CEACAM1 long cytoplasmic domain isoform is associated with invasion and recurrence of hepatocellular carcinoma.

Abstract:

BACKGROUND:The two isoforms of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), 1 with a long cytoplasmic domain (CEACAM1-L) and 1 with a short (CEACAM1-S), are involved in different signaling pathways. β2-spectrin (β2SP) is an adaptor protein that plays critical roles in the proper control of Smad access to activate receptors involved in regulation of TGF-β signaling. In this study, we examined the association between CEACAM1 isoform balance and hepatocellular carcinoma (HCC) malignant potential and investigated the possibility of a molecular interaction between CEACAM1 and β2SP. METHODS:Immunohistochemical analysis was carried out with CEACAM1-L or CEACAM1-S antibodies on 154 HCC tissues to correlate with the factors of malignancy. Invasion assay was performed for the effect of CEACAM1 expression on HCC cell lines. Moreover, immunohistochemical analysis and immunoprecipitation analysis were performed to investigate the association between CEACAM1 isoform balance and β2SP. RESULTS:In immunohistochemical analysis, CEACAM1-L expression dominance was a risk factor for HCC recurrence (p = 0.04) and was significantly associated with a shorter survival compared with CEACAM1-S expression dominance. Invasion assay indicated that CEACAM1-4L-transfected HLF and PLC/PRF/5 cells showed significantly increased invasion (p < 0.0001) and CEACAM1-4S-transfected HLF cells showed significantly decreased invasion. Immunohistochemical analysis of β2SP suggested that the HCCs with CEACAM1-L-dominant expression were more strongly stained with β2SP than the HCCs with CEACAM1-S-dominant expression (p = 0.013), and coprecipitation assays indicated that CEACAM1-L could bind to β2SP. CONCLUSIONS:CEACAM1-L may enhance the HCC invasiveness through an interaction with β2SP and subsequent effects on TGF-β signaling.

journal_name

Ann Surg Oncol

authors

Kiriyama S,Yokoyama S,Ueno M,Hayami S,Ieda J,Yamamoto N,Yamaguchi S,Mitani Y,Nakamura Y,Tani M,Mishra L,Shively JE,Yamaue H

doi

10.1245/s10434-013-3460-1

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

S505-14

eissn

1068-9265

issn

1534-4681

journal_volume

21 Suppl 4

pub_type

杂志文章
  • Cellular immunity delimits adenoviral gene therapy strategies for the treatment of neoplastic diseases.

    abstract:BACKGROUND:Adenoviral gene therapy is a promising new approach for the treatment of neoplastic diseases. To design rational clinical trials and distinguish the effects of therapeutic transgene expression from those caused by viral infection alone, the immune response to the vector must be understood. In these experimen...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-999-0088-2

    authors: DeMatteo RP,Yeh H,Friscia M,Caparrelli D,Burke C,Desai N,Chu G,Markmann JF,Raper SE,Barker CF

    更新日期:1999-01-01 00:00:00

  • Accuracy of biopsy techniques for limb and limb girdle soft tissue tumors.

    abstract:BACKGROUND:The biopsy method of choice for soft tissue sarcomas (STS) of the limb and limb girdle is controversial. There have been no randomized controlled trials that compare incision biopsy with Tru-cut biopsy. We present a large series, which includes an analysis of the effectiveness of Tru-cut core biopsy both in ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-001-0080-y

    authors: Hoeber I,Spillane AJ,Fisher C,Thomas JM

    更新日期:2001-01-01 00:00:00

  • Intraoperative Radiation Therapy (IORT): A Series of 1000 Tumors.

    abstract:BACKGROUND:Two prospective, randomized trials, TARGIT-A and ELIOT, have shown intraoperative radiation therapy to be a safe alternative, with a low-risk of local recurrence, compared with whole breast radiation therapy, following breast-conserving surgery, for selected low-risk patients. We report the first 1000 tumors...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6614-3

    authors: Silverstein MJ,Epstein M,Kim B,Lin K,Khan S,Snyder L,Guerra L,Coleman C,Chen P

    更新日期:2018-10-01 00:00:00

  • Practice patterns for the management of hepatic metastases from colorectal cancer: a mixed methods analysis.

