Novel Prognostic Models Predicting the Cancer-Specific Survival in Patients with Cutaneous Melanoma Based on Metastatic Lymph Node Status.

Abstract:

BACKGROUND:In cutaneous melanoma (CM), the present methods of lymph node (LN) staging have not sufficiently utilized the prognostic information of metastatic LNs. In this study, we aimed to construct prognostic nomograms based on the number of positive LNs (PLNs) and other clinicopathologic characteristics of CM patients. METHODS:Two prognostic models were constructed in the none/single PLN (PLNnone/single) and multiple PLN (PLNmultiple) cohorts, respectively. Independent prognostic predictors associated with cancer-specific survival (CSS) in the above two cohorts were integrated to construct two nomograms for predicting the probability of 2-, 4-, and 6-year CSS in the PLNnone/single and PLNmultiple cohorts. The nomograms were evaluated by the area under the receiver operating characteristic curves (AUC), the calibration plots, and the decision curve analyses (DCAs). RESULTS:A total of 31,065 CM cases were included in this study. Factors included in the prognostic nomogram for patients in the PLNnone/single cohort were age, sex, race, marital status, insurance, primary tumor site, T stage, and number of PLNs, while factors included in the nomogram for cases in the PLNmultiple cohort included age, sex, marital status, insurance, primary tumor site, T stage, and number of PLNs. The AUC values for 2-, 4-, and 6-year CSS in the validation group of the PLNnone/single cohort were 0.833, 0.811, and 0.818, respectively, while in the validation group of the PLNmultiple cohort, the AUC values for 2-, 4,- and 6-year CSS were 0.720, 0.723, and 0.745, respectively. Compared with the American Joint Committee on Cancer 7th edition staging system, our two nomograms showed better predictive values. Additionally, the calibration plots and DCA curves for 2-, 4-, and 6-year CSS prediction demonstrated good coordination and net benefit in both the PLNnone/single and PLNmultiple cohorts. CONCLUSION:Our nomograms, based on the number of PLNs and other clinicopathologic characteristics, showed good predictive ability for predicting the survival of CM patients.

journal_name

Ann Surg Oncol

authors

Li W,Xu X,Zhang Y

doi

10.1245/s10434-020-09556-6

subject

Has Abstract

pub_date

2021-01-11 00:00:00

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-020-09556-6

pub_type

杂志文章
  • Optimization of hyperthermic intraperitoneal chemotherapy with oxaliplatin plus irinotecan at 43 degrees C after compete cytoreductive surgery: mortality and morbidity in 106 consecutive patients.

    abstract:BACKGROUND:Peritoneal carcinomatosis (PC), which has hitherto been regarded as a lethal entity, can now be cured with surgery (treating macroscopic tumor seeding) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) (treating residual microscopic disease). The purpose of this study was to analyze the morbidi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9348-1

    authors: Elias D,Goere D,Blot F,Billard V,Pocard M,Kohneh-Shahri N,Raynard B

    更新日期:2007-06-01 00:00:00

  • Quality of Care for Cervical and Endometrial Cancer Patients: The Impact of Different Techniques of Sentinel Lymph Node Mapping on Patient Satisfaction.

    abstract:OBJECTIVES:The purpose of this study was to assess the quality of care in patients who underwent sentinel lymph node (SLN) mapping for endometrial and cervical cancer staging, and evaluate the impact of different techniques on patient satisfaction, i.e. radiotracer Tc99m versus indocyanine green (ICG) or methylene blue...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5233-0

    authors: Buda A,Elisei F,Palazzi S,De Ponti E,Arosio M,Vecchione F,Dell'Anna T,Cuzzocrea M,Bussi B,Giuliani D,Di Martino G,Crivellaro C

    更新日期:2016-09-01 00:00:00

  • Neoadjuvant chemoradiotherapy affects the indications for lateral pelvic node dissection in mid/low rectal cancer with clinically suspected lateral node involvement: a multicenter retrospective cohort study.

