As a Novel Prognostic Marker, Cysteine/histidine-rich 1 (CYHR1) is a Therapeutic Target in Patients with Esophageal Squamous Cell Carcinoma.

Abstract:

BACKGROUND:Cysteine/histidine-rich 1 (CYHR1) was first discovered in a yeast two-hybrid screen with murine galectin-3, and no previous reports have described a relationship between the CYHR1 gene and human cancer. The current study evaluated the role and significance of CYHR1 in esophageal cancer. METHODS:The human esophageal squamous cell carcinoma (ESCC) cell line TE-8 and the CYHR1 knock-down cell line TE-8/small interfering (si)-CYHR1 were used for in vitro and in vivo assays. For clinical study, ESCC tissues (n = 104) were used. RESULTS:Compared with parental cells, TE-8/si-CYHR1 cells had suppressed proliferation and invasion activities. In the in vivo assay, the tumors from TE-8 cells treated with si-CYHR1 had abrogated tumorigenicity. In the clinical study, the expression of CYHR1 mRNA was associated with lymph node metastasis and stage and shown to be an independent prognostic factor. CONCLUSIONS:As the findings show, CYHR1 may represent not only a valuable prognostic marker but also a therapeutic target for ESCC patients.

journal_name

Ann Surg Oncol

authors

Desaki R,Sawada G,Okumura H,Ikeda R,Tanabe K,Komatsu H,Mimori K,Mori M,Kita Y,Uchikado Y,Arigami T,Uenosono Y,Owaki T,Ishigami S,Natsugoe S

doi

10.1245/s10434-015-5031-0

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

586-593

issue

2

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-015-5031-0

journal_volume

24

pub_type

杂志文章
  • Diagnostic Laparoscopy as a Selection Tool for Patients with Colorectal Peritoneal Metastases to Prevent a Non-therapeutic Laparotomy During Cytoreductive Surgery.

    abstract:OBJECTIVE:The aim of this study was to evaluate the introduction of diagnostic laparoscopy (DLS) in patients with colorectal peritoneal metastases (PM) to prevent non-therapeutic laparotomies during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). METHODS:Patients with histologically...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07957-w

    authors: Hentzen JEKR,Constansia RDN,Been LB,Hoogwater FJH,van Ginkel RJ,van Dam GM,Hemmer PHJ,Kruijff S

    更新日期:2020-04-01 00:00:00

  • Sentinel lymph node biopsy versus axillary lymphadenectomy in patients treated with lumpectomy: an analysis of short-term outcomes.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) has been shown to reduce many of the long-term complications associated with a traditional axillary lymph node dissection (ALND); however, short-term outcomes have yet to be characterized. This study was designed to identify trends and differences in 30-day outcomes of parti...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3248-3

    authors: Khavanin N,Gart MS,Berry T,Thornton B,Saha S,Kim JY

    更新日期:2014-01-01 00:00:00

  • Nonoperative management of primary colorectal cancer in patients with stage IV disease.

    abstract:BACKGROUND:Traditional teaching maintains that patients with primary colorectal adenocarcinoma require timely resection to prevent bleeding, perforation, or obstruction. The true benefits of primary tumor resection remain undocumented for patients presenting with metastatic disease, however. We postulated that resectio...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-999-0651-x

    authors: Scoggins CR,Meszoely IM,Blanke CD,Beauchamp RD,Leach SD

    更新日期:1999-10-01 00:00:00

  • Verification of musculoskeletal FDG-PET-CT findings performed for melanoma staging.

    abstract:BACKGROUND:The purpose of this study is to establish the validity of F-18-deoxyglucose positron emission tomography-computed tomography (FDG-PET-CT) scan staging for cutaneous melanoma when a musculoskeletal image abnormality is detected. METHODS:An institutional review board (IRB)-approved prospective database was qu...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-009-0843-4

    authors: Mansour AA 3rd,Kelley MC,Hatmaker AR,Holt GE,Schwartz HS

    更新日期:2010-04-01 00:00:00

  • Expression profiling of difficult-to-diagnose thyroid histologic subtypes shows distinct expression profiles and identify candidate diagnostic microRNAs.

