High Expression of the Mitophagy-Related Protein Pink1 is Associated with a Poor Response to Chemotherapy and a Poor Prognosis for Patients Treated with Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma.

Abstract:

BACKGROUND:Autophagy plays a major role in cellular homeostasis and is implicated in cancer progression. Damaged mitochondria are scavenged and eliminated by mitochondrial autophagy, referred to as mitophagy, which can promote cancer cell survival. This study investigated the expression and effects of the autophagy-related protein LC3 and the mitophagy-related protein Pink1 in human esophageal squamous cell carcinoma (ESCC). METHODS:Both LC3 and Pink1 were analyzed by immunohistochemistry in tissues from 217 ESCC patients, including 159 patients undergoing neoadjuvant chemotherapy. The relationships between LC3 and Pink1 expression and various clinicopathologic factors were determined. In vitro assays were performed to assess the role of LC3 and Pink1 in ESCC chemoresistance. RESULTS:High LC3 expression was observed in 47.9% and high Pink1 expression in 48.4% of the ESCC patients. Pink1 expression was significantly higher in patients who underwent chemotherapy than in patients who did not (p = 0.032). High LC3 and Pink1 expression was significantly correlated with poor response to chemotherapy (p = 0.004 and p < 0.001, respectively), and high expression of Pink1, but not LC3, was significantly correlated with a poor prognosis for patients treated with preoperative chemotherapy (p = 0.007). Multivariate analysis identified Pink1 expression as an independent prognostic factor (p = 0.042). In vitro assays demonstrated that LC3-II and Pink1 expression increased after chemotherapeutic treatment in the ESCC cell line, and inhibition of autophagy and mitophagy using chloroquine and siPink1, respectively, restored chemosensitivity. CONCLUSIONS:High expression of Pink1 is associated with chemoresistance and a poor prognosis for ESCC patients undergoing neoadjuvant chemotherapy.

journal_name

Ann Surg Oncol

authors

Yamashita K,Miyata H,Makino T,Masuike Y,Furukawa H,Tanaka K,Miyazaki Y,Takahashi T,Kurokawa Y,Yamasaki M,Nakajima K,Takiguchi S,Morii E,Mori M,Doki Y

doi

10.1245/s10434-017-6096-8

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

4025-4032

issue

13

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-017-6096-8

journal_volume

24

pub_type

杂志文章
  • Radiation Therapy After Breast-Conserving Surgery in Women 70 Years of Age and Older: How Wisely Do We Choose?

    abstract:BACKGROUND:Despite data from randomized trials supporting omission of radiation therapy (RT) for women ≥ 70 years of age with T1, estrogen receptor-positive (ER+) tumors undergoing breast-conserving therapy (BCT), RT usage remains high. We reviewed our institutional experience to determine if risk factors for local rec...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-07151-4

    authors: Downs-Canner S,Zabor EC,Wind T,Cobovic A,McCormick B,Morrow M,Heerdt A

    更新日期:2019-04-01 00:00:00

  • Morbidity and mortality associated with gastrectomy for gastric cancer.

    abstract:BACKGROUND:Surgery alone is often inadequate for advanced-stage gastric cancer. Surgical complications may delay adjuvant therapy. Understanding these complications is needed for multidisciplinary planning. MATERIAL AND METHODS:The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-014-3664-z

    authors: Papenfuss WA,Kukar M,Oxenberg J,Attwood K,Nurkin S,Malhotra U,Wilkinson NW

    更新日期:2014-09-01 00:00:00

  • Loss of E-cadherin and MUC2 expressions correlated with poor survival in patients with stages II and III colorectal carcinoma.

    abstract:BACKGROUND:With the recent development of molecular markers, it has become possible to characterize colorectal carcinomas beyond clinical and histologic aspects. When considered together with tumor stage, molecular markers will allow us further insight into individual tumor biologies and prognoses. PURPOSE:To investig...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1338-z

    authors: Kang H,Min BS,Lee KY,Kim NK,Kim SN,Choi J,Kim H

    更新日期:2011-03-01 00:00:00

  • Surgery for Men with Breast Cancer: Do the Same Data Still Apply?

