Molecular phylodynamics of the heterosexual HIV epidemic in the United Kingdom.

abstract：:Increasing evidence suggests important roles for long noncoding RNAs (lncRNAs) as new gene modulators involved in various biological processes. However, the function roles of lncRNAs in lower vertebrates are still unknown. Here, we firstly identify a lncRNA, named MAVS antiviral-related lncRNA (MARL), as a key regulat...

journal_title：PLoS pathogens

authors： Chu Q,Xu T,Zheng W,Chang R,Zhang L

更新日期：2020-07-17 00:00:00

abstract：:Trypanosoma cruzi infection is characterized by chronic parasitism of non-lymphoid tissues and is rarely eliminated despite potent adaptive immune responses. This failure to cure has frequently been attributed to a loss or impairment of anti-T. cruzi T cell responses over time, analogous to the T cell dysfunction desc...

journal_title：PLoS pathogens

authors： Pack AD,Collins MH,Rosenberg CS,Tarleton RL

更新日期：2018-11-12 00:00:00

abstract：:Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies. While natural killer (NK) cells can directly contribute to the control of viral replication, whet...

journal_title：PLoS pathogens

authors： Robbins SH,Bessou G,Cornillon A,Zucchini N,Rupp B,Ruzsics Z,Sacher T,Tomasello E,Vivier E,Koszinowski UH,Dalod M

更新日期：2007-08-24 00:00:00

abstract：:Vibrio parahaemolyticus is an emerging bacterial pathogen which colonizes the gastrointestinal tract and can cause severe enteritis and bacteraemia. During infection, V. parahaemolyticus primarily attaches to the small intestine, where it causes extensive tissue damage and compromises epithelial barrier integrity. We ...

journal_title：PLoS pathogens

authors： Lim J,Stones DH,Hawley CA,Watson CA,Krachler AM

更新日期：2014-09-25 00:00:00

abstract：:Control of virus infection is mediated in part by major histocompatibility complex (MHC) Class Ia presentation of viral peptides to conventional CD8 T cells. Although important, the absolute requirement for MHC Class Ia-dependent CD8 T cells for control of chronic virus infection has not been formally demonstrated. We...

journal_title：PLoS pathogens

authors： Braaten DC,McClellan JS,Messaoudi I,Tibbetts SA,McClellan KB,Nikolich-Zugich J,Virgin HW

更新日期：2006-05-01 00:00:00

abstract：:Gut dysbiosis associated with intestinal inflammation is characterized by the blooming of particular bacteria such as adherent-invasive E. coli (AIEC). However, the precise mechanisms by which AIEC impact on colitis remain largely unknown. Here we show that antibiotic-induced dysbiosis worsened chemically-induced coli...

journal_title：PLoS pathogens

authors： Ohno M,Hasegawa M,Hayashi A,Caballero-Flores G,Alteri CJ,Lawley TD,Kamada N,Núñez G,Inohara N

更新日期：2020-10-07 00:00:00

abstract：:Magnaporthe oryzae, the fungus causing rice blast disease, should contend with host innate immunity to develop invasive hyphae (IH) within living host cells. However, molecular strategies to establish the biotrophic interactions are largely unknown. Here, we report the biological function of a M. oryzae-specific gene,...

journal_title：PLoS pathogens

authors： Nishimura T,Mochizuki S,Ishii-Minami N,Fujisawa Y,Kawahara Y,Yoshida Y,Okada K,Ando S,Matsumura H,Terauchi R,Minami E,Nishizawa Y

更新日期：2016-10-06 00:00:00

abstract：:DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune system. Mice lacking DDX3X during hematopoiesis showed an altered leuk...

journal_title：PLoS pathogens

authors： Szappanos D,Tschismarov R,Perlot T,Westermayer S,Fischer K,Platanitis E,Kallinger F,Novatchkova M,Lassnig C,Müller M,Sexl V,Bennett KL,Foong-Sobis M,Penninger JM,Decker T

更新日期：2018-11-26 00:00:00

abstract：:Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation characterized by the influx of myeloid cells and production of proinflammatory cytokines including interferons (IFNs). It is unclear, however, how the immune system clears the virus without causing lethal immunopathology. Here,...

journal_title：PLoS pathogens

authors： Stifter SA,Bhattacharyya N,Pillay R,Flórido M,Triccas JA,Britton WJ,Feng CG

更新日期：2016-01-05 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a global public health burden for which no licensed vaccine exists. To aid vaccine development via increased understanding of the protective antibody response to RSV prefusion glycoprotein F (PreF), we performed structural and functional studies using the human neutralizing antibod...

