Prognostic value of cytokeratin-positive bone marrow cells of gastric cancer patients.

Abstract:

BACKGROUND:Epithelial cells in the bone marrow of patients with gastric cancer suggest tumor dissemination; however, their prognostic implications are controversial. We prospectively evaluated the correlation of bone marrow findings, recurrence rate, and disease-free survival after long-term follow-up. METHODS:Bone marrow were aspirated from both iliac crests and stained with monoclonal cytokeratin (CK)-18 antibody in 209 patients before their initial operation. Patients were followed up for a median of 56 months. RESULTS:Overall, 39 (19%) of 209 patients and 15 (14%) of 109 R0-resected patients had CK-positive cells. CK-positive patients had more local, regional, and distant recurrence than CK-negative patients (P < .05). We found a significantly shorter disease-free survival (P < .05) in the patients with >2 CK-positive cells per 2 x 10(6) bone marrow cells (mean, 35 months) than in patients with 2 CK-positive cells per 2 x 10(6) bone marrow cells was an independent prognostic factor for tumor-related death (P < .05). CONCLUSIONS:Not only the mere presence of CK-positive epithelial cells in bone marrow, but also the cell number, correlates with prognosis. Our findings suggest that classifying CK-positive bone marrow cells in these patients will facilitate future studies.

journal_name

Ann Surg Oncol

authors

Gretschel S,Schick C,Schneider U,Estevez-Schwarz L,Bembenek A,Schlag PM

doi

10.1245/s10434-006-9039-3

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

373-80

issue

2

eissn

1068-9265

issn

1534-4681

journal_volume

14

pub_type

杂志文章
  • Management of the axilla in women with breast cancer: current clinical practice and a new selective targeted approach.

    abstract:BACKGROUND:Axillary nodal status is the most important prognostic factor for patients with breast cancer. Clinical assessment and imaging modalities are not always reliable. Surgical removal and histopathological examination of axillary lymph nodes remain essential methods of staging the axilla. However, the optimal ma...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-008-9863-8

    authors: Samphao S,Eremin JM,El-Sheemy M,Eremin O

    更新日期:2008-05-01 00:00:00

  • The association of surgical margins and local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy: a meta-analysis.

    abstract:PURPOSE:There is no consensus on what constitutes adequate negative margins in breast-conserving therapy (BCT). We systematically review the evidence on surgical margins in BCT for invasive breast cancer to support the development of clinical guidelines. METHODS:Study-level meta-analysis of studies reporting local rec...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-014-3480-5

    authors: Houssami N,Macaskill P,Marinovich ML,Morrow M

    更新日期:2014-03-01 00:00:00

  • Incidental and nonincidental papillary thyroid microcarcinoma.

    abstract:BACKGROUND:Subtotal thyroidectomy or lobectomy without radioactive iodide ((131)I) treatment is sufficient for postoperative treatment of incidental papillary thyroid microcarcinoma (PTMC). Aggressive surgical treatment with (131)I therapy is indicated for nonincidental PTMC. METHODS:This is a retrospective analysis o...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9958-2

    authors: Lin JD,Kuo SF,Chao TC,Hsueh C

    更新日期:2008-08-01 00:00:00

  • Long-term analysis of gemcitabine-based chemoradiation after surgical resection for pancreatic adenocarcinoma.

    abstract:PURPOSE:To evaluate the efficacy in terms of local control (LC) of 24 h infusion of gemcitabine plus radiotherapy after surgery for pancreatic cancer. METHODS:Weekly gemcitabine (100 mg/m(2)) was provided as a 24-hour infusion during the course of radiotherapy (50.4 Gy to the tumor, 39.6 Gy to the nodes). Patients sub...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2767-7

    authors: Mattiucci GC,Ippolito E,D'Agostino GR,Alfieri S,Antinori A,Crucitti A,Balducci M,Deodato F,Luzi S,Macchia G,Smaniotto D,Morganti AG,Valentini V

