当前位置： SCI文献检索 > ANNALS OF SURGICAL ONCOLOGY期刊下所有文献 > Role of Postmastectomy Radiotherapy After Neoadjuvant Chemotherapy in Breast Cancer Patients: A Study from the Japanese Breast Cancer Registry.

Role of Postmastectomy Radiotherapy After Neoadjuvant Chemotherapy in Breast Cancer Patients: A Study from the Japanese Breast Cancer Registry.

Abstract：

BACKGROUND:The role of postmastectomy radiotherapy (PMRT) in breast cancer patients receiving neoadjuvant chemotherapy (NAC) is controversial. We aimed to evaluate the effectiveness of radiotherapy in patients treated with NAC and mastectomy in the Japanese Breast Cancer Registry. METHODS:We enrolled patients who received NAC and mastectomy for cT1-4 cN0-2 M0 breast cancer. We evaluated the association between radiotherapy and outcomes, locoregional recurrence (LRR), distant disease-free survival (DDFS), and overall survival (OS) based on ypN status by multivariable analysis. RESULTS:Of the 145,530 patients, we identified 3226 who met the inclusion criteria. Among ypN1 patients, no differences were found in LRR, DDFS, or OS between groups with and without radiotherapy (p = 0.72, p = 0.29, and p = 0.36, respectively). Radiotherapy was associated with improved LRR-free survival (p < 0.001), DDFS (p = 0.01), and OS (p < 0.001) in patients with ypN2-3. Multivariable analysis demonstrated that use of radiotherapy was independently associated with improved LRR [hazard ratio (HR) 0.61, 95% confidence interval (CI) 0.45-0.82, p = 0.001] and OS [HR 0.69, 95% CI 0.53-0.89, p = 0.004) for ypN2-3 patients only. The association between radiotherapy and OS was not statistically significant among ypN0 (p = 0.22) and ypN1 patients (p = 0.51). CONCLUSIONS:The results from this nationwide database study did not show significant associations between PMRT and improved survival among ypN0 and ypN1 patients. Radiotherapy may be beneficial only for ypN2-3 breast cancer patients who receive NAC and mastectomy in the modern era.

journal_name

Ann Surg Oncol

journal_title

Annals of surgical oncology

authors

Miyashita M,Niikura N,Kumamaru H,Miyata H,Iwamoto T,Kawai M,Anan K,Hayashi N,Aogi K,Ishida T,Masuoka H,Iijima K,Masuda S,Tsugawa K,Kinoshita T,Tsuda H,Nakamura S,Tokuda Y

doi

10.1245/s10434-019-07453-1

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

2475-2485

issue

8

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-019-07453-1

journal_volume

26

pub_type

杂志文章

相关文献

ANNALS OF SURGICAL ONCOLOGY文献大全
  • Radioactive Seed Localization Versus Wire Localization for Nonpalpable Breast Lesions: A Two-Year Initial Experience at a Large Community Hospital.

    abstract：BACKGROUND:Radioactive seed localization (RSL) is a safe and effective alternative to wire localization (WL) for nonpalpable breast lesions. While several large academic institutions currently utilize RSL, few community hospitals have adopted this technique. OBJECTIVE:The aim of this study was to examine the experienc...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-017-6102-1

    authors： Stelle L,Schoenheit T,Brubaker A,Tang X,Qu P,Cradock K,Higham A

    更新日期：2018-01-01 00:00:00

  • Role of Sentinel Lymph Node Biopsy in Microinvasive Breast Cancer.

    abstract：BACKGROUND:Microinvasive ductal carcinoma (DCISM), defined as DCIS with a focus of invasive carcinoma ≤ 1 mm, can be managed similarly to pure DCIS; however, management of the axilla in DCISM has been a subject of debate. Reports in the literature differ on the utility and necessity of sentinel lymph node biopsy (SLNB)...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-020-08606-3

    authors： Fan B,Pardo JA,Serres S,Alapati AC,Szewczyk J,Mele A,James TA

    更新日期：2020-10-01 00:00:00

  • ASO Author Reflections: Radiation Therapy in Soft Tissue Sarcoma: Who Benefits and How?

    abstract：: ...

    journal_title：Annals of surgical oncology

    pub_type： 评论,杂志文章

    doi：10.1245/s10434-018-6970-z

    authors： Albertsmeier M,Roeder F,Angele MK

    更新日期：2018-12-01 00:00:00

  • Expression profiling of difficult-to-diagnose thyroid histologic subtypes shows distinct expression profiles and identify candidate diagnostic microRNAs.

