Abstract:
BACKGROUND:Inadequately treated multifocal and multicentric disease results in increased local recurrence following breast-conserving surgery. The accurate preoperative diagnosis of multifocal/ centric breast cancer would facilitate the planning of appropriate surgery and prevent reoperation for residual disease. While triple assessment remains the established diagnostic technique, its sensitivity for the diagnosis of multifocal disease remains poor. Dynamic contrast enhanced Magnetic Resonance Imaging (DCE-MRI) of the breast represents an alternative emerging diagnostic modality that has been shown to be highly sensitive for the delineation of primary breast cancer. The aim of this study was to prospectively compare the diagnostic accuracy of DCE-MRI of the breast with conventional triple assessment for the preoperative diagnosis of multifocal/centric breast cancer. METHODS:Patients were recruited from the symptomatic breast clinics. All patients underwent standard triple assessment and DCE-MRI. The MRI scans were reported by a single radiologist blinded to the results of the triple assessment. Surgery was then planned accordingly to all available scan results and the specimens examined by a single pathologist. All patients who did not undergo surgery have been followed up for a minimum of 18 months. RESULTS:A total of 334 women were recruited. There were 178 (52%) cancers that were histologically confirmed and multifocal/centric breast cancer was diagnosed provisionally by the preoperative investigations in 68 (38%); multifocal n = 33, multicentric n = 35, of these patients. In this group, subsequent histology confirmed multifocal/centric disease in 50 (73.5%): multifocal n = 15, multicentric n = 35. Unifocal cancer was found in 15 (22%) and benign disease in 3 (4.4%). The resultant sensitivity, specificity, positive, and negative predictive values were 18%, 100%, 100%, and 76% for triple assessment and 100%, 86%, 73%, and 100% for DCE-MRI. CONCLUSION:DCE-MRI identified a subgroup of breast cancer patients with multifocal/centric disease not evident on standard triple assessment. MRI of the breast should be considered for the preoperative planning of surgery for primary breast cancer.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Drew PJ,Chatterjee S,Turnbull LW,Read J,Carleton PJ,Fox JN,Monson JR,Kerin MJdoi
10.1007/s10434-999-0599-xkeywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
599-603issue
6eissn
1068-9265issn
1534-4681journal_volume
6pub_type
杂志文章abstract:BACKGROUND:The role of postmastectomy radiotherapy (PMRT) in breast cancer patients receiving neoadjuvant chemotherapy (NAC) is controversial. We aimed to evaluate the effectiveness of radiotherapy in patients treated with NAC and mastectomy in the Japanese Breast Cancer Registry. METHODS:We enrolled patients who rece...
journal_title:Annals of surgical oncology
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abstract:: ...
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更新日期:2018-10-01 00:00:00
abstract:: ...
journal_title:Annals of surgical oncology
pub_type: 评论,杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Annals of surgical oncology
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更新日期:2014-12-01 00:00:00
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更新日期:2008-01-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 评论,杂志文章
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-12-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-018-07107-8
更新日期:2019-02-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02306611
更新日期:1997-04-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1007/BF02303525
更新日期:1994-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2012-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00