Liver resection for colorectal metastases in presence of extrahepatic disease: results from an international multi-institutional analysis.


BACKGROUND:Hepatic resection for colorectal liver metastasis (CLM) with concomitant extrahepatic disease (EHD) is a controversial topic. We sought to evaluate the long-term outcome of patients undergoing liver resection for CLM in presence of EHD and identify factors associated with prognosis. METHODS:From 1996 to 2007, a total of 1629 patients who underwent resection of CLM were identified from an international multi-institutional database. One hundred seventy-one patients (10.4%) underwent resection of EHD. Clinicopathologic and outcome data were collected and analyzed by univariate and multivariate analyses. RESULTS:Median number of treated CLM was 2 (range, 1-18); most patients had solitary EHD (n = 114; 66.6%) a single anatomic site of EHD (n = 153; 89.4%). The 5-year survival for patients with EHD was 26% compared with 58% for those without EHD (P < 0.001). Recurrence was common (84%). Among patients with EHD, R1 margin status, multiple EHD sites, and location of EHD were associated with worse survival (all P < 0.05). Patients with multiple EHD sites or aortocaval lymph node metastasis had a 5-year survival of 14% and 7%, respectively. When survival was stratified by the total number of metastases treated, the presence of EHD still had a prognostic impact, but the relative impact of EHD diminished as the total number of metastases treated increased. CONCLUSION:Concurrent resection of hepatic and EHD in well-selected patients may provide the possibility of long-term survival. The risk of recurrence, however, remains high, and a worse outcome is associated with both number of metastases and location of EHD.


Ann Surg Oncol


Pulitanò C,Bodingbauer M,Aldrighetti L,de Jong MC,Castillo F,Schulick RD,Parks RW,Choti MA,Wigmore SJ,Gruenberger T,Pawlik TM




Has Abstract


2011-05-01 00:00:00












  • Her-2/neu gene amplification in esophageal adenocarcinoma and its influence on survival.

    abstract:BACKGROUND:HER-2/neu (c-erbB-2, HER2) gene amplification and protein overexpression have been associated with poor prognosis in several solid tumors, including breast and gastric cancer. Its incidence and significance in esophageal adenocarcinoma is unknown. MATERIALS AND METHODS:Tissue microarrays were successfully c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Thompson SK,Sullivan TR,Davies R,Ruszkiewicz AR

    更新日期:2011-07-01 00:00:00

  • CpG island methylator phenotype associated with tumor recurrence in tumor-node-metastasis stage I hepatocellular carcinoma.

    abstract:BACKGROUND:CpG island methylator phenotype (CIMP), characterized by simultaneous methylation of multiple tumor suppressor genes (TSGs), has been reported to be associated with biological malignancy in many cancers. Whether CIMP is potentially predictive of clinical outcome in hepatocellular carcinoma (HCC) remains unkn...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Li B,Liu W,Wang L,Li M,Wang J,Huang L,Huang P,Yuan Y

    更新日期:2010-07-01 00:00:00

  • Troubleshooting Sentinel Lymph Node Biopsy in Breast Cancer Surgery.

    abstract:BACKGROUND:Performing a sentinel lymph node biopsy (SLNB) is the standard of care for axillary nodal staging in patients with invasive breast cancer and clinically negative nodes. The procedure provides valuable staging information with few complications when performed by experienced surgeons. However, variation in pro...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: James TA,Coffman AR,Chagpar AB,Boughey JC,Klimberg VS,Morrow M,Giuliano AE,Harlow SP

    更新日期:2016-10-01 00:00:00

  • Does increased experience with isolated limb infusion for advanced limb melanoma influence outcome? A comparison of two treatment periods at a single institution.

    abstract:BACKGROUND:Isolated limb infusion (ILI) with cytotoxic drugs has been used since 1992 to treat advanced melanoma confined to a limb. Over this time the technique has undergone progressive modification. In this study we evaluated our experience with ILI by analyzing outcome and toxicity from an "early" and a "late" trea...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章


    authors: Huismans AM,Kroon HM,Kam PC,Thompson JF

    更新日期:2011-07-01 00:00:00

  • Sarcopenia and Comorbidity in Gastric Cancer Surgery as a Useful Combined Factor to Predict Eventual Death from Other Causes.

