Abstract：
OBJECTIVE:Mammary ductoscopy allows direct visualization of the ductal system and a method for directed excision and pathologic diagnosis. We reviewed our experience with mammary ductoscopy in the evaluation of pathologic nipple discharge. METHODS:We reviewed all patients who underwent ductoscopy for pathologic nipple discharge at our institution from 2006-2010. All procedures were performed by a single surgeon. Data included patient and imaging characteristics, indications, operative findings, and pathologic outcomes. Descriptive statistics were used for data summary. RESULTS:During the study period, 121 patients underwent ductoscopy and directed duct excision for pathologic nipple discharge, including 66 (55%) with bloody discharge. Breast imaging [mammography, ultrasound, and/or magnetic resonance imaging (MRI)] revealed BIRADS category I/II/III findings in 112 (93%), BIRADS category IV findings in 6 (5%), and was unknown in 3 (2%) patients. Final pathology revealed papillomas in 64 (53%) patients, duct ectasia and associated benign findings in 48 (40%) patients, ductal carcinoma in situ (DCIS) in 7 (6%) patients, and atypical ductal hyperplasia in 2 (1%) patients. None of the patients with DCIS underwent preductoscopy MRI, but all had BIRADS category I/II/III breast imaging. The extent of DCIS identified by ductoscopy and subsequent surgical excision ranged from <1 cm to 10 cm (median 3 cm). CONCLUSIONS:The majority of patients with pathologic nipple discharge have benign nonproliferative findings or benign papillomas. Although atypia and malignancy were diagnosed in only 7% of patients who underwent ductoscopy for pathologic nipple discharge, there were no routine imaging findings indicative of these diagnoses preoperatively.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Fisher CS,Margenthaler JAdoi
10.1245/s10434-011-1962-2subject
Has Abstractpub_date
2011-10-01 00:00:00pages
3187-91issue
11eissn
1068-9265issn
1534-4681journal_volume
18pub_type
杂志文章abstract：:Hilar cholangiocarcinoma is an uncommon cause of malignant biliary obstruction marked by local tumor spread for which surgery offers the only chance of cure. The diagnostic evaluation and surgical management of this disease continues to evolve. Although direct cholangiography and endoscopic biliary procedures have bee...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,评审
doi：10.1007/s10434-000-0055-4
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:This multicenter analysis evaluated patient outcome and clinical pathologic features of thymic epithelial tumors after complete surgical resection and adjuvant treatment. METHODS:Histologic classification and clinical staging were performed according to WHO classification and Masaoka staging system, respect...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,多中心研究
doi：10.1245/s10434-013-3018-2
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Bone marrow (BM) biopsy has been suggested as an independent prognostic factor in patients with breast cancer. METHODS:Patients operated for breast cancer from June 2000 to April 2008 were enrolled in this protocol after signing an informed consent. After primary surgery, BM aspirate from the iliac crest wa...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-009-0619-x
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:RAS mutation status predicts survival after hepatectomy for colorectal liver metastases (CRLM) and survival after repeat hepatectomy for intrahepatic recurrence. This study was aimed at determining the impact of RAS mutation on amenability of recurrence to local therapy and on post-recurrence survival follow...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-6517-3
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Secretory carcinoma is a distinctive and rare variant of breast carcinoma with a favorable prognosis because these tumors usually behave in an indolent manner. The occurrence of this type of breast cancer in males was studied. METHODS:An extensive literature survey concerning secretory breast cancer in male...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,评审
doi：10.1007/BF02574482
更新日期：2002-08-01 00:00:00
abstract：PURPOSE:With the exception of papillary and follicular thyroid cancer, malignant cancers of the thyroid, parathyroid, adrenal, and endocrine pancreas are uncommon. These rare malignancies present a challenge to both the clinician and patient, because few data exist on their incidence or survival. We analyzed the incide...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-4901-9
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Growing evidence suggests that the tumor immune microenvironment influences breast cancer development and prognosis. Density of tumor-infiltrating lymphocytes (TILs) within invasive breast cancer is correlated with response to therapy, especially in triple-negative disease. The clinical relevance and outcome...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-019-07562-x
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:To determine the risk factors related to adnexal involvement in endometrial cancer (EC) and its implications for ovarian preservation in young women. METHODS:We analyzed a series of 802 patients who were treated at AC Camargo Cancer Center from July 1991 to July 2017. Patients who had peritoneal or systemic di...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-08261-8
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Abnormal phosphatase and tensin analog (PTEN) gene expression has been noted in neoplasms. The PTEN protein cleaves phosphate groups from cellular growth kinases, inhibiting tumor propagation. A downstream target of PTEN is AKT, a serine-threonine kinase that when activated inhibits apoptosis. We sought to d...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02573071
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:The routine use of external beam radiotherapy (EBRT) is not recommended for parathyroid carcinoma (PC). However, case series have demonstrated a potential benefit in preventing local recurrence with EBRT. We aimed to characterize the patient population treated with EBRT and identify any impact of EBRT on ove...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-08825-8
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:The COVID-19 pandemic has posed extraordinary demands from patients, providers, and health care systems. Despite this, surgical oncologists must maintain focus on providing high-quality, empathetic care for the almost 2 million patients nationally who will be diagnosed with operable cancer this year. The foc...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-08673-6
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Despite decreasing rates of subsequent contralateral breast cancer after diagnosis of unilateral primary breast cancer, the proportion of patients electing contralateral prophylactic mastectomy (CPM) is increasing. Our aim was to identify risk factors associated with the identification of occult malignancy (...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-4660-7
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:In 2003, the American Joint Committee on Cancer (AJCC) initiated the 6th edition staging criteria, including pN0(i+) and pN1mi categories for breast cancer. However, the clinical significance of these categories is debated in the literature. METHODS:A prospective registry was used to identify patients stage...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-008-0121-x
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Although controversial, recent data suggest a benefit associated with primary tumor resection (PTR) in metastatic colon cancer (mCC) patients. However, utilization of the various management strategies over time relative to surgery, in particular multimodality treatment (MMT), as well as the impact of age on ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-5073-3
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The diagnostic phase of care is an anxiety-provoking and stressful experience for the potential breast cancer patient. A multidisciplinary team of breast cancer specialists embarked on a new initiative to pilot a Rapid Diagnosis and Support (RADS) Clinic to coordinate the diagnostic workup and nursing suppor...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-3120-5
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:There are many theoretical advantages that a minimally invasive approach to the pancreaticoduodenectomy might offer patients with benign and malignant disease of the head of the pancreas over traditional open techniques, including improved recovery time, decreased hospital stay, and earlier initiation of and...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-2045-0
更新日期：2012-03-01 00:00:00
abstract：: ...
