal_title：Annals of surgical oncology

authors： He TY,Tsai LH,Huang CC,Chou MC,Lee H

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:This study aimed to determine the relationship between mammographic calcifications and magnetic resonance imaging (MRI) tumoral enhancement before and after neoadjuvant chemotherapy (NAC) and to assess the impact of these findings on surgical management. METHODS:This Institutional Review Board-approved, Hea...

journal_title：Annals of surgical oncology

authors： Feliciano Y,Mamtani A,Morrow M,Stempel MM,Patil S,Jochelson MS

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Positive peritoneal cytology is a predictor of poor survival in patients with gastric cancer. Our aim is to more clearly define the natural history of this cohort. METHODS:Review of a prospectively maintained gastric cancer database of patients who had diagnostic laparoscopy with peritoneal washings. Clinic...

journal_title：Annals of surgical oncology

authors： Mezhir JJ,Shah MA,Jacks LM,Brennan MF,Coit DG,Strong VE

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Fine-needle aspiration biopsy (FNAB) of the thyroid categorized as atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is a newly defined category according to the recent Bethesda guidelines. We sought to assess the characteristics and treatment of patients with an A...

journal_title：Annals of surgical oncology

authors： Nagarkatti SS,Faquin WC,Lubitz CC,Garcia DM,Barbesino G,Ross DS,Hodin RA,Daniels GH,Parangi S

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:We have previously reported that older patients with clinical stage I and II primary cutaneous. Melanoma had lower survival rates compared to younger patients. We postulated that the incidence of nodal metastasis would therefore be higher among older melanoma patients. METHODS:The expanded American Joint Commi...

journal_title：Annals of surgical oncology

authors： Balch CM,Thompson JF,Gershenwald JE,Soong SJ,Ding S,McMasters KM,Coit DG,Eggermont AM,Gimotty PA,Johnson TM,Kirkwood JM,Leong SP,Ross MI,Byrd DR,Cochran AJ,Mihm MC Jr,Morton DL,Atkins MB,Flaherty KT,Sondak VK

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Iliosacral resection of pelvic malignant tumors and subsequent reconstruction have tested the ingenuity of orthopedic oncologists because of the difficulty of oncological wide resection and the complex biomechanics of the sacroiliac joint render reconstruction challenging. This study compared the functional ...

journal_title：Annals of surgical oncology

authors： Wang J,Tang Q,Xie X,Yin J,Zhao Z,Li Z,Zou C,Huang G,Shen J

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:For patients with colorectal liver metastases, resection is the treatment of choice. Careful selection of these patients is crucial in order to reduce the chance of unexpected findings at laparotomy and abandoning further surgical intervention. Here, we evaluate the predictive value of CT and FDG-PET of the ...

journal_title：Annals of surgical oncology

authors： Wiering B,Ruers TJ,Krabbe PF,Dekker HM,Oyen WJ

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:The efficacy of chemoprevention for breast cancer risk reduction has been demonstrated in randomized controlled trials; however, use remains low. We sought to determine whether uptake differed by risk factors, and to identify reasons for refusal and termination. METHODS:Women seen in a high-risk c...

journal_title：Annals of surgical oncology

authors： Flanagan MR,Zabor EC,Stempel M,Mangino DA,Morrow M,Pilewskie ML

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Inconsistent data suggests extranodal spread (ENS) is an adverse prognostic factor in Stage III melanoma patients but it remains contentious. By rigorously matching cohorts, this study sought to clarify associations with recurrence and survival. METHODS:Melanoma patients with lymph node metastases (AJCC Sta...

journal_title：Annals of surgical oncology

authors： Crookes TR,Scolyer RA,Lo S,Drummond M,Spillane AJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Limb salvage after primary site failure of extremity soft tissue sarcoma is a challenging problem. Amputation may be the most effective treatment option in selected patients with local recurrence. We compared the outcome of patients treated with amputation versus limb-sparing surgery (LSS) for locally recurr...

journal_title：Annals of surgical oncology

authors： Stojadinovic A,Jaques DP,Leung DH,Healey JH,Brennan MF

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the prognostic significance of the Oncotype DX recurrence score (RS) in T1-2N1M0 estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer based on the prognostic stage in the updated American Joint Commission on Cancer, 8th edition. ...