    abstract:BACKGROUND:Although lateral pelvic node dissection (LPND) is recommended for rectal cancer with clinically metastatic lateral pelvic lymph nodes (LPNs), LPNs may respond to neoadjuvant chemoradiotherapy (nCRT). Our aim was to determine the optimal indication for LPND after nCRT for mid/low rectal cancer. METHODS:Of 2,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-014-3559-z

    authors: Oh HK,Kang SB,Lee SM,Lee SY,Ihn MH,Kim DW,Park JH,Kim YH,Lee KH,Kim JS,Kim JW,Kim JH,Chang TY,Park SC,Sohn DK,Oh JH,Park JW,Ryoo SB,Jeong SY,Park KJ

    更新日期:2014-07-01 00:00:00

  • The Landmark Series: Randomized Trials Examining Surgical Margins for Cutaneous Melanoma.

    abstract::Between 1980 and 2004, six randomized, controlled trials (RCTs) have been performed to evaluate the width of surgical margin excision for primary cutaneous melanoma and its influence on recurrence and survival. These trials have led to the current recommendation of not more than a 2-cm margin excision and have allowed...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-019-07866-y

    authors: Angeles CV,Wong SL,Karakousis G

    更新日期:2020-01-01 00:00:00

  • Uptake and patient outcomes of laparoscopic colon and rectal cancer surgery in a publicly funded system and following financial incentives.

    abstract:PURPOSE:To assess patterns of uptake and outcomes of laparoscopic colon and rectal cancer surgery in Ontario, and the potential influence of surgical fee incentives instituted on October 1, 2005. METHODS:We used Ontario administrative databases from fiscal years 2002 to 2009. Study outcomes were uptake rates of laparo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3123-2

    authors: Simunovic M,Baxter NN,Sutradhar R,Liu N,Cadeddu M,Urbach D

    更新日期:2013-11-01 00:00:00

  • Robotic Lymphadenectomy During Pancreatoduodenectomy with First Superior Mesenteric Artery Dissection.

    abstract:BACKGROUND:An expert consensus meeting had defined the standard lymphadenectomy during pancreatoduodenectomy for an adenocarcinoma of the head of the pancreas. There is a controversy regarding the possibility to perform this optimal lymphadenectomy by minimally invasive approach. PATIENTS:The patient was a 68-year-old...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5421-y

    authors: Memeo R,De Blasi V,Perotto O,Mutter D,Marescaux J,Pessaux P

    更新日期:2016-12-01 00:00:00

  • Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?

    abstract:BACKGROUND:RAS mutation status is an important prognostic factor after resection of liver metastases (LiM) from colorectal cancer (CRC). The prognostic significance of RAS after resection of lung (LuM) and peritoneal (PM) metastases from CRC is unknown. METHODS:Between 2005 and 2014, all consecutive patients with know...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6141-7

    authors: Passot G,Kim BJ,Glehen O,Mehran RJ,Kopetz SE,Goere D,Overman MJ,Pocard M,Marchal F,Conrad C,Aloia TA,Vauthey JN,Chun YS,BIG-RENAPE Working Group.

    更新日期:2018-01-01 00:00:00

  • Trends in contralateral prophylactic mastectomy for unilateral cancer: a report from the National Cancer Data Base, 1998-2007.

    abstract:BACKGROUND:Several studies have reported an increased rate of contralateral prophylactic mastectomy (CPM) in patients with unilateral breast cancer. This study reports on CPM trends from the American College of Surgeon's National Cancer Data Base (NCDB) diagnosed over a 10-year period. METHODS:Data about women diagnos...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1091-3

    authors: Yao K,Stewart AK,Winchester DJ,Winchester DP

    更新日期:2010-10-01 00:00:00

  • Validation of sentinel node mapping in patients with colon cancer.

    abstract:BACKGROUND:Sentinel lymph node (SLN) mapping techniques have been validated in breast cancer and melanoma. This study summarizes our experience with SLN mapping for colon cancer. METHODS:Fifty-five patients with colon cancer underwent intraoperative SLN mapping. One mL of 1% isosulfan blue was injected subserosally ar...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02573890

    authors: Paramo JC,Summerall J,Poppiti R,Mesko TW

    更新日期:2002-07-01 00:00:00

  • The utility of frozen section evaluation for follicular thyroid lesions.