journal_title：PLoS pathogens

authors： Harshbarger W,Tian S,Wahome N,Balsaraf A,Bhattacharya D,Jiang D,Pandey R,Tungare K,Friedrich K,Mehzabeen N,Biancucci M,Chinchilla-Olszar D,Mallett CP,Huang Y,Wang Z,Bottomley MJ,Malito E,Chandramouli S

更新日期：2020-11-02 00:00:00

abstract：:The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large number of alleles....

journal_title：PLoS pathogens

authors： Callaghan MJ,Buckee CO,Jolley KA,Kriz P,Maiden MC,Gupta S

更新日期：2008-03-14 00:00:00

abstract：:Betanodaviruses cause massive mortality in marine fish species with viral nervous necrosis. The structure of a T = 3 Grouper nervous necrosis virus-like particle (GNNV-LP) is determined by the ab initio method with non-crystallographic symmetry averaging at 3.6 Å resolution. Each capsid protein (CP) shows three major ...

journal_title：PLoS pathogens

authors： Chen NC,Yoshimura M,Guan HH,Wang TY,Misumi Y,Lin CC,Chuankhayan P,Nakagawa A,Chan SI,Tsukihara T,Chen TY,Chen CJ

更新日期：2015-10-22 00:00:00

abstract：:Our appreciation for the extent of Epstein Barr virus (EBV) transcriptome complexity continues to grow through findings of EBV encoded microRNAs, new long non-coding RNAs as well as the more recent discovery of over a hundred new polyadenylated lytic transcripts. Here we report an additional layer to the EBV transcrip...

journal_title：PLoS pathogens

authors： Ungerleider N,Concha M,Lin Z,Roberts C,Wang X,Cao S,Baddoo M,Moss WN,Yu Y,Seddon M,Lehman T,Tibbetts S,Renne R,Dong Y,Flemington EK

更新日期：2018-08-06 00:00:00

abstract：:Unique purine-rich mRNA sequences embedded in the coding sequences of a distinct group of gammaherpesvirus maintenance proteins underlie the ability of the latently infected cell to minimize immune recognition. The Epstein-Barr virus nuclear antigen, EBNA1, a well characterized lymphocryptovirus maintenance protein ha...

journal_title：PLoS pathogens

authors： Tellam JT,Lekieffre L,Zhong J,Lynn DJ,Khanna R

更新日期：2012-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA capsids can be enveloped and secreted as stable vir...

journal_title：PLoS pathogens

authors： Heger-Stevic J,Zimmermann P,Lecoq L,Böttcher B,Nassal M

更新日期：2018-12-19 00:00:00

abstract：:The porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine health worldwide and is considered the most significant viral disease in the swine industry today. In past years, studies on the entry of the virus into its host cell have led to the identification of a number of essential virus...

journal_title：PLoS pathogens

authors： Van Breedam W,Van Gorp H,Zhang JQ,Crocker PR,Delputte PL,Nauwynck HJ

更新日期：2010-01-15 00:00:00

abstract：:The factors determining the functional avidity and its relationship with the broad heterogeneity of antiviral T cell responses remain partially understood. We investigated HIV-specific CD8 T cell responses in 85 patients with primary HIV infection (PHI) or chronic (progressive and non-progressive) infection. The funct...

journal_title：PLoS pathogens

authors： Viganò S,Bellutti Enders F,Miconnet I,Cellerai C,Savoye AL,Rozot V,Perreau M,Faouzi M,Ohmiti K,Cavassini M,Bart PA,Pantaleo G,Harari A

更新日期：2013-01-01 00:00:00

abstract：:Candida albicans, a clinically important dimorphic fungal pathogen that can evade immune attack by masking its cell wall beta-glucan from immune recognition, mutes protective host responses mediated by the Dectin-1 beta-glucan receptor on innate immune cells. Although the ability of C. albicans to switch between a yea...

journal_title：PLoS pathogens

authors： Wheeler RT,Kombe D,Agarwala SD,Fink GR

更新日期：2008-12-01 00:00:00

abstract：:Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related ...

journal_title：PLoS pathogens

authors： Cotter PD,Draper LA,Lawton EM,Daly KM,Groeger DS,Casey PG,Ross RP,Hill C

更新日期：2008-09-12 00:00:00

abstract：:Enterococci are robust gram-positive bacteria that are found in a variety of surroundings and that cause a significant number of healthcare-associated infections. The genus possesses a high-efficiency pheromone-responsive plasmid (PRP) transfer system for genetic exchange that allows antimicrobial-resistance determina...

journal_title：PLoS pathogens

authors： Sterling AJ,Snelling WJ,Naughton PJ,Ternan NG,Dooley JSG

更新日期：2020-04-02 00:00:00

abstract：:Translation initiation is a critical early step in the replication cycle of the positive-sense, single-stranded RNA genome of noroviruses, a major cause of gastroenteritis in humans. Norovirus RNA, which has neither a 5´ m7G cap nor an internal ribosome entry site (IRES), adopts an unusual mechanism to initiate protei...