journal_title：Annals of surgical oncology
pub_type： 社论
doi：10.1245/s10434-018-7036-y
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:The impact of primary tumor location on overall survival (OS), recurrence-free survival (RFS), and long-term outcomes has not been well established in patients undergoing potentially curative resection of colorectal liver metastases (CRLM). METHODS:A single-institution database was queried for initial resec...
journal_title：Annals of surgical oncology
pub_type： 临床试验,杂志文章
doi：10.1245/s10434-017-6264-x
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The prognosis of lung cancer remains poor; only 20% of patients can undergo surgery. N2 non-small cell lung cancer (NSCLC) is a heterogeneous disease. We conducted a retrospective study to analyze the impact of N2 location on survival. METHODS:This study included 342 NSCLC with N2 involvement between 1988 a...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-6373-1
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Intraperitoneal chemotherapy has an established role in the treatment of selected patients with colorectal peritoneal metastases. Oxaliplatin is highly suitable as a chemotherapeutic agent for hyperthermic intraperitoneal chemotherapy (HIPEC), but its use to date has been limited because of the morbidity cau...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5665-6
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Surgery for locally advanced rectal cancers beyond the plane of total mesorectal excision (TME) or extramesorectal nodal involvement should include complete resection. This study evaluated the oncologic feasibility and safety of robot-assisted surgery for rectal cancer beyond the TME plane. METHODS:The stud...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5117-3
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:To investigate the efficacy and safety of adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver in partial hepatectomy for ruptured hepatocellular carcinoma. MATERIALS AND METHODS:This is a retrospective study on data that were prospectively collected and entered into a compu...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-010-1484-3
更新日期：2011-06-01 00:00:00
abstract：: ...
journal_title：Annals of surgical oncology
pub_type： 评论,杂志文章
doi：10.1245/s10434-018-6878-7
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Angiotensin receptor blocker (ARB), a commonly used antihypertensive drug, is reported to affect wound healing and flap survival in animal models. However, this has not been elucidated in a clinical series. This study aimed to investigate the impact that perioperative use of ARB has on outcomes after breast ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-019-07293-z
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:The term pseudomyxoma peritonei has been used in reference to any condition, benign or malignant, in which the peritoneal cavity becomes filled with a gelatinous substance. The term is nonspecific and does not denote therapeutic or prognostic significance. Controversy centers around which patients benefit fr...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,评审
doi：10.1007/s10434-999-0797-6
更新日期：1999-12-01 00:00:00
abstract：: ...
journal_title：Annals of surgical oncology
pub_type： 评论,杂志文章
doi：10.1245/s10434-018-6885-8
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has improved the survival in selected colorectal cancer patients with peritoneal metastases. In these patients, the risk of a low anastomosis is sometimes diminished through the creation of a colostomy. Currently, the morbidity...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-3370-2
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Radical cystectomy is a standard treatment for muscle-invasive bladder cancer but frequently entails postoperative pulmonary complications (PPCs). Nutrition is closely associated with postoperative outcomes. Therefore, we evaluated the impact of preoperative prognostic nutritional index (PNI) on PPCs in radi...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-08994-6
更新日期：2020-08-09 00:00:00
abstract：BACKGROUND:The treatment strategy and benefit of extended lymph node dissection among patients with preoperatively diagnosed paraaortic lymph node metastasis (PALNM) in colon cancer remains highly controversial. In the current study, we analyzed the oncologic outcomes of patients who underwent extraregional lymph node ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-5027-9
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Recently, ultrasound (US)-guided needle biopsy has been proposed as an acceptable alternative to open biopsy in women with nonpalpable breast masses. This study evaluated the accuracy of US-guided needle biopsy of nonpalpable breast masses performed by surgeons at the time of the initial clinical examination...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02305766
更新日期：1996-09-01 00:00:00