    abstract:BACKGROUND:Because fine-needle aspiration cannot reliably discriminate between benign and malignant follicular thyroid lesions, some surgeons use intraoperative frozen section (FS) to guide operative management. To determine the utility of FS for these lesions, we reviewed our institutional experience. METHODS:Between...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02524352

    authors: Callcut RA,Selvaggi SM,Mack E,Ozgul O,Warner T,Chen H

    更新日期:2004-01-01 00:00:00

  • Extent of microinvasion in ductal carcinoma in situ is not associated with sentinel lymph node metastases.

    abstract:BACKGROUND:Ductal carcinoma in situ with microinvasion (DCISM) is a rare diagnosis with a good prognosis. Although nodal metastases are uncommon, sentinel lymph node biopsy (SLNB) remains standard care. Volume of disease in invasive breast cancer is associated with SLNB positivity, and, thus we hypothesized that in a l...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3920-2

    authors: Matsen CB,Hirsch A,Eaton A,Stempel M,Heerdt A,Van Zee KJ,Cody HS 3rd,Morrow M,Plitas G

    更新日期:2014-10-01 00:00:00

  • A look into the ductoscope: its role in pathologic nipple discharge.

    abstract:OBJECTIVE:Mammary ductoscopy allows direct visualization of the ductal system and a method for directed excision and pathologic diagnosis. We reviewed our experience with mammary ductoscopy in the evaluation of pathologic nipple discharge. METHODS:We reviewed all patients who underwent ductoscopy for pathologic nipple...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1962-2

    authors: Fisher CS,Margenthaler JA

    更新日期:2011-10-01 00:00:00

  • Level 2 oncoplastic surgery for lower inner quadrant breast cancers: the LIQ-V mammoplasty.

    abstract:BACKGROUND:Oncoplastic surgical techniques offer an option of breast conserving surgery for larger tumors with the use of glandular reshaping to prevent postoperative deformity. A technique for the excision of lower inner quadrant tumors via a V incision is described, the lower-inner quadrant-V (LIQ-V) mammoplasty, and...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3085-4

    authors: Clough KB,Oden S,Ihrai T,Massey E,Nos C,Sarfati I

    更新日期:2013-11-01 00:00:00

  • KRAS Mutation Status Dictates Optimal Surgical Margin Width in Patients Undergoing Resection of Colorectal Liver Metastases.

    abstract:BACKGROUND:The optimal tumor-free margin width remains controversial and may be inappropriate to investigate without considering differences in the underlying tumor biology. METHODS:R1 resection was defined as margin clearance less than 1 mm. R0 resection was further divided into 3 groups: 1-4, 5-9, and ≥10 mm. The im...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5609-1

    authors: Margonis GA,Sasaki K,Andreatos N,Kim Y,Merath K,Wagner D,Wilson A,Buettner S,Amini N,Antoniou E,Pawlik TM

    更新日期:2017-01-01 00:00:00

  • Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer.

    abstract:BACKGROUND:The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze cl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5448-0

    authors: Kim HW,Kim JH,Lim BJ,Kim H,Kim H,Park JJ,Youn YH,Park H,Noh SH,Kim JW,Choi SH

    更新日期:2016-12-01 00:00:00

  • ASO Author Reflections: Proposal of a New Preoperative Prognostic Model for Solitary Hepatocellular Carcinoma.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6796-8

    authors: Yoh T,Seo S

    更新日期:2018-12-01 00:00:00

  • The Incidence and Survival of Rare Cancers of the Thyroid, Parathyroid, Adrenal, and Pancreas.

    abstract:PURPOSE:With the exception of papillary and follicular thyroid cancer, malignant cancers of the thyroid, parathyroid, adrenal, and endocrine pancreas are uncommon. These rare malignancies present a challenge to both the clinician and patient, because few data exist on their incidence or survival. We analyzed the incide...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4901-9

    authors: James BC,Aschebrook-Kilfoy B,Cipriani N,Kaplan EL,Angelos P,Grogan RH

    更新日期:2016-02-01 00:00:00

  • Optimizing Outpatient Pain Management After Thyroid and Parathyroid Surgery: A Two-Institution Experience.

