Intraoperative Ultrasound-Guided Lumpectomy Versus Mammographic Wire Localization for Breast Cancer Patients After Neoadjuvant Treatment.


BACKGROUND:Intraoperative ultrasound (IOUS)-guided lumpectomy in early breast cancer has shown advantages over other techniques. However, the use of IOUS has been less explored after neoadjuvant treatment (NAT). This study aimed to compare IOUS- and wire localization (WL)-guided surgery in breast cancer patients after NAT. METHODS:The study enrolled patients treated with NAT who underwent breast-conserving surgery (BCS) between July 2008 and December 2012. For the patients with a hydrogel marker or residual tumor visible on ultrasound, an IOUS-guided surgery was performed (IOUS group). The patients with a standard marker or hydrogel marker not visible on ultrasound underwent a WL-guided surgery (WL group). RESULTS:The study investigated 214 patients: 145 (67.8 %) in the IOUS group and 69 (32.2 %) in the WL group. The patient and tumor characteristics were comparable between the two groups. For the patients who had a pathologic complete response (pCR) or microscopic disease, the volume excised was lower in the IOUS group (p = 0.03). The rate of reexcision for positive or close margins was similar in the two groups (p = 0.80). After a median follow-up period of 43 months, the local recurrence rates did not differ significantly between the two groups. CONCLUSIONS:Compared with WL surgery, IOUS seems to lower the volume of resection in patients with pCR or minimal microscopic disease after NAT without compromising margins and local recurrences. BCS can easily be achieved with IOUS for patients with a good response after NAT.


Ann Surg Oncol


Rubio IT,Esgueva-Colmenarejo A,Espinosa-Bravo M,Salazar JP,Miranda I,Peg V




Has Abstract


2016-01-01 00:00:00














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    abstract:PURPOSE:To report outcomes for breast-conserving therapy using adjuvant accelerated partial breast irradiation with interstitial multicatheter brachytherapy by a cooperative group of institutions. METHODS:From 1992 to 2013, a total of 1356 patients were treated with breast-conserving surgery and adjuvant accelerated p...

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    更新日期:2015-12-01 00:00:00

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    更新日期:2001-01-01 00:00:00

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    abstract:BACKGROUND:Randomized clinical trials (RCTs) can provide a high level of evidence for medical decision making, but it is unclear if the results apply to patients treated outside such trials. OBJECTIVE:The aim of this study was to retrospectively compare outcomes of patients with esophageal cancer treated within and ou...

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    更新日期:2018-08-01 00:00:00

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    abstract:BACKGROUND:The sentinel lymph node (SLN) is the first lymph node in the regional nodal basin to receive metastatic cells. In-transit nodes are found between the primary melanoma site and regional nodal basins. To date, this is one of the first reports on micrometastasis to in-transit nodes. METHODS:Retrospective datab...

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    pub_type: 杂志文章


    authors: Thelmo MC,Morita ET,Treseler PA,Nguyen LH,Allen RE Jr,Sagebiel RW,Kashani-Sabet M,Leong SP

    更新日期:2001-06-01 00:00:00

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    abstract:PURPOSE:This study was designed to compare the clinical outcomes of patients who underwent limited resection (LR) versus pancreaticoduodenectomy (PD) for duodenal gastrointestinal stromal tumors (GISTs). METHODS:A systematic review of the literature was performed to identify studies analyzing the clinical outcomes of ...

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    authors: Chok AY,Koh YX,Ow MY,Allen JC Jr,Goh BK

    更新日期:2014-10-01 00:00:00

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    abstract:BACKGROUND:For multifocal hepatocellular carcinomas (HCCs) that are untreatable with resection only, locoregional therapies added to hepatectomy have been introduced. However, some preliminary reports have documented average survival results and relatively high complication rates. We evaluated the long-term survival re...