    abstract:PURPOSE:The optimal management of colorectal cancer liver metastases (CRC-LM) has changed during the past two decades. However, clinical practice lags behind best evidence recommendations. We sought to characterize the gap between current practice and best evidence for the management of these patients and to identify b...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2698-3

    authors: Wei AC,Sandhu L,Devitt KS,Gagliardi AR,Kennedy ED,Urbach DR,Gallinger S,Baxter NN

    更新日期:2013-05-01 00:00:00

  • Pure laparoscopic liver resection for large malignant tumors: does size matter?

    abstract:BACKGROUND:Laparoscopic liver resection (LLR) for large malignant tumors can be technically challenging. Data on this topic are scarce, and many question its feasibility, safety, and oncologic efficiency. This study aimed to assess outcomes of LLR for large (≥ 5 cm) and giant (≥ 10 cm) malignant liver tumors. METHODS:...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4107-6

    authors: Shelat VG,Cipriani F,Basseres T,Armstrong TH,Takhar AS,Pearce NW,AbuHilal M

    更新日期:2015-04-01 00:00:00

  • Analysis and comparison of the 7th edition American Joint Committee on Cancer (AJCC) nodal staging system for metastatic cutaneous squamous cell carcinoma of the head and neck.

    abstract:BACKGROUND:The American Joint Committee on Cancer (AJCC) substantially changed the staging of cutaneous squamous cell carcinoma (cSCC) in the 7th edition of its staging manual. We aim to compare the 7th edition AJCC staging of nodal metastases from cSCC with the N1S3 staging system. METHODS:Analysis of 603 patients fr...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-012-2504-2

    authors: Clark JR,Rumcheva P,Veness MJ

    更新日期:2012-12-01 00:00:00

  • Ratio between positive lymph nodes and total excised axillary lymph nodes as an independent prognostic factor for overall survival in patients with nonmetastatic lymph node-positive breast cancer.

    abstract:BACKGROUND:The status of the axillary lymph nodes in nonmetastatic lymph node-positive breast cancer (BC) patients remains the single most important determinant of overall survival (OS). Although the absolute number of nodes involved with cancer is important for prognosis, the role of the total number of excised nodes ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-009-0653-8

    authors: Hatoum HA,Jamali FR,El-Saghir NS,Musallam KM,Seoud M,Dimassi H,Abbas J,Khalife M,Boulos FI,Tawil AN,Geara FB,Salem Z,Shamseddine AA,Al-Feghali K,Shamseddine AI

    更新日期:2009-12-01 00:00:00

  • Positive lymph node ratio is an independent prognostic factor in gastric cancer after d2 resection regardless of the examined number of lymph nodes.

    abstract::The purpose of this study was to clarify the outcome of the ratio between metastatic and examined lymph nodes (N ratio) in gastric cancer patients with < or =15 examined lymph nodes after D2 lymphadenectomy. A retrospective study was performed in 906 patients with gastric cancer who had undergone D2 resection. Patient...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0240-4

    authors: Xu DZ,Geng QR,Long ZJ,Zhan YQ,Li W,Zhou ZW,Chen YB,Sun XW,Chen G,Liu Q

    更新日期:2009-02-01 00:00:00

  • Hospitalization in the Year Preceding Major Oncologic Surgery Increases Risk for Adverse Postoperative Events.

    abstract:BACKGROUND:Hospitalization is associated with negative clinical effects that last beyond discharge. This study aimed to determine whether hospitalization in the year before major oncologic surgery is associated with adverse outcomes. METHODS:Patients 18 years of age or older with stomach, pancreas, colon, or rectal ca...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6032-y

    authors: Sharoky CE,Collier KT,Wirtalla CJ,Sinnamon AJ,Neuwirth MG,Kuo LE,Roses RE,Fraker DL,Karakousis GC,Kelz RR

    更新日期:2017-11-01 00:00:00

  • Postoperative Complications have Minimal Impact on Long-Term Prognosis in Immunodeficient Patients with Esophageal Cancer.

    abstract:BACKGROUND:Postoperative complications have been recognized to have an adverse prognostic impact in various types of cancer. However, in a recent study, it has been reported that postoperative complications of total gastrectomy with splenectomy have little impact on the long-term outcomes of patients with gastric cance...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08245-8

    authors: Maruyama S,Kawaguchi Y,Akaike H,Shoda K,Saito R,Shimizu H,Furuya S,Hosomura N,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D