    abstract:BACKGROUND:Thyroidectomy and parathyroidectomy are the most commonly performed endocrine operations, and are increasingly being completed on a same-day basis; however, few data exist regarding the outpatient postoperative pain requirement of these patients. We aimed to describe the outpatient narcotic medication needs ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-017-5781-y

    authors: Lou I,Chennell TB,Schaefer SC,Chen H,Sippel RS,Balentine C,Schneider DF,Moalem J

    更新日期:2017-07-01 00:00:00

  • Robot versus laparoscopic gastrectomy for cancer by an experienced surgeon: comparisons of surgery, complications, and surgical stress.

    abstract:BACKGROUND:No previous robotic studies present an equivalent surgical quality comparison in an experienced setting for gastric cancer. In addition, a reliable postoperative complication assessment is needed to accurately evaluate surgical outcomes. METHODS:After 20 cases of robotic-assisted gastrectomy (RAG), a total ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2679-6

    authors: Hyun MH,Lee CH,Kwon YJ,Cho SI,Jang YJ,Kim DH,Kim JH,Park SH,Mok YJ,Park SS

    更新日期:2013-04-01 00:00:00

  • Reduced Port Laparoscopic Distal Gastrectomy with D2 Lymphadenectomy.

    abstract:BACKGROUND:Reduced port laparoscopic surgery (RPLS), as a more minimally invasive treatment alternative to conventional laparoscopic surgery (CLS), has been increasing in recent years. 1 With the accumulation of surgical experience and improvements in surgical techniques, the indication of RPLS has been gradually exten...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6066-1

    authors: Lin T,Mou TY,Hu YF,Liu H,Li TJ,Lu YM,Yu J,Li GX

    更新日期:2018-01-01 00:00:00

  • Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database.

    abstract:BACKGROUND:The role of surgical resection in patients with large or multinodular hepatocellular carcinoma (HCC) remains unclear. This study evaluated the long-term outcome of patients with hepatic resection for large (>5 cm in diameter) or multinodular (more than three nodules) HCC by using a multi-institutional databa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/ASO.2005.06.004

    authors: Ng KK,Vauthey JN,Pawlik TM,Lauwers GY,Regimbeau JM,Belghiti J,Ikai I,Yamaoka Y,Curley SA,Nagorney DM,Ng IO,Fan ST,Poon RT,International Cooperative Study Group on Hepatocellular Carcinoma.

    更新日期:2005-05-01 00:00:00

  • Reconstruction patterns in a single institution cohort of women undergoing mastectomy for breast cancer.

    abstract:OBJECTIVES:The purpose of the current study was to conduct a patient-centered investigation of reconstruction practices following mastectomy at our institution. METHODS:A questionnaire was administered to patients who underwent unilateral or bilateral mastectomy for breast cancer from 2006 to 2010. The survey queried ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-012-2530-0

    authors: Elmore L,Myckatyn TM,Gao F,Fisher CS,Atkins J,Martin-Dunlap TM,Margenthaler JA

    更新日期:2012-10-01 00:00:00

  • Upstaging and improved survival of early breast cancer patients after implementation of sentinel node biopsy for axillary staging.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) has become a standard for axillary staging for early breast cancer patients. Prior studies suggest that SLNB may be more sensitive for the identification of lymph node disease than axillary lymph node dissection (ALND). We hypothesized that SLNB use increases the incidence o...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9109-6

    authors: Vanderveen KA,Schneider PD,Khatri VP,Goodnight JE,Bold RJ

    更新日期:2006-11-01 00:00:00

  • Long-term survival of peritoneal carcinomatosis of colorectal origin.

    abstract:BACKGROUND:Peritoneal carcinomatosis of colorectal cancer is probably best treated by cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). In The Netherlands Cancer Institute, this treatment has been performed since 1995. The long tradition of this treatment enabled us to study long-term survival in det...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10434-004-1167-z

    authors: Verwaal VJ,van Ruth S,Witkamp A,Boot H,van Slooten G,Zoetmulder FA

    更新日期:2005-01-01 00:00:00

  • Prognostic Significance of Tumor-Positive Internal Mammary Sentinel Lymph Nodes in Breast Cancer: A Multicenter Cohort Study.