    abstract：BACKGROUND:The incidence of thyroid cancer is increasing worldwide. The findings of up to 30% of thyroid fine-needle aspiration biopsies (FNAB) are inconclusive, primarily as a result of several thyroid histologic subtypes with overlapping cytologic features. MicroRNAs (miRNAs) are small noncoding RNAs and have been im...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-011-1766-4

    authors： Kitano M,Rahbari R,Patterson EE,Xiong Y,Prasad NB,Wang Y,Zeiger MA,Kebebew E

    更新日期：2011-11-01 00:00:00

  • Arteriolovenular shunting critically determines shutdown of microcirculation upon cryotherapy in tumor-bearing rat liver.

    abstract：BACKGROUND:Tissue destruction by cryosurgery not only is mediated by direct cell damage, but also involves secondary mechanisms, such as ischemia due to shutdown of the microcirculation. Clinicians favor repetitive cryoapplication, although there is no proven evidence for a more effective tumor eradication. METHODS:Th...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/ASO.2005.04.014

    authors： Richter S,Pistorius G,Seidel R,Feifel G,Schilling MK,Vollmar B,Menger MD

    更新日期：2005-04-01 00:00:00

  • Cumulative imaging radiation exposure following breast-conservation therapy.

    abstract：INTRODUCTION:Radiation from medical imaging may induce cellular damage and increase the risk of cancer. While health care workers are restricted to an annual dose of 50 milliSieverts (mSv), the exposure to patients is not typically recorded. After breast-conservation therapy (BCT), patients are subjected to screening m...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-010-1279-6

    authors： Marti JL,Dauer LT,Stempel M,Patil S,Kaplan JB,Montgomery LL

    更新日期：2011-01-01 00:00:00

  • Unresectable locally advanced pancreatic cancer: a multimodal treatment using neoadjuvant chemoradiotherapy (gemcitabine plus stereotactic radiosurgery) and subsequent surgical exploration.

    abstract：BACKGROUND:Pancreatic cancer accounts for approximately 3% of cancer deaths in Europe. Locally advanced pancreatic cancer (LAPC) involves vascular structures, and resectability is low, with a median survival time of 6 to 11 months. We conducted a prospective, nonrandomized study of patients with LAPC to assess the effe...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-010-1019-y

    authors： Polistina F,Costantin G,Casamassima F,Francescon P,Guglielmi R,Panizzoni G,Febbraro A,Ambrosino G

    更新日期：2010-08-01 00:00:00

  • Preoperative capecitabine and concurrent radiation for borderline resectable pancreatic cancer.

    abstract：BACKGROUND:Patients with borderline resectable pancreatic ductal adenocarcinoma (PDA) represent a high-risk group of patients due to tumor or patient-related characteristics. The optimal management of these patients has not been fully defined. MATERIALS AND METHODS:All patients undergoing evaluation for PDA between 20...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-010-1456-7

    authors： Stokes JB,Nolan NJ,Stelow EB,Walters DM,Weiss GR,de Lange EE,Rich TA,Adams RB,Bauer TW

    更新日期：2011-03-01 00:00:00

  • Survival among patients with platinum resistant, locally advanced non-small cell lung cancer treated with platinum-based systemic therapy.

    abstract：BACKGROUND:Recent adjuvant chemotherapy trials after resection of stage II and III non-small cell lung cancer (NSCLC) have identified important survival differences among patients with immunohistochemical evidence suggesting platinum resistance. No clinical information exists regarding the impact upon survival of patie...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-009-0608-0

    authors： d'Amato TA,Pettiford BL,Schuchert MJ,Parker R,Ricketts WA,Luketich JD,Landreneau RJ

    更新日期：2009-10-01 00:00:00

  • Metaplastic Breast Cancer Treatment and Outcomes in 2500 Patients: A Retrospective Analysis of a National Oncology Database.

    abstract：BACKGROUND:Metaplastic breast cancer (MBC) is characterized by chemoresistance and hematogenous spread. We sought to identify factors associated with improved MBC outcomes and increased likelihood of MBC diagnosis. METHODS:Women ≥ 18 years of age with stage I-III MBC and non-MBC diagnosed between 2010 and 2014 were id...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-018-6533-3

    authors： Ong CT,Campbell BM,Thomas SM,Greenup RA,Plichta JK,Rosenberger LH,Force J,Hall A,Hyslop T,Hwang ES,Fayanju OM