    abstract:BACKGROUND:The incidence of thyroid cancer is increasing worldwide. The findings of up to 30% of thyroid fine-needle aspiration biopsies (FNAB) are inconclusive, primarily as a result of several thyroid histologic subtypes with overlapping cytologic features. MicroRNAs (miRNAs) are small noncoding RNAs and have been im...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1766-4

    authors: Kitano M,Rahbari R,Patterson EE,Xiong Y,Prasad NB,Wang Y,Zeiger MA,Kebebew E

    更新日期:2011-11-01 00:00:00

  • Clinical and socioeconomic factors influence treatment decisions in Graves' disease.

    abstract:BACKGROUND:Definitive treatment of Graves' disease includes radioactive iodine (RAI) and thyroidectomy, but utilization varies. We hypothesize that, in addition to clinical reasons, there are socioeconomic factors that influence whether a patient undergoes thyroidectomy or RAI. METHODS:Patients treated for Graves' dis...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4095-6

    authors: Elfenbein DM,Schneider DF,Havlena J,Chen H,Sippel RS

    更新日期:2015-04-01 00:00:00

  • Cervicothoracoscopic Approach for Esophageal Cancer in a Patient with Right-Sided Aortic Arch.

    abstract:BACKGROUND:Esophageal cancer frequently metastasizes to lymph nodes along the recurrent laryngeal nerve (RLN),1 therefore it is essential to dissect RLN nodes for curative esophagectomy.2 Right-sided aortic arch (RAA), a rare congenital anomaly, occurs in approximately 0.1% of adults.3 Because RAA forms a vascular ring...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6355-3

    authors: Okamura A,Watanabe M,Yuda M,Shoji Y,Yamashita K,Hayami M,Imamura Y,Mine S

    更新日期:2018-05-01 00:00:00

  • Functional outcome of arthrodesis with a vascularized fibular graft and a rotational latissimus dorsi flap after proximal humerus sarcoma resection.

    abstract:BACKGROUND:The prognosis of humeral sarcomas has improved greatly in the past 20 years. As a result, the challenges for orthopedic oncologists include long-term handicap and local morbidity. METHODS:Shoulder reconstruction after the resection of sarcomas with the proximal humerus was evaluated for 55 patients from 199...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1443-z

    authors: Wang J,Shen J,Dickinson IC

    更新日期:2011-07-01 00:00:00

  • Surgical resection versus laparoscopic radiofrequency ablation in patients with hepatocellular carcinoma and Child-Pugh class a liver cirrhosis.

    abstract:BACKGROUND:This study compared two homogeneous groups of patients submitted to either surgical resection (HR) or laparoscopic radiofrequency ablation (LRFA) for the treatment of hepatocellular carcinoma (HCC). When compatible with the liver functional reserve, HR remains the treatment of choice for HCC, while LRFA seem...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0678-z

    authors: Santambrogio R,Opocher E,Zuin M,Selmi C,Bertolini E,Costa M,Conti M,Montorsi M

    更新日期:2009-12-01 00:00:00

  • Outcomes after robot-assisted pancreaticoduodenectomy for periampullary lesions.

    abstract:BACKGROUND:There are many theoretical advantages that a minimally invasive approach to the pancreaticoduodenectomy might offer patients with benign and malignant disease of the head of the pancreas over traditional open techniques, including improved recovery time, decreased hospital stay, and earlier initiation of and...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2045-0

    authors: Zeh HJ,Zureikat AH,Secrest A,Dauoudi M,Bartlett D,Moser AJ

    更新日期:2012-03-01 00:00:00

  • A contemporary large single-institution evaluation of resected retroperitoneal sarcoma.

