Racial disparities in esophageal cancer outcomes.

Abstract:

BACKGROUND:Racial disparities in outcomes have been documented among patients with esophageal cancer. The purpose of this study is to identify mechanisms for ethnicity/race-related differences in the use of cancer-directed surgery and mortality. METHODS:Data from the Surveillance, Epidemiology and End Results (SEER) program were used to evaluate non-Hispanic black, non-Hispanic white and Hispanic patients diagnosed with non-metastatic esophageal cancer (squamous cell carcinoma or adenocarcinoma) from 2003-2008. Age, marital status, stage, histology and location were examined as predictors of receipt of surgery and mortality in multivariate analyses. RESULTS:A total of 6,737 patient files (84 % white, 10 % black, 6 % Hispanic) were analyzed. Black and Hispanic patients were more likely than whites to have squamous cell carcinoma (86 vs. 41 vs. 26 %, respectively; p < 0.001) and lesions in the midesophagus (58 vs. 38 vs. 26 %, respectively; p < 0.001). Blacks and Hispanics were less likely to undergo esophagectomy (adjusted odds ratio 0.48, 95 % confidence interval (CI) 0.39-0.60 and 0.71, 95 % CI 0.56-0.90]. We noted significant variations in esophagectomy rates among patients with midesophageal cancers; 15 % of blacks underwent esophagectomy compared to 22 % of Hispanics and 29 % of whites (p < 0.001). Black and Hispanic patients had a higher unadjusted risk of mortality (hazard ratio 1.38, 95 % CI 1.25-1.52 and 1.20, 95 % CI 1.05-1.37). However, differences in mortality were no longer significant after adjusting for receipt of surgery. CONCLUSIONS:Disparities in esophageal cancer outcomes are associated with the lower use of cancer-directed surgery. To decrease disparities in mortality it will be necessary to understand and target underlying causes of lower surgery rates in nonwhite patients and develop interventions, especially for midesophageal cancers.

journal_name

Ann Surg Oncol

authors

Revels SL,Morris AM,Reddy RM,Akateh C,Wong SL

doi

10.1245/s10434-012-2807-3

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

1136-41

issue

4

eissn

1068-9265

issn

1534-4681

journal_volume

20

pub_type

杂志文章
  • Cholangiocarcinoma Heterogeneity Revealed by Multigene Mutational Profiling: Clinical and Prognostic Relevance in Surgically Resected Patients.

    abstract:BACKGROUND:Cholangiocarcinoma can be classified in intrahepatic cholangiocarcinoma (ICC) and perihilar cholangiocarcinoma (PCC). Moreover, PCC includes two different forms: extrahepatic (EH) PCC, which arises from the perihilar EH large ducts, and intrahepatic (IH) PCC, in which a significant liver mass invades the per...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5046-6

    authors: Ruzzenente A,Fassan M,Conci S,Simbolo M,Lawlor RT,Pedrazzani C,Capelli P,D'Onofrio M,Iacono C,Scarpa A,Guglielmi A

    更新日期:2016-05-01 00:00:00

  • FOXC2 is a novel prognostic factor in human esophageal squamous cell carcinoma.

    abstract:BACKGROUND:FOXC2 has been implicated in cancer progression through its induction of epithelial-to-mesenchymal transition. We analyzed the clinical significance of FOXC2 in esophageal cancer cases, in which early distant metastasis or invasion to nearby organs is an obstacle to treatment. METHODS:Quantitative reverse t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1274-y

    authors: Nishida N,Mimori K,Yokobori T,Sudo T,Tanaka F,Shibata K,Ishii H,Doki Y,Mori M

    更新日期:2011-02-01 00:00:00

  • Lymph node dissection after chemoradiation in esophageal cancer: a subgroup analysis of patients with and without pathological response.

    abstract:BACKGROUND:Extensive lymph node dissection (LND) is beneficial in primarily resected esophageal cancer patients. Such benefit was believed to be seen in neoadjuvant chemoradiotherapy (CRT)-treated patients, but evidence was inconsistent. We hypothesized that CRT might offset the benefit of LND in certain subgroup of pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2402-7

    authors: Chao YK,Liu HP,Hsieh MJ,Wu YC,Liu YH,Yeh CH,Chang HK,Tseng CK

    更新日期:2012-10-01 00:00:00

  • REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy.

