Comparison Between Familial and Sporadic Non-medullary Thyroid Carcinoma: A Retrospective Individual Risk Factor-Matched Cohort Study.

Abstract:

BACKGROUND:This study aimed to compare clinicopathologic features and outcomes between patients with familial non-medullary thyroid carcinoma (FNMTC) and patients with sporadic non-medullary thyroid carcinoma (SNMTC) after performing individual risk factor-matching. Additionally, the study evaluated a dynamic risk stratification (DRS) system to validate its usefulness for familial-type thyroid carcinoma. METHODS:After individual risk factor-matching, 286 patients remained in the FNMTC group, and 858 patients were assigned to the SNMTC group consisting of papillary thyroid carcinoma (PTC). The prognostic outcomes were compared between the two groups in a matched cohort. RESULTS:During the mean follow-up period of 142 months, recurrences were experienced by 64 patients in the sporadic group (7.5%) and 29 patients in the familial group (10.1%). In the multivariate analysis, the independent risk factors for recurrence were primary tumor size (p = 0.033), gross extrathyroidal extension (p = 0.001), and lymph node metastasis (p < 0.001). The independent risk factors did not include family history alone (p = 1.101) or the number of affected family members (p = 0.122 for 2 members and p = 0.625 for ≥ 3 members). In this matched-cohort study, the DRS system was well adjusted in the FNMTC and SNMTC groups. Moreover, the proportion of DRS categories and the recurrence rate in each DRS category were similar between the familial and sporadic groups. CONCLUSIONS:Family history did not present a statistically significant association with a poor prognosis for PTC patients. With a family history of PTC alone, less aggressive treatment could be considered. In this matched cohort, DRS was adjusted well and could be useful in predicting prognosis, even for PTC patients with a family history of PTC.

journal_name

Ann Surg Oncol

authors

Lee YM,Jeon MJ,Kim WW,Chung KW,Baek JH,Shong YK,Sung TY,Hong SJ

doi

10.1245/s10434-020-09025-0

subject

Has Abstract

pub_date

2020-08-14 00:00:00

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-020-09025-0

pub_type

杂志文章
  • Staging laparoscopy for potentially resectable noncolorectal, nonneuroendocrine liver metastases.

    abstract:BACKGROUND:Carefully selected patients with noncolorectal, nonneuroendocrine (NCNN) liver metastases may benefit from hepatic resection. The incidence of occult unresectable disease and the possible benefits of staging laparoscopy in these patients are not known. METHODS:From December 1997 to July 2000, staging laparo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02557375

    authors: D'Angelica M,Jarnagin W,Dematteo R,Conlon K,Blumgart LH,Fong Y

    更新日期:2002-03-01 00:00:00

  • A modified intracorporeal billroth-I anastomosis after laparoscopic distal gastrectomy for gastric cancer: a safe and feasible technique.

    abstract:BACKGROUND:The delta-shaped gastroduodenostomy, an intracorporeal Billroth-I anastomosis after laparoscopic distal gastrectomy and using only endoscopic linear staplers, has been increasingly adopted by gastrointestinal surgeons.1 (-) 5 We modified this technique to simplify operation procedures and reduce surgical tra...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3862-8

    authors: Huang C,Lin M,Chen Q,Lin J,Zheng C,Li P,Xie J,Wang J,Lu J,Chen T,Yang X

    更新日期:2015-01-01 00:00:00

  • Radioguided parathyroidectomy in patients with familial hyperparathyroidism.

    abstract:BACKGROUND:In patients with sporadic hyperparathyroidism (HPT), radioguided parathyroidectomy (RGP) has been shown to facilitate intraoperative localization of parathyroid glands, reduced operative time, and improve patient outcomes. No studies have focused on the role of RGP in patients with familial HPT. METHODS:Bet...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9254-y

    authors: Lal A,Bianco J,Chen H

    更新日期:2007-02-01 00:00:00

  • Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches.

    abstract:BACKGROUND:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors known to affect humans and carries a dismal prognosis. Our primary aim was to review its epidemiology, biology, risk factors, and prognostic indicators. We also reviewed the individual and combined roles of surgery, radiotherapy, c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/ASO.2006.05.042

    authors: Are C,Shaha AR

    更新日期:2006-04-01 00:00:00

  • Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level.

