Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer.

Abstract:

BACKGROUND:The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze clinicopathological differences between sex groups to reveal sex disparities in GC. METHODS:We retrospectively analyzed 4722 patients with GC who underwent gastrectomy (females: 1586 (33.6 %); males: 3136 (66.4 %), and analyzed clinicopathological features between these sex groups. The overall survival (OS) rate was investigated between the two sex groups, with special reference to the pathologic World Health Organization GC classifications. Immunohistochemistry staining of sex hormone receptors, including the estrogen receptor (ER)-α, ER-β, progesterone receptor, and androgen receptor, was performed according to sex and pathological classification. RESULTS:Female patients were significantly associated with a younger age, poorly differentiated adenocarcinoma, and SRC compared with males. Female patients showed a significantly poorer OS than male patients, especially among those with advanced GC (AGC) aged ≤45 years. In females with AGC, those with SRC had a significantly poorer OS than those with other histologies. Moreover, the expression of ER-β was different between females and males with SRC. CONCLUSIONS:Females with GC were significantly younger and had a different SRC histology compared with males. Furthermore, females had significantly poorer prognostic factors among young patients with SRC. Thus, young female GC patients with SRC are a main target group in which to improve prognosis.

journal_name

Ann Surg Oncol

authors

Kim HW,Kim JH,Lim BJ,Kim H,Kim H,Park JJ,Youn YH,Park H,Noh SH,Kim JW,Choi SH

doi

10.1245/s10434-016-5448-0

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

4344-4351

issue

13

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-016-5448-0

journal_volume

23

pub_type

杂志文章
  • Dynamic contrast enhanced magnetic resonance imaging of the breast is superior to triple assessment for the pre-operative detection of multifocal breast cancer.

    abstract:BACKGROUND:Inadequately treated multifocal and multicentric disease results in increased local recurrence following breast-conserving surgery. The accurate preoperative diagnosis of multifocal/ centric breast cancer would facilitate the planning of appropriate surgery and prevent reoperation for residual disease. While...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-999-0599-x

    authors: Drew PJ,Chatterjee S,Turnbull LW,Read J,Carleton PJ,Fox JN,Monson JR,Kerin MJ

    更新日期:1999-09-01 00:00:00

  • Positive Ultrasound-guided Lymph Node Needle Biopsy in Breast Cancer may not Mandate Axillary Lymph Node Dissection.

    abstract:BACKGROUND:The ACOSOG Z0011 (Z11) trial demonstrated that in patients with nonpalpable axillary lymph nodes (LN) and one to two positive sentinel LN (SLN), axillary LN dissection (ALND) is unnecessary.JAMA 305:569-575, [2011], Ann Surg 264:413-42, [2016] The Z11 trial did not require preoperative axillary ultrasound (a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5935-y

    authors: Harris CK,Tran HT,Lee K,Mylander C,Pack D,Rosman M,Tafra L,Umbricht CB,Andrade R,Liang W,Jackson RS

    更新日期:2017-10-01 00:00:00

  • Hepatobiliary Disease Resection in Patients with Advanced Epithelial Ovarian Cancer: Prognostic Role and Optimal Cytoreduction.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the feasibility and safety in terms of prognostic significance and perioperative morbidity and mortality of cytoreduction in patients affected by advance ovarian cancer and hepato-biliary metastasis. METHODS:Patients with a least one hepatobiliary metastasis who have...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08989-3

    authors: Di Donato V,Giannini A,D'Oria O,Schiavi MC,Di Pinto A,Fischetti M,Lecce F,Perniola G,Battaglia F,Berloco P,Muzii L,Benedetti Panici P

    更新日期:2021-01-01 00:00:00

  • Size and Location are the Most Important Risk Factors for Malignant Behavior in Resected Solitary Fibrous Tumors.

    abstract:PURPOSE:While previously thought to be clinically indolent, recent data suggest significant late metastatic capacity of solitary fibrous tumors (SFTs). We define prognostic factors for recurrence and disease-specific death (DSD) in resected primary SFTs. METHODS:Resected primary SFTs from 1982 to 2015 were identified ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-017-6092-z

    authors: Gholami S,Cassidy MR,Kirane A,Kuk D,Zanchelli B,Antonescu CR,Singer S,Brennan M

