Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?

abstract：BACKGROUND:Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDAC) are well known. Genetic and epigenetic data were correlated with tumor biology to find specific alterations responsible for invasion and metastasis in pancreatic ductal adenocarcinomas. METHODS:A total of 16 hu...

journal_title：Annals of surgical oncology

authors： Mees ST,Mardin WA,Sielker S,Willscher E,Senninger N,Schleicher C,Colombo-Benkmann M,Haier J

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Adrenocortical carcinoma (ACC) is a rare, aggressive disease with no apparent change in treatment or survival in the United States over the past two decades. Our objective was to determine whether treatment patterns or clinical outcomes vary by hospital case volume. METHODS:Patients with ACC were identified...

journal_title：Annals of surgical oncology

authors： Gratian L,Pura J,Dinan M,Reed S,Scheri R,Roman S,Sosa JA

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Adenoviral gene therapy is a promising new approach for the treatment of neoplastic diseases. To design rational clinical trials and distinguish the effects of therapeutic transgene expression from those caused by viral infection alone, the immune response to the vector must be understood. In these experimen...

journal_title：Annals of surgical oncology

authors： DeMatteo RP,Yeh H,Friscia M,Caparrelli D,Burke C,Desai N,Chu G,Markmann JF,Raper SE,Barker CF

更新日期：1999-01-01 00:00:00

abstract：:Information is lacking regarding the interaction of established breast cancer risk factors and patient age. We attempted to study this interaction in high-risk women at the extremes of age in our population. The Women-At-Risk Registry was queried for women who were < or =35 and > or =70 years of age. Enrollment criter...

journal_title：Annals of surgical oncology

authors： Chun J,Pocock B,Joseph KA,El-Tamer M,Klein L,Schnabel F

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The two isoforms of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), 1 with a long cytoplasmic domain (CEACAM1-L) and 1 with a short (CEACAM1-S), are involved in different signaling pathways. β2-spectrin (β2SP) is an adaptor protein that plays critical roles in the proper control of Smad ...

journal_title：Annals of surgical oncology

authors： Kiriyama S,Yokoyama S,Ueno M,Hayami S,Ieda J,Yamamoto N,Yamaguchi S,Mitani Y,Nakamura Y,Tani M,Mishra L,Shively JE,Yamaue H

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis. A recent multicenter European study reported a 90-day mortality rate of 16%, highlighting the importance of patient selection. The authors constructed a risk...

journal_title：Annals of surgical oncology

authors： Klompmaker S,Peters NA,van Hilst J,Bassi C,Boggi U,Busch OR,Niesen W,Van Gulik TM,Javed AA,Kleeff J,Kawai M,Lesurtel M,Lombardo C,Moser AJ,Okada KI,Popescu I,Prasad R,Salvia R,Sauvanet A,Sturesson C,Weiss MJ,Zeh

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Health care reform places primary care (PC) physicians in an increasingly significant role for breast cancer screening and diagnosis. This study assessed the adequacy of traditional PC resident training to prepare physicians for this front-line role. METHODS:Sixty-eight primary care residents, representing ...

journal_title：Annals of surgical oncology

authors： Chalabian J,Formenti S,Russell C,Pearce J,Dunnington G

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to clarify the priority of nodal dissection in Siewert types II and III adenocarcinoma of the esophagogastric junction (AEG). METHODS:The priority of nodal dissection was evaluated based on the therapeutic value index calculated by multiplying of the frequency of metastasis to e...

journal_title：Annals of surgical oncology

authors： Hasegawa S,Yoshikawa T,Rino Y,Oshima T,Aoyama T,Hayashi T,Sato T,Yukawa N,Kameda Y,Sasaki T,Ono H,Tsuchida K,Cho H,Kunisaki C,Masuda M,Tsuburaya A

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Angiotensin 2 is a key biologic peptide in the renin-angiotensin system (RAS) that regulates blood pressure and renal hemodynamics. The potential role of the RAS in the promotion of tumor growth, angiogenesis, and metastasis also has been shown in the past few decades. This study investigated the prognostic ...

journal_title：Annals of surgical oncology

authors： Miyajima A,Yazawa S,Kosaka T,Tanaka N,Shirotake S,Mizuno R,Kikuchi E,Oya M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Autophagy plays a major role in cellular homeostasis and is implicated in cancer progression. Damaged mitochondria are scavenged and eliminated by mitochondrial autophagy, referred to as mitophagy, which can promote cancer cell survival. This study investigated the expression and effects of the autophagy-rel...