    更新日期：2018-08-01 00:00:00

  • A contemporary large single-institution evaluation of resected retroperitoneal sarcoma.

    abstract：PURPOSE:Retroperitoneal sarcomas (RPS) are rare malignancies, comprising just 10-15 % of all soft-tissue sarcomas. These are challenging tumors to treat, with surgical resection being the only modality capable of providing a cure. This study analyzed the management and survival of patients resected at a large academic ...

    journal_title：Annals of surgical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1245/s10434-014-3616-7

    authors： Bremjit PJ,Jones RL,Chai X,Kane G,Rodler ET,Loggers ET,Pollack SM,Pillarisetty VG,Mann GN

    更新日期：2014-07-01 00:00:00

  • Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change.

    abstract：BACKGROUND:The COVID-19 pandemic has posed extraordinary demands from patients, providers, and health care systems. Despite this, surgical oncologists must maintain focus on providing high-quality, empathetic care for the almost 2 million patients nationally who will be diagnosed with operable cancer this year. The foc...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-020-08673-6

    authors： Hwang ES,Balch CM,Balch GC,Feldman SM,Golshan M,Grobmyer SR,Libutti SK,Margenthaler JA,Sasidhar M,Turaga KK,Wong SL,McMasters KM,Tanabe KK

    更新日期：2020-08-01 00:00:00

  • Importance of Absent Neoplastic Epithelium in Patients Treated With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

    abstract：BACKGROUND:The importance of absent neoplastic epithelium in specimens from cytoreductive surgery (CRS) is unknown. This study aimed to investigate the prevalence and prognostic value of histopathology without neoplastic epithelium in patients treated with CRS and hyperthermic intraperitoneal chemotherapy (HIPEC). MET...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-015-4989-y

    authors： Enblad M,Birgisson H,Wanders A,Sköldberg F,Ghanipour L,Graf W

    更新日期：2016-04-01 00:00:00

  • Sarcopenia and Comorbidity in Gastric Cancer Surgery as a Useful Combined Factor to Predict Eventual Death from Other Causes.

    abstract：BACKGROUND:Sarcopenia is recognized as an important prognostic factor in various types of cancer, including gastric cancer. While long-term survival analyses typically focus on overall and disease-specific survival, death from other causes has received far less attention. METHODS:We reviewed medical records of 491 gas...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-018-6354-4

    authors： Kuwada K,Kuroda S,Kikuchi S,Yoshida R,Nishizaki M,Kagawa S,Fujiwara T

    更新日期：2018-05-01 00:00:00

  • A large cohort of consecutive patients confirmed frequent HER2 positivity in gastric carcinomas with advanced stages.

    abstract：BACKGROUND:Trastuzumab in association with systemic cytotoxic chemotherapy is the standard of care for patients with advanced HER2-positive gastric carcinoma (GC). However, HER2 as a prognostic factor in GC remains controversial. METHODS:HER2 overexpression and amplification was evaluated by immunohistochemistry (IHC)...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-012-2818-0

    authors： Cho J,Jeong J,Sung J,Sung CO,Kim KM,Park CK,Choi MG,Sohn TS,Bae JM,Kim S

    更新日期：2013-12-01 00:00:00

  • Prognostic Factors and Significance of Gastrointestinal Leak After Cytoreductive Surgery (CRS) with Heated Intraperitoneal Chemotherapy (HIPEC).

    abstract：BACKGROUND:Gastrointestinal leak (GIL) after cytoreductive surgery with heated intraperitoneal chemotherapy (CRS/HIPEC) is associated with significant morbidity and mortality. This study aimed to identify GIL prognostic factors and its impact on overall survival. METHODS:A retrospective analysis of a prospectively mai...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-016-5738-6

    authors： Chouliaras K,Levine EA,Fino N,Shen P,Votanopoulos KI

    更新日期：2017-04-01 00:00:00

  • Clinicopathological Features and Outcome of Lung Cancer Patients with Hematological Malignancy.

    abstract：PURPOSE:The aim of this study was to report the incidence of lung cancer in patients with hematological malignancy (HM), as well as patient characteristics and outcome. METHODS:We investigated 1503 consecutive patients treated for HM and 1208 patients who underwent surgical resection for lung cancer. RESULTS:Lung can...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-015-4885-5

    authors： Shoji F,Yamazaki K,Kouso H,Mori R,Takase K,Okamura S,Takeo S

    更新日期：2016-02-01 00:00:00

  • Reoperative Surgery in Patients with Multiple Endocrine Neoplasia Type 1 Associated Primary Hyperparathyroidism.