    abstract:BACKGROUND:Men represent a small proportion of breast cancer diagnoses, and they are often excluded from clinical trials. Current treatments are largely extrapolated from evidence in women. We compare practice patterns between men and women with breast cancer following the publication of several landmark clinical trial...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08901-z

    authors: Plichta JK,Ren Y,Marks CE,Thomas SM,Greenup RA,Rosenberger LH,Fayanju OM,McDuff SGR,Hwang ES,Force J

    更新日期:2020-11-01 00:00:00

  • The Ethics of Breast Surgery.

    abstract::Breast surgery has evolved as a subspecialty of general surgery and requires a working knowledge of benign and malignant diseases, surgical techniques, shared decision-making with patients, collaboration with a multi-disciplinary team, and a basic foundation in surgical ethics. Ethics is defined as the practice of ana...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-015-4751-5

    authors: Throckmorton A,VanderWalde L,Brackett C,Dominici L,Eisenhauer T,Johnson N,Kong A,Ludwig K,O'Neill J,Pugliese M,Teller P,Sarantou T

    更新日期:2015-10-01 00:00:00

  • The 1999 James Ewing Lecture: in pursuit of molecules of oncogenesis and neoplastic therapy.

    abstract::Breast cancer is a progressive, phenotypic, genetic and epigenetic alteration, induced by various stimulants of which the principal steroid hormone, estrogen, initiates and promotes neoplastic transformation of normal ductal mammary epithelium to acquire distinct biochemical and molecular characteristics. The molecula...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10434-999-0528-z

    authors: Bland KI

    更新日期:1999-09-01 00:00:00

  • Results of a Phase Ib Trial of Combination Immunotherapy with a CD8+ T Cell Eliciting Vaccine and Trastuzumab in Breast Cancer Patients.

    abstract:BACKGROUND:CD8+ T cell-eliciting vaccines are being investigated in breast cancer patients. Preclinical data showed that trastuzumab increases the susceptibility of tumor cells to lysis by vaccine-generated CD8+ T cells, suggesting potential benefit of a combination immunotherapy strategy. The current trial was underta...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5844-0

    authors: Clifton GT,Litton JK,Arrington K,Ponniah S,Ibrahim NK,Gall V,Alatrash G,Peoples GE,Mittendorf EA

    更新日期:2017-08-01 00:00:00

  • Effect of body composition on outcomes after hepatic resection for hepatocellular carcinoma.

    abstract:PURPOSE:To evaluate the effect of body composition on outcomes after hepatic resection for patients with hepatocellular carcinoma (HCC). METHODS:We performed 190 hepatic resections for HCC and divided the patients into 2 groups on the basis of visceral fat area (VFA), assessed by computed tomographic measurement at th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3686-6

    authors: Itoh S,Shirabe K,Matsumoto Y,Yoshiya S,Muto J,Harimoto N,Yamashita Y,Ikegami T,Yoshizumi T,Nishie A,Maehara Y

    更新日期:2014-09-01 00:00:00

  • Fibrosis-4 Index, a Noninvasive Fibrosis Marker, Predicts Survival Outcomes After Hepatectomy for Colorectal Cancer Liver Metastases.

    abstract:BACKGROUND:Liver fibrosis influences liver regeneration and surgical outcomes, and several noninvasive models based on laboratory data have been developed to predict liver fibrosis. This study was performed to determine whether the Fibrosis-4 (FIB-4) index, a noninvasive fibrosis marker, can predict the prognosis in pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08828-5

    authors: Akiyama T,Miyamoto Y,Imai K,Yamashita Y,Nomoto D,Daitoku N,Sakamoto Y,Kiyozumi Y,Tokunaga R,Eto K,Harada K,Hiyoshi Y,Iwatsuki M,Nagai Y,Iwagami S,Baba Y,Yoshida N,Baba H

    更新日期:2020-09-01 00:00:00

  • Artificial neural network for prediction of lymph node metastases in gastric cancer: a phase II diagnostic study.

