Abstract：
BACKGROUND:Unlike its more common non-invasive form, invasive squamous cell carcinoma (SCC) of the skin can be biologically aggressive and is prone to recur. The objectives of this study were to identify relevant clinicopathologic prognostic factors associated with the outcomes of patients with invasive SCC in order to define a high-risk group. METHODS:We retrospectively reviewed the records of patients with invasive cutaneous SCC of the trunk or extremities who received surgical treatment at a tertiary care cancer center over the past 10 years. We examined the patterns of presentation, all known clinical and histological risk factors for recurrence, and their association with survival. RESULTS:136 patients were identified, of whom 102 (74%) were male. Patterns of presentation included primary (n = 91), locally recurrent (n = 16), regional nodal (n = 24), and distant (n = 5) disease. Univariate analysis identified poorly differentiated carcinomas (hazard ratio [HR] = 2.92, P = .016), scar carcinomas (HR = 3.12, P = .008), tumor size > 2 cm (HR = 3.79, P = .006), and regional nodal disease (HR = 5.77, P < .0001) as significant risk factors for recurrence or death. On multivariate analysis, however, only regional nodal disease at presentation (HR = 7.64, P < .0001) was found to be significant. CONCLUSIONS:Patients with invasive SCCs metastatic to regional nodes constitute a group at high risk for recurrence and death. Such patients should be considered for adjuvant therapy trials.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Mullen JT,Feng L,Xing Y,Mansfield PF,Gershenwald JE,Lee JE,Ross MI,Cormier JNdoi
10.1245/ASO.2006.07.022subject
Has Abstractpub_date
2006-07-01 00:00:00pages
902-9issue
7eissn
1068-9265issn
1534-4681journal_volume
13pub_type
杂志文章abstract：BACKGROUND:Whether breast cancer surgeons are adequately trained, skilled, and experienced to provide breast cancer genetic assessment, testing, and counseling came under debate in September 2013 when a major third-party payer excluded nongenetics specialists from ordering such testing. A literature search having faile...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-3711-9
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Resection has been the standard of care for patients with solitary hepatocellular carcinoma (HCC). Transarterial embolization and percutaneous ablation are alternative therapies often reserved for suboptimal surgical candidates. Here we compare long-term outcomes of patients with solitary HCC treated with re...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-2961-2
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Radiofrequency ablation (RFA) is a recently developed treatment for hepatocellular carcinoma (HCC). Thus far, the prognostic impact of tumor biomarkers has not been evaluated in this treatment. High serum level of vascular endothelial growth factor (VEGF) has been shown to predict microscopic vascular invasi...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-007-9366-z
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:Sarcopenia is recognized as an important prognostic factor in various types of cancer, including gastric cancer. While long-term survival analyses typically focus on overall and disease-specific survival, death from other causes has received far less attention. METHODS:We reviewed medical records of 491 gas...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-6354-4
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The term pseudomyxoma peritonei has been used in reference to any condition, benign or malignant, in which the peritoneal cavity becomes filled with a gelatinous substance. The term is nonspecific and does not denote therapeutic or prognostic significance. Controversy centers around which patients benefit fr...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,评审
doi：10.1007/s10434-999-0797-6
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND:The patients with early gastric cancer who have undergone incomplete endoscopic resection (ER) generally need additional surgery because of the possibility of lymph node metastasis. The aim of study was to evaluate the optimal time interval from ER to additive surgery by evaluating the effect of time interva...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-013-3299-5
更新日期：2014-01-01 00:00:00
abstract：:Investigators at many cancer centers have verified that the sentinel node (SN) is the first lymph node to receive lymphatic drainage from a primary breast cancer and therefore the node most likely to contain metastatic tumor cells. When sentinel lymph node dissection (SLND) is undertaken by an experienced multidiscipl...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND:Although the honeycomb microcystic type is common and typical for a serous cystic tumor (SCT), clinical and radiological features are diverse. Systematic classification of SCT subtypes is not well established. The purpose of this study was to classify the subtypes of SCT and to clarify its clinical and patho...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-008-9959-1
更新日期：2008-08-01 00:00:00
abstract：:In the original article there is a reference missing, in addition to its citations in the text. The reference is as follows. ...
journal_title：Annals of surgical oncology
pub_type： 已发布勘误
doi：10.1245/s10434-020-09191-1
更新日期：2020-12-01 00:00:00
abstract：: ...
