MSH2 rs2303425 Polymorphism is Associated with Early-Onset Breast Cancer in Taiwan.

Abstract:

BACKGROUND:Accumulated evidence indicates that the incidence of early-onset breast cancer has rapidly increased in Taiwan and other Asian compared to Western countries. The mismatch repair (MMR) pathway might be one of the crucial mechanisms of predisposition to early breast cancer. In this study, we explored whether MMR gene polymorphisms contribute to the risk of breast cancer in young women. METHODS:This was a 2-stage case-control study including 737 cases and 719 controls. After eight single nucleotide polymorphisms (SNPs) were genotyped in MMR pathway genes in the stage I study, a promising SNP, MSH2 rs2303425, was selected for validation in the stage II study. A luciferase reporter assay was used to evaluate the transcriptional activity of MSH2. RESULTS:Logistic regression analysis showed that individuals with the MSH2 rs2303425 C/C genotype had a significantly increased risk of breast cancer compared to those with the T/T genotype (adjusted odds ratio 2.0; 95 % confidence interval 1.1-3.8), particularly in early-onset breast cancer patients with the luminal A subtype. The luciferase assay in three cell lines indicated that the MSH2 rs2303425 T/C substitution decreased MSH2 expression, which is consistent with the finding of an association study. CONCLUSIONS:A common variant SNP in MSH2 may contribute to the susceptibility to early-onset breast cancer functionally, particularly for the luminal A subtype.

journal_name

Ann Surg Oncol

authors

Hsieh YC,Cho EC,Tu SH,Wu CH,Hung CS,Hsieh MC,Su CT,Liu YR,Lee CH,Ho YS,Chiou HY

doi

10.1245/s10434-016-5168-5

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

603-610

issue

2

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-016-5168-5

journal_volume

24

pub_type

杂志文章
  • Workload Differentiates Breast Surgical Procedures: NSM Associated with Higher Workload Demand than SSM.

    abstract:BACKGROUND:Breast surgery has evolved with more focus on improving cosmetic outcomes, which requires increased operative time and technical complexity. Implications of these technical advances in surgery for the surgeon are unclear, but they may increase intraoperative demands, both mentally and physically. We prospect...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08159-0

    authors: Hallbeck MS,Law KE,Lowndes BR,Linden AR,Morrow M,Blocker RC,Cain SM,Degnim AC,Hieken TJ,Jakub JW,Racz JM,Farley DR,Nelson H,Boughey JC

    更新日期:2020-05-01 00:00:00

  • The Landmark Series: Minimally Invasive Surgery for Cervical Cancer.

    abstract::Cervical cancer incidence and mortality have declined in developed countries during the past few decades as a result of screening programs and vaccination. However, it remains a significant cause of cancer-related mortality in young women. Early-stage cervical cancer, defined as disease limited to the cervix, has trad...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09265-0

    authors: Basaran D,Leitao MM Jr

    更新日期:2021-01-01 00:00:00

  • Reappraisal of conventional risk stratification for local recurrence based on clinical outcomes in 285 resected phyllodes tumors of the breast.

    abstract:PURPOSE:To ensure a surgical margin of ≥1 cm for the effective treatment of phyllodes tumors of the breast (PTB) a second resection has been recommended, but the outcomes of an extensive series of cases employing the aforementioned criterion cast doubt on this clinical approach. The aim of this study was to identify th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4395-5

    authors: Yom CK,Han W,Kim SW,Park SY,Park IA,Noh DY

    更新日期:2015-09-01 00:00:00

  • Treatment trends and factors associated with survival in T1aN0 and T1bN0 breast cancer patients.

    abstract:BACKGROUND:Breast conservation therapy (BCT) and adjuvant hormonal therapy for estrogen-receptor positive breast cancers have become standard of care. Our objectives were to evaluate trends in the surgical management and adjuvant therapy for early-stage breast cancer and to identify factors predicting survival. METHOD...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9441-5

    authors: Kennedy T,Stewart AK,Bilimoria KY,Patel-Parekh L,Sener SF,Winchester DP

    更新日期:2007-10-01 00:00:00

  • ASO Author Reflections: Health Disparities in Pancreatic Cancer.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6961-0

    authors: Lutfi W,Hogg ME

    更新日期:2018-12-01 00:00:00

  • LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer.