    更新日期:2017-12-01 00:00:00

  • Biomarkers predict outcomes following cytoreductive surgery for hepatic metastases from functional carcinoid tumors.

    abstract:BACKGROUND:Cytoreductive therapy for metastatic carcinoid provides symptomatic relief and improvement in overall survival. We evaluated whether CgA and 5HIAA could predict symptomatic relief and control of disease progression after cytoreductive surgery. METHODS:We retrospectively reviewed 70 patients who underwent cy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9148-z

    authors: Jensen EH,Kvols L,McLoughlin JM,Lewis JM,Alvarado MD,Yeatman T,Malafa M,Shibata D

    更新日期:2007-02-01 00:00:00

  • Survival data justifies resection for pancreatic metastases.

    abstract:BACKGROUND:Pancreatic metastases are uncommon and little is known about the oncologic outcome after resection or prognostic parameters. This study was designed to evaluate perioperative and follow-up results after resection for pancreatic metastases and to define prognostic factors. METHODS:From a prospective database...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0682-3

    authors: Strobel O,Hackert T,Hartwig W,Bergmann F,Hinz U,Wente MN,Fritz S,Schneider L,Büchler MW,Werner J

    更新日期:2009-12-01 00:00:00

  • Higher expression of the heterogeneous nuclear ribonucleoprotein k in melanoma.

    abstract:BACKGROUND:The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an essential RNA and DNA binding protein involved in gene expression and signal transduction. The role of hnRNP K in cancer is relatively understudied. However, several cellular functions strongly indicate that hnRNP K is involved in tumorigenesis. Onc...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1121-1

    authors: Wen F,Shen A,Shanas R,Bhattacharyya A,Lian F,Hostetter G,Shi J

    更新日期:2010-10-01 00:00:00

  • ASO Author Reflections: Survival Benefit of Adjuvant Chemoradiotherapy for Gallbladder Cancer: The Role of Radiation Therapy Revisited.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6894-7

    authors: Kim BH,Chie EK,Kim K

    更新日期:2018-12-01 00:00:00

  • The immunological impact of neoadjuvant chemotherapy on the tumor microenvironment of esophageal squamous cell carcinoma.

    abstract:BACKGROUND:Esophageal cancer is an aggressive cancer with poor prognosis. However, little is known about the immune response in the tumor microenvironment after neoadjuvant chemotherapy. PURPOSE:To investigate the immunological impact of neoadjuvant chemotherapy in the tumor microenvironment of esophageal squamous cel...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1906-x

    authors: Tsuchikawa T,Miyamoto M,Yamamura Y,Shichinohe T,Hirano S,Kondo S

    更新日期:2012-05-01 00:00:00

  • Survival after resection of colorectal cancer based on anatomical segment of involvement.

    abstract:PURPOSE:To determine survival differences for patients undergoing colonic or rectal resection for cancer on the basis of the specific anatomical location of primary tumor. METHODS:A total of 143,747 patients undergoing segmental colectomy, hemicolectomy, anterior resection, or abdominoperineal resection (APER) for ade...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3104-5

    authors: Bhangu A,Kiran RP,Slesser A,Fitzgerald JE,Brown G,Tekkis P

    更新日期:2013-12-01 00:00:00

  • Prediction of recurrence and survival by post-resection CA 19-9 values in patients with adenocarcinoma of the pancreas.

    abstract:BACKGROUND:CA 19-9 levels are useful for the diagnosis of patients with pancreatic adenocarcinoma. However, interest has recently turned toward its use as a prognostic indicator. The purpose of this study is to determine whether postoperative CA 19-9 levels predict disease-free survival (DFS) and median survival (MS) i...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02305535

    authors: Montgomery RC,Hoffman JP,Riley LB,Rogatko A,Ridge JA,Eisenberg BL

    更新日期:1997-10-01 00:00:00

  • Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas.