    abstract:BACKGROUND:Extension of lymphadenectomy in gastric cancer is controversial, and preoperative diagnosis of lymph node metastases (LNM) is difficult. Therefore, knowledge-based systems such as the Maruyama computer program (MCP) are being developed. MCP shows good prognostic value for the compartments; however, for diffe...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/ASO.2004.04.018

    authors: Bollschweiler EH,Mönig SP,Hensler K,Baldus SE,Maruyama K,Hölscher AH

    更新日期:2004-05-01 00:00:00

  • Prognostic Impact of Ventral Versus Dorsal Tumor Location After Total Mesorectal Excision of Rectal Cancer.

    abstract:BACKGROUND:Multidisciplinary treatment of rectal cancer, including neoadjuvant treatment, total mesorectal excision, and adjuvant chemotherapy, have improved oncological outcome. Preoperative radiation therapy is advocated by national and international guidelines in all patients with AJCC stage II and III rectal cancer...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07842-6

    authors: Franz C,Lang HM,Ghamarnejad O,Khajeh E,Mehrabi A,Ulrich A,Schneider M,Büchler MW,Kulu Y

    更新日期:2020-02-01 00:00:00

  • Intraoperative imprint cytology examination of sentinel lymph nodes after neoadjuvant chemotherapy in breast cancer patients.

    abstract:BACKGROUND:Intraoperative imprint cytology (IC) is one of several accurate, proven methods to detect tumor cells in sentinel lymph nodes (SLN) from patients with operable breast cancer. In patients treated with neoadjuvant chemotherapy (NAC), studies have demonstrated the feasibility and accuracy of SLN biopsy procedur...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0952-0

    authors: Gimbergues P,Dauplat MM,Durando X,Abrial C,Le Bouedec G,Mouret-Reynier MA,Cachin F,Kwiatkowski F,Tchirkov A,Dauplat J,Penault-Llorca F

    更新日期:2010-08-01 00:00:00

  • Young-onset rectal cancer: presentation, pattern of care and long-term oncologic outcomes compared to a matched older-onset cohort.

    abstract:BACKGROUND:Recent population-based studies have highlighted a disproportionate increase in the incidence of rectal cancer among adults younger than aged 50 years. To determine whether different intervention and surveillance strategies might be needed for younger patients, the patterns of care and oncologic outcomes amo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1674-7

    authors: You YN,Dozois EJ,Boardman LA,Aakre J,Huebner M,Larson DW

    更新日期:2011-09-01 00:00:00

  • Treatment trends and factors associated with survival in T1aN0 and T1bN0 breast cancer patients.

    abstract:BACKGROUND:Breast conservation therapy (BCT) and adjuvant hormonal therapy for estrogen-receptor positive breast cancers have become standard of care. Our objectives were to evaluate trends in the surgical management and adjuvant therapy for early-stage breast cancer and to identify factors predicting survival. METHOD...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9441-5

    authors: Kennedy T,Stewart AK,Bilimoria KY,Patel-Parekh L,Sener SF,Winchester DP

    更新日期:2007-10-01 00:00:00

  • Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas.

    abstract:BACKGROUND:Small bowel adenocarcinoma is a relatively rare cancer, often diagnosed in an advanced stage. In localized and resectable disease, surgery alone or in combination with adjuvant chemotherapy is the mainstay of treatment. In the recently published National Comprehensive Cancer Network Clinical Practice guideli...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08926-4

    authors: Vanoli A,Grillo F,Guerini C,Neri G,Arpa G,Klersy C,Nesi G,Giuffrida P,Sampietro G,Ardizzone S,Fociani P,Fiocca R,Latella G,Sessa F,D'Errico A,Malvi D,Mescoli C,Rugge M,Ferrero S,Poggioli G,Rizzello F,Macciomei M

    更新日期:2021-02-01 00:00:00

  • Tumor proximity to the recurrent laryngeal nerve in patients with primary hyperparathyroidism undergoing parathyroidectomy.