    abstract:BACKGROUND:Sarcopenia is recognized as an important prognostic factor in various types of cancer, including gastric cancer. While long-term survival analyses typically focus on overall and disease-specific survival, death from other causes has received far less attention. METHODS:We reviewed medical records of 491 gas...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kuwada K,Kuroda S,Kikuchi S,Yoshida R,Nishizaki M,Kagawa S,Fujiwara T

    更新日期:2018-05-01 00:00:00

  • The prognostic significance of nonsentinel lymph node metastasis in melanoma.

    abstract:BACKGROUND:We hypothesized that metastasis beyond the sentinel lymph nodes (SLN) to the nonsentinel nodes (NSN) is an important predictor of survival. MATERIALS AND METHODS:Analysis was performed of a prospective multi-institutional study that included patients with melanoma ≥ 1.0 mm in Breslow thickness. All patients...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Brown RE,Ross MI,Edwards MJ,Noyes RD,Reintgen DS,Hagendoorn LJ,Stromberg AJ,Martin RC,McMasters KM,Scoggins CR

    更新日期:2010-12-01 00:00:00

  • Serious Postoperative Complications Affect Early Recurrence After Cytoreductive Surgery and HIPEC for Colorectal Peritoneal Carcinomatosis.

    abstract:BACKGROUND:The prognosis of patients with peritoneally metastasized colorectal cancer has improved significantly with the introduction of cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). Although a macroscopically complete resection is achieved in nearly every patient, recurren...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Simkens GA,van Oudheusden TR,Luyer MD,Nienhuijs SW,Nieuwenhuijzen GA,Rutten HJ,de Hingh IH

    更新日期:2015-08-01 00:00:00

  • Oncologic Outcomes of Extended Robotic Resection for Rectal Cancer.

    abstract:BACKGROUND:Surgery for locally advanced rectal cancers beyond the plane of total mesorectal excision (TME) or extramesorectal nodal involvement should include complete resection. This study evaluated the oncologic feasibility and safety of robot-assisted surgery for rectal cancer beyond the TME plane. METHODS:The stud...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Shin US,Nancy You Y,Nguyen AT,Bednarski BK,Messick C,Maru DM,Dean EM,Nguyen ST,Hu CY,Chang GJ

    更新日期:2016-07-01 00:00:00

  • Gastric cancer: establishing predictors of biologic behavior with use of population-based data.

    abstract:BACKGROUND:Tumor thickness and nodal status are important predictors of survival following curative resection for gastric cancer. Lymphovascular invasion (LVI) is a potential predictor of biological behavior. The relationship between LVI and tumor thickness (T status) has not been established in population-based studie...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究


    authors: Dicken BJ,Saunders LD,Jhangri GS,de Gara C,Cass C,Andrews S,Hamilton SM

    更新日期:2004-06-01 00:00:00

  • A Population-Based Analysis of Three Treatment Modalities for Malignant Obstruction of the Proximal Colon: Acute Resection Versus Stent or Stoma as a Bridge to Surgery.

    abstract:BACKGROUND:Malignant obstruction of the proximal colon (MOPC) traditionally has been treated with acute resection. However, morbidity and mortality rates following these emergency surgeries are high. Initial bowel decompression by stent placement or stoma construction has been used for distal obstructions as an alterna...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Amelung FJ,Consten ECJ,Siersema PD,Tanis PJ

    更新日期:2016-10-01 00:00:00

  • Defining the Safety Profile for Performing Pancreatoduodenectomy in the Setting of Hyperbilirubinemia.

    abstract:BACKGROUND:Hyperbilirubinemia is commonly observed in patients requiring pancreatoduodenectomy (PD). Thus far, literature regarding the danger of operating in the setting of hyperbilirubinemia is equivocal. What remains undefined is at what specific level of bilirubin there is an adverse safety profile for undergoing P...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Chen B,Trudeau MT,Maggino L,Ecker BL,Keele LJ,DeMatteo RP,Drebin JA,Fraker DL,Lee MK 4th,Roses RE,Vollmer CM Jr