    abstract:AIM:We evaluated preoperative serum carcinoembryonic antigen (CEA) as a prognostic factor for colorectal cancer and determined when surveillance of this marker was useful. METHODS:Serum CEA was measured preoperatively in 1,263 patients who underwent curative resection for colorectal cancer at 3-month intervals for the...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0625-z

    authors: Park IJ,Choi GS,Lim KH,Kang BM,Jun SH

    更新日期:2009-11-01 00:00:00

  • Prognostic Factors and Significance of Gastrointestinal Leak After Cytoreductive Surgery (CRS) with Heated Intraperitoneal Chemotherapy (HIPEC).

    abstract:BACKGROUND:Gastrointestinal leak (GIL) after cytoreductive surgery with heated intraperitoneal chemotherapy (CRS/HIPEC) is associated with significant morbidity and mortality. This study aimed to identify GIL prognostic factors and its impact on overall survival. METHODS:A retrospective analysis of a prospectively mai...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5738-6

    authors: Chouliaras K,Levine EA,Fino N,Shen P,Votanopoulos KI

    更新日期:2017-04-01 00:00:00

  • How to approach thyroid nodules with indeterminate cytology.

    abstract:BACKGROUND:Ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) is an accurate, reliable, and simple procedure to perform, and it is nowadays accepted as a standard diagnostic method for the differential diagnosis of thyroid nodules. However, a major limitation of US-FNAB is indeterminate cytology results at a t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0992-5

    authors: Yoon JH,Kwak JY,Kim EK,Moon HJ,Kim MJ,Kim JY,Koo HR,Kim MH

    更新日期:2010-08-01 00:00:00

  • Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients.

    abstract:BACKGROUND:Unlike other human tumors, gastric cancer remains a great therapeutic challenge since no standardized postoperative treatment exists. Knowledge of molecular pathways determining the behavior of individual gastric tumors seems to be crucial for therapeutic decisions, and evaluation of vascular endothelial gro...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9596-0

    authors: Lieto E,Ferraraccio F,Orditura M,Castellano P,Mura AL,Pinto M,Zamboli A,De Vita F,Galizia G

    更新日期:2008-01-01 00:00:00

  • Race/Ethnicity and County-Level Social Vulnerability Impact Hospice Utilization Among Patients Undergoing Cancer Surgery.

    abstract:BACKGROUND:Integration of palliative care services into the surgical treatment plan is important for holistic patient care. We sought to examine the association between patient race/ethnicity and county-level vulnerability relative to patterns of hospice utilization. PATIENTS AND METHODS:Medicare Standard Analytic Fil...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09227-6

    authors: Abbas A,Madison Hyer J,Pawlik TM

    更新日期:2020-10-14 00:00:00

  • Long-term analysis of gemcitabine-based chemoradiation after surgical resection for pancreatic adenocarcinoma.

    abstract:PURPOSE:To evaluate the efficacy in terms of local control (LC) of 24 h infusion of gemcitabine plus radiotherapy after surgery for pancreatic cancer. METHODS:Weekly gemcitabine (100 mg/m(2)) was provided as a 24-hour infusion during the course of radiotherapy (50.4 Gy to the tumor, 39.6 Gy to the nodes). Patients sub...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2767-7

    authors: Mattiucci GC,Ippolito E,D'Agostino GR,Alfieri S,Antinori A,Crucitti A,Balducci M,Deodato F,Luzi S,Macchia G,Smaniotto D,Morganti AG,Valentini V

    更新日期:2013-02-01 00:00:00

  • Prognosis and Circumferential Margin in Patients with Resected Hilar Cholangiocarcinoma.

    abstract:BACKGROUND:Resection margin status is a known prognosticator in patients who undergo resection for hilar cholangiocarcinoma. However, the influence of an isolated positive circumferential margin on clinical outcome is unclear. METHODS:Patients with resected de novo hilar cholangiocarcinoma from two European hepatobili...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09105-1

    authors: Stremitzer S,Stift J,Laengle J,Schwarz C,Kaczirek K,Jones RP,Quinn LM,Fenwick SW,Diaz-Nieto R,Poston GJ,Malik HZ

