Abstract：
:A common subsequence is a fragment of the amino acid chain that occurs in more than one protein. Common subsequences may be an object of interest for food scientists as biologically active peptides, epitopes, and/or protein markers that are used in comparative proteomics. An individual bioactive fragment, in particular the shortest fragment containing two or three amino acid residues, may occur in many protein sequences. An individual linear epitope may also be present in multiple sequences of precursor proteins. Although recent recommendations for prediction of allergenicity and cross-reactivity include not only sequence identity, but also similarities in secondary and tertiary structures surrounding the common fragment, local sequence identity may be used to screen protein sequence databases for potential allergens in silico. The main weakness of the screening process is that it overlooks allergens and cross-reactivity cases without identical fragments corresponding to linear epitopes. A single peptide may also serve as a marker of a group of allergens that belong to the same family and, possibly, reveal cross-reactivity. This review article discusses the benefits for food scientists that follow from the common subsequences concept.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Minkiewicz P,Darewicz M,Iwaniak A,Sokołowska J,Starowicz P,Bucholska J,Hrynkiewicz Mdoi
10.3390/ijms160920748subject
Has Abstractpub_date
2015-09-01 00:00:00pages
20748-73issue
9issn
1422-0067pii
ijms160920748journal_volume
16pub_type
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