journal_title：Annals of surgical oncology
pub_type： 评论,杂志文章
doi：10.1245/s10434-018-7045-x
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:The 5th edition of Breast Imaging Reporting and Data System subdivides suspicious calcifications into two categories: 4B-amorphous, coarse heterogeneous, and fine pleomorphic calcifications; 4C-fine linear or fine linear branching calcifications. We investigated whether these revised categories are appropria...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-4362-6
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:This study aimed to evaluate the prognostic significance of the Oncotype DX recurrence score (RS) in T1-2N1M0 estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer based on the prognostic stage in the updated American Joint Commission on Cancer, 8th edition. ...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-018-7068-3
更新日期：2019-05-01 00:00:00
abstract：PURPOSE:To prospectively determine the rate of malignancy after surgery in papillary lesions initially diagnosed at ultrasound (US)-guided 11-gauge vacuum-assisted breast biopsies. METHODS:Between May 2007 and December 2009, a total of 85 papillary lesions, including 73 benign papillomas and 12 atypical papillomas wer...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-1617-3
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:The influence of distance traveled for treatment on short- and long-term cancer outcomes is unclear. METHODS:Patients with colon, esophageal, liver, and pancreas cancer from 2003 to 2006 were identified from the National Cancer Data Base (NCDB). Distance traveled for surgical treatment was estimated using z...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5242-z
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:AJCC staging of pancreatic cancer (PAC) is used to determine prognosis, yet survival within each stage shows wide variation and remains unpredictable. We hypothesized that tumor grade might be responsible for some of this variation and that the addition of grade to current AJCC staging would provide improved...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-010-1071-7
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:To investigate the relationship between surgeon caseload and surgery type, and variation in the surgical treatment of early stage breast cancer patients in Alberta, Canada. METHODS:All women diagnosed with stage I to III breast cancer in Alberta from 2002 to 2010 were identified from the Alberta Cancer Registr...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-016-5118-2
更新日期：2016-06-01 00:00:00
abstract：:Hiatal hernia (HH) is an infrequent yet potentially life-threatening complication after esophagectomy. Several studies have reported the incidence of this complication after both open and minimally invasive esophagectomy (MIE). This meta-analysis aimed to determine the pooled incidence of HH after both types of esopha...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,meta分析,评审
doi：10.1245/s10434-016-5155-x
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:To determine whether the benefits of sentinel-node-based management (SNBM) over routine axillary clearance (RAC) persisted to 5 years. METHODS:A total of 1088 women with breast cancer less than 3 cm in diameter and clinically negative axillary nodes were randomized to SNBM with axillary clearance if the sentin...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,随机对照试验
doi：10.1245/s10434-016-5669-2
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The impact of tumor focality on type of surgery, local recurrence rate, and survival after neoadjuvant chemotherapy (NACT) for breast cancer is not fully understood. This study aimed to compare local recurrence-free survival (LRFS), disease-free survival (DFS), and overall survival (OS) according to focality...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1245/s10434-014-4122-7
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Thirty-day mortality after surgery for colorectal cancer may vastly underestimate 1-year mortality. This study aimed to quantify the excess mortality in the first postoperative year of stage I-III colorectal cancer patients and to identify risk factors for excess mortality. METHODS:All 2,131 patients who we...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-012-2294-6
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:An increasing proportion of breast cancer patients undergo contralateral prophylactic mastectomy (CPM) to reduce their risk of contralateral breast cancer (CBC). Our goal was to evaluate CBC risk perception changes over time among breast cancer patients. METHODS:We conducted a prospective, longitudinal study o...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-4442-2
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:The management of state III breast cancer is challenging; it often includes multimodal treatment with systemic therapy and/or radiation therapy and surgery. Immediate breast reconstruction has not traditionally been performed in these patients. We review the results of immediate transverse rectus abdominis m...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/BF02305667
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Postesophagectomy diaphragmatic hernia (DH) is an uncommon problem but an important one to recognize and treat because of the risk of significant complications such as incarceration and strangulation. Diaphragmatic hernia appears to occur more frequently following transhiatal esophagectomy (THE) than after t...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-015-4366-x
更新日期：2015-10-01 00:00:00
abstract：:Isolated hepatic perfusion (IHP) is a proven approach for regional delivery of chemotherapy in patients with unresectable primary and metastatic tumors of the liver. Most trials of IHP have utilized melphalan as the active drug in the perfusate. We performed a phase I trial to evaluate the efficacy, safety, and maximu...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-008-0179-5
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Recently, traditional laparoscopic anterior resection has been used for rectal cancer, offering good functional results compared with open resection and resulting in better early postoperative outcomes. Few studies investigating the role of robot-assisted tumor-specific rectal surgery (RTSRS) have been carri...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,多中心研究
doi：10.1245/s10434-010-0909-3
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:There is conflicting evidence concerning platelet status and hepatocellular carcinoma (HCC) prognosis. We evaluated the prognostic value of platelet-based indices, including platelet count, platelet/lymphocyte ratio (PLR), and aspartate aminotransferase to platelet ratio index (APRI) in HCC after hepatic res...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-014-3771-x
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Patients with palpable melanoma groin metastases have a poor prognosis. There is debate whether a combined superficial and deep groin dissection (CGD) is necessary or if superficial groin dissection (SGD) alone is sufficient. AIM:The aim of this study was to analyze risk factors for deep pelvic nodal involv...
journal_title：Annals of surgical oncology
pub_type： 杂志文章,多中心研究
doi：10.1245/s10434-015-4602-4
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:In cutaneous melanoma (CM), the present methods of lymph node (LN) staging have not sufficiently utilized the prognostic information of metastatic LNs. In this study, we aimed to construct prognostic nomograms based on the number of positive LNs (PLNs) and other clinicopathologic characteristics of CM patien...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-020-09556-6
更新日期：2021-01-11 00:00:00
abstract：BACKGROUND:There is evidence that insulin-like growth factors play a role in the development of breast cancer. Antiestrogens reduce circulating levels of IGF-I, but the influence of other breast cancer treatments, including surgery, is unknown and is investigated in this study. METHODS:Circulating serum concentrations...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1007/s10434-001-0025-5
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Breast cancers (BCs) diagnosed after a recent pregnancy display features associated with poor prognosis, including hormone receptor negativity, but other tumor markers have not been examined. We sought to define the tumor marker profile of these cancers, including HER-2 and p53 expression, and examine the ti...
journal_title：Annals of surgical oncology
pub_type： 杂志文章
doi：10.1245/s10434-011-2104-6
更新日期：2012-04-01 00:00:00