    abstract:BACKGROUND:The prognosis for patients with locally advanced thoracic esophageal cancer is extremely unfavorable. We have been administering neoadjuvant chemoradiotherapy (CRT) followed by esophagectomy to these patients and studying whether REG I expression in untreated endoscopic biopsy specimens is predictive of pati...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9075-z

    authors: Motoyama S,Sugiyama T,Ueno Y,Okamoto H,Takasawa S,Nanjo H,Watanabe H,Maruyama K,Okuyama M,Ogawa J

    更新日期:2006-12-01 00:00:00

  • Comparison of Tissue and Blood Concentrations of Oxaliplatin Administrated by Different Modalities of Intraperitoneal Chemotherapy.

    abstract:BACKGROUND:Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new technology for delivering intraperitoneal chemotherapy. It is generally assumed that with PIPAC, the ratio of peritoneal to systemic drug concentration is superior to liquid hyperthermic intraperitoneal chemotherapy (HIPEC). To date, no direct...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07695-z

    authors: Giger-Pabst U,Bucur P,Roger S,Falkenstein TA,Tabchouri N,Le Pape A,Lerondel S,Demtröder C,Salamé E,Ouaissi M

    更新日期:2019-12-01 00:00:00

  • Regional chemotherapy for colorectal hepatic metastases: evidence for improved survival with new drug combinations.

    abstract:BACKGROUND:In patients with colorectal hepatic metastases, response rates with hepatic arterial infusion (HAI) FUdR (5-Fluoro-2-deoxyuridine) are significantly higher than with systemic fluoropyrimidines. We report a novel animal model of intrahepatic therapy for hepatic metastasis for the study of methods to increase ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02409049

    authors: Sutanto-Ward E,Arisawa Y,Tremiterra S,Sigurdson ER

    更新日期:1996-01-01 00:00:00

  • Current issues in adjuvant treatment of stage II colon cancer.

    abstract:BACKGROUND:Adjuvant chemotherapy with 5-fluorouracil modulated by folinic acid, combined with oxaliplatin, has now become an accepted standard of care for patients with stage III colon cancer. In contrast, the use of adjuvant therapy for stage II patients remains controversial, and the identification of reliable progno...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/ASO.2006.07.003

    authors: André T,Sargent D,Tabernero J,O'Connell M,Buyse M,Sobrero A,Misset JL,Boni C,de Gramont A

    更新日期:2006-06-01 00:00:00

  • Factors predictive of nonsentinel lymph node involvement and clinical outcome in melanoma patients with metastatic sentinel lymph node.

    abstract:BACKGROUND:Identification of melanoma patients who need completion lymphadenectomy and adjuvant treatment after positive sentinel lymph node (SLN) biopsy would be a fundamental step forward toward personalized medicine. This study tested the hypothesis that the microscopic features of metastatic SLNs might predict not ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9734-8

    authors: Rossi CR,De Salvo GL,Bonandini E,Mocellin S,Foletto M,Pasquali S,Pilati P,Lise M,Nitti D,Rizzo E,Montesco MC

    更新日期:2008-04-01 00:00:00

  • Extracapsular lymph node involvement differs between squamous cell and adenocarcinoma of the esophagus.

    abstract::There is increasing evidence regarding extracapsular lymph node involvement (LNI) as a prognostic factor for recurrence and poor prognosis in gastrointestinal malignancies. The aim of this study was to assess the prevalence and prognostic impact of LNI in patients with resected esophageal cancer, comparing adenocarcin...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0248-9

    authors: Metzger R,Drebber U,Baldus SE,Mönig SP,Hölscher AH,Bollschweiler E

    更新日期:2009-02-01 00:00:00

  • The definition of optimal inguinal femoral nodal dissection in the management of vulva squamous cell carcinoma.

    abstract:OBJECTIVES:To reject the hypothesis that the number of nodes removed at time of surgical staging for vulva cancer is not an important prognostic factor. METHODS:Retrospective chart reviews were carried out from 1980-2004 to identify patients with squamous cell vulva carcinoma treated with radical vulvectomy and bilate...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9417-5

    authors: Le T,Elsugi R,Hopkins L,Faught W,Fung-Kee-Fung M

    更新日期:2007-07-01 00:00:00

  • Optimization of hyperthermic intraperitoneal chemotherapy with oxaliplatin plus irinotecan at 43 degrees C after compete cytoreductive surgery: mortality and morbidity in 106 consecutive patients.