    更新日期:2020-09-10 00:00:00

  • Transduction of murine and human tumors using recombinant adenovirus vectors.

    abstract:BACKGROUND:Most cytokine-based cancer gene therapy clinical trials have used labor-intensive, retrovirus-mediated strategies resulting in unpredictable gene expression. Recombinant AdV vectors were evaluated for easier, more reproducible gene transfer into 12 human melanoma, 2 murine fibrosarcomas, and 8 other tumor ce...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02316813

    authors: Toloza EM,Hunt K,Miller AR,McBride W,Lau R,Swisher S,Rhoades K,Arthur J,Choi J,Chen L,Chang P,Chen A,Glaspy J,Economou JS

    更新日期:1997-01-01 00:00:00

  • Internal mammary lymph node drainage patterns in patients with breast cancer documented by breast lymphoscintigraphy.

    abstract:BACKGROUND:Metastases to internal mammary lymph nodes (IMN) may occur in patients with breast cancer and may alter treatment recommendations. The purpose of this study was to identify the frequency of IMN drainage in patients undergoing breast lymphoscintigraphy and sentinel lymph node dissection (SLND). METHODS:The c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-001-0234-y

    authors: Byrd DR,Dunnwald LK,Mankoff DA,Anderson BO,Moe RE,Yeung RS,Schubert EK,Eary JF

    更新日期:2001-04-01 00:00:00

  • Hemithyroidectomy: the optimal initial surgical approach for individuals undergoing surgery for a cytological diagnosis of follicular neoplasm.

    abstract:BACKGROUND:The primary objective of this study was to determine the true proportion and optimal surgical approach for individuals undergoing thyroid operation for a suspicion of cancer based on a fine-needle aspiration biopsy diagnosis of a follicular neoplasm (FN). A secondary objective of this study was to determine ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2006.03.089

    authors: Wiseman SM,Baliski C,Irvine R,Anderson D,Wilkins G,Filipenko D,Zhang H,Bugis S

    更新日期:2006-03-01 00:00:00

  • The Impact of the Affordable Care Act on North Carolinian Breast Cancer Patients Seeking Financial Support for Treatment.

    abstract:BACKGROUND:The Affordable Care Act (ACA) was instated on 23 March 2010 to improve healthcare quality, reduce costs, and increase access. The Pretty in Pink Foundation (PIPF), a non-profit 501(C)(3) organization in North Carolina, provides financial assistance and in-kind support to individuals seeking help with breast ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5311-3

    authors: Obeng-Gyasi S,Tolnitch L,Greenup RA,Shelley Hwang E

    更新日期:2016-10-01 00:00:00

  • Comparative study of surgical margins in oncoplastic surgery and quadrantectomy in breast cancer.

    abstract:BACKGROUND:Oncoplastic surgery for breast cancer is a novel concept that combines a plastic surgical procedure with breast-conserving treatment to improve the final cosmetic results. The aim of this study was to evaluate the oncological safety of oncoplastic procedures by studying the status of the surgical margins of ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.12.046

    authors: Kaur N,Petit JY,Rietjens M,Maffini F,Luini A,Gatti G,Rey PC,Urban C,De Lorenzi F

    更新日期:2005-07-01 00:00:00

  • The Impact of Intraoperative Re-Resection of a Positive Bile Duct Margin on Clinical Outcomes for Hilar Cholangiocarcinoma.

    abstract:BACKGROUND:The impact of re-resection of a positive intraoperative bile duct margin on clinical outcomes for resectable hilar cholangiocarcinoma (HCCA) remains controversial. We sought to define the impact of re-resection of an initially positive frozen-section bile duct margin on outcomes of patients undergoing surger...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6382-0

    authors: Zhang XF,Squires MH 3rd,Bagante F,Ethun CG,Salem A,Weber SM,Tran T,Poultsides G,Son AY,Hatzaras I,Jin L,Fields RC,Weiss M,Scoggins C,Martin RCG,Isom CA,Idrees K,Mogal HD,Shen P,Maithel SK,Schmidt CR,Pawlik TM