    abstract:INTRODUCTION:The introduction of the sentinel lymph node biopsy (SLNB) in breast cancer has renewed interest in lymphatic drainage to the internal mammary (IM) nodes. The clinical impact of tumor positive IM nodes is not completely clear. This study evaluated the incidence and impact on overall survival of metastatic I...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-015-4535-y

    authors: Madsen EV,Aalders KC,van der Heiden-van der Loo M,Gobardhan PD,van Oort PM,van der Ent FW,Rutgers EJ,Valdés Olmes RA,Elias SG,van Dalen T

    更新日期:2015-12-01 00:00:00

  • Effect of Extending the Original CROSS Criteria on Tumor Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer Patients: A National Multicenter Cohort Analysis.

    abstract:BACKGROUND:Extending the original criteria of the Chemoradiotherapy for Oesophageal Cancer followed by Surgery Study (CROSS) in daily practice may increase the treatment outcome of esophageal cancer (EC) patients. This retrospective national cohort study assessed the impact on the pathologic complete response (pCR) rat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09372-y

    authors: Wang HH,de Heer EC,Hulshoff JB,Kats-Ugurlu G,Burgerhof JGM,van Etten B,Plukker JTM,Hospers GAP,Dutch Upper Gastrointestinal Cancer Audit (DUCA) Group.

    更新日期:2020-11-28 00:00:00

  • Long-term morbidity of sentinel node biopsy versus complete axillary dissection for unilateral breast cancer.

    abstract:BACKGROUND:Postoperative changes after axillary lymph node surgery may significantly alter breast cancer survivors' (BCS) quality of life. Although sentinel lymph node biopsy (SLNB) has less immediate morbidity than axillary lymph node dissection (ALND), its long-term impact on shoulder abduction, arm swelling, and neu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9909-y

    authors: Crane-Okada R,Wascher RA,Elashoff D,Giuliano AE

    更新日期:2008-07-01 00:00:00

  • The effect of hospital volume on the outcome of breast cancer surgery.

    abstract:BACKGROUND:This study was conducted to investigate whether annual surgical unit caseload affects extent of breast cancer surgery, breast cancer recurrence or breast cancer-specific survival. METHODS:In a population-based cohort study, 12,604 women diagnosed with breast cancer in Finland during the years 1998-2001 were...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1514-1

    authors: Peltoniemi P,Peltola M,Hakulinen T,Häkkinen U,Pylkkänen L,Holli K

    更新日期:2011-06-01 00:00:00

  • Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time Trends During the Past 15 years.

    abstract:BACKGROUND:This study aimed to investigate changes in treatment strategy and outcome for patients with primary retroperitoneal sarcoma (RPS) undergoing resection at referral centers during a recent period. METHODS:The study enrolled consecutive adult patients with primary non-metastatic RPS who underwent resection wit...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09065-6

    authors: Callegaro D,Raut CP,Ng D,Strauss DC,Honoré C,Stoeckle E,Bonvalot S,Haas RL,Vassos N,Conti L,Gladdy RA,Fairweather M,van Houdt W,Schrage Y,van Coevorden F,Rutkowski P,Miceli R,Gronchi A,Swallow CJ

    更新日期:2020-10-18 00:00:00

  • Pilot study of oncolytic viral therapy using mutant herpes simplex virus (HF10) against recurrent metastatic breast cancer.

    abstract:BACKGROUND:An oncolytic herpes simplex virus type 1 mutant (HF10) has been isolated and evaluated for antitumor efficacy in a syngeneic immunocompetent mouse model, where it was effective against cancer and conferred resistance to rechallenge with tumor cells in all surviving mice. Several studies have shown that HF10 ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2006.08.035

    authors: Kimata H,Imai T,Kikumori T,Teshigahara O,Nagasaka T,Goshima F,Nishiyama Y,Nakao A

    更新日期:2006-08-01 00:00:00