    更新日期:2013-02-01 00:00:00

  • Adnexal Involvement in Endometrial Cancer: Prognostic Factors and Implications for Ovarian Preservation.

    abstract:PURPOSE:To determine the risk factors related to adnexal involvement in endometrial cancer (EC) and its implications for ovarian preservation in young women. METHODS:We analyzed a series of 802 patients who were treated at AC Camargo Cancer Center from July 1991 to July 2017. Patients who had peritoneal or systemic di...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08261-8

    authors: Baiocchi G,Clemente AG,Mantoan H,da Costa WL Jr,Bovolim G,Guimaraes APG,da Costa AABA,De Brot L,Faloppa CC

    更新日期:2020-08-01 00:00:00

  • Stereotactic fine-needle aspiration biopsy for the evaluation of nonpalpable breast lesions: report of an experience based on 2,988 cases.

    abstract:BACKGROUND:The increasing use of mammography has led to a significant increase in the detection of clinically occult lesions, the majority of which prove to be benign. SFNB has been suggested as a means of expediting a diagnosis for lesions that are malignant while limiting surgical biopsies for those that are benign. ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02305799

    authors: Mitnick JS,Vazquez MF,Pressman PI,Harris MN,Roses DF

    更新日期:1996-03-01 00:00:00

  • Lymph node ratio: role in the staging of node-positive colon cancer.

    abstract:BACKGROUND:Recent literature has shown that lymph node ratio (LNR) is superior to the number of positive lymph nodes (pLNs) in predicting the prognosis in several malignances other than colon cancer. We hypothesize that LNR may play a similar role in stage III colon cancer. METHODS:We included 24,477 stage III colon c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9716-x

    authors: Wang J,Hassett JM,Dayton MT,Kulaylat MN

    更新日期:2008-06-01 00:00:00

  • Iliosacral resections of pelvic malignant tumors and reconstruction with nonvascular bilateral fibular autografts.

    abstract:BACKGROUND:Iliosacral resection of pelvic malignant tumors and subsequent reconstruction have tested the ingenuity of orthopedic oncologists because of the difficulty of oncological wide resection and the complex biomechanics of the sacroiliac joint render reconstruction challenging. This study compared the functional ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2339-x

    authors: Wang J,Tang Q,Xie X,Yin J,Zhao Z,Li Z,Zou C,Huang G,Shen J

    更新日期:2012-12-01 00:00:00

  • Impact of tumor grade on prognosis in pancreatic cancer: should we include grade in AJCC staging?

    abstract:BACKGROUND:AJCC staging of pancreatic cancer (PAC) is used to determine prognosis, yet survival within each stage shows wide variation and remains unpredictable. We hypothesized that tumor grade might be responsible for some of this variation and that the addition of grade to current AJCC staging would provide improved...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1071-7

    authors: Wasif N,Ko CY,Farrell J,Wainberg Z,Hines OJ,Reber H,Tomlinson JS

    更新日期:2010-09-01 00:00:00

  • Survival after resection of colorectal cancer based on anatomical segment of involvement.

    abstract:PURPOSE:To determine survival differences for patients undergoing colonic or rectal resection for cancer on the basis of the specific anatomical location of primary tumor. METHODS:A total of 143,747 patients undergoing segmental colectomy, hemicolectomy, anterior resection, or abdominoperineal resection (APER) for ade...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3104-5

    authors: Bhangu A,Kiran RP,Slesser A,Fitzgerald JE,Brown G,Tekkis P

    更新日期:2013-12-01 00:00:00

  • A contemporary large single-institution evaluation of resected retroperitoneal sarcoma.

    abstract:PURPOSE:Retroperitoneal sarcomas (RPS) are rare malignancies, comprising just 10-15 % of all soft-tissue sarcomas. These are challenging tumors to treat, with surgical resection being the only modality capable of providing a cure. This study analyzed the management and survival of patients resected at a large academic ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-014-3616-7

    authors: Bremjit PJ,Jones RL,Chai X,Kane G,Rodler ET,Loggers ET,Pollack SM,Pillarisetty VG,Mann GN