    abstract:BACKGROUND:Liver kinase B1 (LKB1) loss by gene mutation, loss of heterozygosity, and promoter methylation rarely occurs in colorectal cancer. We wondered whether LKB1 loss could be deregulated at the transcriptional level to promote tumor progression and poor outcome in colorectal cancer. METHODS:Mechanistic studies w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3824-1

    authors: He TY,Tsai LH,Huang CC,Chou MC,Lee H

    更新日期:2014-12-01 00:00:00

  • Characterization of the neoplastic potential of solitary solid thyroid lesions with Tc-99m-pertechnetate and Tc-99m-sestamibi scanning.

    abstract:BACKGROUND:Radionuclide scans that use Tc-99m-pertechnetate or I-123 currently lack the specificity to assess the malignant potential of solitary solid lesions of the thyroid gland. Tc-99m-sestamibi scanning was used to determine the neoplastic potential of thyroid lesions. METHODS:Patients with lesions of the thyroid...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02307029

    authors: Wei JP,Burke GJ

    更新日期:1995-05-01 00:00:00

  • Sarcopenia After Resection of Early Non-small Cell Lung Cancer: Is Postoperative Skeletal Muscle Loss a Risk Factor for Poor Outcomes?

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6784-z

    authors: Takamori S,Toyokawa G

    更新日期:2018-12-01 00:00:00

  • Simultaneous indocyanine green and (99m)Tc-antimony sulfur colloid-guided laparoscopic sentinel basin dissection for gastric cancer.

    abstract:BACKGROUND:There are few reports on a dual dye and isotope approach using laparoscopy in gastric cancer sentinel node mapping. The aim of this study is to evaluate the feasibility of laparoscopic sentinel basin dissection for gastric cancer using simultaneous indocyanine green (ICG) and (99m)Tc-antimony sulfur colloid ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1221-y

    authors: Park DJ,Kim HH,Park YS,Lee HS,Lee WW,Lee HJ,Yang HK

    更新日期:2011-01-01 00:00:00

  • Survival data justifies resection for pancreatic metastases.

    abstract:BACKGROUND:Pancreatic metastases are uncommon and little is known about the oncologic outcome after resection or prognostic parameters. This study was designed to evaluate perioperative and follow-up results after resection for pancreatic metastases and to define prognostic factors. METHODS:From a prospective database...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0682-3

    authors: Strobel O,Hackert T,Hartwig W,Bergmann F,Hinz U,Wente MN,Fritz S,Schneider L,Büchler MW,Werner J

    更新日期:2009-12-01 00:00:00

  • Hiatal Hernia After Open versus Minimally Invasive Esophagectomy: A Systematic Review and Meta-analysis.

    abstract::Hiatal hernia (HH) is an infrequent yet potentially life-threatening complication after esophagectomy. Several studies have reported the incidence of this complication after both open and minimally invasive esophagectomy (MIE). This meta-analysis aimed to determine the pooled incidence of HH after both types of esopha...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1245/s10434-016-5155-x

    authors: Oor JE,Wiezer MJ,Hazebroek EJ

    更新日期:2016-08-01 00:00:00

  • Follow-Up Recommendations after Diagnosis of Primary Cutaneous Melanoma: A Population-Based Study in New South Wales, Australia.

    abstract:BACKGROUND:Follow-up practices after diagnosis and treatment of primary cutaneous melanoma vary considerably. We aimed to determine factors associated with recommendations for follow-up setting, frequency, skin surveillance, and concordance with clinical guidelines. METHODS:The population-based Melanoma Patterns of Ca...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6319-z

    authors: Read RL,Madronio CM,Cust AE,Goumas C,Watts CG,Menzies S,Curtin AM,Mann G,Thompson JF,Morton RL

    更新日期:2018-03-01 00:00:00

  • The immunological impact of neoadjuvant chemotherapy on the tumor microenvironment of esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Esophageal cancer is an aggressive cancer with poor prognosis. However, little is known about the immune response in the tumor microenvironment after neoadjuvant chemotherapy. PURPOSE:To investigate the immunological impact of neoadjuvant chemotherapy in the tumor microenvironment of esophageal squamous cel...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1906-x

    authors: Tsuchikawa T,Miyamoto M,Yamamura Y,Shichinohe T,Hirano S,Kondo S

    更新日期:2012-05-01 00:00:00

  • Cellular immunity delimits adenoviral gene therapy strategies for the treatment of neoplastic diseases.