journal_title：Annals of surgical oncology

authors： Wang M,Wu K,Zhang P,Zhang M,Ding A,Chen H

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The Affordable Care Act (ACA) was instated on 23 March 2010 to improve healthcare quality, reduce costs, and increase access. The Pretty in Pink Foundation (PIPF), a non-profit 501(C)(3) organization in North Carolina, provides financial assistance and in-kind support to individuals seeking help with breast ...

journal_title：Annals of surgical oncology

authors： Obeng-Gyasi S,Tolnitch L,Greenup RA,Shelley Hwang E

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:There is no consensus as to the impact of lymph node micrometastasis on survival of patients with gastric cancer. The aim of this study was to clarify the prognostic significance of lymph node micrometastasis in patients with histologically node-negative gastric cancer. METHODS:Lymph nodes (n = 2039) from 6...

journal_title：Annals of surgical oncology

authors： Yasuda K,Adachi Y,Shiraishi N,Inomata M,Takeuchi H,Kitano S

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Ultrasonography and fine-needle aspiration (FNA) are used to evaluate the breast and regional nodes in breast cancer patients. We sought to identify factors influencing the sensitivity of ultrasonography for detection of nodal metastasis. METHODS:Patients with a clinically negative axilla who underwent axil...

journal_title：Annals of surgical oncology

authors： Bedrosian I,Bedi D,Kuerer HM,Fornage BD,Harker L,Ross MI,Ames FC,Krishnamurthy S,Edeiken-Monroe BS,Meric F,Feig BW,Akins J,Singletary SE,Mirza NQ,Hunt KK

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:The main objective of this study was to determine whether there was a correlation in the levels of various angiogenesis-related factors between the tumor drainage and peripheral venous blood and whether appraisal of angiogenic factor levels in the tumor drainage venous blood could provide better prognostic i...

journal_title：Annals of surgical oncology

authors： Tien YW,Chang KJ,Chiu YF,Huang KW,Lee PH

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:More information is needed for selection of patients with peritoneal metastases from endometrial cancer (EC) to undergo cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS:This study analyzed clinical, pathologic, and treatment data for patients with peritoneal metast...

journal_title：Annals of surgical oncology

authors： Cornali T,Sammartino P,Kopanakis N,Christopoulou A,Framarino Dei Malatesta M,Efstathiou E,Spagnoli A,Ciardi A,Biacchi D,Spiliotis J

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Management of patients with neuroendocrine liver metastasis (NELM) remains controversial. We sought to examine the relative efficacy of surgical management versus intra-arterial therapy (IAT) for NELM and determine factors predictive of survival. METHODS:A total of 753 patients who had surgery (n = 339) or ...

journal_title：Annals of surgical oncology

authors： Mayo SC,de Jong MC,Bloomston M,Pulitano C,Clary BM,Reddy SK,Clark Gamblin T,Celinski SA,Kooby DA,Staley CA,Stokes JB,Chu CK,Arrese D,Ferrero A,Schulick RD,Choti MA,Geschwind JF,Strub J,Bauer TW,Adams RB,Aldrighett

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Achieving an undetectable serum thyroglobulin (Tg) level (<1.0 ng/mL) after surgical and radioiodine treatment for papillary thyroid cancer (PTC) is associated with low recurrence rates and has been termed biochemical remission. This study aimed to determine the effectiveness of total thyroidectomy with ther...

journal_title：Annals of surgical oncology

authors： Hughes DT,Miller BS,Cohen MS,Doherty GM,Gauger PG

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Intraoperative imprint cytology (IC) is one of several accurate, proven methods to detect tumor cells in sentinel lymph nodes (SLN) from patients with operable breast cancer. In patients treated with neoadjuvant chemotherapy (NAC), studies have demonstrated the feasibility and accuracy of SLN biopsy procedur...

journal_title：Annals of surgical oncology

authors： Gimbergues P,Dauplat MM,Durando X,Abrial C,Le Bouedec G,Mouret-Reynier MA,Cachin F,Kwiatkowski F,Tchirkov A,Dauplat J,Penault-Llorca F