    更新日期:2018-05-01 00:00:00

  • Effectiveness of OK-432 (Sapylin) to reduce seroma formation after axillary lymphadenectomy for breast cancer.

    abstract:BACKGROUND:The occurrence of seroma formation after axillary lymphadenectomy for breast cancer cannot be ignored. Various approaches have been used in an effort to reduce it, but these results are still controversial. We aimed to describe a new method of application of OK-432 (Sapylin, heat-treated Su strain of Strepto...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-012-2728-1

    authors: Yang Y,Gao E,Liu X,Ye Z,Chen Y,Li Q,Qu J,Dai X,Wang O,Pan Y,Zhang X

    更新日期:2013-05-01 00:00:00

  • Cervicothoracoscopic Approach for Esophageal Cancer in a Patient with Right-Sided Aortic Arch.

    abstract:BACKGROUND:Esophageal cancer frequently metastasizes to lymph nodes along the recurrent laryngeal nerve (RLN),1 therefore it is essential to dissect RLN nodes for curative esophagectomy.2 Right-sided aortic arch (RAA), a rare congenital anomaly, occurs in approximately 0.1% of adults.3 Because RAA forms a vascular ring...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6355-3

    authors: Okamura A,Watanabe M,Yuda M,Shoji Y,Yamashita K,Hayami M,Imamura Y,Mine S

    更新日期:2018-05-01 00:00:00

  • Hyperthermic isolated limb perfusion with low-dose tumor necrosis factor-alpha and melphalan for bulky in-transit melanoma metastases.

    abstract:BACKGROUND:Melphalan (L-PAM) hyperthermic isolated limb perfusion (HILP) is currently considered the standard treatment for patients with in-transit metastases from cutaneous melanoma. We here report on the results of L-PAM and low-dose tumor necrosis factor (TNF)alpha HILP in patients with bulky disease. METHODS:Twen...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/aso.2004.03.019

    authors: Rossi CR,Foletto M,Mocellin S,Pilati P,Lise M

    更新日期:2004-02-01 00:00:00

  • Ratio between positive lymph nodes and total excised axillary lymph nodes as an independent prognostic factor for overall survival in patients with nonmetastatic lymph node-positive breast cancer.

    abstract:BACKGROUND:The status of the axillary lymph nodes in nonmetastatic lymph node-positive breast cancer (BC) patients remains the single most important determinant of overall survival (OS). Although the absolute number of nodes involved with cancer is important for prognosis, the role of the total number of excised nodes ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-009-0653-8

    authors: Hatoum HA,Jamali FR,El-Saghir NS,Musallam KM,Seoud M,Dimassi H,Abbas J,Khalife M,Boulos FI,Tawil AN,Geara FB,Salem Z,Shamseddine AA,Al-Feghali K,Shamseddine AI

    更新日期:2009-12-01 00:00:00

  • Sarcopenia After Resection of Early Non-small Cell Lung Cancer: Is Postoperative Skeletal Muscle Loss a Risk Factor for Poor Outcomes?

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6784-z

    authors: Takamori S,Toyokawa G

    更新日期:2018-12-01 00:00:00

  • Lymph Node Involvement Pattern and Survival Differences of FIGO IIIC and FIGO IIIA1 Ovarian Cancer Patients After Primary Complete Tumor Debulking Surgery: A 10-Year Retrospective Analysis of the Tumor Bank Ovarian Cancer Network.

    abstract:OBJECTIVE:The main goal of the current study was to compare survival differences among subgroups of primary ovarian cancer patients in International Federation of Gynecology and Obstetrics (FIGO) stages IIIC and IIIA1 after complete tumor debulking surgery. METHODS:A total of 218 patients with primary ovarian cancer w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4959-4

    authors: Gasimli K,Braicu EI,Nassir M,Richter R,Babayeva A,Chekerov R,Darb-Esfahani S,Sehouli J,Muallem MZ

    更新日期:2016-04-01 00:00:00

  • (18)F-FDG-PET/CT to select patients with peritoneal carcinomatosis for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

    abstract:BACKGROUND:Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with significantly longer survival in patients with peritoneal carcinomatosis (PC). So far, no morphological imaging method has proven to accurately assess the intra-abdominal tumor spread. This study was design...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0387-7

    authors: Pfannenberg C,Königsrainer I,Aschoff P,Oksüz MO,Zieker D,Beckert S,Symons S,Nieselt K,Glatzle J,Weyhern CV,Brücher BL,Claussen CD,Königsrainer A