    abstract:BACKGROUND:Adenoviral gene therapy is a promising new approach for the treatment of neoplastic diseases. To design rational clinical trials and distinguish the effects of therapeutic transgene expression from those caused by viral infection alone, the immune response to the vector must be understood. In these experimen...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-999-0088-2

    authors: DeMatteo RP,Yeh H,Friscia M,Caparrelli D,Burke C,Desai N,Chu G,Markmann JF,Raper SE,Barker CF

    更新日期:1999-01-01 00:00:00

  • ASO Author Reflections: Incorporating Lymphovascular Invasion to Improve the Prognostic Reliability of the T-Staging System for Adrenocortical Carcinoma-A Multicenter Study.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6876-9

    authors: Poorman CE,Ethun CG,Maithel SK

    更新日期:2018-12-01 00:00:00

  • Determining the association between preoperative computed tomography findings and postoperative outcomes after cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei.

    abstract:BACKGROUND:This study evaluates the accuracy of computed tomography (CT) scoring of the peritoneal cancer index (PCI) and examines its association with surgical morbidity and outcomes in pseudomyxoma peritonei. METHODS:Forty-seven patients with pseudomyxoma peritonei had preoperative evaluation of CT scans and were tr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1492-3

    authors: Chua TC,Al-Zahrani A,Saxena A,Glenn D,Liauw W,Zhao J,Morris DL

    更新日期:2011-06-01 00:00:00

  • The chemokine receptors CXCR4 and CCR7 are associated with tumor size and pathologic indicators of tumor aggressiveness in papillary thyroid carcinoma.

    abstract:BACKGROUND:Functional chemokine receptors are expressed in many malignant tumors, including papillary thyroid carcinoma (PTC). These receptors promote tumor growth and metastasis in response to endogenous chemokines. The purpose of this study was to examine the expression of two chemokine receptors-CXCR4 and CCR7-in a ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0064-2

    authors: Wagner PL,Moo TA,Arora N,Liu YF,Zarnegar R,Scognamiglio T,Fahey TJ 3rd

    更新日期:2008-10-01 00:00:00

  • Sentinel Lymph Node Mapping of Liver.

    abstract:BACKGROUND:Although the sentinel lymph node (SLN) hypothesis has been applied to many tissues and organs, liver has remained unstudied. Currently, it is unclear whether hepatic SLNs even exist. If so, they could alter the management of intrahepatic cholangiocarcinoma and other hepatic malignancies by minimizing the ext...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4601-5

    authors: Wada H,Hyun H,Vargas C,Genega EM,Gravier J,Gioux S,Frangioni JV,Choi HS

    更新日期:2015-12-01 00:00:00

  • Laparoscopic bowel resection in the setting of metastatic colorectal cancer.

    abstract:BACKGROUND:This study aimed to review the outcomes of laparoscopic colorectal resection for patients with stage IV colorectal cancer. METHODS:From the prospectively collected database for patients who underwent surgery for colorectal cancer in our institution, those with stage IV colorectal cancer who underwent electi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9820-6

    authors: Law WL,Fan JK,Poon JT,Choi H,Lo OS

    更新日期:2008-05-01 00:00:00

  • Parietal peritonectomy.

    abstract::Parietal peritonectomy is an initial part of cytoreductive surgery in patients with peritoneal surface malignancy. After this dissection, the necessary visceral resections, other peritonectomy procedures, and perioperative hyperthermic chemotherapy are administered. The parietal peritoneum is an immobile portion of th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2229-2

    authors: Sugarbaker PH

    更新日期:2012-04-01 00:00:00

  • Adverse outcomes associated with noncompliance with melanoma treatment guidelines.

    abstract:BACKGROUND:Clinical practice guidelines have been developed to improve melanoma patient care. However, it is unclear whether failure to comply with these standards (either excessive or inadequate treatment) increases morbidity or relapse rates. Therefore, we undertook this study to evaluate the effect of variance from ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0021-0

    authors: Erickson Foster J,Velasco JM,Hieken TJ

    更新日期:2008-09-01 00:00:00

  • How to approach thyroid nodules with indeterminate cytology.

