Abstract：
PURPOSE:The aim of this review was to examine the incidence of nipple-areola complex (NAC) involvement, the rates of NAC recurrence, and the data regarding the role of radiation therapy (RT) following nipple-sparing mastectomy (NSM). METHODS:A literature review was performed using the PubMed search engine, with articles selected based on standardized criteria. Additional articles included those known to the authors and those obtained by review of references from key studies. RESULTS:The reported incidence of NAC involvement ranges from 0 to 58 %. The most commonly associated factors with NAC involvement include tumor-to-NAC distance, tumor size, central location of the primary tumor, multicentricity/multifocality, and positive axillary lymph nodes. Following NSM, in the setting of proper patient selection, rates of NAC recurrence are generally low, with the majority of studies reporting rates ranging from 0 to 4 %. There is a paucity of data evaluating the role of RT after NSM and a lack of level I evidence, with the largest series documenting low rates of local recurrence with RT but failing to provide a control arm without radiotherapy. CONCLUSIONS:Optimal preoperative patient selection for NSM and intraoperative assessment of the NAC result in acceptably low rates of NAC involvement/recurrence. NSM alone is not adequate justification for post-mastectomy radiation. NSM should be taken into consideration to inform radiation decision making only when preoperative imaging, clinical features, or pathologic findings suggest higher risk for NAC involvement.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Gomez C,Shah C,McCloskey S,Foster N,Vicini Fdoi
10.1245/s10434-013-3446-zsubject
Has Abstractpub_date
2014-07-01 00:00:00pages
2237-44issue
7eissn
1068-9265issn
1534-4681journal_volume
21pub_type
杂志文章,评审abstract：BACKGROUND:This study aimed to review the outcomes of laparoscopic colorectal resection for patients with stage IV colorectal cancer. METHODS:From the prospectively collected database for patients who underwent surgery for colorectal cancer in our institution, those with stage IV colorectal cancer who underwent electi...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-008-9820-6
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Cryotherapy is a method of in situ destruction of tumors by freeze/thaw mechanisms. Cancer cells located in the peripheral zone of the tumor undergoing cryotherapy can die by apoptosis. We hypothesized that p21WAF1 is involved in the mediation of cryotherapy-induced apoptosis. METHODS:HT29 cells grown on a ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/ASO.2005.11.021
更新日期：2005-09-01 00:00:00
abstract：PURPOSE:To determine the risk factors related to adnexal involvement in endometrial cancer (EC) and its implications for ovarian preservation in young women. METHODS:We analyzed a series of 802 patients who were treated at AC Camargo Cancer Center from July 1991 to July 2017. Patients who had peritoneal or systemic di...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-08261-8
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:In cutaneous melanoma (CM), the present methods of lymph node (LN) staging have not sufficiently utilized the prognostic information of metastatic LNs. In this study, we aimed to construct prognostic nomograms based on the number of positive LNs (PLNs) and other clinicopathologic characteristics of CM patien...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-09556-6
更新日期：2021-01-11 00:00:00
abstract：BACKGROUND:In past decade, the treatment of gastric adenocarcinoma has evolved as a result of the publication of two seminal randomized controlled trials. We aimed to examine treatment trends for resectable gastric cancer (stage I-III) using the National Cancer Data Base (NCDB). Our hypothesis was that the use of chemo...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-3314-x
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:As increased focus is placed on quality of care in surgery, readmission is an increasingly important metric by which hospital and surgeon quality is measured. For complex pancreatic surgery, we hypothesized that increased pancreaticoduodenectomy (PD) volume may mitigate readmission rates. METHODS:The Univer...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-4451-1
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Extracapsular invasion (ECI) of metastatic axillary lymph nodes has been associated with aggressive nodal disease but its prognostic role in breast cancer is unclear. The present study evaluated nodal ECI as a predictor of breast cancer recurrence. METHODS:We evaluated 154 women with histologically proven n...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-3941-x
更新日期：2015-01-01 00:00:00
abstract：:Breast surgery has evolved as a subspecialty of general surgery and requires a working knowledge of benign and malignant diseases, surgical techniques, shared decision-making with patients, collaboration with a multi-disciplinary team, and a basic foundation in surgical ethics. Ethics is defined as the practice of ana...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,评审
doi：10.1245/s10434-015-4751-5
更新日期：2015-10-01 00:00:00
abstract：:Tumors treated with preoperative chemotherapy or radiation often demonstrate evidence of response in the resection specimen. Pathologic response is often interpreted as a surrogate for recurrence or survival outcomes. With a valid surrogate for long-term outcomes, investigators can explore treatment strategies with im...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,评审
doi：10.1245/s10434-009-0374-z
更新日期：2009-06-01 00:00:00
abstract：:The purpose of this study was to determine the outcome of surgery for patients with recurrent gastric or gastroesophageal cancer. We queried records from 7,459 patients who presented with gastric or gastroesophageal cancer to our institution from 1973 through 2005 to identify those for whom resection of recurrent dise...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-008-0210-x
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the incidence of microsatellite instability in a series of prim...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02303580
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND:The impact of re-resection of a positive intraoperative bile duct margin on clinical outcomes for resectable hilar cholangiocarcinoma (HCCA) remains controversial. We sought to define the impact of re-resection of an initially positive frozen-section bile duct margin on outcomes of patients undergoing surger...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-6382-0
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:In this study, we report on the changes in psychosocial functioning over 1 year following breast cancer surgery in 3 groups of women, including those with mastectomy alone, those with mastectomy and immediate reconstruction, and those with delayed reconstruction. METHODS:Women with breast cancer at 2 teachi...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,多中心研究