    abstract:BACKGROUND:0.6-12.7% of patients with primary cutaneous melanoma will develop additional melanomas. Pathologic features of tumors in patients with multiple primary cutaneous melanomas have not been well described. In this large, international, multicenter, case-control study, we compared the clinicopathologic features ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-011-2058-8

    authors: Murali R,Goumas C,Kricker A,From L,Busam KJ,Begg CB,Dwyer T,Gruber SB,Kanetsky PA,Orlow I,Rosso S,Thomas NE,Berwick M,Scolyer RA,Armstrong BK,GEM Study Group.

    更新日期:2012-03-01 00:00:00

  • Impact of BRCA1/2 Mutations on the Efficacy of Secondary Cytoreductive Surgery.

    abstract:BACKGROUND:Phase III trials evaluating the role of secondary cytoreductive surgery (SCS) in recurrent ovarian cancer have pointed to the importance of patient selection. Two studies showed conflicting results regarding the benefit of SCS in BRCA1/2 mutation carriers. Our aim was to evaluate the impact of SCS on recurre...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09366-w

    authors: Estati FL,Pirolli R,de Alencar VTL,Ribeiro ARG,Formiga MN,Torrezan GT,Carraro DM,Guimarães APG,Baiocchi G,da Costa AABA

    更新日期:2020-11-21 00:00:00

  • Impact of clinicopathological factors on sensitivity of axillary ultrasonography in the detection of axillary nodal metastases in patients with breast cancer.

    abstract:BACKGROUND:Ultrasonography and fine-needle aspiration (FNA) are used to evaluate the breast and regional nodes in breast cancer patients. We sought to identify factors influencing the sensitivity of ultrasonography for detection of nodal metastasis. METHODS:Patients with a clinically negative axilla who underwent axil...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/aso.2003.12.017

    authors: Bedrosian I,Bedi D,Kuerer HM,Fornage BD,Harker L,Ross MI,Ames FC,Krishnamurthy S,Edeiken-Monroe BS,Meric F,Feig BW,Akins J,Singletary SE,Mirza NQ,Hunt KK

    更新日期:2003-11-01 00:00:00

  • Laparoscopic bowel resection in the setting of metastatic colorectal cancer.

    abstract:BACKGROUND:This study aimed to review the outcomes of laparoscopic colorectal resection for patients with stage IV colorectal cancer. METHODS:From the prospectively collected database for patients who underwent surgery for colorectal cancer in our institution, those with stage IV colorectal cancer who underwent electi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9820-6

    authors: Law WL,Fan JK,Poon JT,Choi H,Lo OS

    更新日期:2008-05-01 00:00:00

  • Chemotherapy with or Without Definitive Radiation Therapy in Inoperable Pancreatic Cancer.

    abstract:BACKGROUND:The LAP07 randomized trial calls into question the role of radiation therapy (RT) in the modern treatment of locally advanced pancreatic cancer (LAPC). However, advances in chemotherapy and RT limit application of the LAP07 results to current clinical practice. Here we utilize the National Cancer Database (N...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6322-4

    authors: Zhong J,Switchenko J,Behera M,Kooby D,Maithel SK,McDonald MW,Lin JY,Cassidy RJ,El-Rayes B,Landry J,Patel PR

    更新日期:2018-04-01 00:00:00

  • Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study.

    abstract:BACKGROUND/AIM:Perioperative administration of immunoenriched diets attenuates the perioperative inflammatory response and reduces postoperative infection complications. However, many questions still remain unresolved in this area, such as the length of diet administration, diet composition, and the mechanisms involved...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-007-9407-7

    authors: Giger U,Büchler M,Farhadi J,Berger D,Hüsler J,Schneider H,Krähenbühl S,Krähenbühl L

    更新日期:2007-10-01 00:00:00

  • Total Laparoscopic Pancreaticoduodenectomy with Venous Reconstruction for Pancreatic Head Cancer with Involvement of the Superior Mesenteric Vein-Portal Vein Confluence.