    更新日期:2020-08-01 00:00:00

  • Complete hepatic venous isolation and extracorporeal chemofiltration as treatment for human hepatocellular carcinoma: a phase I study.

    abstract:BACKGROUND:We performed a phase I study of a novel system of complete hepatic venous isolation and extracorporeal chemofiltration in patients with unresectable hepatocellular carcinoma (HCC) to determine (a) whether systemic exposure to doxorubicin could be limited after high-dose hepatic arterial infusion (HAI), and (...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02303811

    authors: Curley SA,Newman RA,Dougherty TB,Fuhrman GM,Stone DL,Mikolajek JA,Guercio S,Guercio A,Carrasco CH,Kuo MT

    更新日期:1994-09-01 00:00:00

  • Optimal Cutoff Values of Skeletal Muscle Index to Define Sarcopenia for Prediction of Survival in Patients with Advanced Gastric Cancer.

    abstract:BACKGROUND:Sarcopenia, characterized by loss of skeletal muscle mass, is recognized as a prognostic factor in patients with gastric cancer. However, wide variability exists in the cutoff values of muscle mass for defining sarcopenia across previous studies, and the best cutoff values to predict survival remain unknown....

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6728-7

    authors: Nishigori T,Tsunoda S,Obama K,Hisamori S,Hashimoto K,Itatani Y,Okada K,Sakai Y

    更新日期:2018-11-01 00:00:00

  • Posttherapy nodal status, not graded histologic response, predicts survival after neoadjuvant chemotherapy for advanced gastric cancer.

    abstract:BACKGROUND:Neoadjuvant chemotherapy (NAC) has been attempted as a means of improving survival of potentially resectable advanced gastric cancer (AGC). In the course of exploring the most promising NAC regimen, a superior surrogate marker reflecting overall survival (OS) is necessary. We investigated prognostic factors ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2165-6

    authors: Fujitani K,Mano M,Hirao M,Kodama Y,Tsujinaka T

    更新日期:2012-06-01 00:00:00

  • Pitfalls of positive findings in staging esophageal cancer with F-18-fluorodeoxyglucose positron emission tomography.

    abstract:BACKGROUND:18-F-fluorodeoxyglucose positron emission tomography (FDG-PET) is valuable in staging of esophageal cancer. However, FDG-PET may falsely upstage patients leading to incorrect exclusion from surgical treatment. This study was performed to determine the false-positive rate and possible causes. METHODS:The rat...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/aso.2003.03.005

    authors: van Westreenen HL,Heeren PA,Jager PL,van Dullemen HM,Groen H,Plukker JT

    更新日期:2003-11-01 00:00:00

  • Evaluation of Lymph Node Staging Systems as Independent Prognosticators in Remnant Gastric Cancer Patients with an Insufficient Number of Harvested Lymph Nodes.

    abstract:BACKGROUND:The lymph node (LN) ratio (LNR) and the log odds of positive LNs (LODDS) have been proposed as sensitive prognosticators in patients with primary gastric cancer, especially in patients with an insufficient number of harvested LNs. We investigated the association of LNR and LODDS with survival in patients wit...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09433-2

    authors: Kano K,Yamada T,Yamamoto K,Komori K,Watanabe H,Takahashi K,Maezawa Y,Fujikawa H,Numata M,Aoyama T,Tamagawa H,Cho H,Yukawa N,Yoshikawa T,Rino Y,Masuda M,Ogata T,Oshima T

    更新日期:2021-01-03 00:00:00

  • An aggressive approach to extrahepatic cholangiocarcinomas is warranted: margin status does not impact survival after resection.

    abstract:BACKGROUND:With cholangiocarcinoma, the only hope of a cure is resection. This study was undertaken to determine the impact of margin status, stage, tumor location, and adjuvant therapy on survival after resection of extrahepatic cholangiocarcinoma. METHODS:From 1985-2006, 91 patients underwent resections of cholangio...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9756-2

    authors: Hernandez J,Cowgill SM,Al-Saadi S,Villadolid D,Ross S,Kraemer E,Shapiro M,Mullinax J,Cooper J,Goldin S,Zervos E,Rosemurgy A

