Abstract：
:Yeast proteins Ntr1, Ntr2 and Prp43 function in spliceosome disassembly. An Ntr1-Ntr2 protein complex recruits Prp43 to allow the removal of the lariat-intron in late-stage RNA splicing activity. Based on amino-acid sequence similarities across species, TFIP11 and mDEAH9/Dhx15 have been identified as homologues of yeast Ntr1 and Prp43, respectively. The N-terminal region of TFIP11 contains a G-patch, which is a highly conserved domain of many RNA-processing proteins. TFIP11 displays a unique and characteristic subnuclear localization pattern, in close proximity to SC35 nuclear speckles. Transfected GFP-tagged mDEAH9 displays an evenly distributed nuclear localization and is excluded from the nucleoli; however when TFIP11 and mDEAH9 are co-transfected, both proteins colocalize to distinct nuclear speckles. These data show that TFIP11 recruits mDEAH9 suggesting that these two proteins have similar biological activities to their yeast counterparts.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wen X,Tannukit S,Paine MLdoi
10.3390/ijms9112105subject
Has Abstractpub_date
2008-11-01 00:00:00pages
2105-13issue
11issn
1422-0067journal_volume
9pub_type
杂志文章abstract：:Ionizing radiation (IR) has found widespread application in modern medicine, including medical imaging and radiotherapy. As a result, both patients and healthcare professionals are exposed to various IR doses. To minimize the negative side effects of radiation associated with oxidative imbalance, antioxidant therapy h...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-08-13 00:00:00
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更新日期：2017-08-18 00:00:00
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更新日期：2011-01-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-09-07 00:00:00
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journal_title：International journal of molecular sciences
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abstract：BACKGROUND:The aim of this review was to evaluate the adjunctive effect of autologous platelet concentrates (APCs) for the treatment of furcation defects, in terms of scientific quality of the clinical trials and regeneration parameters assessment. METHODS:A systematic search was carried out in the electronic database...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,meta分析
doi：10.3390/ijms20061347
更新日期：2019-03-17 00:00:00