    更新日期:2020-05-01 00:00:00

  • The Ethics of Breast Surgery.

    abstract::Breast surgery has evolved as a subspecialty of general surgery and requires a working knowledge of benign and malignant diseases, surgical techniques, shared decision-making with patients, collaboration with a multi-disciplinary team, and a basic foundation in surgical ethics. Ethics is defined as the practice of ana...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Throckmorton A,VanderWalde L,Brackett C,Dominici L,Eisenhauer T,Johnson N,Kong A,Ludwig K,O'Neill J,Pugliese M,Teller P,Sarantou T

    更新日期:2015-10-01 00:00:00

  • Prediction of Persistent Pain Severity and Impact 12 Months After Breast Surgery Using Comprehensive Preoperative Assessment of Biopsychosocial Pain Modulators.

    abstract:BACKGROUND:Persistent post-mastectomy pain (PPMP) is a significant negative outcome occurring after breast surgery, and understanding which individual women are most at risk is essential to targeting of preventive efforts. The biopsychosocial model of pain suggests that factors from many domains may importantly modulat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Schreiber KL,Zinboonyahgoon N,Flowers KM,Hruschak V,Fields KG,Patton ME,Schwartz E,Azizoddin D,Soens M,King T,Partridge A,Pusic A,Golshan M,Edwards RR

    更新日期:2021-01-15 00:00:00

  • Prediction of recurrence and survival by post-resection CA 19-9 values in patients with adenocarcinoma of the pancreas.

    abstract:BACKGROUND:CA 19-9 levels are useful for the diagnosis of patients with pancreatic adenocarcinoma. However, interest has recently turned toward its use as a prognostic indicator. The purpose of this study is to determine whether postoperative CA 19-9 levels predict disease-free survival (DFS) and median survival (MS) i...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Montgomery RC,Hoffman JP,Riley LB,Rogatko A,Ridge JA,Eisenberg BL

    更新日期:1997-10-01 00:00:00

  • Time to Recurrence After Surgical Resection and Survival After Recurrence Among Patients with Perihilar and Distal Cholangiocarcinomas.

    abstract:BACKGROUND:The differences between perihilar cholangiocarcinoma (PHCC) and distal cholangiocarcinoma (DCC) regarding recurrence and the factors that affect recurrence after surgery are unclear. This study aims to investigate the differences in recurrence patterns between patients with PHCC and those with DCC after surg...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Nakanishi Y,Okamura K,Tsuchikawa T,Nakamura T,Noji T,Asano T,Matsui A,Tanaka K,Murakami S,Ebihara Y,Kurashima Y,Narasaki H,Amano T,Shichinohe T,Hirano S

    更新日期:2020-10-01 00:00:00

  • Hepatobiliary Disease Resection in Patients with Advanced Epithelial Ovarian Cancer: Prognostic Role and Optimal Cytoreduction.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the feasibility and safety in terms of prognostic significance and perioperative morbidity and mortality of cytoreduction in patients affected by advance ovarian cancer and hepato-biliary metastasis. METHODS:Patients with a least one hepatobiliary metastasis who have...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Di Donato V,Giannini A,D'Oria O,Schiavi MC,Di Pinto A,Fischetti M,Lecce F,Perniola G,Battaglia F,Berloco P,Muzii L,Benedetti Panici P

    更新日期:2021-01-01 00:00:00

  • Initial results with preoperative tattooing of biopsied axillary lymph nodes and correlation to sentinel lymph nodes in breast cancer patients.

    abstract:BACKGROUND:Pretreatment evaluation of axillary lymph nodes (ALNs) and marking of biopsied nodes in patients with newly diagnosed breast cancer is becoming routine practice. We sought to test tattooing of biopsied ALNs with a sterile black carbon suspension (Spot™). The intraoperative success of identifying tattooed ALN...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Choy N,Lipson J,Porter C,Ozawa M,Kieryn A,Pal S,Kao J,Trinh L,Wheeler A,Ikeda D,Jensen K,Allison K,Wapnir I