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Poly(ADP-ribose) polymerase (PARP) is an important regulator of programmed cell death in response to alkylating agents such as temozolomide (TMZ). The goal of this study was to determine if a systemically administered PARP-inhibitor (INO-1001) could augment the efficacy of TMZ in a rat model of extremity mal...

journal_title：Annals of surgical oncology

authors： Toshimitsu H,Yoshimoto Y,Augustine CK,Padussis JC,Yoo JS,Angelica Selim M,Pruitt SK,Friedman HS,Ali-Osman F,Tyler DS

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:We prospectively evaluated the effectiveness of major surgery in treating symptoms of advanced malignancies. METHODS:Fifty-nine patients were evaluated for major symptoms of intent to treat and were followed up until death or last clinical evaluation. Surgeons identified planned operations before surgery as...

journal_title：Annals of surgical oncology

authors： McCahill LE,Smith DD,Borneman T,Juarez G,Cullinane C,Chu DZ,Ferrell BR,Wagman LD

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:We sought to determine the competence of medical students and surgery residents in evaluating clinical problems (using both real and simulated patients) in surgical oncology. METHODS:Forty-five third-year medical students, 23 first postgraduate year (PGY-1) residents, and seven second postgraduate year (PGY...

journal_title：Annals of surgical oncology

authors： Sloan DA,Donnelly MB,Schwartz RW,Munch LC,Wells MD,Johnson SB,Strodel WE

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Improved survival has been reported for diffuse malignant peritoneal mesothelioma (DMPM) treated by surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). The significance of lymph node involvement in this disease is still poorly understood. METHODS:Prospectively collected clinical da...

journal_title：Annals of surgical oncology

authors： Baratti D,Kusamura S,Cabras AD,Laterza B,Balestra MR,Deraco M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Computer systems allow the planning of complex liver operations. The segmentation of intrahepatic vessels builds the basis for the calculation of liver segments and resection proposals. For surgical use, it is essential to know the capabilities and limitations of the segmentation. The aim of this study was t...

journal_title：Annals of surgical oncology

authors： Lehmann KS,Ritz JP,Valdeig S,Schenk A,Holmer C,Peitgen HO,Buhr HJ,Frericks BB

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:In recent years, as a result of refinement in molecular biology techniques, significant progress has been made in the understanding of colorectal carcinogenesis. Particular attention has been drawn to identification of genetic mutation that may predispose to colorectal carcinoma (familial syndromes) and may ...

journal_title：Annals of surgical oncology

authors： Pricolo VE,Finkelstein SD,Bland KI

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Findings show that 5-10 % of women with a diagnosis of breast cancer (BCa) have actionable genetic mutations. The National Comprehensive Cancer Network guidelines for testing to detect BRCA1/2 mutations include personal history (PH) variables such as age of 45 years or younger and a family history (FH) varia...

journal_title：Annals of surgical oncology

authors： Kishan AU,Gomez CL,Dawson NA,Dvorak R,Foster NM,Hoyt A,Hurvitz SA,Kusske A,Silver EL,Tseng C,McCloskey SA

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:This study compared two homogeneous groups of patients submitted to either surgical resection (HR) or laparoscopic radiofrequency ablation (LRFA) for the treatment of hepatocellular carcinoma (HCC). When compatible with the liver functional reserve, HR remains the treatment of choice for HCC, while LRFA seem...

journal_title：Annals of surgical oncology

authors： Santambrogio R,Opocher E,Zuin M,Selmi C,Bertolini E,Costa M,Conti M,Montorsi M

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The ToGA trial demonstrated the significant efficacy of trastuzumab in addition to chemotherapy in patients with HER2-positive gastric cancer (GC). Although trastuzumab has become a key drug in breast cancer treatment, resistance to trastuzumab is a major problem in clinical practice. The aim of the current ...

journal_title：Annals of surgical oncology

authors： Eto K,Iwatsuki M,Watanabe M,Ida S,Ishimoto T,Iwagami S,Baba Y,Sakamoto Y,Miyamoto Y,Yoshida N,Baba H

更新日期：2014-01-01 00:00:00