Abstract：
:Estrogen is believed to be pre-initiator in the risk of breast cancer. The BRCA1 is a tumor suppressor gene associated with breast and ovarian cancer risk. This report describes functional analysis of two BRCA1 missense mutations (Asp67Glu and Thr1051Ser) observed in the familial breast/ovarian cancer patients in Thailand. Levels of luciferase activity of the two mutations were relatively lower than in the wild-type BRCA1. It is indicated that mutants may fail to promote the estrogen receptor dependent functions. It is presumed that estrogen and insulin/IGF-1 regulate c-Myc and cyclin D1 during breast cancer cell proliferation. It is also likely to affect ubiquitination mechanism. Since three affected cancer families carry the Asp67Glu mutation, it is believed that this type of mutation could have some effect on breast/ovarian cancer progression.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Pongsavee M,Patmasiriwat P,Saunders GFdoi
10.3390/ijms10094187subject
Has Abstractpub_date
2009-09-24 00:00:00pages
4187-97issue
9issn
1422-0067journal_volume
10pub_type
杂志文章abstract：:Genealogical concordance is a critical overlay of all phylogenetic analyses, irrespective of taxonomic level. To assess such patterns of congruence we have compiled and derived sequence data for two mitochondrial (16S rRNA, COI) and two nuclear (ITS1, p26) markers in 14 American populations of the hypersaline branchio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10125455
更新日期：2009-12-18 00:00:00
abstract：:In the absence of lymphatics, fluid and solutes such as amyloid-β (Aβ) are eliminated from the brain along basement membranes in the walls of cerebral capillaries and arteries-the Intramural Peri-Arterial Drainage (IPAD) pathway. IPAD fails with age and insoluble Aβ is deposited as plaques in the brain and in IPAD pat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041225
更新日期：2020-02-12 00:00:00
abstract：:Cryopreservation of immature testicular tissue (ITT) prior to chemo/radiotherapy is now ethically accepted and is currently the only way to preserve fertility of prepubertal boys about to undergo cancer therapies. So far, three-dimensional culture of testicular cells isolated from prepubertal human testicular tissue w...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215476
更新日期：2019-11-03 00:00:00
abstract：:The insulin signaling (IIS) pathway plays an important role in the metabolism, growth, development, reproduction, and longevity of an organism. As a key member of the IIS pathway, insulin-like growth factor binding proteins (IGFBPs) are widely distributed a family in invertebrates and vertebrates that are critical in ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031056
更新日期：2021-01-21 00:00:00
abstract：:As toxic substances can enter the circulating blood and cross endothelial monolayers to reach parenchymal cells in organs, vascular endothelial cells are an important target compartment for such substances. Reactive sulfur species protect cells against oxidative stress and toxic substances, including heavy metals. Rea...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176053
更新日期：2020-08-22 00:00:00
abstract：:Spinocerebellar ataxia type 3 (SCA3) is a devastating neurodegenerative disease for which there is currently no cure, nor effective treatment strategy. One of nine polyglutamine disorders known to date, SCA3 is clinically heterogeneous and the main feature is progressive ataxia, which in turn affects speech, balance a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215434
更新日期：2019-10-31 00:00:00
abstract：:This study aims to determine whether Lactobacillus casei (L. casei) could relieve liver injury in piglets challenged with lipopolysaccharide (LPS). Piglets were randomly allocated into one of the three groups: control, LPS, and L. casei. The control and LPS groups were fed a corn- and soybean meal-based diet, whereas ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122535
更新日期：2017-11-26 00:00:00
abstract：:Apolipoprotein E (APOE) ε4 gene allele and type 2 diabetes mellitus (T2DM) are prime risk factors for Alzheimer's disease (AD). Despite evidence linking T2DM and apoE4, the mechanism underlying their interaction is yet to be determined. In the present study, we employed a model of APOE-targeted replacement mice and hi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041289
更新日期：2020-02-14 00:00:00
abstract：:Acute liver failure (ALF) leads to neurological symptoms defined as hepatic encephalopathy (HE). Although accumulation of ammonia and neuroinflammation are generally accepted as main contributors to HE pathomechanism, a buildup of bile acids (BA) in the blood is a frequent component of liver injury in HE patients. Rec...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207750
更新日期：2020-10-20 00:00:00
abstract：:It has been well established that hypoxia significantly increases both cellular and tumor resistance to ionizing radiation. Hypoxia associated radiation resistance has been known for some time but there has been limited success in sensitizing cells to radiation under hypoxic conditions. These studies show that, when i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082228
更新日期：2018-07-30 00:00:00
abstract：:A common subsequence is a fragment of the amino acid chain that occurs in more than one protein. Common subsequences may be an object of interest for food scientists as biologically active peptides, epitopes, and/or protein markers that are used in comparative proteomics. An individual bioactive fragment, in particula...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms160920748
更新日期：2015-09-01 00:00:00
abstract：:At a resting sarcomere length of approximately 2.2 µm bony fish muscles put into rigor in the presence of BDM (2,3-butanedione monoxime) to reduce rigor tension generation show the normal arrangement of myosin head interactions with actin filaments as monitored by low-angle X-ray diffraction. However, if the muscles a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19072091
更新日期：2018-07-18 00:00:00
abstract：:Serum amyloid A (SAA) promotes endothelial inflammation and dysfunction that is associated with cardiovascular disease and renal pathologies. SAA is an apoprotein for high-density lipoprotein (HDL) and its sequestration to HDL diminishes SAA bioactivity. Herein we investigated the effect of co-supplementing HDL on SAA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041316
更新日期：2020-02-15 00:00:00