    更新日期:2014-07-01 00:00:00

  • Diagnostic performance of multidetector row computed tomography for assessment of lymph node metastasis in patients with distal rectal cancer.

    abstract:BACKGROUND:The accurate preoperative diagnosis of depth of tumor invasion and nodal status in distal rectal cancer is important because neoadjuvant chemotherapy or lateral pelvic lymph node dissection is indicated for patients with T3-T4 tumor or nodal involvement. This study aimed to determine the optimal cutoff value...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3972-3

    authors: Kobayashi H,Kikuchi A,Okazaki S,Ishiguro M,Ishikawa T,Iida S,Uetake H,Sugihara K

    更新日期:2015-01-01 00:00:00

  • Changing the Default: A Prospective Study of Reducing Discharge Opioid Prescription after Lumpectomy and Sentinel Node Biopsy.

    abstract:BACKGROUND:Whether routinely prescribed opioids are necessary for pain control after discharge among lumpectomy/sentinel node biopsy (Lump/SLNB) patients is unclear. We hypothesize that Lump/SLNB patients could be discharged without opioids, with a failure rate < 10%. This study prospectively examines outcomes after ch...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08886-9

    authors: Moo TA,Pawloski KR,Sevilimedu V,Charyn J,Simon BA,Sclafani LM,Plitas G,Barrio AV,Kirstein LJ,Van Zee KJ,Morrow M

    更新日期:2020-11-01 00:00:00

  • Is pT2 subclassification feasible to predict patient outcome in colorectal cancer?

    abstract:BACKGROUND:This study aimed to evaluate the prognostic impact of pT2 subclassification according to the depth of muscularis propria (MP) invasion and to explore the clinicopathologic factors correlated with lymph node metastasis (LNM) and postoperative hematogenous metastasis in pT2 colorectal cancer. METHODS:A total ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1440-2

    authors: Tong LL,Gao P,Wang ZN,Yue ZY,Song YX,Sun Z,Lu Y,Xing CZ,Xu HM

    更新日期:2011-05-01 00:00:00

  • Composite pelvic exenteration: is it worthwhile?

    abstract:BACKGROUND:In locally advanced pelvic cancer, tumor fixation to the bony pelvis is regarded as unresectable and often inoperable. Few data exist regarding the futility or utility of pelvic exenteration with en bloc resection of involved portions of the bony pelvis. METHODS:Thirty-four of 625 patients undergoing radica...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02524342

    authors: Lopez MJ,Luna-Pérez P

    更新日期:2004-01-01 00:00:00

  • Prognostic value of lymph node yield and metastatic lymph node ratio in medullary thyroid carcinoma.

    abstract:INTRODUCTION:Lymphadenectomy and thyroidectomy is standard treatment for medullary thyroid carcinoma (MTC), but the prognostic importance of the number of lymph nodes removed (lymph node yield, LNY) and the proportion of metastatic lymph nodes resected (metastatic lymph node ratio, MLNR) is unknown. We hypothesized tha...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0022-z

    authors: Leggett MD,Chen SL,Schneider PD,Martinez SR

    更新日期:2008-09-01 00:00:00

  • The chemokine receptors CXCR4 and CCR7 are associated with tumor size and pathologic indicators of tumor aggressiveness in papillary thyroid carcinoma.

    abstract:BACKGROUND:Functional chemokine receptors are expressed in many malignant tumors, including papillary thyroid carcinoma (PTC). These receptors promote tumor growth and metastasis in response to endogenous chemokines. The purpose of this study was to examine the expression of two chemokine receptors-CXCR4 and CCR7-in a ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0064-2

    authors: Wagner PL,Moo TA,Arora N,Liu YF,Zarnegar R,Scognamiglio T,Fahey TJ 3rd

    更新日期:2008-10-01 00:00:00

  • Nutritional support with endoluminal stenting during neoadjuvant therapy for esophageal malignancy.