    abstract:BACKGROUND:Peritoneal carcinomatosis (PC), which has hitherto been regarded as a lethal entity, can now be cured with surgery (treating macroscopic tumor seeding) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) (treating residual microscopic disease). The purpose of this study was to analyze the morbidi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9348-1

    authors: Elias D,Goere D,Blot F,Billard V,Pocard M,Kohneh-Shahri N,Raynard B

    更新日期:2007-06-01 00:00:00

  • Visceral obesity may affect oncologic outcome in patients with colorectal cancer.

    abstract:PURPOSE:Obesity is closely related to the development of colorectal cancer as well as other metabolic complications. We investigated the prognostic significance of visceral obesity and body mass index (BMI) in 161 resectable colorectal cancer patients. METHODS:Ratios of visceral fat area (VFA) to subcutaneous fat area...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9891-4

    authors: Moon HG,Ju YT,Jeong CY,Jung EJ,Lee YJ,Hong SC,Ha WS,Park ST,Choi SK

    更新日期:2008-07-01 00:00:00

  • Clinically-staged T3N0 rectal cancer: is preoperative chemoradiotherapy the optimal treatment?

    abstract:BACKGROUND:Preoperative chemoradiotherapy has been widely adopted as the standard of care for stage II-III rectal cancers. However, patients with T3N0 lesions had been shown to have a better prognosis than other categories of locally advanced tumor. Thus, neoadjuvant chemoradiation is likely to be overtreatment in this...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0796-7

    authors: Lombardi R,Cuicchi D,Pinto C,Di Fabio F,Iacopino B,Neri S,Tardio ML,Ceccarelli C,Lecce F,Ugolini G,Pini S,Di Tullio P,Taffurelli M,Minni F,Martoni A,Cola B

    更新日期:2010-03-01 00:00:00

  • Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management.

    abstract::Gastrointestinal stromal tumors (GIST) are rare tumors of the gastrointestinal (GI) tract that arise from primitive mesenchymal cells. GISTs occur throughout the GI tract but are usually located in the stomach and small intestine. The majority of GISTs are immunohistochemically positive for c-kit protein (CD 117) and ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10434-000-0705-6

    authors: Pidhorecky I,Cheney RT,Kraybill WG,Gibbs JF

    更新日期:2000-10-01 00:00:00

  • Relationship between pathologic T-stage and nodal metastasis after preoperative chemoradiotherapy for locally advanced rectal cancer.

    abstract:BACKGROUND:We investigated the relationship between pathologic T-stage and mesorectal metastases after preoperative chemoradiotherapy (CRT) for clinical stage II to III rectal carcinoma. METHODS:The records of consecutive patients with clinical stage II to III carcinoma of the mid or low rectum who underwent surgery a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.03.044

    authors: Pucciarelli S,Capirci C,Emanuele U,Toppan P,Friso ML,Pennelli GM,Crepaldi G,Pasetto L,Nitti D,Lise M

    更新日期:2005-02-01 00:00:00

  • Toxicity of Immune Checkpoint Inhibitors: Considerations for the Surgeon.

    abstract:BACKGROUND:The use of immunotherapeutic agents, specifically immune checkpoint inhibitors (ICIs) for solid malignancies, is rapidly rising, and many new agents and treatment combinations are in development. However, ICIs have a unique side-effect profile of immune-related adverse events (irAEs) compared with chemothera...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-019-08183-0

    authors: Helmink BA,Roland CL,Kiernan CM,Wargo JA

    更新日期:2020-05-01 00:00:00

  • Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010.

    abstract:BACKGROUND:In 2007, the National Quality Forum (NQF) released four performance measures for the treatment of breast cancer. We proposed to study the degree of adherence with these measures among participating institutions in a multi-institutional trial. METHODS:American College of Surgeons Oncology Group (ACOSOG) Z001...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0980-9

    authors: Wilke LG,Ballman KV,McCall LM,Giuliano AE,Whitworth PW,Blumencranz PW,Reintgen DS,Burak WE,Leitch AM,Hunt KK