    abstract：BACKGROUND:Persistent/recurrent primary hyperparathyroidism (pHPT) occurs frequently in multiple endocrine neoplasia type 1 (MEN1). We assessed the usefulness of intraoperative PTH (IOPTH) and preoperative localizing studies based on the outcome of patients with MEN1-associated pHPT undergoing reoperative surgery. MET...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-016-5467-x

    authors： Keutgen XM,Nilubol N,Agarwal S,Welch J,Cochran C,Marx SJ,Weinstein LS,Simonds WF,Kebebew E

    更新日期：2016-12-01 00:00:00

  • Resection Margins in Merkel Cell Carcinoma: Is a 1-cm Margin Wide Enough?

    abstract：BACKGROUND:Guidelines regarding specific resection margins for primary Merkel cell carcinoma (MCC) are not well established. The current National Comprehensive Cancer Network (NCCN) guidelines recommend 1- to 2-cm resection margins. This study aimed to determine the impact of margin width on local recurrence (LR), dise...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-018-6688-y

    authors： Perez MC,de Pinho FR,Holstein A,Oliver DE,Naqvi SMH,Kim Y,Messina JL,Burke E,Gonzalez RJ,Sarnaik AA,Cruse CW,Wuthrick EJ,Harrison LB,Sondak VK,Zager JS

    更新日期：2018-10-01 00:00:00

  • Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression.

    abstract：BACKGROUND:Thrombomodulin (TM) is a key molecule mediating circulation homeostasis through its binding to thrombin. The TM-thrombin complex can activate protein C and thrombin-activatable fibrinolysis inhibitor to form a tight clot. In many cancer tissues, decrease of TM expression may correlate with cancer metastasis....

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-010-1163-4

    authors： Huang MT,Wei PL,Liu JJ,Liu DZ,Huey-Chun H,An J,Wu CC,Wu CH,Ho YS,Yang YY,Chang YJ

    更新日期：2010-12-01 00:00:00

  • Management of thyroid nodules with atypical cytology on fine-needle aspiration biopsy.

    abstract：BACKGROUND:Fine-needle aspiration biopsy (FNAB) of the thyroid categorized as atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is a newly defined category according to the recent Bethesda guidelines. We sought to assess the characteristics and treatment of patients with an A...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-012-2601-2

    authors： Nagarkatti SS,Faquin WC,Lubitz CC,Garcia DM,Barbesino G,Ross DS,Hodin RA,Daniels GH,Parangi S

    更新日期：2013-01-01 00:00:00

  • Impact of the Interval Between Neoadjuvant Chemotherapy and Gastrectomy on Short- and Long-Term Outcomes for Patients with Advanced Gastric Cancer.

    abstract：BACKGROUND:The optimal time between neoadjuvant chemotherapy (NAC) and gastrectomy for gastric cancer (GC) remains unknown. This study aimed to investigate the association between the time-to-surgery (TTS) interval and the major pathologic response (mPR). METHODS:In this study, 280 consecutive GC patients who underwen...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-020-09507-1

    authors： Bausys A,Ümarik T,Luksta M,Reinsoo A,Rackauskas R,Anglickiene G,Kryzauskas M,Tõnismäe K,Senina V,Seinin D,Bausys R,Strupas K

    更新日期：2021-01-08 00:00:00

  • Annexin II overexpression predicts rapid recurrence after surgery in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy.

    abstract：BACKGROUND:Gemcitabine has been shown to exhibit significant clinical activity against pancreatic cancer and has become a first-line chemotherapeutic for this disease in recent years. However, there are still many patients who do not respond to this treatment and it is expected to improve the clinical outcome if we can...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-008-0061-5

    authors： Takano S,Togawa A,Yoshitomi H,Shida T,Kimura F,Shimizu H,Yoshidome H,Ohtsuka M,Kato A,Tomonaga T,Nomura F,Miyazaki M

    更新日期：2008-11-01 00:00:00

  • As a Novel Prognostic Marker, Cysteine/histidine-rich 1 (CYHR1) is a Therapeutic Target in Patients with Esophageal Squamous Cell Carcinoma.