    abstract:BACKGROUND:Ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) is an accurate, reliable, and simple procedure to perform, and it is nowadays accepted as a standard diagnostic method for the differential diagnosis of thyroid nodules. However, a major limitation of US-FNAB is indeterminate cytology results at a t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0992-5

    authors: Yoon JH,Kwak JY,Kim EK,Moon HJ,Kim MJ,Kim JY,Koo HR,Kim MH

    更新日期:2010-08-01 00:00:00

  • Selecting the Right Tumors for Genomic Testing.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 社论

    doi:10.1245/s10434-018-7036-y

    authors: Euhus DM

    更新日期:2019-02-01 00:00:00

  • Prognostic value of renin-angiotensin system blockade in non-muscle-invasive bladder cancer.

    abstract:BACKGROUND:To determine whether the administration of renin-angiotensin system (RAS) inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), affect disease outcome in non-muscle-invasive bladder cancer (NMIBC). METHODS:A total of 330 patients with initially diag...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2568-z

    authors: Yuge K,Miyajima A,Tanaka N,Shirotake S,Kosaka T,Kikuchi E,Oya M

    更新日期:2012-11-01 00:00:00

  • Laparoscopic versus open surgery for rectal cancer: a meta-analysis.

    abstract:BACKGROUND:Laparoscopic rectal cancer surgery aims to provide patients with curative resection while minimizing postoperative morbidity and mortality. This study used meta-analytical techniques to compare laparoscopic and open surgery as the primary treatment for patients with rectal cancer with regard to short-term an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/ASO.2006.05.045

    authors: Aziz O,Constantinides V,Tekkis PP,Athanasiou T,Purkayastha S,Paraskeva P,Darzi AW,Heriot AG

    更新日期:2006-03-01 00:00:00

  • Preoperative needle biopsy as a potential quality measure in breast cancer surgery.

    abstract::Preoperative needle diagnosis (PND) is being considered as a quality measure in breast cancer surgery. This criterion has not been thoroughly evaluated in the literature. The purpose of this study is to assess ease of access to these data and rate of compliance in a tertiary care center. We retrospectively reviewed al...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0188-4

    authors: Pocock B,Taback B,Klein L,Joseph KA,El-Tamer M

    更新日期:2009-05-01 00:00:00

  • Staging studies for cutaneous melanoma in the United States: a population-based analysis.

    abstract:BACKGROUND:Routine cross-sectional imaging for staging of early-stage cutaneous melanoma is not recommended. This study sought to investigate the use of imaging for staging of cutaneous melanoma in the United States. METHODS:Patients with nonmetastatic cutaneous melanoma newly diagnosed between 2000 and 2007 were iden...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4268-3

    authors: Wasif N,Etzioni D,Haddad D,Gray RJ,Bagaria SP,Pockaj BA

    更新日期:2015-04-01 00:00:00

  • Outcomes of Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation Via Multicatheter Interstitial Brachytherapy: The Pooled Registry of Multicatheter Interstitial Sites (PROMIS) Experience.

    abstract:PURPOSE:To report outcomes for breast-conserving therapy using adjuvant accelerated partial breast irradiation with interstitial multicatheter brachytherapy by a cooperative group of institutions. METHODS:From 1992 to 2013, a total of 1356 patients were treated with breast-conserving surgery and adjuvant accelerated p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4563-7

    authors: Kamrava M,Kuske RR,Anderson B,Chen P,Hayes J,Quiet C,Wang PC,Veruttipong D,Snyder M,Jeffrey Demanes D

    更新日期:2015-12-01 00:00:00

  • Long-term follow-up study of a prospective multicenter sentinel node trial: molecular detection of breast cancer sentinel node metastases.

    abstract:BACKGROUND:This prospective multicenter sentinel lymph node (SLN) trial investigated whether molecular analysis would improve the detection of SLN metastases and their prognostic value. We report mammaglobin quantitative real-time polymerase chain reaction (qRT-PCR) results and clinical outcome for 547 patients (mean f...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-010-1262-2

    authors: Verbanac KM,Min CJ,Mannie AE,Lu J,O'Brien KF,Rosman M,Tafra L,ECU\/AAMC Sentinel Node Study Group.

    更新日期:2010-10-01 00:00:00

  • Racial disparities in esophageal cancer outcomes.

    abstract:BACKGROUND:Racial disparities in outcomes have been documented among patients with esophageal cancer. The purpose of this study is to identify mechanisms for ethnicity/race-related differences in the use of cancer-directed surgery and mortality. METHODS:Data from the Surveillance, Epidemiology and End Results (SEER) p...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2807-3

    authors: Revels SL,Morris AM,Reddy RM,Akateh C,Wong SL

    更新日期:2013-04-01 00:00:00