    更新日期:2010-08-01 00:00:00

  • Open Versus Laparoscopic Adrenalectomy for Adrenocortical Carcinoma: A Meta-analysis of Surgical and Oncological Outcomes.

    abstract:PURPOSE:This study was designed to determine the role of laparoscopic adrenalectomy (LA) in the surgical management of adrenocortical carcinoma (ACC). METHODS:A systematic literature review was performed on January 2, 2015 using PubMed. Article selection proceeded according to PRISMA criteria. Studies comparing open a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-015-4900-x

    authors: Autorino R,Bove P,De Sio M,Miano R,Micali S,Cindolo L,Greco F,Nicholas J,Fiori C,Bianchi G,Kim FJ,Porpiglia F

    更新日期:2016-04-01 00:00:00

  • A comparison of clinical and pathologic assessments for the prediction of occult nipple involvement in nipple-sparing mastectomies.

    abstract:BACKGROUND:Nipple-sparing mastectomy (NSM) for both risk reduction and cancer is increasing. In the cancer setting, most studies suggest the use of both clinical and intraoperative biopsy criteria in patient selection. This study examines the use of both biopsy and clinical criteria in women undergoing total nipple-rem...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2511-3

    authors: Stolier A,Stone JC,Moroz K,Hanemann CW,McNabb L,Jones SD,Lacey M

    更新日期:2013-01-01 00:00:00

  • Role of Postmastectomy Radiotherapy After Neoadjuvant Chemotherapy in Breast Cancer Patients: A Study from the Japanese Breast Cancer Registry.

    abstract:BACKGROUND:The role of postmastectomy radiotherapy (PMRT) in breast cancer patients receiving neoadjuvant chemotherapy (NAC) is controversial. We aimed to evaluate the effectiveness of radiotherapy in patients treated with NAC and mastectomy in the Japanese Breast Cancer Registry. METHODS:We enrolled patients who rece...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07453-1

    authors: Miyashita M,Niikura N,Kumamaru H,Miyata H,Iwamoto T,Kawai M,Anan K,Hayashi N,Aogi K,Ishida T,Masuoka H,Iijima K,Masuda S,Tsugawa K,Kinoshita T,Tsuda H,Nakamura S,Tokuda Y

    更新日期:2019-08-01 00:00:00

  • As a Novel Prognostic Marker, Cysteine/histidine-rich 1 (CYHR1) is a Therapeutic Target in Patients with Esophageal Squamous Cell Carcinoma.

    abstract:BACKGROUND:Cysteine/histidine-rich 1 (CYHR1) was first discovered in a yeast two-hybrid screen with murine galectin-3, and no previous reports have described a relationship between the CYHR1 gene and human cancer. The current study evaluated the role and significance of CYHR1 in esophageal cancer. METHODS:The human es...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5031-0

    authors: Desaki R,Sawada G,Okumura H,Ikeda R,Tanabe K,Komatsu H,Mimori K,Mori M,Kita Y,Uchikado Y,Arigami T,Uenosono Y,Owaki T,Ishigami S,Natsugoe S

    更新日期:2017-02-01 00:00:00

  • Validation of a nomogram to predict the presence of sentinel lymph node metastases in melanoma.

    abstract:BACKGROUND:Lymph node involvement is a very important prognostic factor for cutaneous melanoma. In this paper we try to validate a nomogram that was created at the Memorial Sloan-Kettering Cancer Center, New York, to predict the probability of metastases in the sentinel nodes of patients with cutaneous melanoma. METHO...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0077-x

    authors: Piñero A,Canteras M,Ortiz E,Martínez-Barba E,Parrilla P

    更新日期:2008-10-01 00:00:00

  • Surgical resection versus laparoscopic radiofrequency ablation in patients with hepatocellular carcinoma and Child-Pugh class a liver cirrhosis.

    abstract:BACKGROUND:This study compared two homogeneous groups of patients submitted to either surgical resection (HR) or laparoscopic radiofrequency ablation (LRFA) for the treatment of hepatocellular carcinoma (HCC). When compatible with the liver functional reserve, HR remains the treatment of choice for HCC, while LRFA seem...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0678-z

    authors: Santambrogio R,Opocher E,Zuin M,Selmi C,Bertolini E,Costa M,Conti M,Montorsi M