journal_title：Annals of surgical oncology

authors： Yamashita K,Miyata H,Makino T,Masuike Y,Furukawa H,Tanaka K,Miyazaki Y,Takahashi T,Kurokawa Y,Yamasaki M,Nakajima K,Takiguchi S,Morii E,Mori M,Doki Y

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The aim of this retrospective analysis was to analyze the results of treatment of patients with cervical node metastases from carcinoma of occult primary with a policy including neck dissection and postoperative comprehensive radiotherapy. METHODS:Ninety patients were treated with curative intent from 1990 ...

journal_title：Annals of surgical oncology

authors： Boscolo-Rizzo P,Gava A,Da Mosto MC

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Glioma recurrence usually occurs close to the tumor resection margins as a result of residual infiltrating glioma cells. 5-aminolevulinic acid (ALA) fluorescence-guided resection of gliomas has been demonstrated to enhance discrimination of tumor tissue and to improve survival. ALA-based photodynamic therapy...

journal_title：Annals of surgical oncology

authors： Zhao SG,Chen XF,Wang LG,Yang G,Han DY,Teng L,Yang MC,Wang DY,Shi C,Liu YH,Zheng BJ,Shi CB,Gao X,Rainov NG

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to identify prognostic genes by integrated microarray analysis between comparative genomic hybridization and gene expression with laser microdissection in non-small cell lung cancer (NSCLC). METHODS:Integrated microarray analysis in 11 lung adenocarcinomas was performed, and sever...

journal_title：Annals of surgical oncology

authors： Sakashita H,Inoue H,Akamine S,Ishida T,Inase N,Shirao K,Mori M,Mimori K

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Iliosacral resection of pelvic malignant tumors and subsequent reconstruction have tested the ingenuity of orthopedic oncologists because of the difficulty of oncological wide resection and the complex biomechanics of the sacroiliac joint render reconstruction challenging. This study compared the functional ...

journal_title：Annals of surgical oncology

authors： Wang J,Tang Q,Xie X,Yin J,Zhao Z,Li Z,Zou C,Huang G,Shen J

更新日期：2012-12-01 00:00:00

abstract：: ...

journal_title：Annals of surgical oncology

authors：

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:During the last few years, many surgeons have begun to utilize the LigaSure device or Harmonic scalpel to perform thyroid surgery. Several papers have demonstrated the benefits of these devices compared with traditional hand-tying techniques. The purpose of this study was to examine our institution's experie...

journal_title：Annals of surgical oncology

authors： Zarebczan B,Mohanty D,Chen H

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:CpG island methylator phenotype (CIMP), characterized by simultaneous methylation of multiple tumor suppressor genes (TSGs), has been reported to be associated with biological malignancy in many cancers. Whether CIMP is potentially predictive of clinical outcome in hepatocellular carcinoma (HCC) remains unkn...

journal_title：Annals of surgical oncology

authors： Li B,Liu W,Wang L,Li M,Wang J,Huang L,Huang P,Yuan Y

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Contralateral prophylactic mastectomy (CPM) is expected to add surgical morbidity but this incremental risk has not yet been defined. We sought to quantify the additional risks associated with CPM and determine how these risks influence the time to adjuvant therapy. METHODS:We identified women undergoing ma...

journal_title：Annals of surgical oncology

authors： Eck DL,Perdikis G,Rawal B,Bagaria S,McLaughlin SA

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The aim of this clinical study was to evaluate quality of life (QoL) in early-stage breast cancer patients and to investigate the effects of a comprehensive rehabilitation program comparing women undergoing sentinel node biopsy (SNB) versus complete axillary lymph node dissection (ALND). QoL was assessed wit...

journal_title：Annals of surgical oncology

authors： Pinto e Silva MP,Sarian LO,Morais SS,Pace do Amaral MT,Freire de Oliveira MM,Derchain S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Head and neck oncologic surgery with reconstruction represents one of the most complex operations in otolaryngology. Unplanned return to the operating room represents an objective measure of postoperative complications. The purpose of this study was to identify reasons and risk factors for unplanned return t...

journal_title：Annals of surgical oncology

authors： Tam S,Weber RS,Liu J,Ting J,Hanson S,Lewis CM

更新日期：2020-02-01 00:00:00

abstract：AIMS:To determine the incidence of lymph node (LN) metastasis in patients with apparently early carcinosarcoma of the uterus, to analyze the clinicopathologic factors associated with LN metastasis, and to evaluate the role of pelvic and/or para-aortic lymphadenectomy in treatment of such conditions. METHODS:We retrosp...