    abstract:BACKGROUND:Laparoscopic pancreaticoduodenectomy with venous reconstruction is not commonly performed due to its technical challenges. In this video, we focus on the technical aspects for how to perform this procedure safely. METHODS:In a 69-year-old female with jaundice and diarrhea, a computed tomography scan showed ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6762-5

    authors: Garbarino GM,Fuks D,Cowan J,Ward M,Moisan F,Donatelli G,Beaussier M,Gayet B

    更新日期:2018-12-01 00:00:00

  • Loss of c-met protooncogene in primary and metastatic sites of breast cancer.

    abstract:BACKGROUND:It has been proposed that clones of tumor cells acquire higher metastatic potential as a result of specific genetic alterations. This study was designed to determine the role of the c-met protooncogene in systemic spread by comparing the loss of the c-met protooncogene between primary and metastatic breast c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303675

    authors: Ng EH,Pey HB,Law HY,Ng I,Ji CY,Lin V,Soo KC

    更新日期:1997-09-01 00:00:00

  • Multicenter Phase II Study of Intraoperative Radiotherapy of Early Breast Cancer: Ipsilateral Tumor Recurrence.

    abstract:BACKGROUND:We performed a multicenter phase II study on the efficacy and safety of intraoperative radiotherapy (IORT) as partial breast irradiation using multiple devices. METHODS:The primary endpoint was ipsilateral breast tumor recurrence (IBTR). Key inclusion criteria were T < 2.5 cm, age > 50 years, surgical margi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-019-07350-7

    authors: Sawaki M,Miyamoto T,Fujisawa T,Itoh Y,Ebara T,Tachibana H,Kodaira T,Kikumori T,Yanagita Y,Iwata H

    更新日期:2019-08-01 00:00:00

  • Twenty-year outcomes after breast-conserving surgery and definitive radiotherapy for mammographically detected ductal carcinoma in situ.

    abstract:BACKGROUND:Management of mammographically detected ductal carcinoma in situ (DCIS) at a single institution was reviewed to determine long-term clinical outcomes after treatment with breast-conserving therapy (BCT). METHODS:Data from all patient-cases with DCIS who received BCT between 1980 and 1993 were reviewed. Pati...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-012-2412-5

    authors: Wilkinson JB,Vicini FA,Shah C,Shaitelman S,Jawad MS,Ye H,Kestin LL,Goldstein NS,Martinez AA,Benitez P,Chen PY

    更新日期:2012-11-01 00:00:00

  • Prediction of Persistent Pain Severity and Impact 12 Months After Breast Surgery Using Comprehensive Preoperative Assessment of Biopsychosocial Pain Modulators.

    abstract:BACKGROUND:Persistent post-mastectomy pain (PPMP) is a significant negative outcome occurring after breast surgery, and understanding which individual women are most at risk is essential to targeting of preventive efforts. The biopsychosocial model of pain suggests that factors from many domains may importantly modulat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09479-2

    authors: Schreiber KL,Zinboonyahgoon N,Flowers KM,Hruschak V,Fields KG,Patton ME,Schwartz E,Azizoddin D,Soens M,King T,Partridge A,Pusic A,Golshan M,Edwards RR

    更新日期:2021-01-15 00:00:00

  • The role of thyroidectomy in metastatic disease to the thyroid gland.

    abstract:BACKGROUND:Whether thyroidectomy for metastases to the thyroid is associated with a survival benefit remains debatable; in general, palliation and disease control are accepted goals in this setting. We evaluated the clinical features and overall survival of patients with thyroid metastasis treated by thyroid resection ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3282-1

    authors: Romero Arenas MA,Ryu H,Lee S,Morris LF,Grubbs EG,Lee JE,Perrier ND

    更新日期:2014-02-01 00:00:00

  • Development and evaluation of a checklist to support decision making in cancer multidisciplinary team meetings: MDT-QuIC.