    更新日期:2008-03-01 00:00:00

  • Functional outcome of arthrodesis with a vascularized fibular graft and a rotational latissimus dorsi flap after proximal humerus sarcoma resection.

    abstract:BACKGROUND:The prognosis of humeral sarcomas has improved greatly in the past 20 years. As a result, the challenges for orthopedic oncologists include long-term handicap and local morbidity. METHODS:Shoulder reconstruction after the resection of sarcomas with the proximal humerus was evaluated for 55 patients from 199...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1443-z

    authors: Wang J,Shen J,Dickinson IC

    更新日期:2011-07-01 00:00:00

  • EGFR nuclear import in gallbladder carcinoma: nuclear phosphorylated EGFR upregulates iNOS expression and confers independent prognostic impact.

    abstract:BACKGROUND:The understanding of epidermal growth factor receptor (EGFR) deregulation in carcinogenesis remains incomplete. We investigated the implications of EGFR gene status and EGFR nuclear translocation in gallbladder carcinoma (GBCA). METHODS:Subcellular localization of EGFR and phosphorylated EGFR (pEGFR) was an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1942-6

    authors: Li CF,Fang FM,Wang JM,Tzeng CC,Tai HC,Wei YC,Li SH,Lee YT,Wang YH,Yu SC,Shiue YL,Chu PY,Wang WL,Chen LT,Huang HY

    更新日期:2012-02-01 00:00:00

  • Predicting the Value of Adjuvant Therapy in Esophageal Squamous Cell Carcinoma by Combining the Total Number of Examined Lymph Nodes with the Positive Lymph Node Ratio.

    abstract:BACKGROUND:The value of adjuvant therapy for esophageal squamous cell carcinoma (ESCC) has been controversial, at least partially due to the lack of efficient criteria for selecting suitable patients. This study aimed to explore the existence of parameters related to lymph node (LN) status that can predict the value of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07489-3

    authors: Li Y,Zhao W,Ni J,Zou L,Yang X,Yu W,Fu X,Zhao K,Zhang Y,Chen H,Xiang J,Xie C,Zhu Z

    更新日期:2019-08-01 00:00:00

  • ASO Author Reflections: Surgery and Bevacizumab in Ovarian Cancer.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-7024-2

    authors: Petrillo M,Scambia G,Fagotti A

    更新日期:2018-12-01 00:00:00

  • ASO Author Reflections: Transoral Robotic Surgery Combined with Neoadjuvant Chemotherapy for Management of Advanced Laryngohypopharyngeal Cancer.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6850-6

    authors: Park YM,Kim SH

    更新日期:2018-12-01 00:00:00

  • The Incidence and Survival of Rare Cancers of the Thyroid, Parathyroid, Adrenal, and Pancreas.

    abstract:PURPOSE:With the exception of papillary and follicular thyroid cancer, malignant cancers of the thyroid, parathyroid, adrenal, and endocrine pancreas are uncommon. These rare malignancies present a challenge to both the clinician and patient, because few data exist on their incidence or survival. We analyzed the incide...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4901-9

    authors: James BC,Aschebrook-Kilfoy B,Cipriani N,Kaplan EL,Angelos P,Grogan RH

    更新日期:2016-02-01 00:00:00

  • Perioperative hyperfractionated high-dose rate brachytherapy for the treatment of soft tissue sarcomas: multicentric experience.

    abstract:BACKGROUND:Low-dose rate brachytherapy is a well-established adjuvant treatment for soft tissue sarcomas (STS). The experience with high-dose rate brachytherapy (HDR BT) in this indication is limited. The purpose of our study was to evaluate the viability of perioperative hyperfractionated HDR BT for STS. METHODS:Fort...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-009-0684-1

    authors: Petera J,Soumarová R,Růzicková J,Neumanová R,Dusek L,Sirák I,Macingová Z,Paluska P,Kasaová L,Hodek M,Vosmik M

    更新日期:2010-01-01 00:00:00

  • Total Laparoscopic Resection of Hilar Cholangiocarcinoma Type 3b: Applying a Parachute Technique for Hepaticojejunostomy.

    abstract:BACKGROUND:Laparoscopic liver resection for perihilar cholangiocarcinoma (pCCA) is still in its infancy. The biliary-enteric reconstruction represents one of the most delicate parts of this minimally invasive procedure. METHODS:In this study, a 78-year old woman with perihilar cholangiocarcinoma (pCCA) type 3b underwe...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09175-1

    authors: Sucher R,Scheuermann U,Seehofer D

    更新日期:2020-09-30 00:00:00

  • Is FGFR2 a Suitable Target to Treat Scirrhous-Type Gastric Cancer?