    更新日期:2009-12-01 00:00:00

  • Effect of intraoperative radiocolloid injection on sentinel lymph node biopsy in patients with breast cancer.

    abstract:BACKGROUND:Preoperative injection of radiocolloid before a sentinel lymph node (SLN) biopsy is painful for patients with breast cancer. Injection after anesthesia eliminates this discomfort but allows less time for radiocolloid migration. Our goal was to validate the efficacy of intraoperative injection. METHODS:In th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0537-y

    authors: Stell VH,Flippo-Morton TS,Norton HJ,White RL Jr

    更新日期:2009-08-01 00:00:00

  • Do hospital attributes predict guideline-recommended gastric cancer care in the United States?

    abstract:BACKGROUND:Hospital attributes have been shown to impact short- and long-term outcomes after cancer surgery. However, the effect of hospital attributes on processes of cancer care in terms of delivery of guideline recommended care has not been evaluated. We examined the impact of hospital attributes (volume and type) o...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1973-z

    authors: Dudeja V,Gay G,Habermann EB,Tuttle TM,Tseng JF,Feig BW,Al-Refaie WB

    更新日期:2012-02-01 00:00:00

  • Surgical downstaging in an open-label phase II trial of denosumab in patients with giant cell tumor of bone.

    abstract:BACKGROUND:Surgical resection with curative intent for giant cell tumor of bone (GCTB) may be associated with severe morbidity. This interim analysis evaluated reduction in surgical invasiveness after denosumab treatment in patients with resectable GCTB. METHODS:Patients with primary or recurrent GCTB, for whom the in...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4634-9

    authors: Rutkowski P,Ferrari S,Grimer RJ,Stalley PD,Dijkstra SP,Pienkowski A,Vaz G,Wunder JS,Seeger LL,Feng A,Roberts ZJ,Bach BA

    更新日期:2015-09-01 00:00:00

  • Adjuvant therapy with capecitabine postpones recurrence of hepatocellular carcinoma after curative resection: a randomized controlled trial.

    abstract:BACKGROUND:Postoperative recurrence of hepatocellular carcinoma (HCC) is a major problem after surgical resection. To date, adjuvant chemotherapy or other adjuvant modalities have not been proven effective in preventing or delaying recurrence. The aim of this prospective randomized study was to evaluate the effectivene...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-010-1148-3

    authors: Xia Y,Qiu Y,Li J,Shi L,Wang K,Xi T,Shen F,Yan Z,Wu M

    更新日期:2010-12-01 00:00:00

  • Prospective evaluation of laparoscopic celiac plexus block in patients with unresectable pancreatic adenocarcinoma.

    abstract:INTRODUCTION:The efficacy of laparoscopic celiac plexus block (CPB) in patients with unresectable pancreatic cancer has not been reported. METHODS:Patients with elevated pain scores scheduled for laparoscopy for diagnosis/staging of unresectable pancreatic adenocarcinoma were eligible. The study was designed to evalua...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1372-x

    authors: Allen PJ,Chou J,Janakos M,Strong VE,Coit DG,Brennan MF

    更新日期:2011-03-01 00:00:00

  • Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma.

    abstract:PURPOSE:The risk of tumor recurrence after resection of soft tissue sarcoma (STS) necessitates surveillance in follow-up. The objective of this study was to determine the frequency/timing of metastasis and local recurrence following treatment for soft tissue sarcoma, and to use these data to justify an evidence-based f...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08240-z

    authors: Wilson DAJ,Gazendam A,Visgauss J,Perrin D,Griffin AM,Chung PW,Catton CN,Shultz D,Ferguson PC,Wunder JS

    更新日期:2020-06-01 00:00:00

  • Prognostic significance of the highest peripancreatic lymph node in biliary tract adenocarcinoma.

    abstract:BACKGROUND:Patients with biliary tract adenocarcinoma with nodal involvement have a poor prognosis. There is currently no standardized method for intraoperative lymph node assessment. The current study aimed to determine the prognostic significance of the highest peripancreatic lymph node (HPLN) in biliary tract malign...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3352-4

    authors: Kelly KJ,Dukleska K,Kuk D,Kingham TP,D'Angelica MI,DeMatteo RP,Allen PJ,Jarnagin WR,Fong Y

    更新日期:2014-03-01 00:00:00