abstract：:Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural functions are increasingly recognized. The machinery of TGF-β signaling, including the serine kinase type transmembrane receptors, is present in the central nervous system. However, the 3 mammalian TGF-β subtypes have distinct ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13078219
更新日期：2012-01-01 00:00:00
abstract：:Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca2+) homeostasis after stimuli. Cerebellar ataxias and corticospinal motor neuron degeneration are determined by gain/loss in ATXN2 f...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186673
更新日期：2020-09-12 00:00:00
abstract：:Acute lung injury is characterized by the infiltration of neutrophils into lungs and the subsequent impairment of lung function. Here we explored the role of TDAG8 in lung injury induced by lipopolysaccharide (LPS) administrated intratracheally. In this model, cytokines and chemokines released from resident macrophage...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161226145
更新日期：2015-12-04 00:00:00
abstract：:Urothelial carcinoma of the bladder (UCB) and upper tracts (UTUC) is often regarded as one entity and is managed generally with similar principles. While neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) is an established standard of care in UCB, strong evidence for a similar approach is lacking in UT...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20040793
更新日期：2019-02-13 00:00:00
abstract：:In previous work, a 93-mer aptamer was selected against the anaphylactic allergen, β-conglutin and truncated to an 11-mer, improving the affinity by two orders of magnitude, whilst maintaining the specificity. This 11-mer was observed to fold in a G-quadruplex, and preliminary results indicated the existence of a comb...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031150
更新日期：2021-01-24 00:00:00
abstract：:Both long-term undernutrition and overnutrition disturb metabolic balance, which is mediated partially by the action of two adipokines, leptin and resistin (RSTN). In this study, we manipulated the diet of ewes to produce either a thin (lean) or fat (fat) body condition and investigated how RSTN affects endocrine and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124238
更新日期：2020-06-14 00:00:00
abstract：:HD-Zip proteins are unique to plants, and contain a homeodomain closely linked to a leucine zipper motif, which are involved in dimerization and DNA binding. Based on homology in the HD-Zip domain, gene structure and the presence of additional motifs, HD-Zips are divided into four families, HD-Zip I⁻IV. Phylogenetic a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19124047
更新日期：2018-12-14 00:00:00
abstract：:Immune system deterioration in space represents a major risk, which has to be mitigated for exploration-class missions into the solar system. Altered gravitational forces have been shown to regulate adaptation processes in cells of the immune system, which are important for appropriate risk management, monitoring and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020436
更新日期：2019-01-20 00:00:00
abstract：:Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects, however, remain unclear. The inhibitory effects of these antidepre...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18112483
更新日期：2017-11-21 00:00:00
abstract：:Nanoencapsulation of thiamine dilauryl sulfate (TDS), a vitamin B1 derivative, was proved to effectively inhibit the spore germination of Fusarium oxysporum f. sp. raphani (F. oxysporum), as well as mycelial growth. The average diameter of nanoparticles was measured as 136 nm by being encapsulated with an edible encap...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14024283
更新日期：2013-02-21 00:00:00
abstract：:A defining challenge of the 21st century is meeting the nutritional demands of the growing human population, under a scenario of limited land and water resources and under the specter of climate change. The Vavilov seed bank contains numerous landraces collected nearly a hundred years ago, and thus may contain 'geneti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113952
更新日期：2020-05-31 00:00:00
abstract：:Of the multiple sources of reactive oxygen species (ROS) in the blood vessel, NADPH oxidases are the primary source. Whereas several studies have implicated NADPH oxidases in the initiation of atherosclerosis, their roles in disease progression are incompletely understood. Our objective was to determine the potential ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140817017
更新日期：2013-08-19 00:00:00
abstract：:The emergence of antibiotic-resistant strains in facultative anaerobic Gram-positive coccal bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), is a global health issue. Typically, MRSA strains are found associated with institutions like hospitals but recent data suggest that they are becoming more p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047851
更新日期：2015-04-08 00:00:00
abstract：:Over the past 10 years, it has become increasingly evident that nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects multiple extra-hepatic organ systems and interacts with the regulation of several metabolic and immunological pathways. In this review we discuss the rapidly expanding body of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17020217
更新日期：2016-02-05 00:00:00
abstract：:Cadmium (Cd) is an anthropogenic as well as a naturally occurring toxicant associated with prediabetes and T2DM in humans and experimental models of Cd exposure. However, relatively few studies have examined the mechanism(s) of Cd-induced hyperglycemia. The purpose of this study was to examine the role of pancreatic i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010360
更新日期：2020-12-31 00:00:00
abstract：BACKGROUND:Vinegars based on fruit juices could conserve part of the health-associated compounds present in the fruits. However, in general very limited knowledge exists on the consequences of vinegar-making on different antioxidant compounds from fruit. In this study vinegars derived from apple and grape are studied. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101658
更新日期：2016-09-29 00:00:00
abstract：:Staphylococcus argenteus is an emerging species responsible for infections comparable to those induced by Staphylococcus aureus. It has been involved in few chronic or persistent infections so far. In this study, we described a case of a persistent prosthetic-joint infection (PJI) affecting a young woman. We investiga...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176245
更新日期：2020-08-28 00:00:00