    abstract:BACKGROUND:Perioperative nutrition remains a significant problem in patients undergoing neoadjuvant treatment for esophageal cancer. The aim of this study was to evaluate the effectiveness of esophageal stenting, feeding tube placement, or observation among esophageal cancer patients receiving neoadjuvant therapy. MET...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0630-2

    authors: Bower M,Jones W,Vessels B,Scoggins C,Martin R

    更新日期:2009-11-01 00:00:00

  • Uptake and patient outcomes of laparoscopic colon and rectal cancer surgery in a publicly funded system and following financial incentives.

    abstract:PURPOSE:To assess patterns of uptake and outcomes of laparoscopic colon and rectal cancer surgery in Ontario, and the potential influence of surgical fee incentives instituted on October 1, 2005. METHODS:We used Ontario administrative databases from fiscal years 2002 to 2009. Study outcomes were uptake rates of laparo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3123-2

    authors: Simunovic M,Baxter NN,Sutradhar R,Liu N,Cadeddu M,Urbach D

    更新日期:2013-11-01 00:00:00

  • Clinical Relevance of microRNA Expressions in Breast Cancer Validated Using the Cancer Genome Atlas (TCGA).

    abstract:BACKGROUND:MicroRNAs (miRNAs) play a critical role in the carcinogenesis and progression of breast cancer. MiRNA-205 has tumor suppressive properties, whereas miRNA-18a has both oncogenic and tumor suppressive roles. MiRNA-744's role in breast cancer is unknown but is tumor-suppressive in vitro. We hypothesize that hig...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5984-2

    authors: Kim SY,Kawaguchi T,Yan L,Young J,Qi Q,Takabe K

    更新日期:2017-10-01 00:00:00

  • Nomogram predicting severe adverse events after musculoskeletal tumor surgery: analysis of a national administrative database.

    abstract:BACKGROUND:There have been no nationwide surveys of postoperative adverse events (AEs) after musculoskeletal tumor surgery focusing on their severity. Therefore, we developed a nomogram to predict severe AEs after musculoskeletal tumor surgery. METHODS:We identified patients in the Diagnosis Procedure Combination data...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3760-0

    authors: Ogura K,Yasunaga H,Horiguchi H,Fushimi K,Tanaka S,Kawano H

    更新日期:2014-10-01 00:00:00

  • Modified Appleby Procedure, Distal Splenopancreatectomy with Celiac Axis Resection.

    abstract:BACKGROUND:Modified Appleby procedure could be indicated in stage III locally advanced body pancreatic ductal adenocarcinoma (PDAC) involving the celiac axis after neoadjuvant treatment. PATIENTS AND METHODS:We report the case of a 38-year-old woman presenting a tumor arising from the body of the pancreas, involving t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09212-z

    authors: Triki H,Bergeat D,Bougard M,Robin F,Sulpice L

    更新日期:2020-10-21 00:00:00

  • Intraoperative Margin Management in Breast-Conserving Surgery: A Systematic Review of the Literature.

    abstract:BACKGROUND:Breast surgeons have a wide variety of intraoperative techniques available to help achieve low rates for positive margins of excision, with variable levels of evidence. METHODS:A systematic review of the medical literature from 1995 to July 2016 was conducted, with 434 abstracts identified and evaluated. Th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-016-5756-4

    authors: Gray RJ,Pockaj BA,Garvey E,Blair S

    更新日期:2018-01-01 00:00:00

  • Management of Dysphagia in Esophageal Adenocarcinoma Patients Undergoing Neoadjuvant Chemotherapy: Can Invasive Tube Feeding be Avoided?