    更新日期:2009-05-01 00:00:00

  • Prognostic Impact of Preoperative Nutritional Risk in Patients Who Undergo Surgery for Pancreatic Adenocarcinoma.

    abstract:BACKGROUND:Nutritional derangements are common hallmarks of pancreatic cancer (PC). Their early detection and management are usually overlooked in routine practice. This study aimed to explore preoperative nutritional status and its prognostic value in patients undergoing surgery for PC. METHODS:Data from 73 patients ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08515-5

    authors: Trestini I,Paiella S,Sandini M,Sperduti I,Elio G,Pollini T,Melisi D,Auriemma A,Soldà C,Bonaiuto C,Tregnago D,Avancini A,Secchettin E,Bonamini D,Lanza M,Pilotto S,Malleo G,Salvia R,Bovo C,Gianotti L,Bassi C,Milel

    更新日期:2020-12-01 00:00:00

  • Phase II Trial of Adjuvant Dendritic Cell Vaccine in Combination with Celecoxib, Interferon-α, and Rintatolimod in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastases.

    abstract:BACKGROUND:Peritoneal metastases portend poor prognosis in the setting of standard chemotherapy. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) improves outcomes, but relapse is common. We report a phase II trial evaluating the safety and efficacy of adjuvant αDC1 vaccination with chemo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09464-9

    authors: Ramanathan R,Choudry H,Jones H,Girgis M,Gooding W,Kalinski P,Bartlett DL

    更新日期:2021-01-05 00:00:00

  • Suitability of sentinel node mapping as an index of metastasis in early gastric cancer following endoscopic resection.

    abstract:BACKGROUND:When pathological diagnosis following endoscopic resection (ER) for early gastric cancer (EGC) suggests probable lymph node metastasis, additional surgery with lymphadenectomy should be performed. The sentinel node (SN) concept has yet to be applied to tumors following ER. The aim of this study was to evalua...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3662-1

    authors: Mayanagi S,Takeuchi H,Kamiya S,Niihara M,Nakamura R,Takahashi T,Wada N,Kawakubo H,Saikawa Y,Omori T,Nakahara T,Mukai M,Kitagawa Y

    更新日期:2014-09-01 00:00:00

  • The Ethics of Breast Surgery.

    abstract::Breast surgery has evolved as a subspecialty of general surgery and requires a working knowledge of benign and malignant diseases, surgical techniques, shared decision-making with patients, collaboration with a multi-disciplinary team, and a basic foundation in surgical ethics. Ethics is defined as the practice of ana...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-015-4751-5

    authors: Throckmorton A,VanderWalde L,Brackett C,Dominici L,Eisenhauer T,Johnson N,Kong A,Ludwig K,O'Neill J,Pugliese M,Teller P,Sarantou T

    更新日期:2015-10-01 00:00:00

  • Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer.

    abstract:BACKGROUND:The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze cl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5448-0

    authors: Kim HW,Kim JH,Lim BJ,Kim H,Kim H,Park JJ,Youn YH,Park H,Noh SH,Kim JW,Choi SH

    更新日期:2016-12-01 00:00:00

  • Conditional survival after surgical resection of gastric cancer: a multi-institutional analysis of the us gastric cancer collaborative.

    abstract:BACKGROUND:Survival estimates following surgical resection of gastric adenocarcinoma are traditionally reported as survival from the date of surgery. Conditional survival (CS) estimates, however, may be more clinically relevant by accounting for time already survived. We assessed CS following surgical resection for gas...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4116-5

    authors: Kim Y,Ejaz A,Spolverato G,Squires MH,Poultsides G,Fields RC,Bloomston M,Weber SM,Votanopoulos K,Acher AW,Jin LX,Hawkins WG,Schmidt C,Kooby D,Worhunsky D,Saunders N,Cho CS,Levine EA,Maithel SK,Pawlik TM

    更新日期:2015-02-01 00:00:00