journal_title：PLoS pathogens

authors： Leen EN,Sorgeloos F,Correia S,Chaudhry Y,Cannac F,Pastore C,Xu Y,Graham SC,Matthews SJ,Goodfellow IG,Curry S

更新日期：2016-01-06 00:00:00

abstract：:Bursaphelenchus xylophilus is the nematode responsible for a devastating epidemic of pine wilt disease in Asia and Europe, and represents a recent, independent origin of plant parasitism in nematodes, ecologically and taxonomically distinct from other nematodes for which genomic data is available. As well as being an ...

journal_title：PLoS pathogens

authors： Kikuchi T,Cotton JA,Dalzell JJ,Hasegawa K,Kanzaki N,McVeigh P,Takanashi T,Tsai IJ,Assefa SA,Cock PJ,Otto TD,Hunt M,Reid AJ,Sanchez-Flores A,Tsuchihara K,Yokoi T,Larsson MC,Miwa J,Maule AG,Sahashi N,Jones JT,Berr

更新日期：2011-09-01 00:00:00

abstract：:Intracellular Toll-like receptors (TLRs) expressed by dendritic cells recognize nucleic acids derived from pathogens and play an important role in the immune responses against the influenza virus (IAV), a single-stranded RNA sensed by different receptors including TLR7. However, the importance of TLR7 processing in th...

journal_title：PLoS pathogens

authors： Maschalidi S,Hässler S,Blanc F,Sepulveda FE,Tohme M,Chignard M,van Endert P,Si-Tahar M,Descamps D,Manoury B

更新日期：2012-01-01 00:00:00

abstract：:One of the hallmarks of adaptive immunity is the development of a long-term pathogen specific memory response. While persistent memory T cells certainly impact the immune response during a secondary challenge, their role in unrelated infections is less clear. To address this issue, we utilized lymphocytic choriomening...

journal_title：PLoS pathogens

authors： Crosby EJ,Goldschmidt MH,Wherry EJ,Scott P

更新日期：2014-02-27 00:00:00

abstract：:Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood vaccinations, but the cellular basis for this is poorly understood. Here, we investigated the effects of maternal Schistosoma mansoni infection on steady-state offspring immunity, as ...

journal_title：PLoS pathogens

authors： Cortés-Selva D,Gibbs L,Ready A,Ekiz HA,O'Connell R,Rajwa B,Fairfax KC

更新日期：2021-02-01 00:00:00

abstract：:Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide. Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of both innate and adaptive immune responses. In the present study, we demonstrate that nucleotide-binding oligomerization domain 2 (NOD2)...

journal_title：PLoS pathogens

authors： Ferwerda G,Girardin SE,Kullberg BJ,Le Bourhis L,de Jong DJ,Langenberg DM,van Crevel R,Adema GJ,Ottenhoff TH,Van der Meer JW,Netea MG

更新日期：2005-11-01 00:00:00

abstract：:Herpesviruses infect most humans. Their infections can be associated with pathological conditions and significant changes in T cell repertoire but evidences of symbiotic effects of herpesvirus latency have never been demonstrated. We tested the hypothesis that HCMV and EBV-specific CD8 T cells contribute to the hetero...

journal_title：PLoS pathogens

authors： Sandalova E,Laccabue D,Boni C,Tan AT,Fink K,Ooi EE,Chua R,Shafaeddin Schreve B,Ferrari C,Bertoletti A

更新日期：2010-08-19 00:00:00

abstract：:Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol from plasma membranes of epithel...

journal_title：PLoS pathogens

authors： Crowley JT,Toledo AM,LaRocca TJ,Coleman JL,London E,Benach JL

更新日期：2013-01-01 00:00:00

abstract：:Certain cutaneous human papillomaviruses (HPVs), which are ubiquitous and acquired early during childhood, can cause a variety of skin tumors and are likely involved in the development of non-melanoma skin cancer, especially in immunosuppressed patients. Hence, the burden of these clinical manifestations demands for a...

journal_title：PLoS pathogens

authors： Vinzón SE,Braspenning-Wesch I,Müller M,Geissler EK,Nindl I,Gröne HJ,Schäfer K,Rösl F

更新日期：2014-02-20 00:00:00

abstract：:Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little is known about its possible wider regulatory role in this organism...

journal_title：PLoS pathogens

authors： De Majumdar S,Yu J,Fookes M,McAteer SP,Llobet E,Finn S,Spence S,Monahan A,Monaghan A,Kissenpfennig A,Ingram RJ,Bengoechea J,Gally DL,Fanning S,Elborn JS,Schneiders T

更新日期：2015-01-29 00:00:00