    abstract:PURPOSE:Retroperitoneal sarcomas (RPS) are rare malignancies, comprising just 10-15 % of all soft-tissue sarcomas. These are challenging tumors to treat, with surgical resection being the only modality capable of providing a cure. This study analyzed the management and survival of patients resected at a large academic ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-014-3616-7

    authors: Bremjit PJ,Jones RL,Chai X,Kane G,Rodler ET,Loggers ET,Pollack SM,Pillarisetty VG,Mann GN

    更新日期:2014-07-01 00:00:00

  • Risk of colorectal cancer in chronic kidney disease: a matched cohort study based on administrative data.

    abstract:BACKGROUND:The risk of colorectal cancer (CRC) in chronic kidney disease (CKD) patients relative to the general population is unknown. The aim of this population-based study was to investigate the risk of CRC in patients with CKD. METHODS:The study cohort included patients aged ≥18 years diagnosed with CKD between 200...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-013-3065-8

    authors: Wu MY,Chang TC,Chao TY,Huang MT,Lin HW

    更新日期:2013-11-01 00:00:00

  • Defining venous involvement in borderline resectable pancreatic cancer.

    abstract:BACKGROUND:Pancreatic adenocarcinoma impinging the portal and/or superior mesenteric vein (PV-SMV) is classified as borderline resectable, and preoperative chemoradiation is recommended to increase the margin-negative resection rate. There is no consensus about what degree of venous impingement constitutes borderline r...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1284-9

    authors: Chun YS,Milestone BN,Watson JC,Cohen SJ,Burtness B,Engstrom PF,Haluszka O,Tokar JL,Hall MJ,Denlinger CS,Astsaturov I,Hoffman JP

    更新日期:2010-11-01 00:00:00

  • Adverse outcomes associated with noncompliance with melanoma treatment guidelines.

    abstract:BACKGROUND:Clinical practice guidelines have been developed to improve melanoma patient care. However, it is unclear whether failure to comply with these standards (either excessive or inadequate treatment) increases morbidity or relapse rates. Therefore, we undertook this study to evaluate the effect of variance from ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0021-0

    authors: Erickson Foster J,Velasco JM,Hieken TJ

    更新日期:2008-09-01 00:00:00

  • A new policy regarding ovarian resection in young women treated for peritoneal carcinomatosis.

    abstract:OBJECTIVE:To appreciate if the ovaries can be preserved in selected young women with peritoneal carcinomatosis (PC). BACKGROUND:The traditional rule is to resect the ovaries systematically when PC is found at surgery. METHODS:A new policy was developed to preserve the ovaries when they were macroscopically normal in ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-2879-8

    authors: Elias D,Duchalais E,Dartigues P,Duvillard P,Poirot C,Goéré D

    更新日期:2013-06-01 00:00:00

  • Cytoreduction and hyperthermic intraperitoneal chemoperfusion in women with heavily pretreated recurrent ovarian cancer.

    abstract:BACKGROUND:Limited data are available on the use of cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (HIPEC) in patients with recurrent stage III ovarian cancer. METHODS:Patients with recurrent, heavily pretreated ovarian cancer were enrolled onto a phase II multimodal protocol consisting of exte...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0878-6

    authors: Ceelen WP,Van Nieuwenhove Y,Van Belle S,Denys H,Pattyn P

    更新日期:2012-07-01 00:00:00

  • Population-Based Study on Risk Factors for Tumor-Positive Resection Margins in Patients with Gastric Cancer.

    abstract:BACKGROUND:Radical gastrectomy is the cornerstone of the treatment of locally advanced gastric cancer. This study was designed to evaluate factors associated with a tumor-positive resection margin after gastrectomy and to evaluate the influence of hospital volume. METHODS:In this Dutch cohort study, patients with junc...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07381-0

    authors: van der Werf LR,Cords C,Arntz I,Belt EJT,Cherepanin IM,Coene PLO,van der Harst E,Heisterkamp J,Langenhoff BS,Lamme B,van Berge Henegouwen MI,Lagarde SM,Wijnhoven BPL

    更新日期:2019-07-01 00:00:00

  • Extrahepatic disease should not preclude transarterial chemoembolization for metastatic neuroendocrine carcinoma.