doi：10.1245/s10434-011-1828-7
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Controversy over the need for sentinel node biopsy (SNB) continues to exist for the optimal treatment of breast cancer in patients ≥ 70 years of age, especially in those with lower-risk disease. Clinicians must balance competing risks to give the best individualized care. METHODS:The American Society of B...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-6617-0
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:With cholangiocarcinoma, the only hope of a cure is resection. This study was undertaken to determine the impact of margin status, stage, tumor location, and adjuvant therapy on survival after resection of extrahepatic cholangiocarcinoma. METHODS:From 1985-2006, 91 patients underwent resections of cholangio...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-007-9756-2
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:The prognostic value of c-erbB-2 and vascular endothelial growth factor (VEGF) expression in colorectal liver metastases (CLM) is unclear. The purpose of this study was to clarify the relationship of c-erbB-2 and VEGF with the clinicopathological parameters and the survival results in CLM. METHODS:For 44 pa...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-009-0897-3
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:The association between procedure volume and clinical outcomes has led many to advocate centralization of cancer procedures at high-volume centers (HVCs). Regional studies show practice patterns changing with increasing centralization of esophageal and pancreatic procedures at HVCs but little change for colo...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-010-1159-0
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Myxoid liposarcoma (MLS), the second most common subtype of liposarcoma, occurs predominantly in the extremities of young adults and has a disproportionately high tendency to metastasize to unusual soft tissue locations, before disseminated spread or pulmonary metastases. Anecdotal evidence, mainly supported...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-006-9306-3
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Lymphadenectomy is important in the surgical treatment of apparent early epithelial ovarian cancers (eEOC); however, its extent is not well defined. We evaluated the role of systematic lymphadenectomy, the risk factors related with lymph node metastases, the implications, and the morbidity of comprehensive s...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-012-2439-7
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Unlike its more common non-invasive form, invasive squamous cell carcinoma (SCC) of the skin can be biologically aggressive and is prone to recur. The objectives of this study were to identify relevant clinicopathologic prognostic factors associated with the outcomes of patients with invasive SCC in order to...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/ASO.2006.07.022
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:The keystone flap is being promoted as an advance in oncological surgical reconstruction. Wound closure with this island flap involves two V-Y advancements toward the center and along the long axis of the island, at right angles to the line of maximum tension when the wound is closed. It is implied that the ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-012-2684-9
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:Our aim was to investigate the detrusor muscle sampling rate after monopolar versus bipolar transurethral resection of bladder tumor (TURBT). METHODS:This was a single-center, prospective, randomized, phase III trial on monopolar versus bipolar TURBT. Baseline patient characteristics, disease characteristics a...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,随机对照试验
doi：10.1245/s10434-016-5700-7
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:The routine use of external beam radiotherapy (EBRT) is not recommended for parathyroid carcinoma (PC). However, case series have demonstrated a potential benefit in preventing local recurrence with EBRT. We aimed to characterize the patient population treated with EBRT and identify any impact of EBRT on ove...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-08825-8
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to examine the frequency, pattern, and predictive factors associated with occult level II lymph node (LN) metastases in papillary thyroid carcinoma (PTC) patients with clinically metastatic lymph nodes in the lateral neck (level III, IV, and/or V) by preoperative ultrasonography...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-010-0958-7
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Isolated hepatic perfusion (IHP) of chemotherapy has been proposed to deliver high doses of drug while avoiding systemic toxicity. Hypotonic cisplatin has a high in vitro activity on human colon cancer cells. We studied the safety of a 30-min hypoxic single-pass IHP with hypotonic cisplatin. METHODS:A preli...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-009-0775-z
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:There are various methods for the detection of sentinel lymph nodes (SLNs) in breast cancer by using a combined method with blue dye and radioisotope (RI) tracers. The purpose of the study was to reveal any correlation between concordance of the tracers and the order of harvest with the presence of metastase...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/ASO.2005.07.013
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:There is substantial variation in the surgical complexity of hepatectomy. Currently, the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) risk adjusts for hospital quality comparisons using only the primary procedure code. Our objectives were to (1) assess the associatio...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-3500-5
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:This study aimed to compare clinicopathologic features and outcomes between patients with familial non-medullary thyroid carcinoma (FNMTC) and patients with sporadic non-medullary thyroid carcinoma (SNMTC) after performing individual risk factor-matching. Additionally, the study evaluated a dynamic risk stra...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-09025-0
更新日期：2020-08-14 00:00:00
abstract：BACKGROUND:Multicystic peritoneal mesothelioma (MPM) and well-differentiated papillary peritoneal mesothelioma (WDPPM) are exceedingly uncommon lesions with uncertain malignant potential and no uniform treatment strategy. The aim of the current study was to review our experience with cytoreduction and hyperthermic intr...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-007-9475-8
更新日期：2007-10-01 00:00:00
abstract：: ...
journal_title：Annals of surgical oncology
pub_type： 社论
doi：10.1245/s10434-018-6338-4
更新日期：2018-07-01 00:00:00