journal_title：Annals of surgical oncology

authors： Park JY,Kim DY,Kim JH,Kim YM,Kim YT,Nam JH

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Nonsurgical assessment of sentinel nodes (SNs) would offer advantages over surgical SN excision by reducing morbidity and costs. Proton magnetic resonance spectroscopy (MRS) of fine-needle aspirate biopsy (FNAB) specimens identifies melanoma lymph node metastases. This study was undertaken to determine the a...

journal_title：Annals of surgical oncology

authors： Stretch JR,Somorjai R,Bourne R,Hsiao E,Scolyer RA,Dolenko B,Thompson JF,Mountford CE,Lean CL

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Extraskeletal myxoid chondrosarcoma (EMC) is a rare sarcoma of uncertain origin, marked by specific chromosomal translocations involving the NR4A3 gene, and usually characterized by an indolent course. Surgery (with or without radiotherapy) is the treatment of choice in localized disease. The treatment for a...

journal_title：Annals of surgical oncology

authors： Paioli A,Stacchiotti S,Campanacci D,Palmerini E,Frezza AM,Longhi A,Radaelli S,Donati DM,Beltrami G,Bianchi G,Barisella M,Righi A,Benini S,Fiore M,Picci P,Gronchi A

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Aromatic amines, well-known bladder carcinogens, derived from cigarette smoke are activated by acidic urine. We herein determined whether urinary pH levels are associated with bladder recurrence in upper tract urothelial carcinoma patients with a positive smoking history. METHODS:A total of 256 upper tract uro...

journal_title：Annals of surgical oncology

authors： Ide H,Kikuchi E,Hagiwara M,Hayakawa N,Hongo H,Miyajima A,Oya M

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The American Society of Clinical Oncology (ASCO) guidelines include incorporation of fertility preservation guidelines in the care of breast oncology patients. This study aimed to examine the baseline knowledge and preferences concerning fertility preservation among women of childbearing age with newly diagn...

journal_title：Annals of surgical oncology

authors： Goldfarb SB,Kamer SA,Oppong BA,Eaton A,Patil S,Junqueira MJ,Olcese C,Kelvin JF,Gemignani ML

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:It has been reported that the abnormal activation of receptor tyrosine kinases is associated with the development of many human carcinomas and the high activation of EGFR and Met mediates the tumorigenicity of laryngeal carcinoma. In this study, we have done the therapeutic efficacy of ME22S (a novel EGFR/Met b...

journal_title：Annals of surgical oncology

authors： Lee BS,Kim HJ,Hwang JW,Cheong KH,Kim KA,Cha HY,Lee JM,Kim CH

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Cytotoxic T lymphocyte-associated antigen (CTLA)-4 can inhibit T-cell responses and is involved in tolerance against self antigens. We previously reported autoimmune manifestations and objective cancer regressions in patients with metastatic melanoma treated with CTLA-4 blockade. The possibility of activatin...

journal_title：Annals of surgical oncology

authors： Maker AV,Phan GQ,Attia P,Yang JC,Sherry RM,Topalian SL,Kammula US,Royal RE,Haworth LR,Levy C,Kleiner D,Mavroukakis SA,Yellin M,Rosenberg SA

更新日期：2005-12-01 00:00:00

abstract：:Selected patients with hepatocellular carcinoma are candidates to receive potentially curative treatments, such as hepatic resection or liver transplantation, but nevertheless there is a high risk of tumor recurrence. Microvascular invasion is a histological feature of hepatocellular carcinoma related to aggressive bi...

journal_title：Annals of surgical oncology

authors： Rodríguez-Perálvarez M,Luong TV,Andreana L,Meyer T,Dhillon AP,Burroughs AK

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:There are various methods for the detection of sentinel lymph nodes (SLNs) in breast cancer by using a combined method with blue dye and radioisotope (RI) tracers. The purpose of the study was to reveal any correlation between concordance of the tracers and the order of harvest with the presence of metastase...

journal_title：Annals of surgical oncology

authors： Wada N,Imoto S,Yamauchi C,Hasebe T,Ochiai A,Ebihara S

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:The quality of decision-making in cancer multidisciplinary team (MDT) meetings is variable, which can result in suboptimal clinical decision making. We developed MDT-QuIC, an evidence-based tool to support clinical decision making by MDTs, which was evaluated by key users. METHODS:Following a literature rev...

journal_title：Annals of surgical oncology

authors： Lamb BW,Sevdalis N,Vincent C,Green JS

更新日期：2012-06-01 00:00:00