    abstract:BACKGROUND:Transarterial chemoembolization (TACE) is often utilized for patients with inoperable neuroendocrine carcinoma liver metastases. Often, metastatic disease is not limited to the liver. The impact of extrahepatic disease (EHD) on outcomes and response after TACE has not been described. METHODS:We reviewed 192...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2786-4

    authors: Arrese D,McNally ME,Chokshi R,Feria-Arias E,Schmidt C,Klemanski D,Gregory G,Khabiri H,Shah M,Bloomston M

    更新日期:2013-04-01 00:00:00

  • Sentinel Lymph Node Biopsy in Thin Cutaneous Melanoma: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Most patients with melanoma have a thin (≤1.00 mm) lesion. There is uncertainty as to which patients with thin melanoma should undergo sentinel lymph node (SN) biopsy. We sought to quantify the proportion of SN metastases in patients with thin melanoma and to determine the pooled effect of high-risk features...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-016-5137-z

    authors: Cordeiro E,Gervais MK,Shah PS,Look Hong NJ,Wright FC

    更新日期:2016-12-01 00:00:00

  • The illusion of the learning phase for lymphatic mapping.

    abstract:BACKGROUND:We provide a statistical analysis of the learning phase for sentinel node biopsy. METHODS:Four learning phases were analyzed: 25, 50, 75, and 150 procedures with a corresponding number of 10, 20, 30, and 60 tumor-positive cases. Critical values of nonidentification rate and false-negative rate were defined....

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02557365

    authors: Tanis PJ,Nieweg OE,Hart AA,Kroon BB

    更新日期:2002-03-01 00:00:00

  • Her-2/neu gene amplification in esophageal adenocarcinoma and its influence on survival.

    abstract:BACKGROUND:HER-2/neu (c-erbB-2, HER2) gene amplification and protein overexpression have been associated with poor prognosis in several solid tumors, including breast and gastric cancer. Its incidence and significance in esophageal adenocarcinoma is unknown. MATERIALS AND METHODS:Tissue microarrays were successfully c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1554-1

    authors: Thompson SK,Sullivan TR,Davies R,Ruszkiewicz AR

    更新日期:2011-07-01 00:00:00

  • Ratio between positive lymph nodes and total excised axillary lymph nodes as an independent prognostic factor for overall survival in patients with nonmetastatic lymph node-positive breast cancer.

    abstract:BACKGROUND:The status of the axillary lymph nodes in nonmetastatic lymph node-positive breast cancer (BC) patients remains the single most important determinant of overall survival (OS). Although the absolute number of nodes involved with cancer is important for prognosis, the role of the total number of excised nodes ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-009-0653-8

    authors: Hatoum HA,Jamali FR,El-Saghir NS,Musallam KM,Seoud M,Dimassi H,Abbas J,Khalife M,Boulos FI,Tawil AN,Geara FB,Salem Z,Shamseddine AA,Al-Feghali K,Shamseddine AI

    更新日期:2009-12-01 00:00:00

  • Relationship between pathologic T-stage and nodal metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer.

    abstract:BACKGROUND:We investigated the relationship between pathologic T-stage and mesorectal metastases after preoperative chemoradiotherapy (CRT) for clinical stage II to III rectal carcinoma. METHODS:The records of consecutive patients with clinical stage II to III carcinoma of the mid or low rectum who underwent surgery a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.03.044

    authors: Pucciarelli S,Capirci C,Emanuele U,Toppan P,Friso ML,Pennelli GM,Crepaldi G,Pasetto L,Nitti D,Lise M

    更新日期:2005-02-01 00:00:00

  • The definition of optimal inguinal femoral nodal dissection in the management of vulva squamous cell carcinoma.

    abstract:OBJECTIVES:To reject the hypothesis that the number of nodes removed at time of surgical staging for vulva cancer is not an important prognostic factor. METHODS:Retrospective chart reviews were carried out from 1980-2004 to identify patients with squamous cell vulva carcinoma treated with radical vulvectomy and bilate...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9417-5

    authors: Le T,Elsugi R,Hopkins L,Faught W,Fung-Kee-Fung M

    更新日期:2007-07-01 00:00:00

  • Tumor Involvement of the Nipple in Total Skin-Sparing Mastectomy: Strategies for Management.