    abstract:BACKGROUND:Neoadjuvant chemotherapy is an accepted standard for locally advanced esophagogastric junction adenocarcinoma. However, the dysphagia frequently associated with this condition may interfere with patient tolerance of this treatment. In many centers, invasive tube feeding, placed either endoscopically, radiogr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4270-9

    authors: Cools-Lartigue J,Jones D,Spicer J,Zourikian T,Rousseau M,Eckert E,Alcindor T,Vanhuyse M,Asselah J,Ferri LE

    更新日期:2015-01-01 00:00:00

  • Epidermal growth factor-containing fibulin-like extracellular matrix protein 1, EFEMP1, a novel tumor-suppressor gene detected in hepatocellular carcinoma using double combination array analysis.

    abstract:BACKGROUND:Although hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, the underlying molecular mechanisms contributing to hepatocarcinogenesis are still not clear. METHODS:In this study, we performed double array analysis, consisting of both expression profiling and karyotyping analysis using s...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0790-0

    authors: Nomoto S,Kanda M,Okamura Y,Nishikawa Y,Qiyong L,Fujii T,Sugimoto H,Takeda S,Nakao A

    更新日期:2010-03-01 00:00:00

  • Meta-analysis of the clamp-crushing technique for transection of the parenchyma in elective hepatic resection: back to where we started?

    abstract:BACKGROUND:After introduction of the clamp-crushing technique in the 1970s, various devices have been developed for transection of the liver with the aim of further reducing blood loss and improving the outcome of patients who undergo hepatic resection. We performed a meta-analysis to quantitatively compare the clamp-c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-008-0266-7

    authors: Rahbari NN,Koch M,Schmidt T,Motschall E,Bruckner T,Weidmann K,Mehrabi A,Büchler MW,Weitz J

    更新日期:2009-03-01 00:00:00

  • Breast cancer screening at the Breast Examination Center of Harlem.

    abstract:BACKGROUND:This study was designed to describe patient, disease, and treatment characteristics of women diagnosed with breast cancer at the Breast Examination Center of Harlem (BECH) and to determine whether these characteristics have changed over time. METHODS:Retrospective chart review of women diagnosed with breast...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4240-2

    authors: Manning AT,Eaton A,Azu M,Sampson M,Patil S,Godfrey D,Beesen AA,Liberman L,Gemignani ML

    更新日期:2015-01-01 00:00:00

  • A Population-Based Analysis of Three Treatment Modalities for Malignant Obstruction of the Proximal Colon: Acute Resection Versus Stent or Stoma as a Bridge to Surgery.

    abstract:BACKGROUND:Malignant obstruction of the proximal colon (MOPC) traditionally has been treated with acute resection. However, morbidity and mortality rates following these emergency surgeries are high. Initial bowel decompression by stent placement or stoma construction has been used for distal obstructions as an alterna...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5247-7

    authors: Amelung FJ,Consten ECJ,Siersema PD,Tanis PJ

    更新日期:2016-10-01 00:00:00

  • Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas.

    abstract:BACKGROUND:Small bowel adenocarcinoma is a relatively rare cancer, often diagnosed in an advanced stage. In localized and resectable disease, surgery alone or in combination with adjuvant chemotherapy is the mainstay of treatment. In the recently published National Comprehensive Cancer Network Clinical Practice guideli...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08926-4

    authors: Vanoli A,Grillo F,Guerini C,Neri G,Arpa G,Klersy C,Nesi G,Giuffrida P,Sampietro G,Ardizzone S,Fociani P,Fiocca R,Latella G,Sessa F,D'Errico A,Malvi D,Mescoli C,Rugge M,Ferrero S,Poggioli G,Rizzello F,Macciomei M

    更新日期:2021-02-01 00:00:00

  • Selecting the Right Tumors for Genomic Testing.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 社论

    doi:10.1245/s10434-018-7036-y

    authors: Euhus DM

    更新日期:2019-02-01 00:00:00