    abstract:BACKGROUND:The quality of decision-making in cancer multidisciplinary team (MDT) meetings is variable, which can result in suboptimal clinical decision making. We developed MDT-QuIC, an evidence-based tool to support clinical decision making by MDTs, which was evaluated by key users. METHODS:Following a literature rev...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2187-0

    authors: Lamb BW,Sevdalis N,Vincent C,Green JS

    更新日期:2012-06-01 00:00:00

  • Radiographic Surveillance of Patients with Non-BRCA1/2 Pathogenic Variants.

    abstract:INTRODUCTION:The National Comprehensive Cancer Network (NCCN) developed clinical practice guidelines for germline pathogenic variants in highly penetrant genes, such as TP53 and PTEN, and in moderately penetrant genes, such as CHEK2, ATM and PALB2. Whether the practice of radiographic surveillance of patients with path...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08191-0

    authors: Hudson L,Gower N,Lenarcic S,Trufan SJ,White RL Jr

    更新日期:2020-07-01 00:00:00

  • Expression profiling of difficult-to-diagnose thyroid histologic subtypes shows distinct expression profiles and identify candidate diagnostic microRNAs.

    abstract:BACKGROUND:The incidence of thyroid cancer is increasing worldwide. The findings of up to 30% of thyroid fine-needle aspiration biopsies (FNAB) are inconclusive, primarily as a result of several thyroid histologic subtypes with overlapping cytologic features. MicroRNAs (miRNAs) are small noncoding RNAs and have been im...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1766-4

    authors: Kitano M,Rahbari R,Patterson EE,Xiong Y,Prasad NB,Wang Y,Zeiger MA,Kebebew E

    更新日期:2011-11-01 00:00:00

  • Protein expression of epidermal growth factor receptor in laryngeal squamous cell carcinoma index tumors correlates with diagnosis of second primary tumors of the upper aero-digestive tract.

    abstract:BACKGROUND:Field cancerization is a feature of HNSCCs. No biological marker in the index tumor has correlated with second primary tumor (SPTs) development. Changes in MDM-2 and epidermal growth factor receptor (EGFR) expression are known to be early neoplastic changes in HNSCC. EGFR expression is correlated with clinic...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0649-4

    authors: Farhadieh RD,Salardini A,Rees CG,Russell PJ,Yang JL,Smee R

    更新日期:2009-10-01 00:00:00

  • Low Lymph Node Retrieval After Preoperative Chemoradiation for Rectal Cancer is Associated with Improved Prognosis in Patients with a Good Tumor Response.

    abstract:PURPOSE:To examine the association between the number of lymph nodes retrieved and oncologic outcome after preoperative chemoradiation for rectal cancer according to tumor regression grade. METHODS:Patients with rectal cancer who underwent curative surgery between May 2004 and December 2012 were analyzed retrospective...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4235-z

    authors: Kim HJ,Jo JS,Lee SY,Kim CH,Kim YJ,Kim HR

    更新日期:2015-01-01 00:00:00

  • The Suggestion of Revised Criteria for Endoscopic Resection of Differentiated-Type Submucosal Gastric Cancer.

    abstract:BACKGROUND:Early gastric cancer that meets the expanded criteria for endoscopic resection (ER) is expected to be associated with a negligible risk for lymph node metastasis (LNM); however, recent studies have reported LNM in submucosal gastric cancer patients who met the existing criteria. In this study, we develop the...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-019-08102-3

    authors: Ma DW,Lee SJ,Kook MC,Park DY,Ahn S,Ryu KW,Choi IJ,Noh SH,Kim H,Lee YC,Kim JH

    更新日期:2020-03-01 00:00:00

  • Her-2/neu gene amplification in esophageal adenocarcinoma and its influence on survival.

    abstract:BACKGROUND:HER-2/neu (c-erbB-2, HER2) gene amplification and protein overexpression have been associated with poor prognosis in several solid tumors, including breast and gastric cancer. Its incidence and significance in esophageal adenocarcinoma is unknown. MATERIALS AND METHODS:Tissue microarrays were successfully c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1554-1

    authors: Thompson SK,Sullivan TR,Davies R,Ruszkiewicz AR

    更新日期:2011-07-01 00:00:00