Effect of body composition on outcomes after hepatic resection for hepatocellular carcinoma.

Abstract:

PURPOSE:To evaluate the effect of body composition on outcomes after hepatic resection for patients with hepatocellular carcinoma (HCC). METHODS:We performed 190 hepatic resections for HCC and divided the patients into 2 groups on the basis of visceral fat area (VFA), assessed by computed tomographic measurement at the level of the umbilicus, into high VFA (H-VFA) (n = 106) and low VFA (L-VFA) (n = 84) groups. We compared the surgical outcomes between the two groups. RESULTS:L-VFA was significantly correlated with a lower body mass index, sarcopenia, lower serum albumin, and liver cirrhosis. There was no difference in the incidence of postoperative complications and mortality between the 2 groups. Patients in the L-VFA group had a significantly poorer prognosis than those in the H-VFA group in terms of both overall (P = 0.043) and recurrence-free (P = 0.001) survival. The results of multivariate analysis showed that sarcopenia rather than L-VFA was an independent and prognostic indicator after hepatic resection with HCC. CONCLUSIONS:Body composition is an important factor affecting cancer outcomes after hepatic resection for HCC in Japan.

journal_name

Ann Surg Oncol

authors

Itoh S,Shirabe K,Matsumoto Y,Yoshiya S,Muto J,Harimoto N,Yamashita Y,Ikegami T,Yoshizumi T,Nishie A,Maehara Y

doi

10.1245/s10434-014-3686-6

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

3063-8

issue

9

eissn

1068-9265

issn

1534-4681

journal_volume

21

pub_type

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