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Palpable breast cancers are inherently different from nonpalpable breast cancers.

Abstract：

BACKGROUND:We examined the clinicopathologic profile of T1 cancers to determine whether palpable cancers are different from nonpalpable cancers. METHODS:A prospective database was reviewed. Palpable T1 cancers were compared with nonpalpable T1 cancers. Initial significance was determined by chi2 analysis. Factors found to be significant were then reanalyzed. controlling for tumor size by logistic or linear regression, as appropriate. RESULTS:Of 1263 T1 cancers treated between 1981 and 2000, 857 (68%) were palpable and 401 (32%) were nonpalpable. Palpability correlated with pathologic tumor size, mitotic grade, nuclear grade, high S-phase, lymphovascular invasion, nodal positivity, and lack of extensive intraductal component, multifocality, and multicentricity. There was no significant difference in estrogen receptor, progesterone receptor or Her-2/neu status, ploidy, or DNA index. Breast cancer-specific survival was worse for patients with palpable cancers. CONCLUSIONS:Palpable cancers are inherently different from nonpalpable cancers, with a less diffuse growth pattern, higher metastatic potential, higher proliferative activity, more nuclear abnormalities, and a worse prognosis.

journal_name

Ann Surg Oncol

journal_title

Annals of surgical oncology

authors

Skinner KA,Silberman H,Sposto R,Silverstein MJ

doi

10.1007/s10434-001-0705-1

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

705-10

issue

9

eissn

1068-9265

issn

1534-4681

journal_volume

8

pub_type

杂志文章

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