    更新日期:2015-02-01 00:00:00

  • Tooth Loss Predicts Long-Term Prognosis of Esophageal Cancer After Esophagectomy.

    abstract:BACKGROUND:Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE:The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS:This study includ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Miura S,Nakamura T,Hasegawa T,Miura Y,Takiguchi G,Urakawa N,Hasegawa H,Yamamoto M,Kanaji S,Matsuda Y,Yamashita K,Matsuda T,Oshikiri T,Suzuki S,Akashi M,Kakeji Y

    更新日期:2020-03-01 00:00:00

  • Perceptions of contralateral breast cancer: an overestimation of risk.

    abstract:INTRODUCTION:The rate of contralateral prophylactic mastectomy (CPM) has recently increased. The aim of this study is to assess perceptions of contralateral breast cancer (CBC) risk among breast cancer patients and to evaluate tumor and patient factors associated with risk perception. METHODS:We conducted a prospectiv...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Abbott A,Rueth N,Pappas-Varco S,Kuntz K,Kerr E,Tuttle T

    更新日期:2011-10-01 00:00:00

  • Robotic Lymphadenectomy During Pancreatoduodenectomy with First Superior Mesenteric Artery Dissection.

    abstract:BACKGROUND:An expert consensus meeting had defined the standard lymphadenectomy during pancreatoduodenectomy for an adenocarcinoma of the head of the pancreas. There is a controversy regarding the possibility to perform this optimal lymphadenectomy by minimally invasive approach. PATIENTS:The patient was a 68-year-old...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Memeo R,De Blasi V,Perotto O,Mutter D,Marescaux J,Pessaux P

    更新日期:2016-12-01 00:00:00

  • Outcomes of Sentinel Lymph Node-Positive Breast Cancer Patients Treated with Mastectomy Without Axillary Therapy.

    abstract:PURPOSE:Early-stage breast cancer patients with minimal axillary disease identified by sentinel lymph node dissection (SLND) have low regional recurrence rates when treated with breast-conserving surgery and radiation therapy (XRT) and many avoid a completion axillary lymph node dissection (CLND). As the incidence of t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: FitzSullivan E,Bassett RL,Kuerer HM,Mittendorf EA,Yi M,Hunt KK,Babiera GV,Caudle AS,Black DM,Bedrosian I,Reyna C,Teshome M,Meric-Bernstam F,Hwang R

    更新日期:2017-03-01 00:00:00

  • Hypomethylation of long interspersed nuclear element-1 (LINE-1) is associated with poor prognosis via activation of c-MET in hepatocellular carcinoma.

    abstract:BACKGROUND:Long interspersed nuclear element-1 (LINE-1) methylation status, representing global DNA methylation levels, is associated with patient prognosis in several types of cancer. This study was designed to examine the prognostic significance of LINE-1 methylation in patients with hepatocellular carcinoma (HCC) an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Zhu C,Utsunomiya T,Ikemoto T,Yamada S,Morine Y,Imura S,Arakawa Y,Takasu C,Ishikawa D,Imoto I,Shimada M

    更新日期:2014-12-01 00:00:00

  • The microRNA-21/PTEN pathway regulates the sensitivity of HER2-positive gastric cancer cells to trastuzumab.

    abstract:BACKGROUND:The ToGA trial demonstrated the significant efficacy of trastuzumab in addition to chemotherapy in patients with HER2-positive gastric cancer (GC). Although trastuzumab has become a key drug in breast cancer treatment, resistance to trastuzumab is a major problem in clinical practice. The aim of the current ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Eto K,Iwatsuki M,Watanabe M,Ida S,Ishimoto T,Iwagami S,Baba Y,Sakamoto Y,Miyamoto Y,Yoshida N,Baba H

    更新日期:2014-01-01 00:00:00

  • Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level.