    abstract:BACKGROUND:Recurrent laryngeal nerve (RLN) injury is a rare complication for patients undergoing neck exploration for primary hyperparathyroidism (pHPT). Distances between RLNs and parathyroid adenomas have not been previously published. In this study we used a RLN monitor to identify the RLN and to measure the proximi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2495-z

    authors: Untch BR,Adam MA,Danko ME,Barfield ME,Dixit D,Scheri RP,Olson JA

    更新日期:2012-11-01 00:00:00

  • Staging laparoscopy for potentially resectable noncolorectal, nonneuroendocrine liver metastases.

    abstract:BACKGROUND:Carefully selected patients with noncolorectal, nonneuroendocrine (NCNN) liver metastases may benefit from hepatic resection. The incidence of occult unresectable disease and the possible benefits of staging laparoscopy in these patients are not known. METHODS:From December 1997 to July 2000, staging laparo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02557375

    authors: D'Angelica M,Jarnagin W,Dematteo R,Conlon K,Blumgart LH,Fong Y

    更新日期:2002-03-01 00:00:00

  • Biomarkers predict outcomes following cytoreductive surgery for hepatic metastases from functional carcinoid tumors.

    abstract:BACKGROUND:Cytoreductive therapy for metastatic carcinoid provides symptomatic relief and improvement in overall survival. We evaluated whether CgA and 5HIAA could predict symptomatic relief and control of disease progression after cytoreductive surgery. METHODS:We retrospectively reviewed 70 patients who underwent cy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9148-z

    authors: Jensen EH,Kvols L,McLoughlin JM,Lewis JM,Alvarado MD,Yeatman T,Malafa M,Shibata D

    更新日期:2007-02-01 00:00:00

  • 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis.

    abstract:BACKGROUND:Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity. METHODS:8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5374-1

    authors: Sugimachi K,Yamaguchi R,Eguchi H,Ueda M,Niida A,Sakimura S,Hirata H,Uchi R,Shinden Y,Iguchi T,Morita K,Yamamoto K,Miyano S,Mori M,Maehara Y,Mimori K

    更新日期:2016-08-01 00:00:00

  • Relevance of Dissection of the Posterior Superior Pancreaticoduodenal Lymph Nodes in Gallbladder Carcinoma.

    abstract:BACKGROUND:This study was designed to evaluate the prognostic value of positive posterior superior pancreaticoduodenal lymph nodes to clarify the need for dissection of these nodes. METHODS:A total of 148 patients with gallbladder carcinoma who underwent radical resection including dissection of the posterior superior...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5939-7

    authors: Sakata J,Kobayashi T,Tajima Y,Ohashi T,Hirose Y,Takano K,Takizawa K,Miura K,Wakai T

    更新日期:2017-09-01 00:00:00

  • Comprehensive needs assessment of clinical breast evaluation skills of primary care residents.

    abstract:BACKGROUND:Health care reform places primary care (PC) physicians in an increasingly significant role for breast cancer screening and diagnosis. This study assessed the adequacy of traditional PC resident training to prepare physicians for this front-line role. METHODS:Sixty-eight primary care residents, representing ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303850

    authors: Chalabian J,Formenti S,Russell C,Pearce J,Dunnington G

    更新日期:1998-03-01 00:00:00

  • Surgical resection of primary tumors in patients who present with stage IV colorectal cancer: an analysis of surveillance, epidemiology, and end results data, 1988 to 2000.

    abstract:BACKGROUND:Surgical resection of the primary tumor for patients who present with incurable stage IV colorectal cancer is controversial. National practice patterns have not been described. We evaluated the use of primary tumor resection in patients presenting with stage IV colorectal cancer. METHODS:Patients with stage...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.06.012

    authors: Cook AD,Single R,McCahill LE

    更新日期:2005-08-01 00:00:00

  • Suppression of beta-catenin by antisense oligomers augments tumor response to isolated limb perfusion in a rodent model of adenomatous polyposis coli-mutant colon cancer.

    abstract:BACKGROUND:Isolated hepatic perfusion has been used in patients with colorectal cancer (CRC) metastatic to the liver. We sought to determine whether perfusion with antisense oligodeoxynucleotides results in the downregulation of beta-catenin and whether this improves tumor response to isolated limb perfusion (ILP) in a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.10.005

    authors: Canter RJ,Kesmodel SB,Heitjan DF,Veeramachaneni NK,Mokadam NA,Drebin JA,Fraker DL