    abstract：BACKGROUND:Cysteine/histidine-rich 1 (CYHR1) was first discovered in a yeast two-hybrid screen with murine galectin-3, and no previous reports have described a relationship between the CYHR1 gene and human cancer. The current study evaluated the role and significance of CYHR1 in esophageal cancer. METHODS:The human es...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-015-5031-0

    authors： Desaki R,Sawada G,Okumura H,Ikeda R,Tanabe K,Komatsu H,Mimori K,Mori M,Kita Y,Uchikado Y,Arigami T,Uenosono Y,Owaki T,Ishigami S,Natsugoe S

    更新日期：2017-02-01 00:00:00

  • Outcomes of Lymph Node Dissection for Non-metastatic Pancreatic Neuroendocrine Tumors: A Propensity Score-Weighted Analysis of the National Cancer Database.

    abstract：BACKGROUND:Although the National Comprehensive Cancer Network (NCCN) guidelines recommend use of lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) > 2 cm, there is limited evidence to support the association between use of LND and overall survival (OS). METHODS:Patients with resecte...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-019-07506-5

    authors： Mao R,Zhao H,Li K,Luo S,Turner M,Cai JQ,Blazer D 3rd

    更新日期：2019-09-01 00:00:00

  • Toward better soft tissue sarcoma staging: building on american joint committee on cancer staging systems versions 6 and 7.

    abstract：BACKGROUND:Based on review of patient data in case conferences over time, we hypothesized that clinically relevant data are omitted in routine soft tissue sarcoma staging. METHODS:We examined subsets of a prospectively collected single institution soft tissue sarcoma database with respect to criteria of the AJCC versi...

    journal_title：Annals of surgical oncology

    pub_type： 临床试验,杂志文章

    doi：10.1245/s10434-013-3052-0

    authors： Maki RG,Moraco N,Antonescu CR,Hameed M,Pinkhasik A,Singer S,Brennan MF

    更新日期：2013-10-01 00:00:00

  • Practical Value of Molecular Pathology in Stage I-III Lung Cancer: Implications for the Clinical Surgeon.

    abstract：:Over a decade since the discovery of EGFR mutation, and 6 years since prospective clinical trial data proved that routine molecular pathology tests improve survival in stage IV lung cancer, there is still debate whether to test patients with earlier stages of disease (stage I-III). As discoveries of targeted drugs for...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章,评审

    doi：10.1245/s10434-015-4704-z

    authors： Azzoli CG

    更新日期：2015-10-01 00:00:00

  • Survival benefit of hyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer: a multi-institutional case control study.

    abstract：BACKGROUND:Hyperthermic intraperitoneal chemotherapy (HIPEC) and complete surgical removal of the tumor, in relapsing patients may provide a clinical benefit. There is no consensus considering the place of HIPEC for patients who had first ovarian cancer relapse. To assess for possible efficacy of HIPEC on overall survi...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1245/s10434-014-3693-7

    authors： Le Brun JF,Campion L,Berton-Rigaud D,Lorimier G,Marchal F,Ferron G,Oger AS,Dravet F,Jaffre I,Classe JM

    更新日期：2014-10-01 00:00:00

  • Development and trends of surgical modalities for breast cancer in China: a review of 16-year data.

    abstract：BACKGROUND:Surgery is the most important treatment for nonmetastatic breast cancer; however, the utilization of modern surgical techniques in management of breast cancer in mainland China has not been reported. METHODS:The medical records of 5887 consecutive breast cancer patients treated surgically in the past 16 yea...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-007-9436-2

    authors： Yu KD,Di GH,Wu J,Lu JS,Shen KW,Shen ZZ,Shao ZM

    更新日期：2007-09-01 00:00:00

  • Determining the association between preoperative computed tomography findings and postoperative outcomes after cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei.

    abstract：BACKGROUND:This study evaluates the accuracy of computed tomography (CT) scoring of the peritoneal cancer index (PCI) and examines its association with surgical morbidity and outcomes in pseudomyxoma peritonei. METHODS:Forty-seven patients with pseudomyxoma peritonei had preoperative evaluation of CT scans and were tr...

    journal_title：Annals of surgical oncology

    pub_type： 杂志文章

    doi：10.1245/s10434-010-1492-3

    authors： Chua TC,Al-Zahrani A,Saxena A,Glenn D,Liauw W,Zhao J,Morris DL

    更新日期：2011-06-01 00:00:00