    abstract:AIM:We evaluated preoperative serum carcinoembryonic antigen (CEA) as a prognostic factor for colorectal cancer and determined when surveillance of this marker was useful. METHODS:Serum CEA was measured preoperatively in 1,263 patients who underwent curative resection for colorectal cancer at 3-month intervals for the...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Park IJ,Choi GS,Lim KH,Kang BM,Jun SH

    更新日期:2009-11-01 00:00:00

  • A systematic review of microvascular invasion in hepatocellular carcinoma: diagnostic and prognostic variability.

    abstract::Selected patients with hepatocellular carcinoma are candidates to receive potentially curative treatments, such as hepatic resection or liver transplantation, but nevertheless there is a high risk of tumor recurrence. Microvascular invasion is a histological feature of hepatocellular carcinoma related to aggressive bi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审


    authors: Rodríguez-Perálvarez M,Luong TV,Andreana L,Meyer T,Dhillon AP,Burroughs AK

    更新日期:2013-01-01 00:00:00

  • Hypoxic single-pass isolated hepatic perfusion of hypotonic Cisplatin: safety study in the pig.

    abstract:BACKGROUND:Isolated hepatic perfusion (IHP) of chemotherapy has been proposed to deliver high doses of drug while avoiding systemic toxicity. Hypotonic cisplatin has a high in vitro activity on human colon cancer cells. We studied the safety of a 30-min hypoxic single-pass IHP with hypotonic cisplatin. METHODS:A preli...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Ortega-Deballon P,Facy O,Consolo D,Magnin G,Tixier H,Simonet M,Rat P,Chauffert B

    更新日期:2010-03-01 00:00:00

  • Long-Term Outcomes of Local Excision Following Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.

    abstract:BACKGROUND:Local excision might represent an alternative to total mesorectal excision for patients with locally advanced rectal cancer who achieve a major or complete clinical response after neoadjuvant chemoradiotherapy. METHODS:Between August 2005 and July 2011, 63 patients with mid-low rectal adenocarcinoma who had...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: D'Alimonte L,Bao QR,Spolverato G,Capelli G,Del Bianco P,Albertoni L,De Paoli A,Guerrieri M,Mantello G,Gambacorta MA,Canzonieri V,Valentini V,Coco C,Pucciarelli S

    更新日期:2020-10-30 00:00:00

  • A look into the ductoscope: its role in pathologic nipple discharge.

    abstract:OBJECTIVE:Mammary ductoscopy allows direct visualization of the ductal system and a method for directed excision and pathologic diagnosis. We reviewed our experience with mammary ductoscopy in the evaluation of pathologic nipple discharge. METHODS:We reviewed all patients who underwent ductoscopy for pathologic nipple...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Fisher CS,Margenthaler JA

    更新日期:2011-10-01 00:00:00

  • The Negative Survival Impact of Infectious Complications After Surgery is Canceled Out by the Response of Neoadjuvant Chemotherapy in Patients with Esophageal Cancer.

    abstract:BACKGROUND:This study was designed to investigate whether postoperative infectious complications (ICs) are a risk factor for the prognosis in esophageal cancer patients who receive neoadjuvant chemotherapy by stratifying the response to neoadjuvant chemotherapy. METHODS:The present study retrospectively examined patie...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Kano K,Aoyama T,Yoshikawa T,Maezawa Y,Nakajima T,Hayashi T,Yamada T,Sato T,Oshima T,Rino Y,Masuda M,Cho H,Ogata T

    更新日期:2018-07-01 00:00:00

  • Accelerated hepatic arginine transport in the tumor-bearing rat.

    abstract:BACKGROUND:Arginine plays a pivotal role in regulating ureagenesis, polyamine biosynthesis, and nitric oxide production, metabolic pathways that may be stimulated in the liver of the tumor-bearing host. Normally, plasma arginine is excluded from the hepatocyte intracellular space by the low basal activity of its membra...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章


    authors: Espat NJ,Copeland EM,Souba WW

    更新日期:1994-03-01 00:00:00