    abstract:BACKGROUND:Despite a growing body of literature on oncologic and reconstructive outcomes after total skin-sparing mastectomy (TSSM), some questions related to this approach remain unanswered, including strategies for managing tumor involvement of the nipple while maintaining the aesthetic benefits of TSSM. METHODS:A p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4646-5

    authors: Amara D,Peled AW,Wang F,Ewing CA,Alvarado M,Esserman LJ

    更新日期:2015-11-01 00:00:00

  • Impact of Sarcopenia on Surgical Outcomes in Non-small Cell Lung Cancer.

    abstract:BACKGROUND:Sarcopenia influences overall survival (OS) and tumor progression in non-small cell lung cancer (NSCLC) patients. However, the impact of postoperative complications and the outcome of limited surgery have not been highlighted. Therefore, the aim of this study is to elucidate the prognostic impact of sarcopen...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08224-z

    authors: Shinohara S,Otsuki R,Kobayashi K,Sugaya M,Matsuo M,Nakagawa M

    更新日期:2020-07-01 00:00:00

  • Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas.

    abstract:BACKGROUND:0.6-12.7% of patients with primary cutaneous melanoma will develop additional melanomas. Pathologic features of tumors in patients with multiple primary cutaneous melanomas have not been well described. In this large, international, multicenter, case-control study, we compared the clinicopathologic features ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-011-2058-8

    authors: Murali R,Goumas C,Kricker A,From L,Busam KJ,Begg CB,Dwyer T,Gruber SB,Kanetsky PA,Orlow I,Rosso S,Thomas NE,Berwick M,Scolyer RA,Armstrong BK,GEM Study Group.

    更新日期:2012-03-01 00:00:00

  • Phase II Trial of Neoadjuvant Chemotherapy, Chemoradiotherapy, and Laparoscopic Surgery with Selective Lateral Node Dissection for Poor-Risk Low Rectal Cancer.

    abstract:PURPOSE:The aim of this study is to evaluate the safety and efficacy of induction modified 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus bevacizumab followed by S- 1-based chemoradiotherapy in magnetic resonance imaging (MRI)-defined poor-risk locally advanced low rectal cancer. PATIENTS AND METHODS:This...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07342-7

    authors: Konishi T,Shinozaki E,Murofushi K,Taguchi S,Fukunaga Y,Nagayama S,Fujimoto Y,Akiyoshi T,Nagasaki T,Suenaga M,Chino A,Kawachi H,Yamamoto N,Ishikawa Y,Oguchi M,Ishizuka N,Ueno M,Yamaguchi K

    更新日期:2019-08-01 00:00:00

  • Involvement of CD40 targeting miR-224 and miR-486 on the progression of pancreatic ductal adenocarcinomas.

    abstract:BACKGROUND:Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDAC) are well known. Genetic and epigenetic data were correlated with tumor biology to find specific alterations responsible for invasion and metastasis in pancreatic ductal adenocarcinomas. METHODS:A total of 16 hu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0531-4

    authors: Mees ST,Mardin WA,Sielker S,Willscher E,Senninger N,Schleicher C,Colombo-Benkmann M,Haier J

    更新日期:2009-08-01 00:00:00

  • Breast cancer screening at the Breast Examination Center of Harlem.

    abstract:BACKGROUND:This study was designed to describe patient, disease, and treatment characteristics of women diagnosed with breast cancer at the Breast Examination Center of Harlem (BECH) and to determine whether these characteristics have changed over time. METHODS:Retrospective chart review of women diagnosed with breast...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4240-2

    authors: Manning AT,Eaton A,Azu M,Sampson M,Patil S,Godfrey D,Beesen AA,Liberman L,Gemignani ML

    更新日期:2015-01-01 00:00:00