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    pub_type: 杂志文章


    authors: Choi D,Lim HK,Joh JW,Kim SJ,Kim MJ,Rhim H,Kim YS,Yoo BC,Paik SW,Park CK

    更新日期:2007-12-01 00:00:00

  • Positive bone marrow biopsy is associated with a decreased disease-free survival in patients with operable breast cancer.

    abstract:BACKGROUND:Bone marrow (BM) biopsy has been suggested as an independent prognostic factor in patients with breast cancer. METHODS:Patients operated for breast cancer from June 2000 to April 2008 were enrolled in this protocol after signing an informed consent. After primary surgery, BM aspirate from the iliac crest wa...

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    pub_type: 杂志文章


    authors: Fortunato L,Mascaro A,Baldi A,Farina M,Cortese G,Ventrone MA,Amini M,Vitelli C

    更新日期:2009-11-01 00:00:00

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    abstract:BACKGROUND:Postoperative changes after axillary lymph node surgery may significantly alter breast cancer survivors' (BCS) quality of life. Although sentinel lymph node biopsy (SLNB) has less immediate morbidity than axillary lymph node dissection (ALND), its long-term impact on shoulder abduction, arm swelling, and neu...

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    authors: Crane-Okada R,Wascher RA,Elashoff D,Giuliano AE

    更新日期:2008-07-01 00:00:00

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    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) has become a standard for axillary staging for early breast cancer patients. Prior studies suggest that SLNB may be more sensitive for the identification of lymph node disease than axillary lymph node dissection (ALND). We hypothesized that SLNB use increases the incidence o...

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    更新日期:2006-11-01 00:00:00

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    authors: Higashiyama M,Ito T,Tanaka E,Shimada Y

    更新日期:2007-12-01 00:00:00

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  • Effects of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Treatment of Goblet Cell Carcinoma: A Prospective Cohort Study.

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    abstract:BACKGROUND:Isolated regional failure of nasopharyngeal carcinoma (NPC) after primary treatment is traditionally treated with radical neck dissection (RND). The roles of modified radical neck dissection (MRND) and postoperative radiotherapy after salvage surgery currently remain unclear. METHODS:Medical records from ou...

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    abstract:BACKGROUND:Accumulated evidence indicates that the incidence of early-onset breast cancer has rapidly increased in Taiwan and other Asian compared to Western countries. The mismatch repair (MMR) pathway might be one of the crucial mechanisms of predisposition to early breast cancer. In this study, we explored whether M...

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    更新日期:2017-02-01 00:00:00

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    abstract:BACKGROUND:Preoperative chemotherapy has been shown to improve outcome of patients with adenocarcinoma of the esophagogastric junction (AEG) and gastric cancer (GC), and histopathologic response has been identified as an independent prognostic parameter in these patients. A recent meta-analysis has identified patients ...

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Mayanagi S,Takeuchi H,Kamiya S,Niihara M,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Mukai M,Kitagawa Y

    更新日期:2014-09-01 00:00:00

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Bhangu A,Kiran RP,Slesser A,Fitzgerald JE,Brown G,Tekkis P

    更新日期:2013-12-01 00:00:00

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Pulitanò C,Bodingbauer M,Aldrighetti L,de Jong MC,Castillo F,Schulick RD,Parks RW,Choti MA,Wigmore SJ,Gruenberger T,Pawlik TM

    更新日期:2011-05-01 00:00:00

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kanda M,Nomoto S,Oya H,Takami H,Shimizu D,Hibino S,Hashimoto R,Kobayashi D,Tanaka C,Yamada S,Fujii T,Nakayama G,Sugimoto H,Koike M,Fujiwara M,Kodera Y

    更新日期:2016-02-01 00:00:00

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Mogal H,Fields R,Maithel SK,Votanopoulos K

    更新日期:2019-09-01 00:00:00

  • Impact of routine cavity shave margins on breast cancer re-excision rates.

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    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kobbermann A,Unzeitig A,Xie XJ,Yan J,Euhus D,Peng Y,Sarode V,Moldrem A,Marilyn Leitch A,Andrews V,Stallings C,Rao R

    更新日期:2011-05-01 00:00:00