    更新日期:2005-09-01 00:00:00

  • The utility of frozen section evaluation for follicular thyroid lesions.

    abstract:BACKGROUND:Because fine-needle aspiration cannot reliably discriminate between benign and malignant follicular thyroid lesions, some surgeons use intraoperative frozen section (FS) to guide operative management. To determine the utility of FS for these lesions, we reviewed our institutional experience. METHODS:Between...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02524352

    authors: Callcut RA,Selvaggi SM,Mack E,Ozgul O,Warner T,Chen H

    更新日期:2004-01-01 00:00:00

  • Secretory carcinoma of the male breast.

    abstract:BACKGROUND:Secretory carcinoma is a distinctive and rare variant of breast carcinoma with a favorable prognosis because these tumors usually behave in an indolent manner. The occurrence of this type of breast cancer in males was studied. METHODS:An extensive literature survey concerning secretory breast cancer in male...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02574482

    authors: de Bree E,Askoxylakis J,Giannikaki E,Chroniaris N,Sanidas E,Tsiftsis DD

    更新日期:2002-08-01 00:00:00

  • Profiling Surgeon Performance for Breast Cancer Lumpectomy by Composite Measurement of Reoperations, Cosmetic Outcomes, and Patient Preferences.

    abstract:BACKGROUND:Patients want information to search for destination of care for breast-conserving surgery (BCS). To inform patients wanting a lumpectomy, we aimed to develop a pilot project that communicated composite quality measure (QM) results using a '4-star' rating system. Two patient-centered QMs were included in the ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6479-5

    authors: Dunham AL,Ramirez LD,Vang CA,Linebarger JH,Landercasper J

    更新日期:2018-07-01 00:00:00

  • Adjuvant therapy with capecitabine postpones recurrence of hepatocellular carcinoma after curative resection: a randomized controlled trial.

    abstract:BACKGROUND:Postoperative recurrence of hepatocellular carcinoma (HCC) is a major problem after surgical resection. To date, adjuvant chemotherapy or other adjuvant modalities have not been proven effective in preventing or delaying recurrence. The aim of this prospective randomized study was to evaluate the effectivene...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-010-1148-3

    authors: Xia Y,Qiu Y,Li J,Shi L,Wang K,Xi T,Shen F,Yan Z,Wu M

    更新日期:2010-12-01 00:00:00

  • Correlation between concordance of tracers, order of harvest, and presence of metastases in sentinel lymph nodes with breast cancer.

    abstract:BACKGROUND:There are various methods for the detection of sentinel lymph nodes (SLNs) in breast cancer by using a combined method with blue dye and radioisotope (RI) tracers. The purpose of the study was to reveal any correlation between concordance of the tracers and the order of harvest with the presence of metastase...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.07.013

    authors: Wada N,Imoto S,Yamauchi C,Hasebe T,Ochiai A,Ebihara S

    更新日期:2005-06-01 00:00:00

  • Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Patients with High-Grade, High-Volume Disseminated Mucinous Appendiceal Neoplasms.

    abstract:BACKGROUND:High-grade (HG) mucinous appendiceal neoplasms (MAN) have a worse prognosis than low-grade histology. Our objective was to assess the safety and efficacy of cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) in patients with high-grade, high-volume (HG-HV) peritoneal metastase...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4838-z

    authors: Polanco PM,Ding Y,Knox JM,Ramalingam L,Jones H,Hogg ME,Zureikat AH,Holtzman MP,Pingpank J,Ahrendt S,Zeh HJ,Bartlett DL,Choudry HA

    更新日期:2016-02-01 00:00:00

  • ASO Author Reflections: Rate of Axillary Lymph Node Dissection has Decreased in Patients Treated with Neoadjuvant Systemic Therapy.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-7045-x

    authors: Nguyen TT,Boughey JC

    更新日期:2018-12-01 00:00:00