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 社论

    doi:10.1245/s10434-018-07146-1

    authors: Yasui W

    更新日期:2019-04-01 00:00:00

  • Influence of nonclinical factors on choice of therapy for early hepatocellular carcinoma.

    abstract:BACKGROUND:Initial therapy for early hepatocellular carcinoma (HCC) with well-compensated cirrhosis is controversial. While we previously reported on the effect of clinical factors and surgeon specialty on choice of therapy for early HCC, other nonclinical factors also may impact decision-making. METHODS:Surgeons who ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2619-5

    authors: Nathan H,Segev DL,Bridges JF,Massie AB,Cameron AM,Hirose K,Schulick RD,Choti MA,Pawlik TM

    更新日期:2013-02-01 00:00:00

  • Intraperitoneal Administration of Paclitaxel Combined with S-1 Plus Oxaliplatin as Induction Therapy for Patients with Advanced Gastric Cancer with Peritoneal Metastases.

    abstract:BACKGROUND:Intraperitoneal (IP) administration of paclitaxel (PTX) has a great pharmacokinetic advantage to control peritoneal lesions and can be combined with various systemic chemotherapies. In this study, we evaluate the efficacy and tolerability of a combination of IP-PTX and systemic S-1/oxaliplatin (SOX) for indu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09388-4

    authors: Saito S,Yamaguchi H,Ohzawa H,Miyato H,Kanamaru R,Kurashina K,Hosoya Y,Lefor AK,Sata N,Kitayama J

    更新日期:2020-12-03 00:00:00

  • Substaging Nodal Status in Ampullary Carcinomas has Significant Prognostic Value: Proposed Revised Staging Based on an Analysis of 313 Well-Characterized Cases.

    abstract:BACKGROUND:Current nodal staging (N-staging) of ampullary carcinoma in the TNM staging system distinguishes between node-negative (N0) and node-positive (N1) disease but does not consider the metastatic lymph node (LN) number. METHODS:Overall, 313 patients who underwent pancreatoduodenectomy for ampullary adenocarcino...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4499-y

    authors: Balci S,Basturk O,Saka B,Bagci P,Postlewait LM,Tajiri T,Jang KT,Ohike N,Kim GE,Krasinskas A,Choi H,Sarmiento JM,Kooby DA,El-Rayes BF,Knight JH,Goodman M,Akkas G,Reid MD,Maithel SK,Adsay V

    更新日期:2015-12-01 00:00:00

  • Biomarkers predict outcomes following cytoreductive surgery for hepatic metastases from functional carcinoid tumors.

    abstract:BACKGROUND:Cytoreductive therapy for metastatic carcinoid provides symptomatic relief and improvement in overall survival. We evaluated whether CgA and 5HIAA could predict symptomatic relief and control of disease progression after cytoreductive surgery. METHODS:We retrospectively reviewed 70 patients who underwent cy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9148-z

    authors: Jensen EH,Kvols L,McLoughlin JM,Lewis JM,Alvarado MD,Yeatman T,Malafa M,Shibata D

    更新日期:2007-02-01 00:00:00

  • Is head and neck melanoma different from trunk and extremity melanomas with respect to sentinel lymph node status and clinical outcome?

    abstract:BACKGROUND:Previous studies showed conflicting and inconsistent results regarding the effect of anatomic location of the melanoma on sentinel lymph node (SLN) positivity and/or survival. This study was conducted to evaluate and compare the effect of the anatomic locations of primary melanoma on long-term clinical outco...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-2977-7

    authors: Fadaki N,Li R,Parrett B,Sanders G,Thummala S,Martineau L,Cardona-Huerta S,Miranda S,Cheng ST,Miller JR 3rd,Singer M,Cleaver JE,Kashani-Sabet M,Leong SP

    更新日期:2013-09-01 00:00:00